LOCUS       NM_011574               2255 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UTP4 small subunit processome component (Utp4),
            transcript variant 1, mRNA.
ACCESSION   NM_011574
VERSION     NM_011574.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2255)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2255)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2255)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   4  (bases 1 to 2255)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (bases 1 to 2255)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (bases 1 to 2255)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2255)
  AUTHORS   Chagnon,P., Michaud,J., Mitchell,G., Mercier,J., Marion,J.F.,
            Drouin,E., Rasquin-Weber,A., Hudson,T.J. and Richter,A.
  TITLE     A missense mutation (R565W) in cirhin (FLJ14728) in North American
            Indian childhood cirrhosis
  JOURNAL   Am J Hum Genet 71 (6), 1443-1449 (2002)
   PUBMED   12417987
REFERENCE   8  (bases 1 to 2255)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 2255)
  AUTHORS   Lopez-Fernandez,L.A., Parraga,M. and del Mazo,J.
  TITLE     Tex261, a novel gene presumably related but distinct from
            steroidogenic acute regulatory (StAR) gene, is regulated during the
            development of germ cells
  JOURNAL   Biochem Biophys Res Commun 242 (3), 565-569 (1998)
   PUBMED   9464256
REFERENCE   10 (bases 1 to 2255)
  AUTHORS   Lopez-Fernandez,L.A. and del Mazo,J.
  TITLE     Characterization of genes expressed early in mouse spermatogenesis,
            isolated from a subtractive cDNA library
  JOURNAL   Mamm Genome 7 (9), 698-700 (1996)
   PUBMED   8703127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN718589.1, BC068113.1 and DV658234.1.
            
            On Dec 28, 2007 this sequence version replaced NM_011574.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068113.1, AK146263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CN718589.1         1-11
            12-2243             BC068113.1         1-2232
            2244-2255           DV658234.1         262-273
FEATURES             Location/Qualifiers
     source          1..2255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.32 cM"
     gene            1..2255
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /note="UTP4 small subunit processome component"
                     /db_xref="GeneID:21771"
                     /db_xref="MGI:MGI:1096573"
     exon            1..73
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            74..234
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2136
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /note="testis-expressed gene 292 protein; cirrhosis,
                     autosomal recessive 1A"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein 4
                     homolog"
                     /protein_id="NP_035704.2"
                     /db_xref="CCDS:CCDS52664.1"
                     /db_xref="GeneID:21771"
                     /db_xref="MGI:MGI:1096573"
                     /translation="MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYN
                     LSANYFQEKFFPGHESRGTEALCWAGGQRLFSAGLNGEILEYDLQALNIKYTLDAFGG
                     PIWSMTASPSGSQLLVGCEDGSVKLFEVTPEKIQFARNFDRQKSRILSLCWHPAGTHV
                     AAGSLDYISVFDVKSGSIIRKMVLDRQHLGVTKSRCIVWGVAFLSDGTVISVDSVGKV
                     QLWDSATGTLVKSHLVANADVQSIAVADQEDSFVVGTAEGTVFHFQLVSMTSNSSEKQ
                     WVRTKPFQHHTHDVRAVAHSPTALISGGTDTHLVIRPLMERVEVKNYDAALRKITFPH
                     RRLISCSKRRQLLLFQFAHHLELWRLGSTSATGKNGDTLPLSKNADHLLHLKTKGPEN
                     IICSCVSPCGSWIAYSTASRFFLYRLKYERDNISLQRVSKLPSFLRSALHILFSEDST
                     KLLVASNQGSLHIVHLSEGSFKHLHTFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGV
                     HVYDLHHLKLHCTVPAYNFPVTALAIAPNTNNLVIAHSDQQVFEFSIPEKQYTEWSRS
                     LQKQGFHQLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNEKTVLYNPL
                     PPKNESDVFLRRTTHGFKMSKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKK
                     KFGT"
     exon            235..426
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            427..511
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            512..601
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            602..813
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            814..985
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1077
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1174
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1239
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1362
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1519
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1626
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1722
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1908
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2019
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2249
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2222..2227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /note="hexamer: AATAAA"
     polyA_site      2243
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgcaa gcgcgcacgt ggggccgggg cggagagaag cgaggtccgg ggttggcgag
       61 ttcccggcgg taggaatggg tgaatttaag gtccatcgag tacgtttctt taattacgtt
      121 ccatcaggta tccggtgtgt ggcttacaat aatcagtcaa acagattggc tgtttcacga
      181 acagatggca cggtggaaat ttataacttg tcagcaaact attttcagga gaaatttttc
      241 ccaggtcatg agtctcgggg taccgaagcc ctgtgttggg caggaggaca gcggctcttt
      301 agtgctggac tgaacggaga aatccttgag tatgacctac aggcactaaa catcaagtac
      361 actttggatg cctttggagg acccatctgg agtatgaccg ccagccccag tggctctcaa
      421 cttttggttg gttgtgaaga tggctccgtg aaactatttg aagtcacccc agaaaaaatc
      481 cagtttgcaa gaaattttga tcggcaaaaa agtcggattc tcagtctctg ctggcaccct
      541 gcgggtaccc acgtcgcagc tggttcctta gactacatta gcgtgtttga tgtcaaatca
      601 gggagcataa ttcgtaagat ggttttagat aggcaacacc tgggagtgac taagtccagg
      661 tgcatagtgt ggggtgttgc cttcttgtcc gacggcactg tcataagtgt ggactctgtt
      721 ggaaaggtgc agttgtggga ctctgctact gggacactcg ttaagagtca tctcgtcgca
      781 aatgctgatg tgcagtctat tgctgttgct gatcaagaag acagttttgt ggtgggcacc
      841 gccgagggca cggtattcca tttccagctg gtgtccatga cttccaacag cagtgagaag
      901 cagtgggtgc ggacgaaacc gttccagcat cacactcatg acgtgcgtgc tgtggcccac
      961 agcccaacag ccctgatctc aggaggcacc gacacccacc tggttattcg gcctctcatg
     1021 gagagagtgg aggtaaagaa ttacgatgct gctctccgaa agatcacgtt cccccatcgg
     1081 cgtctcattt cctgttcaaa aagaaggcag cttctccttt tccagttcgc gcatcacttg
     1141 gaactgtgga gactaggatc cacatctgca acaggcaaga acggagatac tcttccactc
     1201 tctaaaaacg cagatcatct cctgcacctc aagacaaagg gccctgagaa cattatctgc
     1261 agctgtgtct ccccgtgtgg aagctggata gcctattcta cagcgtctcg cttttttctc
     1321 tatcgattga aatatgaacg cgataacata agcctccaaa gagtttccaa attgccatca
     1381 ttcctgcgct ctgcccttca tattctgttt tctgaagatt caacaaagct ccttgtggca
     1441 tccaatcaag ggtctctgca tattgttcat ctgtcggaag gaagcttcaa gcacttgcat
     1501 actttccagc cgcagtcagg tacagtggag gccatgtgtc ttttggcagt cagtccagat
     1561 gggaactggc tagctgcatc gggtaccagt gctggagtcc acgtatatga tctgcatcat
     1621 ctaaagcttc actgcacagt gcctgcttac aacttcccag tgaccgctct ggccatcgcc
     1681 cccaatacca acaacctggt cattgctcat tctgaccagc aggtatttga attcagcatc
     1741 ccagaaaagc agtatacaga gtggagccgc tctctccaga agcaaggatt tcaccagctg
     1801 tggctccaaa gggatactcc catcacacac atcagctttc atcccaagag accaatgcac
     1861 atcctcctcc atgatgccta catgttctgc atcattgaca agtcattgcc acttccaaat
     1921 gagaaaactg tgctttataa tccacttcct ccgaaaaatg aatcagatgt cttcttgagg
     1981 cggacaaccc atgggtttaa aatgtcaaag atatataagc ccttgctctt tatggatctt
     2041 ttggatgaaa ggacacttgt ggcagtagag cgacccctgg acgacatcat tgctcaactc
     2101 ccaccaccca tcaaaaagaa gaaatttgga acttaaaaca gggcactgtc tgtgtccttt
     2161 cttgaactgt ctatcctgtt gttttgtttg tttgtttgtt tgttttttcc caaatcatga
     2221 taataaaaca aagttattct ttaggactaa aaaaa
//
