LOCUS       NM_144826               3871 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UTP6 small subunit processome component (Utp6), mRNA.
ACCESSION   NM_144826
VERSION     NM_144826.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3871)
  AUTHORS   Venturin,M., Carra,S., Gaudenzi,G., Brunelli,S., Gallo,G.R.,
            Moncini,S., Cotelli,F. and Riva,P.
  TITLE     ADAP2 in heart development: a candidate gene for the occurrence of
            cardiovascular malformations in NF1 microdeletion syndrome
  JOURNAL   J Med Genet 51 (7), 436-443 (2014)
   PUBMED   24711647
REFERENCE   3  (bases 1 to 3871)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 3871)
  AUTHORS   Piddubnyak,V., Rigou,P., Michel,L., Rain,J.C., Geneste,O.,
            Wolkenstein,P., Vidaud,D., Hickman,J.A., Mauviel,A. and Poyet,J.L.
  TITLE     Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting
            protein, and its putative role in the physiopathology of NF1
            microdeletion syndrome patients
  JOURNAL   Cell Death Differ 14 (6), 1222-1233 (2007)
   PUBMED   17380155
  REMARK    GeneRIF: Results suggest that reduced expression of HCA66, owing to
            haploinsufficiency of HCA66 gene, could render NF1 microdeleted
            patients-derived cells less susceptible to apoptosis.
REFERENCE   5  (bases 1 to 3871)
  AUTHORS   Venturin,M., Bentivegna,A., Moroni,R., Larizza,L. and Riva,P.
  TITLE     Evidence by expression analysis of candidate genes for congenital
            heart defects in the NF1 microdeletion interval
  JOURNAL   Ann Hum Genet 69 (Pt 5), 508-516 (2005)
   PUBMED   16138909
REFERENCE   6  (bases 1 to 3871)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   7  (bases 1 to 3871)
  AUTHORS   Jenne,D.E., Tinschert,S., Dorschner,M.O., Hameister,H., Stephens,K.
            and Kehrer-Sawatzki,H.
  TITLE     Complete physical map and gene content of the human NF1 tumor
            suppressor region in human and mouse
  JOURNAL   Genes Chromosomes Cancer 37 (2), 111-120 (2003)
   PUBMED   12696059
REFERENCE   8  (bases 1 to 3871)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK029151.1.
            
            On Apr 5, 2007 this sequence version replaced NM_144826.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029151.1, SRR1660821.122685.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3871              AK029151.1         2-3872
FEATURES             Location/Qualifiers
     source          1..3871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 47.29 cM"
     gene            1..3871
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /note="UTP6 small subunit processome component"
                     /db_xref="GeneID:216987"
                     /db_xref="MGI:MGI:2445193"
     exon            1..170
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1872
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /note="hepatocellular carcinoma-associated antigen 66;
                     multiple hat domains protein; UTP6, small subunit (SSU)
                     processome component, homolog"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein 6
                     homolog"
                     /protein_id="NP_659075.1"
                     /db_xref="CCDS:CCDS25124.1"
                     /db_xref="GeneID:216987"
                     /db_xref="MGI:MGI:2445193"
                     /translation="MAEIIQERIEDRIPELEQLERIGLFSHAEIKAIIKKASDLEYKI
                     HRRTLLKEDFINYVQYEINLLELIQRRRARIKYSFKKDEIEYSMVHRVQGVFGRASAK
                     WKDDVQLWLSYIVFCKKWGTKTHLSKIFSAMLAIHSNKPALWIMAAKWEMEDRLSSES
