LOCUS       NM_013840                617 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ubiquitously expressed prefoldin like chaperone (Uxt),
            transcript variant 1, mRNA.
ACCESSION   NM_013840
VERSION     NM_013840.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 617)
  AUTHORS   Pan,M., Yin,Y., Wang,X., Wang,Q., Zhang,L., Hu,H. and Wang,C.
  TITLE     Mice deficient in UXT exhibit retinitis pigmentosa-like features
            via aberrant autophagy activation
  JOURNAL   Autophagy 17 (8), 1873-1888 (2021)
   PUBMED   32744119
  REMARK    GeneRIF: Mice deficient in UXT exhibit retinitis pigmentosa-like
            features via aberrant autophagy activation.
REFERENCE   2  (bases 1 to 617)
  AUTHORS   Thomas,P.A., Schafler,E.D., Ruff,S.E., Voisin,M., Ha,S. and
            Logan,S.K.
  TITLE     UXT in Sertoli cells is required for blood-testis barrier
            integritydagger
  JOURNAL   Biol Reprod 103 (4), 880-891 (2020)
   PUBMED   32678429
  REMARK    GeneRIF: UXT in Sertoli cells is required for blood-testis barrier
            integritydagger.
REFERENCE   3  (bases 1 to 617)
  AUTHORS   Wang,Y., Schafler,E.D., Thomas,P.A., Ha,S., David,G., Adney,E.,
            Garabedian,M.J., Lee,P. and Logan,S.K.
  TITLE     Prostate-specific loss of UXT promotes cancer progression
  JOURNAL   Oncotarget 10 (7), 707-716 (2019)
   PUBMED   30774773
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 617)
  AUTHORS   Schafler,E.D., Thomas,P.A., Ha,S., Wang,Y., Bermudez-Hernandez,K.,
            Tang,Z., Fenyo,D., Vigodner,M. and Logan,S.K.
  TITLE     UXT is required for spermatogenesis in mice
  JOURNAL   PLoS One 13 (4), e0195747 (2018)
   PUBMED   29649254
  REMARK    GeneRIF: Our study has revealed the first in vivo function for UXT
            in the mammalian germline as a regulator of distinct
            transcriptional programs in SSCs and differentiating spermatogonia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 617)
  AUTHORS   Sanchez-Morgan,N., Kirsch,K.H., Trackman,P.C. and Sonenshein,G.E.
  TITLE     UXT Is a LOX-PP Interacting Protein That Modulates Estrogen
            Receptor Alpha Activity in Breast Cancer Cells
  JOURNAL   J Cell Biochem 118 (8), 2347-2356 (2017)
   PUBMED   28106301
  REMARK    GeneRIF: UXT Is a LOX-PP Interacting Protein That Modulates
            Estrogen Receptor Alpha Activity in Breast Cancer Cells.
REFERENCE   6  (bases 1 to 617)
  AUTHORS   Huang,Y., Chen,L., Zhou,Y., Liu,H., Yang,J., Liu,Z. and Wang,C.
  TITLE     UXT-V1 protects cells against TNF-induced apoptosis through
            modulating complex II formation
  JOURNAL   Mol Biol Cell 22 (8), 1389-1397 (2011)
   PUBMED   21307340
  REMARK    GeneRIF: Ubiquitously expressed transcript, UXT-V1, is a novel
            regulator of TNF-induced apoptosis. It protects cells against
            TNF-induced apoptosis through modulating complex II formation.
REFERENCE   7  (bases 1 to 617)
  AUTHORS   McGilvray,R., Walker,M. and Bartholomew,C.
  TITLE     UXT interacts with the transcriptional repressor protein EVI1 and
            suppresses cell transformation
  JOURNAL   FEBS J 274 (15), 3960-3971 (2007)
   PUBMED   17635584
REFERENCE   8  (bases 1 to 617)
  AUTHORS   Sun,S., Tang,Y., Lou,X., Zhu,L., Yang,K., Zhang,B., Shi,H. and
            Wang,C.
  TITLE     UXT is a novel and essential cofactor in the NF-kappaB
            transcriptional enhanceosome
  JOURNAL   J Cell Biol 178 (2), 231-244 (2007)
   PUBMED   17620405
  REMARK    GeneRIF: Uxt is a novel and essential cofactor in the NF-kappa B
            transcriptional enhanceosome.
REFERENCE   9  (bases 1 to 617)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 617)
  AUTHORS   Schroer,A., Schneider,S., Ropers,H. and Nothwang,H.
  TITLE     Cloning and characterization of UXT, a novel gene in human Xp11,
            which is widely and abundantly expressed in tumor tissue
  JOURNAL   Genomics 56 (3), 340-343 (1999)
   PUBMED   10087202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671853.7.
            
            On Mar 18, 2023 this sequence version replaced NM_013840.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK793338.1, CK791463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL671853.7         50719-50805         c
            88-194              AL671853.7         50465-50571         c
            195-276             AL671853.7         48723-48804         c
            277-344             AL671853.7         48520-48587         c
            345-452             AL671853.7         48143-48250         c
            453-516             AL671853.7         40993-41056         c
            517-617             AL671853.7         40708-40808         c
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.46 cM"
     gene            1..617
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /note="ubiquitously expressed prefoldin like chaperone"
                     /db_xref="GeneID:22294"
                     /db_xref="MGI:MGI:1277988"
     exon            1..87
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            88..194
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..570
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein UXT; ubiquitously expressed transcript protein"
                     /codon_start=1
                     /product="protein UXT isoform 1"
                     /protein_id="NP_038868.2"
                     /db_xref="CCDS:CCDS30049.1"
                     /db_xref="GeneID:22294"
                     /db_xref="MGI:MGI:1277988"
                     /translation="MATPPKRRALDTVGEKVLRYETFISDVLQRDLQKVLDHRDKVYE
                     QLSVYLQLRNVIERLQETNHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELT
                     LAEALKFIDRKSSLLTELSDSLTKDSMNIKAHIHMMLEGLRELQGLQNFPEPSPH"
     exon            195..276
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            277..344
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            345..452
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            453..516
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            517..617
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      593..598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      617
                     /gene="Uxt"
                     /gene_synonym="0910002B17Rik"
                     /note="major polyA site"
ORIGIN      
        1 atcatccatc cgcgccaccc ggaagccgcg gctcatacta acagttattg ccggtggccc
       61 tacggtaaac gccgtactcc tgtaccggtg cccgtcatgg cgacgccccc gaaacggcgg
      121 gccttggata cggtggggga gaaagtgctg cggtacgaga cctttatcag tgacgtactg
      181 cagcgagact tgcaaaaggt gctggatcat cgagacaagg tatatgagca gctgtccgta
      241 tatcttcaac taagaaatgt cattgagcga ctccaggaaa ctaatcactc ggagttatat
      301 atgcaggtgg atttgggctg taacttcttc gttgacacag tggtcccaga tacttcacgc
      361 atctatgtgg ccctgggata tggttttttc ctggaactga cactggctga agcactcaag
      421 ttcattgacc gaaagagttc tctcctcaca gagctcagcg acagcctcac caaggactcc
      481 atgaatatca aggcccatat ccacatgatg ctagagggac ttagagaact acaaggcctg
      541 cagaatttcc cagagccatc tccccattga ctgcatcttc ccagcctcca atattaaagc
      601 acctgaatgc cttggaa
//
