LOCUS       NM_001136226            3778 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus UTP14B small subunit processome component (Utp14b),
            transcript variant 1, mRNA.
ACCESSION   NM_001136226
VERSION     NM_001136226.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3778)
  AUTHORS   Song,H.W., Bettegowda,A., Oliver,D., Yan,W., Phan,M.H., de
            Rooij,D.G., Corbett,M.A. and Wilkinson,M.F.
  TITLE     shRNA off-target effects in vivo: impaired endogenous siRNA
            expression and spermatogenic defects
  JOURNAL   PLoS One 10 (3), e0118549 (2015)
   PUBMED   25790000
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3778)
  AUTHORS   Shetty,G., Porter,K.L., Zhou,W., Shao,S.H., Weng,C.C. and
            Meistrich,M.L.
  TITLE     Androgen suppression-induced stimulation of spermatogonial
            differentiation in juvenile spermatogonial depletion mice acts by
            elevating the testicular temperature
  JOURNAL   Endocrinology 152 (9), 3504-3514 (2011)
   PUBMED   21733828
REFERENCE   3  (bases 1 to 3778)
  AUTHORS   Zhou,W., Wang,G., Small,C.L., Liu,Z., Weng,C.C., Yang,L.,
            Griswold,M.D. and Meistrich,M.L.
  TITLE     Gene expression alterations by conditional knockout of androgen
            receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice
  JOURNAL   Biol Reprod 83 (5), 759-766 (2010)
   PUBMED   20650881
  REMARK    Erratum:[Biol Reprod. 2011 Feb;84(2):400-8. doi:
            10.1095/biolreprod.110.090530.. PMID: 21312389]
REFERENCE   4  (bases 1 to 3778)
  AUTHORS   Wang,G., Weng,C.C., Shao,S.H., Zhou,W., de Gendt,K., Braun,R.E.,
            Verhoeven,G. and Meistrich,M.L.
  TITLE     Androgen receptor in Sertoli cells is not required for
            testosterone-induced suppression of spermatogenesis, but
            contributes to Sertoli cell organization in Utp14b jsd mice
  JOURNAL   J Androl 30 (3), 338-348 (2009)
   PUBMED   19136388
REFERENCE   5  (bases 1 to 3778)
  AUTHORS   Shetty,G., Shao,S.H. and Weng,C.C.
  TITLE     p53-dependent apoptosis in the inhibition of spermatogonial
            differentiation in juvenile spermatogonial depletion (Utp14bjsd)
            mice
  JOURNAL   Endocrinology 149 (6), 2773-2781 (2008)
   PUBMED   18356279
  REMARK    GeneRIF: In adult male mice homozygous for the juvenile
            spermatogonial depletion (Utp14b jsd) mutation in the Utp14b gene,
            type A spermatogonia proliferate but undergo apoptosis before
            differentiation.
REFERENCE   6  (bases 1 to 3778)
  AUTHORS   Zhao,M., Rohozinski,J., Sharma,M., Ju,J., Braun,R.E., Bishop,C.E.
            and Meistrich,M.L.
  TITLE     Utp14b: a unique retrogene within a gene that has acquired multiple
            promoters and a specific function in spermatogenesis
  JOURNAL   Dev Biol 304 (2), 848-859 (2007)
   PUBMED   17291484
  REMARK    GeneRIF: The novel cell-type-specific promoter for Utp14b likely
            evolved later, as the protein may have acquired a germ
            cell-specific function in spermatid development.
REFERENCE   7  (bases 1 to 3778)
  AUTHORS   Yomogida,K., Ohtani,H., Harigae,H., Ito,E., Nishimune,Y.,
            Engel,J.D. and Yamamoto,M.
  TITLE     Developmental stage- and spermatogenic cycle-specific expression of
            transcription factor GATA-1 in mouse Sertoli cells
  JOURNAL   Development 120 (7), 1759-1766 (1994)
   PUBMED   7924983
REFERENCE   8  (bases 1 to 3778)
  AUTHORS   Mizunuma,M., Dohmae,K., Tajima,Y., Koshimizu,U., Watanabe,D. and
            Nishimune,Y.
