LOCUS       NM_023054               1646 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus UTP3 small subunit processome component (Utp3), mRNA.
ACCESSION   NM_023054 XM_976938
VERSION     NM_023054.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1646)
  AUTHORS   Choi,S.Y., Pi,J.H., Jeong,S.E. and Kang,C.J.
  TITLE     Crlz-1 Homozygous Null Knockout Mouse Embryos Are Lethally Stopped
            in Their Early Development
  JOURNAL   Genes (Basel) 13 (3), 511 (2022)
   PUBMED   35328065
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1646)
  AUTHORS   Choi,S.Y., Pi,J.H., Park,S.K. and Kang,C.J.
  TITLE     Crlz-1 Controls Germinal Center Reaction by Relaying a Wnt Signal
            to the Bcl-6 Expression in Centroblasts during Humoral Immune
            Responses
  JOURNAL   J Immunol 203 (10), 2630-2643 (2019)
   PUBMED   31586036
  REMARK    GeneRIF: Crlz-1, which is induced by canonical Wnt/beta-catenin
            signaling, controls Germinal Center reaction by regulating the
            expression of Bcl-6 in centroblasts.
REFERENCE   3  (bases 1 to 1646)
  AUTHORS   Choi,S.Y., Park,S.K., Yoo,H.W., Pi,J.H. and Kang,C.J.
  TITLE     Charged Amino Acid-rich Leucine Zipper-1 (Crlz-1) as a Target of
            Wnt Signaling Pathway Controls Pre-B Cell Proliferation by
            Affecting Runx/CBFbeta-targeted VpreB and lambda5 Genes
  JOURNAL   J Biol Chem 291 (29), 15008-15019 (2016)
   PUBMED   27226553
  REMARK    GeneRIF: the mechanistic view that the proliferative function of
            Crlz-1 is caused by relaying Wnt/beta-catenin to pre-B cell
            receptor signaling pathways through the regulation of Runx/CBFbeta
            heterodimerization was verified
REFERENCE   4  (bases 1 to 1646)
  AUTHORS   Lim,J.H., Choi,S.Y., Yoo,H.W., Cho,S.J., Son,Y. and Kang,C.J.
  TITLE     Crlz-1 is prominently expressed in spermatogonia and Sertoli cells
            during early testis development and in spermatids during late
            spermatogenesis
  JOURNAL   J Histochem Cytochem 61 (7), 522-528 (2013)
   PUBMED   23525569
  REMARK    GeneRIF: expression of the Crlz-1 gene in mouse testis
REFERENCE   5  (bases 1 to 1646)
  AUTHORS   Park,S.K., Lim,J.H. and Kang,C.J.
  TITLE     Crlz1 activates transcription by mobilizing cytoplasmic CBFbeta
            into the nucleus
  JOURNAL   Biochim Biophys Acta 1789 (11-12), 702-708 (2009)
   PUBMED   19735751
  REMARK    GeneRIF: Data show that the cytoplasmic CBFbeta was shown to be
            mobilized into the nucleus when it was coexpressed with the nuclear
            Crlz1.
REFERENCE   6  (bases 1 to 1646)
  AUTHORS   Lim,J.H., Cho,S.J., Park,S.K., Kim,J., Cho,D., Lee,W.J. and
            Kang,C.J.
  TITLE     Stage-specific expression of two neighboring Crlz1 and IgJ genes
            during B cell development is regulated by their chromatin
            accessibility and histone acetylation
  JOURNAL   J Immunol 177 (8), 5420-5429 (2006)
   PUBMED   17015728
  REMARK    GeneRIF: H3 and H4 histones toward the chromatin of the Crlz1 gene
            are found to be hyperacetylated, especially on H3, in the pre-B
            cells, whereas those toward the chromatin of the IgJ gene are found
            to be hyperacetylated in the plasma cells
REFERENCE   7  (bases 1 to 1646)
  AUTHORS   Kim,J.Y., Park,S.K., Kim,H.G., Cho,S.J., Kim,J. and Kang,C.J.
  TITLE     The HSS3/4 enhancer of Crlz1-IgJ locus is another target of EBF in
            the pre-B cell stage of B cell development
  JOURNAL   Immunol Lett 107 (1), 63-70 (2006)
   PUBMED   16962668
  REMARK    GeneRIF: identifies the HSS3/4 enhancer of Crlz1-IgJ locus as
            another target of EBG in early developmental stage of B cells
REFERENCE   8  (bases 1 to 1646)
  AUTHORS   Sakuma,T., Li,Q.L., Jin,Y., Choi,L.B., Kim,E.G., Ito,K., Ito,Y.,
            Nomura,S. and Bae,S.C.
  TITLE     Cloning and expression pattern of a novel PEBP2 beta-binding
            protein (charged amino acid rich leucine zipper-1[Crl-1]) in the
            mouse
  JOURNAL   Mech Dev 104 (1-2), 151-154 (2001)
   PUBMED   11404095
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145637.1 and BF458645.1.
