LOCUS       NP_848750                698 aa            linear   ROD 04-JUN-2024
DEFINITION  UV radiation resistance-associated protein [Mus musculus].
ACCESSION   NP_848750
VERSION     NP_848750.3
DBSOURCE    REFSEQ: accession NM_178635.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 698)
  AUTHORS   Kim,M.J., Febbraro,D., Farkona,S., Gillmore,T., Son,J.E.,
            Regeenes,R., Chang,H.H., Pollock-Tahiri,E., Yang,J., Park,Y.J.,
            Sivasubramaniyam,T., Oh,S.J., Saraon,P., Stagljar,I.,
            Rocheleau,J.V., Hui,C.C., Caniggia,I., Hao,Z., Mak,T.W.,
            Konvalinka,A. and Woo,M.
  TITLE     Distinct roles of UVRAG and EGFR signaling in skeletal muscle
            homeostasis
  JOURNAL   Mol Metab 47, 101185 (2021)
   PUBMED   33561544
  REMARK    GeneRIF: Distinct roles of UVRAG and EGFR signaling in skeletal
            muscle homeostasis.
REFERENCE   2  (residues 1 to 698)
  AUTHORS   Song,Y., Quach,C. and Liang,C.
  TITLE     UVRAG in autophagy, inflammation, and cancer
  JOURNAL   Autophagy 16 (2), 387-388 (2020)
   PUBMED   31905312
  REMARK    GeneRIF: UVRAG in autophagy, inflammation, and cancer.
REFERENCE   3  (residues 1 to 698)
  AUTHORS   Quach,C., Song,Y., Guo,H., Li,S., Maazi,H., Fung,M., Sands,N.,
            O'Connell,D., Restrepo-Vassalli,S., Chai,B., Nemecio,D., Punj,V.,
            Akbari,O., Idos,G.E., Mumenthaler,S.M., Wu,N., Martin,S.E.,
            Hagiya,A., Hicks,J., Cui,H. and Liang,C.
  TITLE     A truncating mutation in the autophagy gene UVRAG drives
            inflammation and tumorigenesis in mice
  JOURNAL   Nat Commun 10 (1), 5681 (2019)
   PUBMED   31831743
  REMARK    GeneRIF: UVRAG is a crucial autophagy regulator in vivo, and
            autophagy promotion may help prevent/treat inflammatory disease and
            cancer in susceptible individuals.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 698)
  AUTHORS   Ferder,I.C., Fung,L., Ohguchi,Y., Zhang,X., Lassen,K.G., Capen,D.,
            Brown,D., Xavier,R.J. and Wang,N.
  TITLE     Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1
            expression during spermatogenesis in mice
  JOURNAL   PLoS Genet 15 (5), e1008084 (2019)
   PUBMED   31059511
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 698)
  AUTHORS   An,L., Hu,X.W., Zhang,S., Hu,X., Song,Z., Naz,A., Zi,Z., Wu,J.,
            Li,C., Zou,Y., He,L. and Zhu,H.
  TITLE     UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity
  JOURNAL   Sci Rep 7, 43251 (2017)
   PUBMED   28225086
  REMARK    GeneRIF: Collectively, these data suggest that UVRAG deficiency
            exacerbates doxorubicin-induced cardiotoxicity, at least in part,
            through aggravation of doxorubicin-induced impaired autophagic
            flux.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 698)
  AUTHORS   Takahashi,Y., Coppola,D., Matsushita,N., Cualing,H.D., Sun,M.,
            Sato,Y., Liang,C., Jung,J.U., Cheng,J.Q., Mule,J.J., Pledger,W.J.
            and Wang,H.G.
  TITLE     Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy
            and tumorigenesis
  JOURNAL   Nat Cell Biol 9 (10), 1142-1151 (2007)
   PUBMED   17891140
  REMARK    GeneRIF: through ultraviolet irradiation resistance-associated gene
            (UVRAG), Bif-1 interacts with Beclin 1 and functions as a positive
            mediator of the class III PI(3) kinase (PI(3)KC3).
REFERENCE   7  (residues 1 to 698)
  AUTHORS   Ding,S., Wu,X., Li,G., Han,M., Zhuang,Y. and Xu,T.
  TITLE     Efficient transposition of the piggyBac (PB) transposon in
            mammalian cells and mice
  JOURNAL   Cell 122 (3), 473-483 (2005)
   PUBMED   16096065
REFERENCE   8  (residues 1 to 698)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 698)
  AUTHORS   Iida,A., Emi,M., Matsuoka,R., Hiratsuka,E., Okui,K., Ohashi,H.,
            Inazawa,J., Fukushima,Y., Imai,T. and Nakamura,Y.
