LOCUS       NM_009497               2164 bp    mRNA    linear   ROD 14-SEP-2024
DEFINITION  Mus musculus vesicle-associated membrane protein 2 (Vamp2), mRNA.
ACCESSION   NM_009497
VERSION     NM_009497.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2164)
  AUTHORS   Liu,H., Su,P., Li,Y., Hoover,A., Hu,S., King,S.A., Zhao,J.,
            Guan,J.L., Chen,S.Y., Zhao,Y., Tan,M. and Wu,X.
  TITLE     VAMP2 controls murine epidermal differentiation and carcinogenesis
            by regulation of nucleophagy
  JOURNAL   Dev Cell 59 (15), 2005-2016 (2024)
   PUBMED   38810653
  REMARK    GeneRIF: VAMP2 controls murine epidermal differentiation and
            carcinogenesis by regulation of nucleophagy.
REFERENCE   2  (bases 1 to 2164)
  AUTHORS   Xu,H., Oses-Prieto,J.A., Khvotchev,M., Jain,S., Liang,J.,
            Burlingame,A. and Edwards,R.H.
  TITLE     Adaptor protein AP-3 produces synaptic vesicles that release at
            high frequency by recruiting phospholipid flippase ATP8A1
  JOURNAL   Nat Neurosci 26 (10), 1685-1700 (2023)
   PUBMED   37723322
REFERENCE   3  (bases 1 to 2164)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2164)
  AUTHORS   Chang,H.F., Schirra,C., Ninov,M., Hahn,U., Ravichandran,K.,
            Krause,E., Becherer,U., Balint,S., Harkiolaki,M., Urlaub,H.,
            Valitutti,S., Baldari,C.T., Dustin,M.L., Jahn,R. and Rettig,J.
  TITLE     Identification of distinct cytotoxic granules as the origin of
            supramolecular attack particles in T lymphocytes
  JOURNAL   Nat Commun 13 (1), 1029 (2022)
   PUBMED   35210420
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2164)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2164)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (bases 1 to 2164)
  AUTHORS   Yeung,R.S., Hino,O., Vilensky,M., Buetow,K., Szpirer,C.,
            Szpirer,J., Klinga-Levan,K., Levan,G. and Knudson,A.G.
  TITLE     Assignment of 22 loci in the rat by somatic hybrid and linkage
            analysis
  JOURNAL   Mamm Genome 4 (10), 585-588 (1993)
   PUBMED   8268657
REFERENCE   8  (bases 1 to 2164)
  AUTHORS   Kondo,Y., Mori,M., Kuramoto,T., Yamada,J., Beckmann,J.S.,
            Simon-Chazottes,D., Montagutelli,X., Guenet,J.L. and Serikawa,T.
  TITLE     DNA segments mapped by reciprocal use of microsatellite primers
            between mouse and rat
  JOURNAL   Mamm Genome 4 (10), 571-576 (1993)
   PUBMED   8268655
REFERENCE   9  (bases 1 to 2164)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   10 (bases 1 to 2164)
  AUTHORS   Archer,B.T. 3rd, Ozcelik,T., Jahn,R., Francke,U. and Sudhof,T.C.
  TITLE     Structures and chromosomal localizations of two human genes
            encoding synaptobrevins 1 and 2
  JOURNAL   J Biol Chem 265 (28), 17267-17273 (1990)
   PUBMED   1976629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645527.20.
            
            [WARNING] On Feb 5, 2025 this sequence was replaced by NM_009497.4.