                     ARQLFLRALRFHPECPKLYQEYFRMELMHAEKLRKEKQEFEKAAMDMGDFDHPEEILK
                     GELARIIYKNSISKIKGAEFHVSLLAIAQLFDFAKDLQKEIYDDLQALHTDDPLTWDY
                     VARRELEIESQPGEEQPVSKQAKAVEMGRREERCCAVYEEAVKALPTEAMWKCYITFC
                     LERFSKKTSSVPLRGQRLERTMLAFRKAHELKLLSEVQYKQWIDLLLRQDLFKEALQV
                     AEAGTELFKDSVTMWQTKLQVLIDSKSPDVEMRFEEAFAHLKPQVCLPLWISWAEWSE
                     SAKSQEDTEAIFKKAIIAVTGASSVTLKEKYLDWAYRSGGYKKARAVFKSLQESRPFS
                     VEFFRKMMQFEKEQEPCKMVNLREYYERALREFGTSDSDLWMDYIKEELNHPFGKPEN
                     CGQIYWRAMKMLQGQSAELFVAKHAMHQAGH"
     exon            171..255
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            256..297
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            298..390
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            391..438
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            439..502
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            503..621
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            622..699
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            700..781
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            782..863
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1048
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1128
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1206
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1386
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1467
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1577
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1644
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1717
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..3871
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2052..2057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /note="hexamer: AATACA"
     polyA_site      2071
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /note="major polyA site"
     regulatory      3005..3010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
                     /note="hexamer: AATAAA"
     polyA_site      3028
                     /gene="Utp6"
                     /gene_synonym="4732497O03Rik; HCA66"
ORIGIN      
        1 aatcactaag agtgaggctg aaaggtggct gttctctacg cttatcggcc gcccggctgc
       61 ttgtgaagtt ccagcctcat ggcggagata attcaggaac gtatagaaga tcgaatcccg
      121 gagttggaac agctggagcg catcggactc ttcagtcacg cggagattaa ggctatcatc
      181 aagaaggctt ccgacctaga atacaaaata catcggagaa cccttctcaa ggaagacttt
      241 atcaactatg ttcaatatga aattaatctt ttggagctga tccagagaag aagagcaaga
      301 attaaatatt catttaagaa ggatgagatt gaatattcta tggtacatcg ggtccagggt
      361 gtctttggtc gtgcttcagc gaagtggaaa gatgatgttc agctctggct ctcctatata
      421 gttttctgta agaaatgggg caccaaaact caccttagca agatattctc tgccatgctt
      481 gccattcact caaacaagcc agctttgtgg atcatggcag ccaaatggga aatggaagac
      541 cgcttgtctt cagaaagtgc caggcagtta tttcttcgag ctctacgctt tcatcccgag
      601 tgtccaaagc tctatcaaga atactttagg atggagctga tgcatgctga gaaactgaga
      661 aaggagaagc aagaatttga aaaagccgcc atggacatgg gggattttga tcatcctgaa
      721 gaaatcctta aaggcgagtt ggcacggatc atttataaaa attctataag caagattaaa
      781 ggtgcagaat tccatgtgtc acttcttgct attgctcagc tatttgattt tgccaaagat
      841 ctacagaagg aaatttatga tgaccttcaa gctctgcaca ccgatgaccc actcacttgg
      901 gattatgtgg cgcggcgaga attagagatc gagtcccaac caggtgaaga acagcctgtg
      961 tcgaaacaag ccaaagcagt ggaaatgggc cgaagggaag agaggtgctg cgcggtgtat
