LOCUS       NM_011910                538 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus urotensin 2 (Uts2), mRNA.
ACCESSION   NM_011910
VERSION     NM_011910.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 538)
  AUTHORS   Pan,Y., Zhou,T., Dong,X., Wu,L., Wang,P., Wang,S. and Zhang,A.
  TITLE     Urotensin II can Induce Skeletal Muscle Atrophy Associated with
            Upregulating Ubiquitin-Proteasome System and Inhibiting the
            Differentiation of Satellite Cells in CRF Mice
  JOURNAL   Calcif Tissue Int 112 (5), 603-612 (2023)
   PUBMED   36892588
  REMARK    GeneRIF: Urotensin II can Induce Skeletal Muscle Atrophy Associated
            with Upregulating Ubiquitin-Proteasome System and Inhibiting the
            Differentiation of Satellite Cells in CRF Mice.
REFERENCE   2  (bases 1 to 538)
  AUTHORS   Pan,Y.J., Zhou,S.J., Feng,J., Bai,Q., A,L.T. and Zhang,A.H.
  TITLE     Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with
            Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type
            III Domain Containing 5) Expression in Chronic Renal Failure
  JOURNAL   Kidney Blood Press Res 44 (4), 479-495 (2019)
   PUBMED   31238319
  REMARK    GeneRIF: UII induces mice skeletal muscle atrophy associated with
            enhanced skeletal muscle autophagy and inhibited FNDC5 expression
            in chronic renal failure.
REFERENCE   3  (bases 1 to 538)
  AUTHORS   Ugan,R.A., Cadirci,E., Halici,Z., Toktay,E. and Cinar,I.
  TITLE     The role of urotensin-II and its receptors in sepsis-induced lung
            injury under diabetic conditions
  JOURNAL   Eur J Pharmacol 818, 457-469 (2018)
   PUBMED   29133126
  REMARK    GeneRIF: role of urotensin-II and its receptors in sepsis-induced
            lung injury under diabetic conditions
REFERENCE   4  (bases 1 to 538)
  AUTHORS   Liu,L.M., Tu,W.J., Zhu,T., Wang,X.T., Tan,Z.L., Zhong,H., Gao,D.Y.
            and Liang,D.Y.
  TITLE     IRF3 is an important molecule in the UII/UT system and mediates
            immune inflammatory injury in acute liver failure
  JOURNAL   Oncotarget 7 (31), 49027-49041 (2016)
   PUBMED   27448985
  REMARK    GeneRIF: IRF3 expression and activation depend on the signal
            transduction of the the urotensin II/urotensin receptor (UII/UT)
            system, and play important roles in UII/UT-mediated immune
            inflammatory injury in the liver
REFERENCE   5  (bases 1 to 538)
  AUTHORS   Liu,L.M., Zhao,L., Liang,D.Y., Yu,F.P., Ye,C.G., Tu,W.J. and Zhu,T.
  TITLE     Effects of urotensin-II on cytokines in early acute liver failure
            in mice
  JOURNAL   World J Gastroenterol 21 (11), 3239-3244 (2015)
   PUBMED   25805930
  REMARK    GeneRIF: Urotensin II plays a role in the pathogenesis and priming
            of acute liver failure by triggering an inflammatory cascade and
            driving the early release of TNF-alpha and Il1beta.
REFERENCE   6  (bases 1 to 538)
  AUTHORS   Shiraishi,Y., Watanabe,T., Suguro,T., Nagashima,M., Kato,R.,
            Hongo,S., Itabe,H., Miyazaki,A., Hirano,T. and Adachi,M.
  TITLE     Chronic urotensin II infusion enhances macrophage foam cell
            formation and atherosclerosis in apolipoprotein E-knockout mice
  JOURNAL   J Hypertens 26 (10), 1955-1965 (2008)
   PUBMED   18806619
  REMARK    GeneRIF: increased plasma urotensin II level stimulates oxidized
            low-density lipoprotein and reactive oxygen species production and
            macrophage foam cell formation
REFERENCE   7  (bases 1 to 538)
  AUTHORS   Dubessy,C., Cartier,D., Lectez,B., Bucharles,C., Chartrel,N.,
            Montero-Hadjadje,M., Bizet,P., Chatenet,D., Tostivint,H.,
            Scalbert,E., Leprince,J., Vaudry,H., Jegou,S. and Lihrmann,I.
  TITLE     Characterization of urotensin II, distribution of urotensin II,
            urotensin II-related peptide and UT receptor mRNAs in mouse:
            evidence of urotensin II at the neuromuscular junction
  JOURNAL   J Neurochem 107 (2), 361-374 (2008)
   PUBMED   18710417
  REMARK    GeneRIF: In the CNS UII mRNAs are expressed in brainstem and spinal
            motoneurons, also expressed in the medial vestibular nucleus, locus
            coeruleus and the ventral medulla.
