LOCUS       NM_178635               3438 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus UV radiation resistance associated gene (Uvrag), mRNA.
ACCESSION   NM_178635
VERSION     NM_178635.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3438)
  AUTHORS   Kim,M.J., Febbraro,D., Farkona,S., Gillmore,T., Son,J.E.,
            Regeenes,R., Chang,H.H., Pollock-Tahiri,E., Yang,J., Park,Y.J.,
            Sivasubramaniyam,T., Oh,S.J., Saraon,P., Stagljar,I.,
            Rocheleau,J.V., Hui,C.C., Caniggia,I., Hao,Z., Mak,T.W.,
            Konvalinka,A. and Woo,M.
  TITLE     Distinct roles of UVRAG and EGFR signaling in skeletal muscle
            homeostasis
  JOURNAL   Mol Metab 47, 101185 (2021)
   PUBMED   33561544
  REMARK    GeneRIF: Distinct roles of UVRAG and EGFR signaling in skeletal
            muscle homeostasis.
REFERENCE   2  (bases 1 to 3438)
  AUTHORS   Song,Y., Quach,C. and Liang,C.
  TITLE     UVRAG in autophagy, inflammation, and cancer
  JOURNAL   Autophagy 16 (2), 387-388 (2020)
   PUBMED   31905312
  REMARK    GeneRIF: UVRAG in autophagy, inflammation, and cancer.
REFERENCE   3  (bases 1 to 3438)
  AUTHORS   Quach,C., Song,Y., Guo,H., Li,S., Maazi,H., Fung,M., Sands,N.,
            O'Connell,D., Restrepo-Vassalli,S., Chai,B., Nemecio,D., Punj,V.,
            Akbari,O., Idos,G.E., Mumenthaler,S.M., Wu,N., Martin,S.E.,
            Hagiya,A., Hicks,J., Cui,H. and Liang,C.
  TITLE     A truncating mutation in the autophagy gene UVRAG drives
            inflammation and tumorigenesis in mice
  JOURNAL   Nat Commun 10 (1), 5681 (2019)
   PUBMED   31831743
  REMARK    GeneRIF: UVRAG is a crucial autophagy regulator in vivo, and
            autophagy promotion may help prevent/treat inflammatory disease and
            cancer in susceptible individuals.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3438)
  AUTHORS   Ferder,I.C., Fung,L., Ohguchi,Y., Zhang,X., Lassen,K.G., Capen,D.,
            Brown,D., Xavier,R.J. and Wang,N.
  TITLE     Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1
            expression during spermatogenesis in mice
  JOURNAL   PLoS Genet 15 (5), e1008084 (2019)
   PUBMED   31059511
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3438)
  AUTHORS   An,L., Hu,X.W., Zhang,S., Hu,X., Song,Z., Naz,A., Zi,Z., Wu,J.,
            Li,C., Zou,Y., He,L. and Zhu,H.
  TITLE     UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity
  JOURNAL   Sci Rep 7, 43251 (2017)
   PUBMED   28225086
  REMARK    GeneRIF: Collectively, these data suggest that UVRAG deficiency
            exacerbates doxorubicin-induced cardiotoxicity, at least in part,
            through aggravation of doxorubicin-induced impaired autophagic
            flux.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3438)
  AUTHORS   Takahashi,Y., Coppola,D., Matsushita,N., Cualing,H.D., Sun,M.,
            Sato,Y., Liang,C., Jung,J.U., Cheng,J.Q., Mule,J.J., Pledger,W.J.
            and Wang,H.G.
  TITLE     Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy
            and tumorigenesis
  JOURNAL   Nat Cell Biol 9 (10), 1142-1151 (2007)
   PUBMED   17891140
  REMARK    GeneRIF: through ultraviolet irradiation resistance-associated gene
            (UVRAG), Bif-1 interacts with Beclin 1 and functions as a positive
            mediator of the class III PI(3) kinase (PI(3)KC3).
REFERENCE   7  (bases 1 to 3438)
  AUTHORS   Ding,S., Wu,X., Li,G., Han,M., Zhuang,Y. and Xu,T.
  TITLE     Efficient transposition of the piggyBac (PB) transposon in
            mammalian cells and mice
  JOURNAL   Cell 122 (3), 473-483 (2005)
   PUBMED   16096065
REFERENCE   8  (bases 1 to 3438)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3438)
  AUTHORS   Iida,A., Emi,M., Matsuoka,R., Hiratsuka,E., Okui,K., Ohashi,H.,
            Inazawa,J., Fukushima,Y., Imai,T. and Nakamura,Y.
  TITLE     Identification of a gene disrupted by inv(11)(q13.5;q25) in a
            patient with left-right axis malformation
  JOURNAL   Hum Genet 106 (3), 277-287 (2000)
   PUBMED   10798355
REFERENCE   10 (bases 1 to 3438)
  AUTHORS   Perelman,B., Dafni,N., Naiman,T., Eli,D., Yaakov,M., Feng,T.L.,
            Sinha,S., Weber,G., Khodaei,S., Sancar,A., Dotan,I. and Canaani,D.
