LOCUS       NM_026430               4664 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus UDP-glucuronate decarboxylase 1 (Uxs1), transcript
            variant 2, mRNA.
ACCESSION   NM_026430
VERSION     NM_026430.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4664)
  AUTHORS   Rios,J.J., Denton,K., Russell,J., Kozlitina,J., Ferreira,C.R.,
            Lewanda,A.F., Mayfield,J.E., Moresco,E., Ludwig,S., Tang,M., Li,X.,
            Lyon,S., Khanshour,A., Paria,N., Khalid,A., Li,Y., Xie,X.,
            Feng,J.Q., Xu,Q., Lu,Y., Hammer,R.E., Wise,C.A. and Beutler,B.
  TITLE     Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice
  JOURNAL   J Bone Miner Res 36 (8), 1548-1565 (2021)
   PUBMED   33905568
REFERENCE   2  (bases 1 to 4664)
  AUTHORS   Eixelsberger,T., Sykora,S., Egger,S., Brunsteiner,M.,
            Kavanagh,K.L., Oppermann,U., Brecker,L. and Nidetzky,B.
  TITLE     Structure and mechanism of human UDP-xylose synthase: evidence for
            a promoting role of sugar ring distortion in a three-step catalytic
            conversion of UDP-glucuronic acid
  JOURNAL   J Biol Chem 287 (37), 31349-31358 (2012)
   PUBMED   22810237
REFERENCE   3  (bases 1 to 4664)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 4664)
  AUTHORS   Moriarity,J.L., Hurt,K.J., Resnick,A.C., Storm,P.B., Laroy,W.,
            Schnaar,R.L. and Snyder,S.H.
  TITLE     UDP-glucuronate decarboxylase, a key enzyme in proteoglycan
            synthesis: cloning, characterization, and localization
  JOURNAL   J Biol Chem 277 (19), 16968-16975 (2002)
   PUBMED   11877387
REFERENCE   5  (bases 1 to 4664)
  AUTHORS   WALLACE,M.E.
  TITLE     Locus of the gene 'fidget' in the house mouse
  JOURNAL   Nature 166 (4218), 407 (1950)
   PUBMED   14775691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159092.11.
            
            On Feb 2, 2019 this sequence version replaced NM_026430.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037049.1, AK076166.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC159092.11        50943-51167
            226-253             AC159092.11        71405-71432
            254-302             AC159092.11        73108-73156
            303-346             AC159092.11        73386-73429
            347-407             AC159092.11        81477-81537
            408-588             AC159092.11        88138-88318
            589-693             AC159092.11        98613-98717
            694-753             AC159092.11        103906-103965
            754-875             AC159092.11        106980-107101
            876-995             AC159092.11        113773-113892
            996-1039            AC159092.11        118218-118261
            1040-1100           AC159092.11        121750-121810
            1101-1158           AC159092.11        123026-123083
            1159-1262           AC159092.11        124962-125065
            1263-4664           AC159092.11        128420-131821
FEATURES             Location/Qualifiers
     source          1..4664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.46 cM"
     gene            1..4664
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /note="UDP-glucuronate decarboxylase 1"
                     /db_xref="GeneID:67883"
                     /db_xref="MGI:MGI:1915133"
     exon            1..225
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1394
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /EC_number="4.1.1.35"
                     /note="isoform 2 is encoded by transcript variant 2;
                     UDP-glucuronic acid decarboxylase 1; UGD; UXS-1"
                     /codon_start=1
                     /product="UDP-glucuronic acid decarboxylase 1 isoform 2"
                     /protein_id="NP_080706.1"
                     /db_xref="CCDS:CCDS35551.1"
                     /db_xref="GeneID:67883"
                     /db_xref="MGI:MGI:1915133"
                     /translation="MVSKGLLRLVSSVNRRRMKLLLGIALFAYAASVWGNFVNMRSIQ
                     ENGELKIESKIEEIVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGS
                     HLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLA
                     SPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDY
                     WGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSN
                     FILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEF
                     AQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFR
                     KELEYQANNQYIPKPKPARVKKGRTRHS"
     exon            226..253
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            254..302
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            303..346
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            347..407
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            408..588
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            589..693
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..753
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            754..875
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            876..995
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1039
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1100
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1158
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1262
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..4664
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1988
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
     regulatory      2075..2080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2093
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /note="major polyA site"
     polyA_site      2333
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
     regulatory      2680..2685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2705
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
     regulatory      4638..4643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4659
                     /gene="Uxs1"
                     /gene_synonym="1600025I13Rik"
ORIGIN      
        1 gcagtggttt agccggcagg aagccgggcg cgcgggggtg gggctggtgc acgggggcgg
       61 ggctcgggcc gccgcgcatt gtgctgcggc tggccggcgc ggcaggcccc ggacccgagc
      121 ggttcccggg catggtgagc aaggggctgt tgcgccttgt ctcttcagtc aaccgcagga
      181 ggatgaagct tctgctcggc atcgcgctgt tcgcctacgc cgcctctgtt tggggcaact
      241 ttgttaacat gaggtctatc caggaaaatg gagaactaaa gatcgaaagc aagattgaag
      301 agattgttga accattaaga gagaaaatca gagatttgga aaaaagtttt acccagaaat
      361 acccgcctgt aaagttttta tcagaaaagg accggaaaag gattttgatc actggaggtg
      421 caggctttgt gggctcccat ctaactgaca aactcatgat ggatggccat gaggtgaccg
      481 tggtggacaa cttcttcaca ggcaggaaga gaaatgtgga acactggatt ggccatgaga
      541 acttcgagct gattaaccat gatgtggtcg agccgctcta catagaagtt gaccagatat
      601 atcatctggc atctccagcc tccccaccaa actacatgta caaccccatc aagacactga
      661 agactaatac aattggaaca ctaaacatgt tgggattggc aaagcgcgtg ggtgcccgtc
      721 tgctcttggc ctccacttcc gaggtatatg gagatcctga ggtccaccct caaagtgagg
      781 actactgggg ccatgtgaat cccataggac cccgagcctg ctatgatgag ggcaaacgtg
      841 ttgcagagac catgtgctat gcctacatga agcaggaagg tgtggaagta cgggtggcaa
      901 ggatcttcaa cacctttggg ccgagaatgc acatgaatga tgggcgggtg gtcagcaact
      961 tcatcttaca agcactacaa ggggagccac tcacagtcta tggctctggg tctcagacac
     1021 gggcattcca gtacgtaagt gatctggtga atggcctggt agcactgatg aacagcaatg
     1081 tcagcagtcc tgtcaacttg ggaaatccag aagaacacac aatcctggaa tttgctcagt
     1141 taattaaaaa ccttgttggt agtggaagtg aaattcagtt tctctctgaa gcccaggatg
     1201 acccacagaa aagaaaacca gacatcaaaa aagcaaaact gatgctgggg tgggaacctg
     1261 tggttccatt ggaggaagga ttgaacaaag ccatccacta cttccggaag gaattagagt
     1321 accaggctaa taaccagtac atccccaaac ccaagcccgc cagagtgaag aagggccgga
     1381 cgcgccacag ctgagttagt tagccttagg ttatgagact ctgttttacc cgtatgaggt
     1441 ggacttttgt gggatttttt tttttatttt ttaaagactt caacaggtgt catgaagaac
