LOCUS       NM_198166                851 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus urotensin 2B (Uts2b), mRNA.
ACCESSION   NM_198166 XM_148671
VERSION     NM_198166.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 851)
  AUTHORS   Hata,K., Wakamori,K., Hirakawa-Yamamura,A., Ichiyama-Kobayashi,S.,
            Yamaguchi,M., Okuzaki,D., Takahata,Y., Murakami,T., Uzawa,N.,
            Yamashiro,T. and Nishimura,R.
  TITLE     Serinc5 Regulates Sequential Chondrocyte Differentiation by
            Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes
  JOURNAL   J Cell Physiol 240 (1), e31490 (2025)
   PUBMED   39568258
REFERENCE   2  (bases 1 to 851)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 851)
  AUTHORS   Yoshioka,Y., Tachibana,Y., Uesaka,T., Hioki,H., Sato,Y.,
            Fukumoto,T. and Enomoto,H.
  TITLE     Uts2b is a microbiota-regulated gene expressed in vagal afferent
            neurons connected to enteroendocrine cells producing
            cholecystokinin
  JOURNAL   Biochem Biophys Res Commun 608, 66-72 (2022)
   PUBMED   35390674
  REMARK    GeneRIF: Uts2b is a microbiota-regulated gene expressed in vagal
            afferent neurons connected to enteroendocrine cells producing
            cholecystokinin.
REFERENCE   4  (bases 1 to 851)
  AUTHORS   Sawai,A., Pfennig,S., Bulajic,M., Miller,A., Khodadadi-Jamayran,A.,
            Mazzoni,E.O. and Dasen,J.S.
  TITLE     PRC1 sustains the integrity of neural fate in the absence of PRC2
            function
  JOURNAL   Elife 11, e72769 (2022)
   PUBMED   34994686
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 851)
  AUTHORS   Bai,L., Mesgarzadeh,S., Ramesh,K.S., Huey,E.L., Liu,Y., Gray,L.A.,
            Aitken,T.J., Chen,Y., Beutler,L.R., Ahn,J.S., Madisen,L., Zeng,H.,
            Krasnow,M.A. and Knight,Z.A.
  TITLE     Genetic Identification of Vagal Sensory Neurons That Control
            Feeding
  JOURNAL   Cell 179 (5), 1129-1143 (2019)
   PUBMED   31730854
REFERENCE   6  (bases 1 to 851)
  AUTHORS   Dykes,I.M., van Bueren,K.L., Ashmore,R.J., Floss,T., Wurst,W.,
            Szumska,D., Bhattacharya,S. and Scambler,P.J.
  TITLE     HIC2 is a novel dosage-dependent regulator of cardiac development
            located within the distal 22q11 deletion syndrome region
  JOURNAL   Circ Res 115 (1), 23-31 (2014)
   PUBMED   24748541
REFERENCE   7  (bases 1 to 851)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 851)
  AUTHORS   Singh,S., Robinson,M., Ismail,I., Saha,M., Auer,H., Kornacker,K.,
            Robinson,M.L., Bates,C.M. and McHugh,K.M.
  TITLE     Transcriptional profiling of the megabladder mouse: a unique model
            of bladder dysmorphogenesis
  JOURNAL   Dev Dyn 237 (1), 170-186 (2008)
   PUBMED   18069694
REFERENCE   9  (bases 1 to 851)
  AUTHORS   Egginger,J.G. and Calas,A.
  TITLE     A novel hypothalamic neuroendocrine peptide: URP
            (urotensin-II-related peptide)?
  JOURNAL   C R Biol 328 (8), 724-731 (2005)
   PUBMED   16125650
  REMARK    GeneRIF: novel hypothalamic neuroendocrine peptide co-localized and
            possible co-released with gonadotropin releasing hormone
REFERENCE   10 (bases 1 to 851)
  AUTHORS   Sugo,T., Murakami,Y., Shimomura,Y., Harada,M., Abe,M.,
            Ishibashi,Y., Kitada,C., Miyajima,N., Suzuki,N., Mori,M. and
            Fujino,M.
  TITLE     Identification of urotensin II-related peptide as the urotensin
            II-immunoreactive molecule in the rat brain
  JOURNAL   Biochem Biophys Res Commun 310 (3), 860-868 (2003)
   PUBMED   14550283
  REMARK    GeneRIF: URP is the endogenous and functional ligand for UII
            receptor in the mouse
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB611261.1, AB116020.1, AV144685.2 and AW490879.1.
            
            On Mar 24, 2005 this sequence version replaced NM_198166.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO039816.1, BB611261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BB611261.1         2-54
            54-451              AB116020.1         1-398
            452-829             AV144685.2         466-843
            830-851             AW490879.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.93 cM"
     gene            1..851
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /note="urotensin 2B"
                     /db_xref="GeneID:224065"
                     /db_xref="MGI:MGI:2677064"
     exon            1..203
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..445
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /note="urotensin II-related peptide; urotensin IIB; UIIB;
                     U-IIB; urotensin-2 domain-containing protein"
                     /codon_start=1
                     /product="urotensin-2B precursor"
                     /protein_id="NP_937809.1"
                     /db_xref="CCDS:CCDS28091.1"
                     /db_xref="GeneID:224065"
                     /db_xref="MGI:MGI:2677064"
                     /translation="MKVFSTSLWCGLLTLLSVMNLFKSVRGRPHLSSGHELFPAKEHA
                     AQEKLTRNPGLQRPFHAGGDLPSKLEELRQVKKLRDWIMEAKNTGLSNALDNLSSSHT
                     KKRACFWKYCV"
     exon            204..287
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
     exon            288..325
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
     exon            326..419
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
     exon            420..835
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      775..780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /note="hexamer: AATAAA"
     polyA_site      797
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /note="major polyA site"
     regulatory      812..817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /note="hexamer: AATAAA"
     polyA_site      835
                     /gene="Uts2b"
                     /gene_synonym="Gm538; U2B; Urp; Uts2d"
                     /note="major polyA site"
ORIGIN      
        1 aggcaggctc gctcgttcag gggcattcca cggacggcca ttgaagtatc tgacttgact
       61 tgaaaatttg gtttctctgt taggacagga agagattttt aacatgaagg tcttttcaac
      121 ctctctctgg tgtggactcc tgactttgtt gtctgtaatg aaccttttca aatctgtgcg
      181 tggacggcca catctgagct caggacatga gttgtttcca gctaaagaac atgcagctca
      241 agagaagttg acccgaaatc ctggtttaca gaggcccttc cacgctggtg gagatcttcc
      301 cagcaaactg gaagaactta gacaggtaaa gaagttgaga gactggatta tggaagcaaa
      361 gaacactggg ctgtccaatg ctttagacaa tttatcttct tctcacacta aaaaacgagc
      421 ttgtttttgg aagtactgtg tctgagatat ttctgaatag acagaagaga agaaaactag
      481 aaaaattaca tatatatgta atgcatatat acataatatg catattaaag tttacttctg
      541 tttcaagctc taagaaactg gcccttgttc tgcacatcat ttttctcact ttgtgaacct
      601 gctcctccct gggttacggc ttacttaatg ctcattcagt gaacaattgc actggctgca
      661 ctctggaatg gaactgtcat caaaatggct ttagtgataa aacttggggg attgagctgt
      721 tgtatgcttt catgaagtcc attgtcctct ctcaatgttt tgtttttggc tgtcaataaa
      781 aaatatttta aaaggcatct tagaaagtta aaataaattg cattgtttca actcaaaaaa
      841 aaaaaaaaaa a
//