     1021 gaggaggcag tgaaggccct gcctacagag gccatgtgga agtgttacat caccttttgc
     1081 ttggagaggt tttctaagaa gaccagtagt gtgcccctca gagggcagag gctggaaaga
     1141 accatgcttg cattcaggaa ggcccatgaa ctgaagctgc tttctgaagt ccagtacaag
     1201 cagtggattg acttgttgct gcgccaggac ctcttcaaag aagcactgca ggtggcagag
     1261 gctgggaccg aattgttcaa ggactctgta acaatgtggc agacgaagct ccaggtgctc
     1321 attgactcaa agagcccgga tgtagagatg cgctttgagg aagcctttgc acacctcaaa
     1381 ccccaggttt gtctgccctt gtggatttct tgggcagagt ggagtgaaag tgctaaaagc
     1441 caggaggaca cggaagccat ctttaagaaa gctattatag ctgtcacagg tgccagttca
     1501 gtaactctga aggagaaata cctggattgg gcctatcgga gtggaggcta caaaaaggcc
     1561 agagcagtgt ttaaaagttt acaggaaagc cgtccatttt cggttgagtt tttcaggaaa
     1621 atgatgcagt ttgaaaagga gcaggaaccc tgcaagatgg taaacctgag ggagtattac
     1681 gagagggcgc tgagagagtt tgggacttca gattctgatc tttggatgga ttacatcaag
     1741 gaagaattga accatccctt cggtaaacct gagaactgcg gacagatcta ttggcgagcc
     1801 atgaaaatgt tgcagggaca gtcagcagag ctgtttgtag ctaaacacgc catgcaccag
     1861 gctggccact agtggtcgag caccaccagt tggctgaagt tgtgatgcaa gtctcggggc
     1921 aggtttgtga tgagctggtg tgtgaattgt cgagagctgg cagaagaacg gattgatttt
     1981 tgtaacatac ttttacttgg tgttaatctt tggttccaga aatgagtact gctagtgcct
     2041 gttaaatcta aaatacacag aaatcatatg attcagcttc aattcttgtt ccaggctaag
     2101 catatacagc tctaatctag actaggtgtg agggacccag ttcaaaccca agagaaagta
     2161 tagttttgtg tgttctcttc ttgttgtgaa agcctgcatg atacctgtgg agataggagg
     2221 gacgagggtg tggatggact gcctcaaccc tccagctccc gaatactgat taagagactt
     2281 tatttatgaa agcttagtcc ttatggctta gccatgttta ccacctggct gatcacctct
     2341 cctcagcccc gtacattcaa gttccaagtc tggccggcag atctcccacc tctcaattct
     2401 tcccagagtt ccgatctctt cttggatgtc ccacctttac tctcctgccc agccatcagc
     2461 tgtttatcaa acaaatcaga agtgatagag gagaatgtgt acaatcttcg atgcaggtga
     2521 tgcttcataa aaataacagt accaaagtcc ggacagtact ctactggttc aaaaatcaac
     2581 actgaatact acaaagacag cctttacagt gcccaagatt atcccaacac tagggcagag
     2641 cagagcagaa agtcacttag atcaccgaag tgaggctgaa cagtgacttc ttttcctgta
     2701 tctgaattgg atctgtactt ttaaatcaat cattcaagaa atagcgcctt ccttcacctg
     2761 caggaaaaag ggagacttgg aagatgagtg acagagaagg aggcgctggg tattgggaga
     2821 agtttgtctt ttaagaaggt tgaggtggca caggaaacga tttaccccaa ggatggacag
     2881 gccaagaatg gcatggagga tgcccagctt tgtggcgggg gagggagtgg gaagtgcctc
     2941 agtagggggt ggaggggcag attggcacaa aggagggcat ttggggagta agggaggaag
     3001 ctgaaataaa tcctttcatt ttttttgata ctgggtattt gtttgtttgt gataaaccta
     3061 aatttgcatt tgaggcaaga gctttaccac tgagacagac cccaggcatc tttttatttt
     3121 ctgttttgag caggtctcac taagttttgg ctggcctgaa aagttctcag gtctaggcag
     3181 gccttgaact ttgaatgctc ttgcctcagc ctctcaagtg gctgaggtta caggcctcaa
     3241 cagctggacc ttaacatttt gatatcattg ggaaagtatt ttgaacaagt tacttaatag
     3301 taagccttaa ttaatattaa gttcatttaa taacatggaa aacacctaat gaattcatag
     3361 cattcccttg tcttaattaa tctcctgtgg ctatagtttt ttaaaagtat aaacgatatt
     3421 ggtgaagatt cttgtcaatc tttggttaca ttcactggca cttccttagg ggacttactt
     3481 gacagtggaa ttactgaatt aggtaaaaga acaaaatttg ccaatttgct ctttccagca
     3541 tcacatgcag gaggcaacgc ccttgtctgc actggggatt acgtacttcc ttttcatcat
     3601 tttataattc accactcagt agatgaaagc ggtacatcat cacttaagct actttttctt
     3661 attaattttt gtcttaaaaa tacattgaga gagccagggg agatggctca gcggttaaga
     3721 ctgactgctc ttccagatgt cccaagttca attcccagca accacatggt ggctcacaac
     3781 catctgtaat gggatccgat atcctcttct ggtgtgtctg aagacagtgt agtcatagac
     3841 ataaaatgaa taaataaatc tttaaaaaaa c
//