REFERENCE   8  (bases 1 to 538)
  AUTHORS   Egginger,J.G., Camus,A. and Calas,A.
  TITLE     Urotensin-II expression in the mouse spinal cord
  JOURNAL   J Chem Neuroanat 31 (2), 146-154 (2006)
   PUBMED   16361078
  REMARK    GeneRIF: mouse UII is expressed in a subpopulation of motoneurons
            in the spinal cord
REFERENCE   9  (bases 1 to 538)
  AUTHORS   Do-Rego,J.C., Chatenet,D., Orta,M.H., Naudin,B., Le Cudennec,C.,
            Leprince,J., Scalbert,E., Vaudry,H. and Costentin,J.
  TITLE     Behavioral effects of urotensin-II centrally administered in mice
  JOURNAL   Psychopharmacology (Berl) 183 (1), 103-117 (2005)
   PUBMED   16160878
  REMARK    GeneRIF: 17 amino acid seq and effects on body temperature, water
            and food consumption, locomotion, exploratory behavior, etc.
REFERENCE   10 (bases 1 to 538)
  AUTHORS   Coulouarn,Y., Jegou,S., Tostivint,H., Vaudry,H. and Lihrmann,I.
  TITLE     Cloning, sequence analysis and tissue distribution of the mouse and
            rat urotensin II precursors
  JOURNAL   FEBS Lett 457 (1), 28-32 (1999)
   PUBMED   10486557
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL607143.14 and BC107299.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_011910.3.
            
            On Jul 29, 2009 this sequence version replaced NM_011910.1.
            
            Summary: This gene encodes a member of the urotensin family of
            peptide hormones. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, functional hormone before
            secretion into the plasma. Mice lacking the encoded protein have a
            significantly decreased low density lipoprotein cholesterol profile
            and hepatic steatosis that is consistent with decreased hepatocyte
            de novo cholesterol synthesis and apolipoprotein B secretion.
            [provided by RefSeq, Sep 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF172175.1, BC107299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL607143.14        76002-76013
            13-470              BC107299.1         1-458
            471-538             AL607143.14        80648-80715
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 81.53 cM"
     gene            1..538
                     /gene="Uts2"
                     /gene_synonym="prepro-UII; Ucn2; UII"
                     /note="urotensin 2"
                     /db_xref="GeneID:24111"
                     /db_xref="MGI:MGI:1346329"
     exon            1..139
                     /gene="Uts2"
                     /gene_synonym="prepro-UII; Ucn2; UII"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..408
                     /gene="Uts2"
                     /gene_synonym="prepro-UII; Ucn2; UII"
                     /note="urotensin-II"
                     /codon_start=1
                     /product="urotensin-2 preproprotein"
                     /protein_id="NP_036040.1"
                     /db_xref="CCDS:CCDS18977.1"
                     /db_xref="GeneID:24111"
                     /db_xref="MGI:MGI:1346329"
                     /translation="MDRVPFCCLLFIGLLNPLLSLPVTDTGERTLQLPVLEEDALRAL
                     EELERMALLQTLRQTMGTEAGESPGEAGPSTETPTPRGSMRKAFAGQNSNTVLSRLLA
                     RTRKQHKQHGAAPECFWKYCI"
     exon            140..250
                     /gene="Uts2"
                     /gene_synonym="prepro-UII; Ucn2; UII"
                     /inference="alignment:Splign:2.1.0"
     exon            251..294
                     /gene="Uts2"
                     /gene_synonym="prepro-UII; Ucn2; UII"
                     /inference="alignment:Splign:2.1.0"
     exon            295..538
                     /gene="Uts2"
                     /gene_synonym="prepro-UII; Ucn2; UII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagagcaga cgcccagacg gacttctcgc cgcatcatgg acagggtgcc cttctgctgc
       61 ctgctcttca taggacttct gaatccactg ctgtcccttc ccgtcacgga cactggtgag
      121 aggactcttc agcttccagt gcttgaggaa gacgctcttc gggctctgga ggagctggag
      181 aggatggccc tcctgcagac cctgcgtcag accatgggca cggaagcagg ggagagccct
      241 ggagaagcag gtcccagcac tgagactccc actccacggg gaagcatgag gaaggctttc
      301 gctgggcaaa attctaacac tgtactgagt cgtctcttgg caagaaccag gaaacaacat
      361 aagcaacacg gggctgcccc agagtgcttc tggaaatact gcatttgagg agacacaagc
      421 gcccgttggt ctctcagaac cattgcttca ggaaacgggc agagcagatg cttgaagcaa
      481 aatcacgcta acgacgcctt gttcttcatt atgagaaata aatcctctat gtttctca
//
