LOCUS       NM_148943               8094 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 9, Y chromosome (Usp9y),
            mRNA.
ACCESSION   NM_148943 XM_905498
VERSION     NM_148943.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8094)
  AUTHORS   Kuroki,S., Okashita,N., Baba,S., Maeda,R., Miyawaki,S., Yano,M.,
            Yamaguchi,M., Kitano,S., Miyachi,H., Itoh,A., Yoshida,M. and
            Tachibana,M.
  TITLE     Rescuing the aberrant sex development of H3K9 demethylase
            Jmjd1a-deficient mice by modulating H3K9 methylation balance
  JOURNAL   PLoS Genet 13 (9), e1007034 (2017)
   PUBMED   28949961
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8094)
  AUTHORS   Satou,K. and Suto,J.
  TITLE     Effect of the Y chromosome on testis weight in mice
  JOURNAL   J Vet Med Sci 77 (6), 753-759 (2015)
   PUBMED   25716571
  REMARK    GeneRIF: Variations in Usp9y and the number of CAG repeats in Sry
            are significantly associated with testes weight.
REFERENCE   3  (bases 1 to 8094)
  AUTHORS   Stegeman,S., Jolly,L.A., Premarathne,S., Gecz,J., Richards,L.J.,
            Mackay-Sim,A. and Wood,S.A.
  TITLE     Loss of Usp9x disrupts cortical architecture, hippocampal
            development and TGFbeta-mediated axonogenesis
  JOURNAL   PLoS One 8 (7), e68287 (2013)
   PUBMED   23861879
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8094)
  AUTHORS   Kogo,H., Tsutsumi,M., Ohye,T., Inagaki,H., Abe,T. and Kurahashi,H.
  TITLE     HORMAD1-dependent checkpoint/surveillance mechanism eliminates
            asynaptic oocytes
  JOURNAL   Genes Cells 17 (6), 439-454 (2012)
   PUBMED   22530760
REFERENCE   5  (bases 1 to 8094)
  AUTHORS   Yao,C.J., Xu,W.J., Gong,X.L., Zhou,Y., Yan,Z.Q., Zhu,Z.J.,
            Wang,Z.X., Li,Q.L., Guo,X.B., Wang,L.Y., Ma,D. and Qiao,Z.D.
  TITLE     The role of Dby mRNA in early development of male mouse zygotes
  JOURNAL   Asian J Androl 12 (4), 567-577 (2010)
   PUBMED   20543856
REFERENCE   6  (bases 1 to 8094)
  AUTHORS   Hall,N.M., Brown,G.M., Furlong,R.A., Sargent,C.A., Mitchell,M.,
            Rocha,D. and Affara,N.A.
  TITLE     Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated
            with a functional promoter and encodes an intact open reading frame
            homologous to Usp9x that is under selective constraint
  JOURNAL   Mamm Genome 14 (7), 437-447 (2003)
   PUBMED   12925892
  REMARK    GeneRIF: Selection is acting to maintain the amino acid sequence of
            both the X and the Y-linked genes.
REFERENCE   7  (bases 1 to 8094)
  AUTHORS   Xu,J., Burgoyne,P.S. and Arnold,A.P.
  TITLE     Sex differences in sex chromosome gene expression in mouse brain
  JOURNAL   Hum Mol Genet 11 (12), 1409-1419 (2002)
   PUBMED   12023983
REFERENCE   8  (bases 1 to 8094)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 8094)
  AUTHORS   Mazeyrat,S., Saut,N., Sargent,C.A., Grimmond,S., Longepied,G.,
            Ehrmann,I.E., Ellis,P.S., Greenfield,A., Affara,N.A. and
            Mitchell,M.J.
  TITLE     The mouse Y chromosome interval necessary for spermatogonial
            proliferation is gene dense with syntenic homology to the human
            AZFa region
  JOURNAL   Hum Mol Genet 7 (11), 1713-1724 (1998)
   PUBMED   9736773
REFERENCE   10 (bases 1 to 8094)
  AUTHORS   Brown,G.M., Furlong,R.A., Sargent,C.A., Erickson,R.P.,
            Longepied,G., Mitchell,M., Jones,M.H., Hargreave,T.B., Cooke,H.J.
            and Affara,N.A.