  TITLE     Molecular cloning of a novel human gene encoding a 63-kDa protein
            and its sublocalization within the 11q13 locus
  JOURNAL   Genomics 41 (3), 397-405 (1997)
   PUBMED   9169138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY024873.1, AK078085.1, AK030814.1 and BB530952.1.
            
            On Mar 22, 2008 this sequence version replaced NM_178635.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078085.1, AK154903.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY024873.1         22-29
            9-1682              AK078085.1         1-1674
            1683-3433           AK030814.1         1614-3364
            3434-3438           BB530952.1         334-338
FEATURES             Location/Qualifiers
     source          1..3438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.92 cM"
     gene            1..3438
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /note="UV radiation resistance associated gene"
                     /db_xref="GeneID:78610"
                     /db_xref="MGI:MGI:1925860"
     exon            1..311
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2291
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /note="UV radiation resistance-associated gene protein; UV
                     radiation resistance associated protein"
                     /codon_start=1
                     /product="UV radiation resistance-associated protein"
                     /protein_id="NP_848750.3"
                     /db_xref="CCDS:CCDS21476.1"
                     /db_xref="GeneID:78610"
                     /db_xref="MGI:MGI:1925860"
                     /translation="MSSCASLGGPVPLPPPGPSAALTSGAPARALHVELPSQQRRLRH
                     LRNIAARNIVNRNGHQLLDTYFTLHLCDNEKIFKEFYRSEVIKNSLNPTWRSLDFGIM
                     PDRLDTSVSCFVVKIWGGKEEAFQLLIEWKVYLDGLKYLGQQIHARNQNEIIFGLNDG
                     YYGAPCEHKGHPNAQKNLLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQRLGKE
                     IEEKLRLTSTSNELKKESECLRLKILVLRNELERQKKALGREVAFLHKQQMALQDKGS
                     AFSTEHGKLQLQKDSLSELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNE
                     NKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRS
                     TIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL
                     PNLKNFMEHGLMVRCDRHHISNAIPVPKRQSSTFGGADGGFSAGIPSPDKVHRKRASS
                     ENERLQYKTPPPSYNSALTQPGVAMPTSGDSERKVAPLSSSLDTSLDFSKENKKAGVD
                     LGSSVSGDHGNSDSGQEQGEALPGHLAAVNGTALPSEQAGPAGTLLPGSCHPAPSAEL
                     CCAVEQAEEIIGLEATGFTSGDQLEALSCIPVDSAVAVECDEQVLGEFEEFSRRIYAL
                     SENVSSFRRPRRSSDK"
     exon            312..429
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            430..464
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            465..626
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            627..701
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            702..784
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            785..890
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1017
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1102
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1190
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1251
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1417
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1496
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1588
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..3438
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3369..3374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /note="hexamer: AAGAAA"
     regulatory      3408..3413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /note="hexamer: AATAAA"
     polyA_site      3414
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /note="major polyA site"
     polyA_site      3434
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /note="major polyA site"
ORIGIN      
        1 gccgggtgga ggggttgcac tgcggtaata tggctcttcc ttagccagcg gcggtggcca
       61 gcgcgggcgc agagctgctg gggctctcgg tgcccggttt ctaggctgta ggggctctgc