     1501 aaactggaat tttattctga agcttgcttt aaagacactg atgtgcctaa acgctccctt
     1561 gaaagctgca gactttgcct tgcactttta aatctgtctt tgttatgtac aacagcctag
     1621 atgcatctct gctattttca ggtttttatc ttctgttaga gtgtatgctg taactgtcat
     1681 tgacagtttt atttactggt ttctttgtga agctgaaaag aaacattaaa tggggtggaa
     1741 aatgtcaatt ttatttataa aagtgggtac ttataaatga gatgttacac tatgcataaa
     1801 gaataaaaat cctagaggta ctgtcgggtg ggtggggcac cagtgtttgt tggggacaga
     1861 tgaaaggact cagttgggaa gctttgtctt tctcttttaa ttcagagttt tctgaaggtc
     1921 tagttttcag ttgcaaactt gactttgaaa catccctgtt ggttcttgat caaagatatt
     1981 tgaaatcact actgtgttgt gctgcatatt ggggtggggg tggggggaca acgttaacat
     2041 attcttggtt aaccatggtt aaatatgcta ttttaataaa atattgaaac tcatcagaca
     2101 tgggttttga gctacaaaga ttgacatctg ctttacatca gatgtgtggt ggctgagaag
     2161 aacacttgag atcttagttt aagggaattc tgagaacatc caggtttata ccatatttaa
     2221 cttgatatgt aactgttaga accatctgtg tgctctctgg gctgaatctg tgcatatgat
     2281 acacacatgt gtatatgtct ttatctgaaa tacttaaaac caactgtttc aaatttcagg
     2341 attgattttg tttaactcgg gaatattttc ctgaactatg caatttgagc atcctcaatc
     2401 ccaaagatga agtgttctga agtctcaaat cccagtgtct cttcagcact ggggatttgg
     2461 agcttggagc ccaaattaac tgtggtgtga agttttcaga actcagcctg ggttaagttt
     2521 tgtgtcctgt agcagcacaa accaggtgga acaaaaactt ccatttttct ggtgtagaat
     2581 tcaaacaagt tttgctgagt caaacgaaaa ctttaggagt ttttattttc attaagaact
     2641 ttctcaaggt gtgtgctagg attttatttt gtaccttaaa ataaatggga ggaaaacaca
     2701 atgcacaaaa tgcagtctat ctccaaccag attagcctta catggtaaca gcagaaaccc
     2761 ttacaaatgc ccaaggaata aaggtgtgga ccaggtgata gaagtaacta gaaacaggag
     2821 cacatgtaat atctgagctt ggtctatttt tcaaaaccat gttgggctgc tttttaaaaa
     2881 aaaaataggg tgtgtgtgtg tgtatttata tttattttat gaaaggctct agaattcagg
     2941 caaagatgct ctgactctgt catgctaaat ttaccagaag attctgaaac tgaaccaaag
     3001 attgaacatg atataagaaa aaagaatcaa gaataaccta cacaaacata cacactagct
     3061 aagcacttac ttggtcacta actacacccc cagcctcttt ctcttaggcc ccgttatttt
     3121 ggtctgaact gagtgacaca tcatttacag aaaaaaaaaa aaaaaagcag aagcttgctt
     3181 ggaaattagt aatgctaaat ttggaccaaa gaaaaatgtg gacagaaata gctcagagct
     3241 ttacgtataa ttaggagtat cgaaaagtct gaagacccag aattccctta gcttattgca
     3301 cactaatatc tggaattctt tcataagatt cactcttctg gtatccatag agtattttca
     3361 aagtagtaga agagaaacag atgtgtataa cgtcctctaa gaaagtgagt aatgcattgt
     3421 agaaaacact gagttttgaa ttaagtatga tagtatctta ggcagagagg gaaatgaagc
     3481 tgagaggtag gtaggtgatg gcggctgtgg tccagcagga tctacatgta ggtacctact
     3541 ctttggtgca atagtgttac gaaagatgag gtatctgtac aaactgatga aggcagaggg
     3601 ggaccctttc tgtagttcct ggctcttgct tgctccttct attgattgct actctgagaa
     3661 agcaccatct gtgaaccaga acgtggccct tccacactcc aaaatctgtc agcactttga
     3721 tcttagactt tgtagctccc agaactataa gcaataaatc cctactgttt attaactact
     3781 gaatctataa ctttttagaa atagcaactg gaagctgcat tttggaagtg gcttcctttg
     3841 ggacgtcact gctgttgctt acaggggaga gattgctaca gtttgggctc cagcaaggta
     3901 caaaccatag actaagtgta ctggattgca gctgtggaac tgaatactga gcccagcctt
     3961 ctagtcaggt agagcttcat tgcattatct ttgattatga ccctggtggt cctcagtcat
     4021 gtgaccttga tagaagctag ggtgagtcct gtattgccat caagttttgt ctcgtaagac
     4081 tgtagggagt ttggaggttc tttagagatt cttcagaaac aagaattgcg agttaacttt
     4141 gccatgtgtc tgtcaaaata acttgcttag ttgacctagc ctttcttggt ggttggttgg
     4201 tacctttgat gagatgttag agaattctgt aattctgaaa atttgatacc acagtatcag
     4261 aaggcaaacg agactttact attttcagca ccaaggatag cccacataca tgtcttgttt
     4321 gcatcttact taccatgata gagatggggc catgttcatc tacaattaca ttataggaag
     4381 gaaaatacag atttttcatc aggaaactta agctgtggag tgggtggagc tggaatggag
     4441 cttgaaggtt catgtgacaa cattcagctc cattttttga ggtactgaga gggtggaaac
     4501 tttttcttaa gatggtgctc caaggaggtg tcatgatgtg gaacttggct cttccagcac
     4561 catgtctgcc tgtaagctac catgcttccc tccatgatga taatagactg aacctctgca
     4621 actgtaagcc agcccctatt aaatgttttc taagagttac cttg
//
