LOCUS       NM_009482               1160 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus undifferentiated embryonic cell transcription factor 1
            (Utf1), mRNA.
ACCESSION   NM_009482
VERSION     NM_009482.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1160)
  AUTHORS   Han,D., Wu,G., Chen,R., Drexler,H.C.A., MacCarthy,C.M., Kim,K.P.,
            Adachi,K., Gerovska,D., Mavrommatis,L., Bedzhov,I.,
            Arauzo-Bravo,M.J. and Scholer,H.R.
  TITLE     A balanced Oct4 interactome is crucial for maintaining pluripotency
  JOURNAL   Sci Adv 8 (7), eabe4375 (2022)
   PUBMED   35171666
REFERENCE   2  (bases 1 to 1160)
  AUTHORS   Raina,K., Dey,C., Thool,M., Sudhagar,S. and Thummer,R.P.
  TITLE     An Insight into the Role of UTF1 in Development, Stem Cells, and
            Cancer
  JOURNAL   Stem Cell Rev Rep 17 (4), 1280-1293 (2021)
   PUBMED   33517544
  REMARK    GeneRIF: An Insight into the Role of UTF1 in Development, Stem
            Cells, and Cancer.
            Review article
REFERENCE   3  (bases 1 to 1160)
  AUTHORS   Ge,W., Wang,J.J., Zhang,R.Q., Tan,S.J., Zhang,F.L., Liu,W.X.,
            Li,L., Sun,X.F., Cheng,S.F., Dyce,P.W., De Felici,M. and Shen,W.
  TITLE     Dissecting the initiation of female meiosis in the mouse at
            single-cell resolution
  JOURNAL   Cell Mol Life Sci 78 (2), 695-713 (2021)
   PUBMED   32367190
REFERENCE   4  (bases 1 to 1160)
  AUTHORS   Tosic,J., Kim,G.J., Pavlovic,M., Schroder,C.M., Mersiowsky,S.L.,
            Barg,M., Hofherr,A., Probst,S., Kottgen,M., Hein,L. and Arnold,S.J.
  TITLE     Eomes and Brachyury control pluripotency exit and germ-layer
            segregation by changing the chromatin state
  JOURNAL   Nat Cell Biol 21 (12), 1518-1531 (2019)
   PUBMED   31792383
  REMARK    Erratum:[Nat Cell Biol. 2020 Jan;22(1):135. doi:
            10.1038/s41556-019-0452-9.. PMID: 31844271]
REFERENCE   5  (bases 1 to 1160)
  AUTHORS   Mochizuki,K., Tando,Y., Sekinaka,T., Otsuka,K., Hayashi,Y.,
            Kobayashi,H., Kamio,A., Ito-Matsuoka,Y., Takehara,A., Kono,T.,
            Osumi,N. and Matsui,Y.
  TITLE     SETDB1 is essential for mouse primordial germ cell fate
            determination by ensuring BMP signaling
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30446626
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1160)
  AUTHORS   Nishimoto,M., Fukushima,A., Miyagi,S., Suzuki,Y., Sugano,S.,
            Matsuda,Y., Hori,T., Muramatsu,M. and Okuda,A.
  TITLE     Structural analyses of the UTF1 gene encoding a transcriptional
            coactivator expressed in pluripotent embryonic stem cells
  JOURNAL   Biochem Biophys Res Commun 285 (4), 945-953 (2001)
   PUBMED   11467843
REFERENCE   7  (bases 1 to 1160)
  AUTHORS   Nishimoto,M., Fukushima,A., Okuda,A. and Muramatsu,M.
  TITLE     The gene for the embryonic stem cell coactivator UTF1 carries a
            regulatory element which selectively interacts with a complex
            composed of Oct-3/4 and Sox-2
  JOURNAL   Mol Cell Biol 19 (8), 5453-5465 (1999)
   PUBMED   10409735
REFERENCE   8  (bases 1 to 1160)
  AUTHORS   Fukushima,A., Nishimoto,M., Okuda,A. and Muramatsu,M.
  TITLE     Carboxy-terminally truncated form of a coactivator UTF1 stimulates
            transcription from a variety of gene promoters through the TATA Box
  JOURNAL   Biochem Biophys Res Commun 258 (3), 519-523 (1999)
   PUBMED   10329418
REFERENCE   9  (bases 1 to 1160)
  AUTHORS   Fukushima,A., Okuda,A., Nishimoto,M., Seki,N., Hori,T.A. and
            Muramatsu,M.
