LOCUS       NP_033522                118 aa            linear   ROD 04-JUN-2024
DEFINITION  vesicle-associated membrane protein 1 isoform a [Mus musculus].
ACCESSION   NP_033522
VERSION     NP_033522.1
DBSOURCE    REFSEQ: accession NM_009496.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 118)
  AUTHORS   Hoogstraaten,R.I., van Keimpema,L., Toonen,R.F. and Verhage,M.
  TITLE     Tetanus insensitive VAMP2 differentially restores synaptic and
            dense core vesicle fusion in tetanus neurotoxin treated neurons
  JOURNAL   Sci Rep 10 (1), 10913 (2020)
   PUBMED   32616842
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 118)
  AUTHORS   Guo,L., Zhu,Z., Wang,G., Cui,S., Shen,M., Song,Z. and Wang,J.H.
  TITLE     microRNA-15b contributes to depression-like behavior in mice by
            affecting synaptic protein levels and function in the nucleus
            accumbens
  JOURNAL   J Biol Chem 295 (20), 6831-6848 (2020)
   PUBMED   32209659
  REMARK    GeneRIF: microRNA-15b contributes to depression-like behavior in
            mice by affecting synaptic protein levels and function in the
            nucleus accumbens.
REFERENCE   3  (residues 1 to 118)
  AUTHORS   Liu,Y., Sugiura,Y., Sudhof,T.C. and Lin,W.
  TITLE     Ablation of All Synaptobrevin vSNAREs Blocks Evoked But Not
            Spontaneous Neurotransmitter Release at Neuromuscular Synapses
  JOURNAL   J Neurosci 39 (31), 6049-6066 (2019)
   PUBMED   31160536
REFERENCE   4  (residues 1 to 118)
  AUTHORS   Vuong,C.K., Wei,W., Lee,J.A., Lin,C.H., Damianov,A., de la
            Torre-Ubieta,L., Halabi,R., Otis,K.O., Martin,K.C., O'Dell,T.J. and
            Black,D.L.
  TITLE     Rbfox1 Regulates Synaptic Transmission through the Inhibitory
            Neuron-Specific vSNARE Vamp1
  JOURNAL   Neuron 98 (1), 127-141 (2018)
   PUBMED   29621484
  REMARK    GeneRIF: Vamp1 is strongly down-regulated in Rbfox1 knock-out mice
            which contributes to regulation of synaptic transmission.
REFERENCE   5  (residues 1 to 118)
  AUTHORS   Oliveros,A., Starski,P., Lindberg,D., Choi,S., Heppelmann,C.J.,
            Dasari,S. and Choi,D.S.
  TITLE     Label-Free Neuroproteomics of the Hippocampal-Accumbal Circuit
            Reveals Deficits in Neurotransmitter and Neuropeptide Signaling in
            Mice Lacking Ethanol-Sensitive Adenosine Transporter
  JOURNAL   J Proteome Res 16 (4), 1445-1459 (2017)
   PUBMED   27998058
  REMARK    GeneRIF: These pathways are consistent with previously reported
            behavioral and biochemical phenotypes that typify mice lacking
            ENT1. Moreover, we validated decreased expression of the SNARE
            complex protein VAMP1 (synaptobrevin-1) in the dHip as well as
            decreased expression of pro-dynorphin (PDYN), neuroendocrine
            convertase (PCSK1), and Leu-Enkephalin (dynorphin-A) in the nucleus
            accumbens
REFERENCE   6  (residues 1 to 118)
  AUTHORS   Footz,T.K., Birren,B., Minoshima,S., Asakawa,S., Shimizu,N.,
            Riazi,M.A. and McDermid,H.E.
  TITLE     The gene for death agonist BID maps to the region of human 22q11.2
            duplicated in cat eye syndrome chromosomes and to mouse chromosome
            6
  JOURNAL   Genomics 51 (3), 472-475 (1998)
   PUBMED   9721221
REFERENCE   7  (residues 1 to 118)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   8  (residues 1 to 118)
  AUTHORS   Martin,S., Tellam,J., Livingstone,C., Slot,J.W., Gould,G.W. and
            James,D.E.
  TITLE     The glucose transporter (GLUT-4) and vesicle-associated membrane
            protein-2 (VAMP-2) are segregated from recycling endosomes in
            insulin-sensitive cells
  JOURNAL   J Cell Biol 134 (3), 625-635 (1996)
   PUBMED   8707843
REFERENCE   9  (residues 1 to 118)
  AUTHORS   Ivanova,N.B. and Belyavsky,A.V.
  TITLE     Identification of differentially expressed genes by restriction
            endonuclease-based gene expression fingerprinting
  JOURNAL   Nucleic Acids Res 23 (15), 2954-2958 (1995)
   PUBMED   7659517
REFERENCE   10 (residues 1 to 118)
  AUTHORS   Archer,B.T. 3rd, Ozcelik,T., Jahn,R., Francke,U. and Sudhof,T.C.
  TITLE     Structures and chromosomal localizations of two human genes
            encoding synaptobrevins 1 and 2
  JOURNAL   J Biol Chem 265 (28), 17267-17273 (1990)
   PUBMED   1976629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018783.1, BY640283.1 and BU700508.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018783.1, AK078156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..118
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.32 cM"
     Protein         1..118
                     /product="vesicle-associated membrane protein 1 isoform a"
                     /note="synaptobrevin-1"
                     /calculated_mol_wt=12759
     Region          1..36
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62442.1)"
     Region          32..94
                     /region_name="R-SNARE_VAMP2"
                     /note="SNARE motif of VAMP2; cd15870"
                     /db_xref="CDD:277223"
     Site            order(33..35,37..38,40..45,47..49,51,54..55,57..59,61..66,
                     68..73,75..80,82..87,89..91,94)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277223"
     Site            58
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277223"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q62442.1)"
     Site            68..69
                     /site_type="other"
                     /note="(Microbial infection) Cleavage, by C.botulinum
                     neurotoxin type X (BoNT/X).
                     /evidence=ECO:0000269|PubMed:28770820; propagated from
                     UniProtKB/Swiss-Prot (Q62442.1)"
     Site            97..116
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62442.1)"
     CDS             1..118
                     /gene="Vamp1"
                     /gene_synonym="lew; Syb-1; Syb1; VAMP-1"
                     /coded_by="NM_009496.3:146..502"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS20546.1"
                     /db_xref="GeneID:22317"
                     /db_xref="MGI:MGI:1313276"
ORIGIN      
        1 msapaqppae gtegaapggg ppgpppnmts nrrlqqtqaq veevvdimrv nvdkvlerdq
       61 klselddrad alqagasqfe ssaaklkrky wwknckmmim lgaicaiivv viviyfft
//