  TITLE     Loss of sperm in juvenile spermatogonial depletion (jsd) mutant
            mice is ascribed to a defect of intratubular environment to support
            germ cell differentiation
  JOURNAL   J Cell Physiol 150 (1), 188-193 (1992)
   PUBMED   1346141
REFERENCE   9  (bases 1 to 3778)
  AUTHORS   Barton,D.E., Yang-Feng,T.L., Mason,A.J., Seeburg,P.H. and
            Francke,U.
  TITLE     Mapping of genes for inhibin subunits alpha, beta A, and beta B on
            human and mouse chromosomes and studies of jsd mice
  JOURNAL   Genomics 5 (1), 91-99 (1989)
   PUBMED   2767687
REFERENCE   10 (bases 1 to 3778)
  AUTHORS   Beamer,W.G., Cunliffe-Beamer,T.L., Shultz,K.L., Langley,S.H. and
            Roderick,T.H.
  TITLE     Juvenile spermatogonial depletion (jsd): a genetic defect of germ
            cell proliferation of male mice
  JOURNAL   Biol Reprod 38 (4), 899-908 (1988)
   PUBMED   3401545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156613.9.
            
            On Jul 8, 2022 this sequence version replaced NM_001136226.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029972.1, BB616382.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AC156613.9         94909-95218         c
            311-375             AC156613.9         93179-93243         c
            376-515             AC156613.9         90289-90428         c
            516-3778            AC156613.9         85981-89243         c
FEATURES             Location/Qualifiers
     source          1..3778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 40.84 cM"
     gene            1..3778
                     /gene="Utp14b"
                     /gene_synonym="4932411L21Rik; jsd"
                     /note="UTP14B small subunit processome component"
                     /db_xref="GeneID:195434"
                     /db_xref="MGI:MGI:2445092"
     exon            1..310
                     /gene="Utp14b"
                     /gene_synonym="4932411L21Rik; jsd"
                     /inference="alignment:Splign:2.1.0"
     exon            311..375
                     /gene="Utp14b"
                     /gene_synonym="4932411L21Rik; jsd"
                     /inference="alignment:Splign:2.1.0"
     exon            376..515
                     /gene="Utp14b"
                     /gene_synonym="4932411L21Rik; jsd"
                     /inference="alignment:Splign:2.1.0"
     exon            516..3778
                     /gene="Utp14b"
                     /gene_synonym="4932411L21Rik; jsd"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..2919
                     /gene="Utp14b"
                     /gene_synonym="4932411L21Rik; jsd"
                     /note="juvenile spermatogonial depletion protein; UTP14,
                     U3 small nucleolar ribonucleoprotein, homolog B"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein 14
                     homolog B"
                     /protein_id="NP_001129698.1"
                     /db_xref="CCDS:CCDS15086.1"
                     /db_xref="GeneID:195434"
                     /db_xref="MGI:MGI:2445092"