  TITLE     Characterization of functional domains of an embryonic stem cell
            coactivator UTF1 which are conserved and essential for potentiation
            of ATF-2 activity
  JOURNAL   J Biol Chem 273 (40), 25840-25849 (1998)
   PUBMED   9748258
REFERENCE   10 (bases 1 to 1160)
  AUTHORS   Okuda,A., Fukushima,A., Nishimoto,M., Orimo,A., Yamagishi,T.,
            Nabeshima,Y., Kuro-o,M., Nabeshima,Yi., Boon,K., Keaveney,M.,
            Stunnenberg,H.G. and Muramatsu,M.
  TITLE     UTF1, a novel transcriptional coactivator expressed in pluripotent
            embryonic stem cells and extra-embryonic cells
  JOURNAL   EMBO J 17 (7), 2019-2032 (1998)
   PUBMED   9524124
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC107822.18.
            
            On Nov 17, 2006 this sequence version replaced NM_009482.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D31647.1, AY606111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               AC107822.18        148573-149146
            575-1160            AC107822.18        149244-149829
FEATURES             Location/Qualifiers
     source          1..1160
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 84.91 cM"
     gene            1..1160
                     /gene="Utf1"
                     /note="undifferentiated embryonic cell transcription
                     factor 1"
                     /db_xref="GeneID:22286"
                     /db_xref="MGI:MGI:1276125"
     exon            1..574
                     /gene="Utf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1038
                     /gene="Utf1"
                     /codon_start=1
                     /product="undifferentiated embryonic cell transcription
                     factor 1"
                     /protein_id="NP_033508.1"
                     /db_xref="CCDS:CCDS21958.1"
                     /db_xref="GeneID:22286"
                     /db_xref="MGI:MGI:1276125"
                     /translation="MLLRPRRLPAFSPPSPASPDAELRSAGDVPVTTSDAFATSGGMA
                     EPGSPKAPVSPDSAQRTPWSARETELLLGTLLQPAMWRSLLLDRRQTLPTYRRVSAAL
                     ARQQVRRTPAQCRRRYKFLKDKLRDSQGQPSGPFDNQIRQLMGLLGDDGPPRVRRRST
                     GPGRPQRRGRSSLSALAPAPAPVEQEAELPLAAENDEPAPALRFSSSTTKSAGAHRIT
                     SSPPLTSTDTLPPEPGHTFESSPTPTPDHDVETPNEPPGLSQGRASSPQVAPQSLNTA
                     LLQTLTHLGDISTVLGPLRDQLSTLNQHVEHLRGSFDQTVSLAVGFILGSAASERGIL
                     GDLRQ"
     exon            575..1160
                     /gene="Utf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1136..1141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Utf1"
                     /note="hexamer: AATAAA"
     polyA_site      1160
                     /gene="Utf1"
                     /note="major polyA site"
ORIGIN      
        1 cctctacctg gctcagggat gctgcttcgt ccccggaggt tgcccgcttt ttctccgccg
       61 tcgccagcta gccccgacgc tgagctgcgg tcggccgggg atgtcccggt gactacgtct
      121 gatgccttcg ctacttcggg cgggatggct gaacccggct cgcccaaggc tcccgtgtcc
      181 ccggactcgg cgcagcgcac gccctggagt gcccgagaga cggagctact tctgggcacg
      241 ctgctgcagc cggccatgtg gcgctcacta ctgctggacc gcaggcagac tctgcctact
      301 taccgccgcg tgtccgccgc actggcccgt cagcaagttc ggcgcacgcc cgctcagtgc
      361 cgccgtcgct acaagttcct caaggacaaa ctccgagact cccagggcca gccgtccgga
      421 cccttcgata accagatccg ccaactcatg gggctattgg gggacgatgg gccgccgagg
      481 gttcgccgcc gctctactgg ccctggacgt ccccagcgcc gcggccgctc gtccctctcc
      541 gcgttagcac ccgcacctgc accggtggag caagaggccg agctgccgct ggctgcggaa
      601 aatgacgaac ctgcccctgc gctcagattc agttcttcca cgacgaagtc tgcaggtgcc
      661 caccgcatta ccagctctcc tcctcttacg agcaccgaca ctctgcctcc tgagccgggc
      721 cataccttcg aatcctcccc gacgccaacc cccgaccacg acgtggagac cccgaatgag
      781 cctcctggcc tttcccaggg ccgtgcttct tccccgcagg ttgctcccca gtcgttgaat
      841 accgcgttgc tgcagacctt gacgcacttg ggcgacatct caacagttct gggccctctg
      901 cgcgaccagc tgtcgaccct gaaccagcac gtggagcatc tacgaggttc cttcgaccaa
      961 accgtttctc tggcggtggg gttcattctg ggcagtgcag cctccgagcg gggcatcctt
     1021 ggggacttgc gccaataaag ctttgttatc agtcctcttc tccagaaacg actcccagtc
     1081 taccccgacc cctgttactg tccccatccc catctcaaac ctaggttctt accaaaataa
     1141 agattgtgtt ttctacttaa
//