            
            On Sep 28, 2017 this sequence version replaced NM_023054.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1628              AK145637.1         2-1629
            1629-1646           BF458645.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.74 cM"
     gene            1..1646
                     /gene="Utp3"
                     /gene_synonym="2400011K09Rik; Crl-1; Crl1; Crlz1; Sas10"
                     /note="UTP3 small subunit processome component"
                     /db_xref="GeneID:65961"
                     /db_xref="MGI:MGI:1919230"
     exon            1..1629
                     /gene="Utp3"
                     /gene_synonym="2400011K09Rik; Crl-1; Crl1; Crlz1; Sas10"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1562
                     /gene="Utp3"
                     /gene_synonym="2400011K09Rik; Crl-1; Crl1; Crlz1; Sas10"
                     /note="disrupter of silencing SAS10; charged amino
                     acid-rich leucine zipper 1; UTP3 homolog"
                     /codon_start=1
                     /product="something about silencing protein 10"
                     /protein_id="NP_075541.1"
                     /db_xref="CCDS:CCDS19402.1"
                     /db_xref="GeneID:65961"
                     /db_xref="MGI:MGI:1919230"
                     /translation="MVKKSRRRGAAQWAAVRAQAGLTATDENEDDLGLPPSPGDSSYY
                     QDQVDEFHEARSRAVLAKGWNEVESGEEDGDEEEEVLPLDIDDGDDEDGESSEEEEVG
                     EDDDGGSSVQSEAEASVDPSLSWGQRKKLYYDTDYGSKSRGRQSQQEVEEEEREEEEE
                     AQIIQRRLAQALQEDDFGVAWVEAFAKPVPQVDEAETRVVKDLAKVSVKEKLKMLKKE
                     SPELLELIEDLQAKLTEVKDELEPLLQLVEKGVIPTGRGSEYLKTKYNLYLNYCANIS
                     FYLILKARRVPAHGHPVIERLVTYRNLINKLSVVDQKLSSEIRHLLTAKDGAVKKEMT
                     PKAKLTKTKPKSVKQAAAVALTDEPDFDGAALKYYKEMEDRQELKRKKEENSAEEQAL
                     EEQNAKRAITYQIAKNRGLTPRRKKIDRNPRVKHREKFRKAKIRRRGQVREVRREEQR
                     YSGELSGIRAGVKKSIKLK"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Utp3"
                     /gene_synonym="2400011K09Rik; Crl-1; Crl1; Crlz1; Sas10"
                     /note="hexamer: AATAAA"
     polyA_site      1625
                     /gene="Utp3"
                     /gene_synonym="2400011K09Rik; Crl-1; Crl1; Crlz1; Sas10"
                     /note="major polyA site"
ORIGIN      
        1 ctttcccaga ctctctgctc cggtggtcac cgacttgggt tcgcggagcg tgctggtgct
       61 gaaagcctcc gcttgccggc atcattctgg gcggaggtca gaagtggcgg aaatcgcggc
      121 gtcgcttggg aacccgggac cgctggtgag ccatggtgaa gaaatcacgg cggcgtggag
      181 cggctcagtg ggccgccgtg cgggcccagg caggtctcac cgccacggac gaaaatgagg
      241 acgacttggg gttgccgccc tctccagggg actccagcta ctaccaagac caggtagatg
      301 agttccatga agcgcgatct cgggcagtcc tggccaaggg ctggaacgaa gtcgagagtg
      361 gggaggagga tggcgatgag gaggaagagg tgctacctct agatattgat gatggagatg
      421 acgaagatgg agagagttcg gaggaggagg aggttggaga ggatgatgac ggcggaagct
      481 ccgtgcagag tgaggctgag gcctctgtgg accctagctt gtcctggggt cagagaaaaa
      541 agctttatta cgatacggac tatggttcca aatcccgagg ccgtcagagt cagcaagaag
      601 tagaagagga ggaaagagaa gaagaggagg aggcacagat aattcagcgg cgcttggccc
      661 aagccctgca agaggatgat tttggagtcg cttgggtgga ggcctttgca aagccggtgc
      721 cccaggtaga cgaagctgag acaagggttg tgaaggattt ggctaaagtc tcggtaaaag
      781 agaagctgaa aatgttgaag aaagaatcac cagagctctt agagctcata gaagacctcc
      841 aagccaagtt gacagaggtg aaggatgagt tagaaccctt gttacagttg gtggagaaag
      901 gggtcattcc aactggaaga ggaagcgaat acctgaagac taagtataat ctctacttga
      961 actattgcgc caacattagc ttttatttga tcttaaaagc ccggagagtc cctgcacatg
     1021 gacatcctgt tatagaaagg cttgttacct acagaaatct gatcaacaag ctgtcggttg
     1081 tggatcagaa actgtcctct gaaatccgtc acctcctcac agccaaggat ggtgctgtaa
     1141 agaaagaaat gactccaaaa gcaaaattaa ccaaaaccaa gcccaagtct gtaaagcagg
     1201 ctgctgctgt tgccctgact gatgagcctg attttgatgg ggctgctctc aagtactata
     1261 aggaaatgga agacaggcaa gagttgaaga gaaagaagga agaaaacagt gctgaagaac
     1321 aggctctcga agaacaaaat gcaaagagag ccattaccta ccagattgct aaaaataggg
     1381 gacttacacc caggagaaag aagattgata gaaatcccag agtgaaacat agggaaaagt
     1441 tcagaaaagc caaaatccga cgacgaggcc aggttcgtga agttcgcaga gaagaacagc
     1501 ggtacagtgg tgaactctct ggcattcgtg ctggagttaa gaagagcatt aagcttaagt
     1561 aaagttgctc tttggcctag cttttggcaa ttattttagg tcaataaaaa gtgttttgaa
     1621 gtaaagtgaa aaaaaaaaaa aaaaaa
//