                     /translation="MKPKMRPDPSSRANRPCEKKEAATMNMARNVTDLLALSQQEELV
                     DLPENYPLSTSEDEGDSDGEGKRQKLLEAVSSLGRKNKWKLAERSEASRMVSEFNVTS
                     EGSGEKLVLSDLLGSATALSSVAAVKKQLHRVKSKTLTPPLNKEEADRALREAAFSKT
                     SQMLSRWDPVVLKNRQAEQLIFPMEKEPPAVAPIEHVFTDWKVRTPLEREVFNLLHKN
                     KQPVTDPLLTPVETASIRAMSLEEAKIRRAELQRTRALQSYYEARARREKRIKSKKYH
                     RALKKGKAKKALKEFEELWKDCPNAALQELEKMEKARMTERMSLKHQGSGKWAKSKAI
                     MAKYDPEARKAMQEQLAKNRELTQKLQVVSESEEEDGCTEEGIVSVSHGMDDLQMNAD
                     GVNPWMLSSCNSNAKRGEIKTDPEQMPEFVAHVSSESEGDERPVAEELVLKERSFQER
                     VDPNNAKLMDGQETEDSDSQEVLQKLNKESHQSDNQKVSSEENVLHIQREDLASEKLL
                     VLQRLERAHVLEQQGELSKEEHYPKKGLSRPLLKGDWKEMKPLTNPDASGGKKKKEQM
                     IDLRNLLTANSSPVRSLAVPTIQQLEDEVETDHKQLIREAFAGDDVIREFLKEKREAI
                     ETNKPKDLDLSLPGWGEWVGMGLKPSAKKRRRFLIKAPESSPRKDKNLPNVIISEKRN
                     IHAAAHQVRALPHPFTHQQQFERTIQNPIGYMWNTQRTFQKLTVPKVGTKLGHIIKPI
                     KAENVGYCSSTRSDLSILQSSQKCLSRKQQKQLKKLSSAD"
     regulatory      3759..3764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Utp14b"
                     /gene_synonym="4932411L21Rik; jsd"
                     /note="hexamer: AATAAA"
     polyA_site      3778
                     /gene="Utp14b"
                     /gene_synonym="4932411L21Rik; jsd"
                     /note="major polyA site"
ORIGIN      
        1 accgcggcct cctccgcggg cgcgggcacg tgggtggggt cgtcccgctc cacgcggccg
       61 cgcggcgtcc gtgggaggta ccagcgccca gagggtccct gaaaactgcg ggtgtgggac
      121 aggaaatgcg ggtgcgggcg gtgggaatgg cgtggggaac ctctggtgtc tcctcctaag
      181 tgcgttttag tctcggacga gtcagtcatg agatgcatac ataggcagcc ccgggggtca
      241 cttgtgatcc ccgtgatggg atttcacaga tgaagatcca actgtatggt ccgttctggt
      301 tctagaacag ttcttaggaa gcaagaaaac catgcatgaa ttgggatata gatatctatt
      361 caaacacttc aaaagggtct tactgtttac tccttgaact tgctgtgagg ctcaggttgg
      421 ccttgaactt gagatccatc tgtcttagcc tcctgagtgg catatcacca actttgggtt
      481 gctgagtgga ttgccatccg tgtatataac acttgacatc tcaataaata aggttctcag
      541 aaaacatcta tgtcagagac agtgggcagt aaatagatga agccaaagat gagaccagat
      601 ccttcttcaa gagctaacag gccctgtgag aagaaggagg ctgctaccat gaacatggcc
      661 aggaatgtga cagaccttct ggctttgagc cagcaggaag aactagtgga tttgccagaa
      721 aactatccac tgagtacgag tgaagatgag ggggacagtg atggagaagg aaaacgtcaa
      781 aaacttctgg aagcagtcag ttcccttggt agaaagaata aatggaagtt ggcagagaga
      841 tctgaggcta gtcggatggt ttcagagttc aatgtcactt ctgaaggatc aggtgaaaag
      901 ctggtccttt ccgatttgct tgggtctgct acagcattat cttcggtggc tgctgtgaaa
      961 aaacagctgc atagagtcaa gtcaaagacg ctcaccccac cccttaacaa agaagaggct
     1021 gaccgagccc tcagggaagc agcattcagc aaaacctcac aaatgctctc caggtgggat
     1081 ccggtggttc tgaagaaccg gcaggcagag cagttgattt ttcccatgga gaaggagccg
     1141 ccagcggttg cacccattga acatgttttt actgactgga aagtaagaac ccctctggaa
     1201 cgagaagttt ttaaccttct tcataagaac aagcagccag taacagaccc tttattgact
     1261 cccgtggaaa cagcctccat cagagccatg agcctggaag aagccaagat acgccgagca