      121 gaatcacagc tcgggaggca gcggccgatg cgggaggact gcccacctgg ccgctcggcg
      181 gctcaggggt ccagatgagc tcctgcgcct cgctcggggg cccggtgccc ctgccacccc
      241 cgggcccgtc cgccgcgctg acgtccggtg cccccgcgcg ggccctgcat gtggagctgc
      301 cgtctcagca gcggcgtctc cgacatctcc ggaacatcgc tgctcggaac attgttaata
      361 gaaatggcca tcagcttctg gatacctact tcactcttca tttgtgtgat aatgagaaaa
      421 tctttaaaga attttatagg agtgaagtga ttaagaattc cttgaatccg acgtggagga
      481 gtcttgactt tggaataatg ccggatcgtc tggatacatc tgtgtcctgc tttgtggtga
      541 agatttgggg tggaaaggaa gaggcctttc agctgttgat agagtggaaa gtctacctgg
      601 atgggctgaa gtacttggga cagcagatcc atgcccgcaa ccagaatgaa atcatttttg
      661 ggctgaatga tggctactac ggtgctccct gtgaacacaa gggtcatcca aacgcacaga
      721 agaacctcct tcaggtggac cagaactgtg ttcgcaattc ttacgatgtc ttctctttgc
      781 tgcggcttca tagagcccag tgtgcaatta aacagactca ggtaactgtt cagagacttg
      841 gaaaggaaat tgaagaaaaa ctaagactca catcgacaag caatgagctg aaaaaagaaa
      901 gtgaatgtct gcgattgaaa attttggtgc ttcgaaatga actggaaaga cagaagaaag
      961 cgctggggcg ggaggtggcc ttcctgcata agcaacagat ggctctacag gacaaaggaa
     1021 gtgcattttc cactgagcat ggcaagctcc agctgcagaa ggactccctg agtgagctga
     1081 ggaaggagtg tactgccaaa agggaactct ttctgaagac taatgctcag ttgaccatcc
     1141 gctgcaggca gctactctca gagctgtcct acatttaccc tattgatttg aatgagaaca
     1201 aggattattt tgtatgtggt gtcaagttgc ctaattccga ggacttccaa gcaaaagatg
     1261 atggaagcat tgccgtcgcc cttggttaca ctgcacattt ggtctccatg atctccttct
     1321 tcctacaagt acccctcagg tatcccataa ttcacaaggg gtccagatca acaatcaaag
     1381 ataacatcaa cgacaagctg acagaaaagg agcgagagtt tccactgtat ccaaagggag
     1441 gggagaagct gcagtttgac tatggtgtct accttctgaa caagaacata gcacagctga
     1501 gataccagca tggcctgggg actccagact tgaggcaaac tcttcctaac ctgaaaaact
     1561 tcatggagca cggactgatg gtcaggtgtg acagacatca catctccaat gccatccctg
     1621 tcccgaagag acaaagctcc acgtttgggg gtgcagatgg aggcttctct gcgggtatcc
     1681 catcaccaga taaagtccat cgcaagcggg ccagctcaga gaacgagaga ctccagtaca
     1741 aaaccccacc tcccagctac aattcagcat tgacacagcc cggggtggcc atgcccacct
     1801 cgggagactc tgagagaaag gtcgcccctc tgtcctcctc cctggacacc tccctggact
     1861 tctccaaaga aaacaagaaa gcaggagtag acctgggcag cagtgtgagc ggagaccacg
     1921 gaaactcgga ctccggccaa gagcaggggg aagccctgcc tgggcacctg gcagccgtga
     1981 atggcactgc actgcccagc gagcaggctg gccctgccgg caccctgctg ccaggctcgt
     2041 gccacccggc cccctcagct gagctctgct gtgcagtgga gcaagcagag gaaatcatcg
     2101 ggctggaagc cacaggcttc acctcgggtg accagctgga ggcgctcagc tgcatcccgg
     2161 tggacagcgc agtggcagtg gagtgtgacg agcaggtgct gggggagttt gaggagttct
     2221 ctcgcaggat ctatgccctc agcgagaacg tgtccagctt ccgccggcct cgcaggagtt
     2281 ccgacaagtg aggcaggcag gcaggcaggc aggcaggcag gcagaccgta ggaccaggga
     2341 gagccgctgc cctccctggg gccaagcttc acttcatctt tgaataattc cgacacaaat
     2401 gatgtcagtg gagcagattc ctcgtaaagg ctgactttgg gaactgaggg gactcagggt
     2461 cattgggtac cagtggggcc agttcgtgag attagctttc caggcctggc ggttgtttct
     2521 gggcaaaggt cgccctctgc ttacagctca agtcccgtta taggcatttg tctgcggttt
     2581 atttacactt ctgtgttctc ctcagaggga agatgggaat ctgtgtaaca gaaggagctc
     2641 acctttagtt tctcataagc atccgccctc tccatcattt ggaacacttt gcaaaatgga
     2701 atattcaaaa ataactttcc acccttgaga ggcctgtacc catcctttag attgagaata
     2761 agaaacagtg tgatggtctc tgttccgggc cctcggccct gagaaccata gtcagcctgc
     2821 agaccccgct gttgccctgc ttcctcaaga tgggccatgc atcctgaaag atggggcaat
     2881 aaacccacta gtccaaagcc agcaggaatg atgttctgtc tctgtctagt gtgccatacc
     2941 ctcatgaaaa attgtcctgt ggtggacccc aggggaccct aagaaacctc acgtttacca
     3001 cagtcagatg gcagccagat ttctttgggg gccaaagttt ttatgtggtc caaaattggg
     3061 cacacctctg gcaatacaca ccccagataa agacccccta gatataaatc ctgttaactt
     3121 attacttttc cgtcagaagg aagccattat acatgacaaa gcatagggag aggcaggatg
     3181 cccagtgtgc agaccacgag acagttgaga tagttgggtt aagagactag acaaagcata
     3241 gctgtgtgca acgtcacgat gttcaattat gtttctaagt ccattgtccc tgcacattca
     3301 gactccattc gctgttgcat tatacattat gtacccacag acattgcctc agggttgcaa
     3361 gctcttaaaa gaaaaattta tccacatatc catgtattgt aaagaagaat aaaagttgaa
     3421 tttacttcac atgacctg
//
