LOCUS       NM_001115149            3772 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin specific peptidase like 1 (Uspl1),
            transcript variant 2, mRNA.
ACCESSION   NM_001115149
VERSION     NM_001115149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3772)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3772)
  AUTHORS   Liu,H., Shafey,D., Moores,J.N. and Kothary,R.
  TITLE     Neurodevelopmental consequences of Smn depletion in a mouse model
            of spinal muscular atrophy
  JOURNAL   J Neurosci Res 88 (1), 111-122 (2010)
   PUBMED   19642194
REFERENCE   3  (bases 1 to 3772)
  AUTHORS   Baumer,D., Lee,S., Nicholson,G., Davies,J.L., Parkinson,N.J.,
            Murray,L.M., Gillingwater,T.H., Ansorge,O., Davies,K.E. and
            Talbot,K.
  TITLE     Alternative splicing events are a late feature of pathology in a
            mouse model of spinal muscular atrophy
  JOURNAL   PLoS Genet 5 (12), e1000773 (2009)
   PUBMED   20019802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY203045.1, AK050969.1, AK168702.1 and BC086664.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (A).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.182390.1,
                                           SRR1660821.12770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY203045.1         2-17
            17-2962             AK050969.1         1-2946
            2963-3753           AK168702.1         2788-3578
            3754-3772           BC086664.1         3097-3115
FEATURES             Location/Qualifiers
     source          1..3772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 89.18 cM"
     gene            1..3772
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /note="ubiquitin specific peptidase like 1"
                     /db_xref="GeneID:231915"
                     /db_xref="MGI:MGI:2442342"
     exon            1..247
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            248..416
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..3584
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /note="isoform A is encoded by transcript variant 2;
                     ubiquitin-specific peptidase-like protein 1; SUMO-specific
                     isopeptidase USPL1"
                     /codon_start=1
                     /product="SUMO-specific isopeptidase USPL1 isoform A"
                     /protein_id="NP_001108621.1"
                     /db_xref="CCDS:CCDS51704.1"
                     /db_xref="GeneID:231915"
                     /db_xref="MGI:MGI:2442342"
                     /translation="MTDDSLKIGNGLPLVGPGTDVGISSLPMLGYLGKNYASAKVTTD
                     GHCPACRAKGKLSALKPYRISFQESVFLCEDLQCIYPLGSESLTNLISPDSEDCPTPS
                     KPQKRKRLETNCRNSPLPVHSKKTRSHIVTDSEPIVNGKYNGEVCDDFSASFPDTSAH
                     QDPASTAASVEQSEALEADDVVVAATEDPATVSVTSELEMPAKSRCLPLCQTLCVQWK
                     NTQALCWLDCILSALVHLEVLRKTVLEACSREECVFGRLFEMYHQADELLHTHHLHGV
                     TGEDCKKLTSEIFTEIDTCLNKVRDEIFAKLQPKLRCTLGDMESPVFALPVLLKLEPH
                     VESLFTYSFSWNFECSHCGHQYQNRCVKSLVTFTNIVPEWHPLNAAHFGPCNSCNSKS
                     QIRKMVLERASPILMLHFVEGLPRRDLQHYAFHFEGSLYQVTSVIQYQANNHFITWFL