     1321 gagcttcaga ggacgcgagc tctacagtcc tattatgagg ctagagctcg aagagagaag
     1381 agaatcaaga gtaagaagta tcacagagct ctaaagaaag gaaaggccaa gaaagcctta
     1441 aaagagtttg aagagctgtg gaaagactgc ccaaatgctg cattgcaaga actggagaaa
     1501 atggaaaagg ccagaatgac agaacggatg agccttaagc accagggcag tgggaaatgg
     1561 gcaaagtcaa aggcaattat ggccaaatat gaccctgagg ctcgaaaagc tatgcaagaa
     1621 caattggcta agaacagaga actgacacag aaactccagg tagtttcaga gagtgaggaa
     1681 gaggacggat gcacagaaga gggaatagtc tctgtctccc atggaatgga tgacctacag
     1741 atgaatgcag atggtgtaaa tccctggatg cttagcagtt gcaacagcaa tgcaaagcgg
     1801 ggtgagatca agaccgatcc tgaacagatg cctgagtttg tggcccatgt gtcttctgag
     1861 agtgagggag atgaaagacc agtggcagaa gaacttgtgt taaaagaaag atcctttcaa
     1921 gaaagagttg atcccaacaa tgctaagcta atggatggcc aagaaacaga agactctgat
     1981 agccaggagg tattacagaa actcaacaag gaaagtcatc aatctgacaa tcaaaaagtg
     2041 agttcagagg aaaatgttct ccatatccag agagaggacc ttgcctcaga gaagttgttg
     2101 gtgcttcaaa ggctagagag agcacatgtt ctggaacaac aaggagagtt gagcaaagaa
     2161 gaacattatc caaaaaaagg gctttccaga cctttgttga aaggggattg gaaggagatg
     2221 aagccactca ccaaccctga tgcctctgga gggaagaaaa agaaggaaca aatgattgat
     2281 ctacggaacc tcctaactgc taactcatct cctgtgaggt ctttggctgt gcccacaata
     2341 cagcagttag aagatgaagt ggagaccgat cacaagcagc taataaggga agcttttgct
     2401 ggggatgatg tcataagaga gttcttaaaa gagaagaggg aagctataga gacaaataaa
     2461 ccaaaggact tggacctgtc attgcctgga tggggtgagt gggttggtat gggcctgaag
     2521 cccagcgcca agaaaagacg ccgttttctt attaaagctc ctgagagttc tccaagaaaa
     2581 gacaagaatt tgccgaatgt gattatcagt gagaagcgca acatccatgc agctgctcat
     2641 caggtgcggg cgcttccaca cccattcacc caccagcagc agtttgaaag gactatccaa
     2701 aaccctattg ggtacatgtg gaacacccag aggaccttcc aaaagctgac agttcccaag
     2761 gttggcacca agctaggcca tatcattaag cccataaaag cagaaaatgt agggtactgc
     2821 tcttccacaa ggtctgacct ctctatccta cagagcagtc agaagtgcct ctccagaaaa
     2881 cagcaaaaac aactgaagaa gttgagctct gcagattgag cttccagcag agtagcatct
     2941 ttatgacctg gggctaggaa cctctagtgt ttctcttggt tgcatcattg tgcttcaggg
     3001 tcatttccta aattgacaaa cactgtgtac ttaagccaca ttgtagaaat aaggcatttt
     3061 tatcgaatga agagcttaca ttccattttg aggtatatga taaatttaga aatgattcac
     3121 ttatgggaaa aatgcagagt tacctatatt ggtacctatc ctgggcttag agagggatgt
     3181 gtggacagag aagttcagcc tgggactggg cagaggaagc gtgggcagca aaaaatgctc
     3241 agttagttta gatagtaagt taatcgatcc tgatctagta gctcatatat gtaatcagcg
     3301 ttcttcgagg ctgagaatca gttagttgag gccacagaat gagaattggc tcaaaaacaa
     3361 acaaacaaac aagcccaaaa agattctagg aagagtttat aggcagaatg acttggagaa
     3421 gacagacaat gaagatagag acgagtaaaa tttaagaata aagtgttata gtttgccatt
     3481 cccagatagc tttcctgaga tttcctggtg caaaatggag gactcccttt ccttagtggg
     3541 tttcctcttc acctgatatg gggaacctga ccccagtcta cctagggaat gtcatgtaat
     3601 ccttggagga agttacaagt tcaatttcct ggaatgtctt aacatgcaaa tgtggtatcc
     3661 cctgaacctt aaacctcagc taatgaaact tcaccttaag aagaacccct tcccactctc
     3721 caggatcaat atatctatat agcctttgct ccaccctgaa taaagtatat gtgcacaa
//