            
            On Nov 17, 2006 this sequence version replaced NM_009497.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055105.1, AK090178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AL645527.20        5091-5190
            101-221             AL645527.20        5669-5789
            222-380             AL645527.20        6294-6452
            381-432             AL645527.20        6539-6590
            433-2164            AL645527.20        7213-8944
FEATURES             Location/Qualifiers
     source          1..2164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.36 cM"
     gene            1..2164
                     /gene="Vamp2"
                     /gene_synonym="Syb-2; Syb2; sybII; Vamp-2"
                     /note="vesicle-associated membrane protein 2"
                     /db_xref="GeneID:22318"
                     /db_xref="MGI:MGI:1313277"
     exon            1..100
                     /gene="Vamp2"
                     /gene_synonym="Syb-2; Syb2; sybII; Vamp-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..449
                     /gene="Vamp2"
                     /gene_synonym="Syb-2; Syb2; sybII; Vamp-2"
                     /note="vesicle-associated membrane 2; synaptobrevin-2;
                     synaptobrevin II"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 2"
                     /protein_id="NP_033523.1"
                     /db_xref="CCDS:CCDS24881.1"
                     /db_xref="GeneID:22318"
                     /db_xref="MGI:MGI:1313277"
                     /translation="MSATAATVPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVD
                     IMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVI
                     CAIILIIIIVYFST"
     exon            101..221
                     /gene="Vamp2"
                     /gene_synonym="Syb-2; Syb2; sybII; Vamp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..380
                     /gene="Vamp2"
                     /gene_synonym="Syb-2; Syb2; sybII; Vamp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            381..432
                     /gene="Vamp2"
                     /gene_synonym="Syb-2; Syb2; sybII; Vamp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..2164
                     /gene="Vamp2"
                     /gene_synonym="Syb-2; Syb2; sybII; Vamp-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccgggt agccagcgcc agtcggagcc agcgcgagcc gccgccgccg ccgtcgccgt
       61 cactgcctct gccaagtcca ctgcccgcta cccccgccat gtcggctacc gctgccaccg
      121 tcccgcctgc cgccccggcc ggcgagggtg gcccccctgc acctcctcca aaccttacta
      181 gtaacaggag actgcagcag acccaggccc aggtggatga ggtggtggac atcatgaggg
      241 tgaatgtgga caaggtcctg gagcgggacc agaagttgtc ggagctggat gaccgtgcag
      301 atgccctcca ggcaggggcc tcccagtttg aaacaagtgc agccaagctc aagcgcaaat
      361 actggtggaa aaacctcaag atgatgatca tcttgggagt gatctgcgcc atcatcctca
      421 tcatcatcat cgtttacttc agcacttaaa tccctgagga gtctgccctg cctaagaagg
      481 gcctctcccc cacccccagc cgttcctcca cctctcagcc atatctttca gccccctccc
      541 ttggatccgt gtgtgtgtgt gtgtccgtgt gtgtgccccc tgtaaatagc cagctgttat
      601 ttatacatat ataatattat atatatttgg tctgtttgta gttttattac tagaagattt
      661 tttccggttg tccttaacac cccttcctga ggttcccatc acctctctct caccctctgt
      721 cccttttcct ctttcctgat cagccccaag tcccttcatt tgcatctgct atgcaatagc
      781 ccctctcctc cttcccttgg atttaaccga tctttccctt atcttccctg tacaatccca
      841 ggccctccca aaacaaaagc aaaccccaca gaaacaaaca gaacacccca cctgtctagg
      901 cttccctagg ctgcatcttt gtatcccttg ggaggctctg agactggttc cacttggtcc
      961 taagaatccc aagattttct gggagcttcc aacatgttga ttagcatatc atttgcatac
     1021 gctgtctgtt tcattttgtt ttgtttgtta gttttttgtt tcctttctga tccatcactc
     1081 ttcactcttc tgtgtttttt ctttctttct tttcggaaga gtcagtctcc attggtcctc
     1141 ttaccacact tttattagca cgacattatc tgcaggtggt ggggagtctg gacttttggg
     1201 gaaccaggct gctctggacc ccaaggtttc ctcctcccaa cccctctagt ctagtttgct
     1261 tcccttaccc cgtttcccac acctcttgta ccctcctctc cctcccccag ctggtgtgta
     1321 agtgtcttgg agttcagtgt gttatgatgg accaataatt ctgccactcg gggtctctcc
     1381 ctacattcct gctccccagt tttcatgtgg ggcactcaac tgacattccc agggggtctc
     1441 gctccctccc atctgcctga tctgctgcct cctcccatca ggagaactgg gggccgacca
     1501 caatctggtt ctttgaggag gggtggctcc agtgtgtggg ggtcatcact gccttgggga
     1561 ggagtgggac aaaacagaat ccccctaatt cctgcctgaa gtctctggcc tcatccttgc
     1621 tagaggttcg actgaaaact ttcctcccca gtctgggggg ggggtattac ccccatcact
     1681 gcccagctcc tctgactgcc cccctgtatt cagggtgggg gtactagtca ctgccaatat
     1741 gtgttgggac ttgctggagg atggggatcc tcgtccttct ccagggctgt tgagcccaga
     1801 gagagagagt gtgagagaga aagcaagcta tttccttgtt gagtacaatg atagaggaag
     1861 gatctaatct ttttaaatgg cacagtttta gggatctgag ggtacagccc cttaacctgc
     1921 cttggggggg gttgttcccc aaactcttgc cccccacaca ccaggttttc tgtgtggagg
     1981 ggaaccaagg agatctaaac tgtggtgtga aagggtagga gagatgctgg gggtgggggt
     2041 gcttgtgttt tagaccccca atattatccc agtgtcccct gccttccttc ttcccctgcc
     2101 ccatgccccc aattctgtgg cgcatccaga ttgtgaaaat gtacaataaa cgtgtaatga
     2161 gtaa
//