                     DADGSWLECDDLKGPCAKRHVTCEVPASETHIVIWERKSQVPIEEAACLPCMKPNVQP
                     VSGEEQPTCPALCSLAGTATSEPSVAHPTSMAGAPQTLPEIQAVAHGDSVLSGAKGMV
                     DSILPSALEETIQETASVSQVDSKDCLLEDKPVAGSAALVRVLAFQPQDSPGSSGSSL
                     VSSLCEGKLVAPCVDSSFPSQAVSTDLQAVLSQAGDTVVPNPVTDAPVPVLVQELKSL
                     ATEKDSQTQLLPLKTEKLDPEQPGKSQASNLRKRETTASSKTVAARSAQNQPRKEDQK
                     RAFVGSWVKGLLSRGGAFMPTCVLSQSRAVSDLQPSVKGASNFDGFKTKSISRRSKRM
                     SRKAKHMEELSPRNSSPPLSWTAALTQAAENATSALLREQEGSRPAPLRHRSPGNESA
                     ISPASRGDAAEDQVHKLRLKLLKKLKAKKKKLAALISSPHREPSLSDHSEPASHCGTP
                     ASDQSEPVSHCGSPNDCESIEDLLKELQHQIDLADSKSGCTSAPDATSNNSQSHEEIL
                     AELLSPTAMSEPSESGELELRYLEMGDSTPAQAPSEFSVVSQNTCLKQDHDYCSPEKG
                     QREVDLHSVMDSACIRTLNLGSPMKTDIFDDFFSTSALNSLTNDTLDIPHFDDSLFEN
                     C"
     exon            417..545
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            546..1146
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1260
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1390
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1516
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1674
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..3757
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3737..3742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3757
                     /gene="Uspl1"
                     /gene_synonym="E430026A01Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtcttcccc ttccccggcc ctgcccgcgt gctctcaagc agggctgcct gccgcaggaa
       61 agtgtttgtg gggtagctct tgggcggcgg actcgcaggc ggaagttgct ttcctggcgg
      121 agagggctgt gggggaggag ccgtccgagg gaacgtgggt tgaacgttac ggttagatgg
      181 tggggacctc aagctggaag aggagttcgg gtccactgta tgcgaagaag gagcgtactt
      241 cgggaggggt tcattgaaaa atccttagtg attttgacat gttccaagtg acataaatta
      301 gccaatgact cggaatgacg gatgattctc tgaagattgg aaatggtttg ccactggttg
      361 gaccagggac tgatgtaggg atatcttcac tccccatgct ggggtacttg ggaaaaaatt
      421 atgcttcagc taaagtcaca acagacgggc attgccctgc ttgtagagcg aaaggcaagc
      481 taagtgcctt aaaaccttac cgcattagct tccaagaatc tgtctttctg tgtgaggatc
      541 ttcagtgcat ttatcctttg ggctctgagt cacttactaa tttaatttct cctgattcag
      601 aagattgtcc cactccaagt aagcctcaaa aacgaaaaag attggaaacc aactgtagga
      661 attcacctct tccagtacat tctaaaaaga ctagaagtca cattgtcact gatagtgaac
      721 caattgtgaa tggtaaatat aatggagaag tgtgtgatga cttctcagca agcttcccag
      781 ataccagtgc tcaccaggat cctgccagca cagctgcttc tgtggagcag agtgaggctt
      841 tggaggctga tgatgtggtt gtggccgcta cagaagatcc tgctacagtt agtgtcacat
      901 ctgagctgga aatgccagct aagagcagat gtttaccact ttgccagact ctgtgtgtcc
      961 agtggaaaaa cacccaggcc ctgtgctggt tagactgtat cctgtcagcc ctggtgcact
     1021 tggaggtgtt gaggaagact gtgctggagg cgtgctccag ggaggagtgt gtatttggaa
     1081 ggctgtttga aatgtaccac caagcagatg agctgctgca cacccatcac ctgcatggcg
     1141 tcacaggtga agattgtaaa aaattgacat cagaaatatt tacagaaata gatacctgtt
     1201 tgaataaagt tagagatgaa atttttgcta aacttcaacc gaagcttaga tgcacattag
