LOCUS       NP_035704                686 aa            linear   ROD 30-APR-2024
DEFINITION  U3 small nucleolar RNA-associated protein 4 homolog [Mus musculus].
ACCESSION   NP_035704
VERSION     NP_035704.2
DBSOURCE    REFSEQ: accession NM_011574.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 686)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 686)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   4  (residues 1 to 686)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (residues 1 to 686)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (residues 1 to 686)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 686)
  AUTHORS   Chagnon,P., Michaud,J., Mitchell,G., Mercier,J., Marion,J.F.,
            Drouin,E., Rasquin-Weber,A., Hudson,T.J. and Richter,A.
  TITLE     A missense mutation (R565W) in cirhin (FLJ14728) in North American
            Indian childhood cirrhosis
  JOURNAL   Am J Hum Genet 71 (6), 1443-1449 (2002)
   PUBMED   12417987
REFERENCE   8  (residues 1 to 686)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (residues 1 to 686)
  AUTHORS   Lopez-Fernandez,L.A., Parraga,M. and del Mazo,J.
  TITLE     Tex261, a novel gene presumably related but distinct from
            steroidogenic acute regulatory (StAR) gene, is regulated during the
            development of germ cells
  JOURNAL   Biochem Biophys Res Commun 242 (3), 565-569 (1998)
   PUBMED   9464256
REFERENCE   10 (residues 1 to 686)
  AUTHORS   Lopez-Fernandez,L.A. and del Mazo,J.
  TITLE     Characterization of genes expressed early in mouse spermatogenesis,
            isolated from a subtractive cDNA library
  JOURNAL   Mamm Genome 7 (9), 698-700 (1996)
   PUBMED   8703127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN718589.1, BC068113.1 and DV658234.1.
            
            On Dec 28, 2007 this sequence version replaced NP_035704.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068113.1, AK146263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.32 cM"
     Protein         1..686
                     /product="U3 small nucleolar RNA-associated protein 4
                     homolog"
                     /note="testis-expressed gene 292 protein; cirrhosis,
                     autosomal recessive 1A"
                     /calculated_mol_wt=76778
     Region          <7..306
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          14..53
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          21..57
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          57..96
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          63..99
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          99..138
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          104..142
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          143..181
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          149..189
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          193..231
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          198..230
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          234..273
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          239..284
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          285..322
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          324..359
                     /region_name="WD 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          334..374
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          343..>550
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          435..474
                     /region_name="WD 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          443..479
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          482..521
                     /region_name="WD 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     Region          487..524
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          524..563
                     /region_name="WD 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2N2.3)"
     CDS             1..686
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /coded_by="NM_011574.2:76..2136"
                     /db_xref="CCDS:CCDS52664.1"
                     /db_xref="GeneID:21771"
                     /db_xref="MGI:MGI:1096573"
ORIGIN      
        1 mgefkvhrvr ffnyvpsgir cvaynnqsnr lavsrtdgtv eiynlsanyf qekffpghes
       61 rgtealcwag gqrlfsagln geileydlqa lnikytldaf ggpiwsmtas psgsqllvgc
      121 edgsvklfev tpekiqfarn fdrqksrils lcwhpagthv aagsldyisv fdvksgsiir
      181 kmvldrqhlg vtksrcivwg vaflsdgtvi svdsvgkvql wdsatgtlvk shlvanadvq
      241 siavadqeds fvvgtaegtv fhfqlvsmts nssekqwvrt kpfqhhthdv ravahsptal
      301 isggtdthlv irplmervev knydaalrki tfphrrlisc skrrqlllfq fahhlelwrl
      361 gstsatgkng dtlplsknad hllhlktkgp eniicscvsp cgswiaysta srfflyrlky
      421 erdnislqrv sklpsflrsa lhilfsedst kllvasnqgs lhivhlsegs fkhlhtfqpq
      481 sgtveamcll avspdgnwla asgtsagvhv ydlhhlklhc tvpaynfpvt alaiapntnn
      541 lviahsdqqv fefsipekqy tewsrslqkq gfhqlwlqrd tpithisfhp krpmhillhd
      601 aymfciidks lplpnektvl ynplppknes dvflrrtthg fkmskiykpl lfmdlldert
      661 lvaverpldd iiaqlpppik kkkfgt
//