  TITLE     Identification of a gene disrupted by inv(11)(q13.5;q25) in a
            patient with left-right axis malformation
  JOURNAL   Hum Genet 106 (3), 277-287 (2000)
   PUBMED   10798355
REFERENCE   10 (residues 1 to 698)
  AUTHORS   Perelman,B., Dafni,N., Naiman,T., Eli,D., Yaakov,M., Feng,T.L.,
            Sinha,S., Weber,G., Khodaei,S., Sancar,A., Dotan,I. and Canaani,D.
  TITLE     Molecular cloning of a novel human gene encoding a 63-kDa protein
            and its sublocalization within the 11q13 locus
  JOURNAL   Genomics 41 (3), 397-405 (1997)
   PUBMED   9169138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY024873.1, AK078085.1, AK030814.1 and BB530952.1.
            
            On Mar 22, 2008 this sequence version replaced NP_848750.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078085.1, AK154903.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.92 cM"
     Protein         1..698
                     /product="UV radiation resistance-associated protein"
                     /note="UV radiation resistance-associated gene protein; UV
                     radiation resistance associated protein"
                     /calculated_mol_wt=77394
     Region          1..21
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K245.2)"
     Region          39..436
                     /region_name="VPS38"
                     /note="Vacuolar protein sorting 38; pfam17649"
                     /db_xref="CDD:435943"
     Region          199..268
                     /region_name="Sufficient for interaction with STX7, VTI1B
                     AND STX8. /evidence=ECO:0000250|UniProtKB:Q9P2Y5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K245.2)"
     Region          269..441
                     /region_name="Sufficient for interaction with VPS16,
                     required for interaction with CEP63.
                     /evidence=ECO:0000250|UniProtKB:Q9P2Y5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K245.2)"
     Region          442..698
                     /region_name="Required for interaction with PRKDC, XRCC6
                     and XRCC5. /evidence=ECO:0000250|UniProtKB:Q9P2Y5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K245.2)"
     Region          477..551
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K245.2)"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2Y5; propagated from
                     UniProtKB/Swiss-Prot (Q8K245.2)"
     Site            497
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000250|UniProtKB:Q9P2Y5; propagated from
                     UniProtKB/Swiss-Prot (Q8K245.2)"
     Site            507
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2Y5; propagated from
                     UniProtKB/Swiss-Prot (Q8K245.2)"
     Site            517
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2Y5; propagated from
                     UniProtKB/Swiss-Prot (Q8K245.2)"
     Site            521
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2Y5; propagated from
                     UniProtKB/Swiss-Prot (Q8K245.2)"
     Site            548
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2Y5; propagated from
                     UniProtKB/Swiss-Prot (Q8K245.2)"
     Site            549
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2Y5; propagated from
                     UniProtKB/Swiss-Prot (Q8K245.2)"
     Region          565..586
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K245.2)"
     Site            570
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2Y5; propagated from
                     UniProtKB/Swiss-Prot (Q8K245.2)"
     Site            688
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K245.2)"
     CDS             1..698
                     /gene="Uvrag"
                     /gene_synonym="9530039D02Rik; Uvrag1; Uvragl"
                     /coded_by="NM_178635.3:195..2291"
                     /db_xref="CCDS:CCDS21476.1"
                     /db_xref="GeneID:78610"
                     /db_xref="MGI:MGI:1925860"
ORIGIN      
        1 msscaslggp vplpppgpsa altsgapara lhvelpsqqr rlrhlrniaa rnivnrnghq
       61 lldtyftlhl cdnekifkef yrseviknsl nptwrsldfg impdrldtsv scfvvkiwgg
      121 keeafqllie wkvyldglky lgqqiharnq neiifglndg yygapcehkg hpnaqknllq
      181 vdqncvrnsy dvfsllrlhr aqcaikqtqv tvqrlgkeie eklrltstsn elkkeseclr
      241 lkilvlrnel erqkkalgre vaflhkqqma lqdkgsafst ehgklqlqkd slselrkect
      301 akrelflktn aqltircrql lselsyiypi dlnenkdyfv cgvklpnsed fqakddgsia
      361 valgytahlv smisfflqvp lrypiihkgs rstikdnind kltekerefp lypkggeklq
      421 fdygvyllnk niaqlryqhg lgtpdlrqtl pnlknfmehg lmvrcdrhhi snaipvpkrq
      481 sstfggadgg fsagipspdk vhrkrassen erlqyktppp synsaltqpg vamptsgdse
      541 rkvaplsssl dtsldfsken kkagvdlgss vsgdhgnsds gqeqgealpg hlaavngtal
      601 pseqagpagt llpgschpap saelccaveq aeeiigleat gftsgdqlea lscipvdsav
      661 avecdeqvlg efeefsrriy alsenvssfr rprrssdk
//