     1261 gtgacatgga aagtcctgtg tttgcacttc ctgtactgtt aaagcttgaa ccccatgttg
     1321 aaagcctctt tacatattct ttttcttgga attttgaatg ttcccattgt ggacaccagt
     1381 accaaaacag gtgtgtgaag agtctggtca cctttaccaa tattgttcct gagtggcatc
     1441 cactcaatgc tgcccatttt ggtccatgta acagctgcaa cagtaaatca caaataagaa
     1501 aaatggtgtt ggaaagagcg tcgcccatac tcatgctgca cttcgtggag ggcttaccaa
     1561 ggagggattt gcaacactat gccttccact ttgaaggaag cctttatcaa gtcacgtcgg
     1621 taatacagta ccaagcaaat aaccatttta taacatggtt tttagatgct gatgggagtt
     1681 ggctggagtg tgatgaccta aagggtccct gtgctaaaag gcacgtgacc tgtgaagtgc
     1741 cagcttcaga gacacatatc gttatttggg aaagaaaatc ccaggtgcca attgaagaag
     1801 ctgcctgcct tccatgcatg aagccaaatg tgcagcctgt atcaggtgag gagcagccga
     1861 cttgtccagc actgtgttct ctggctggga ccgccacctc agaaccctca gtcgcccatc
     1921 ccacatctat ggcaggcgct cctcagactc ttccagaaat ccaagctgta gctcatggag
     1981 atagtgtact ttcaggagca aaaggcatgg tcgacagcat tttaccctca gcacttgaag
     2041 aaaccatcca ggaaactgcc tctgtttctc aggttgactc caaagattgc ctgttggaag
     2101 acaaacccgt ggcaggaagt gcagcactgg tcagagtact tgcttttcag ccacaggact
     2161 ccccggggtc ttcggggtct tccttagtgt ccagcctgtg tgaaggaaag ctagttgccc
     2221 catgtgtgga ttcaagtttc ccatcccaag ctgtgagcac agacctgcag gcagtactgt
     2281 cccaggcagg ggacactgtg gttcctaacc ctgtgactga tgcccctgtt cctgttcttg
     2341 ttcaggaatt gaagtccctg gcaactgaga aggactctca gacacagttg ctgccactga
     2401 aaactgagaa gttagatcct gagcaacctg gtaaatctca ggcatctaat ttgagaaaac
     2461 gagaaaccac agcgtcttct aaaacagtag cagccaggtc agcacagaat cagcctcgga
     2521 aagaagatca gaagagagcc ttcgtgggaa gttgggtgaa ggggctattg agcaggggtg
     2581 gtgcttttat gccaacctgt gttttgtctc agagtagagc agtaagtgac ctgcaacctt
     2641 ctgttaaagg agccagtaat tttgatggct ttaaaacgaa aagtataagc cgcaggtcta
     2701 aaagaatgtc caggaaagct aagcacatgg aggaactgtc tccaaggaac agctctccac
     2761 cattgagctg gacagctgct ctgacccagg ctgctgagaa cgccacctca gctctgttga
     2821 gggagcagga aggctcacgt ccagctcccc tcaggcacag atctcctggc aatgaaagcg
     2881 ccatctctcc agcaagccgt ggagatgcgg ctgaagatca ggttcataag cttcggctca
     2941 aacttcttaa aaaattaaag gcaaaaaaga agaaactagc tgccctcatt tcttccccgc
     3001 accgtgaacc atctctaagt gaccactcag agcctgcgtc ccattgtgga acacctgcaa
     3061 gtgaccagtc agagcctgta tcccattgtg gatctccaaa tgactgtgag tccatagaag
     3121 atctgttaaa agagctacag catcaaattg accttgcaga cagcaaatct gggtgcacct
     3181 ctgctcctga tgccacctca aataacagcc agagtcatga ggagatttta gcagagttgc
     3241 tgtcgcctac agccatgtca gagccctcag aaagtgggga gcttgagttg aggtacttgg
     3301 aaatggggga cagcacccca gcacaagcac ctagtgaatt cagtgttgtc tcccagaaca
     3361 catgtctgaa acaggaccat gattactgca gccctgagaa aggccagcgg gaagttgatc
     3421 tgcattcagt catggacagt gcctgtataa gaaccttgaa cttggggagt cccatgaaga
     3481 ctgatatctt tgatgatttt ttttccacct cagcactgaa ttctttaaca aacgacacat
     3541 tagacatacc tcattttgat gactctctgt ttgagaattg ctgagtgcgt gctagtgttt
     3601 tagttaaata ctgaccactg ctgctaggag gctgtgcctc ttgggtagta ttggctgaaa
     3661 tgcatagcct tgtgttctag ccatgggaag ctgtgagcta ctggagtctg cctgtgagac
     3721 atgagatcta ctgcaaatta aagacctccg cccagttaaa aaaaaaaaaa aa
//