  TITLE     Characterisation of the coding sequence and fine mapping of the
            human DFFRY gene and comparative expression analysis and mapping to
            the Sxrb interval of the mouse Y chromosome of the Dffry gene
  JOURNAL   Hum Mol Genet 7 (1), 97-107 (1998)
   PUBMED   9384609
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145592.3 and AC145393.4.
            
            On Dec 28, 2006 this sequence version replaced NM_148943.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ307017.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC145592.3         165460-165719       c
            261-295             AC145592.3         164823-164857       c
            296-372             AC145592.3         160545-160621       c
            373-514             AC145592.3         160107-160248       c
            515-660             AC145592.3         154788-154933       c
            661-740             AC145592.3         152767-152846       c
            741-853             AC145592.3         150440-150552       c
            854-1072            AC145592.3         148322-148540       c
            1073-1188           AC145592.3         141196-141311       c
            1189-1440           AC145592.3         140743-140994       c
            1441-1576           AC145592.3         140240-140375       c
            1577-1729           AC145592.3         138110-138262       c
            1730-1834           AC145592.3         118355-118459       c
            1835-2041           AC145592.3         101547-101753       c
            2042-2178           AC145592.3         99906-100042        c
            2179-2312           AC145592.3         97212-97345         c
            2313-2400           AC145592.3         91207-91294         c
            2401-2743           AC145592.3         90129-90471         c
            2744-2839           AC145592.3         89253-89348         c
            2840-3054           AC145592.3         87121-87335         c
            3055-3295           AC145592.3         73965-74205         c
            3296-3448           AC145592.3         72993-73145         c
            3449-3569           AC145592.3         70598-70718         c
            3570-3700           AC145393.4         163955-164085       c
            3701-3979           AC145393.4         163360-163638       c
            3980-4105           AC145393.4         159371-159496       c
            4106-4231           AC145393.4         159083-159208       c
            4232-4401           AC145393.4         157747-157916       c
            4402-4510           AC145393.4         148993-149101       c
            4511-4657           AC145393.4         148642-148788       c
            4658-4804           AC145393.4         147213-147359       c
            4805-5027           AC145393.4         143485-143707       c
            5028-5248           AC145393.4         140835-141055       c
            5249-5439           AC145393.4         139542-139732       c
            5440-5613           AC145393.4         132080-132253       c
            5614-5755           AC145393.4         126278-126419       c
            5756-6503           AC145393.4         123684-124431       c
            6504-6627           AC145393.4         123146-123269       c
            6628-6865           AC145393.4         121784-122021       c
            6866-6995           AC145393.4         120949-121078       c
            6996-7181           AC145393.4         117731-117916       c
            7182-7402           AC145393.4         115072-115292       c
            7403-7491           AC145393.4         114901-114989       c
            7492-7648           AC145393.4         111834-111990       c
            7649-7861           AC145393.4         111507-111719       c
            7862-7957           AC145393.4         110594-110689       c
            7958-8094           AC145393.4         106182-106318       c
FEATURES             Location/Qualifiers
     source          1..8094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="Y"
                     /map="Y"
     gene            1..8094
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /note="ubiquitin specific peptidase 9, Y chromosome"
                     /db_xref="GeneID:107868"
                     /db_xref="MGI:MGI:1313274"
     exon            1..260
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..295
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..372
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            373..514
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..8089
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 9, Y chromosome"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 9Y"
                     /protein_id="NP_683745.2"
                     /db_xref="CCDS:CCDS30544.1"
                     /db_xref="GeneID:107868"
                     /db_xref="MGI:MGI:1313274"
                     /translation="MTITTRGSPVGENESQGQTSDGQPQPSFQQNQISSSDSSNETSP
                     TTPPYEQGQGDAPPQHEEEDPSFPHTDLAKLEDMINRSRWVVPVLPKGELEVLLEASI
                     DLTKKGLDVKSEACQRFFRDVLTVSFSKILMDEAVSGWKFEIHRCIINNTHRLVELCV
                     AKLSQDWFPFLELLAIALNPHCKFHVYNGARPCESVSSSVQFPEDELFACSPDLHSPK
                     GWLVDLINTFGTLNGFQILHDRFTSGSALNVQTIAALIKPFGQCYEFLTQHTLRKYFI
                     PVIEVVPQILQKLTNEELKKETKTEVKNDTISMIIKFLKNLASRIPGQEETVKNLETF
                     RLKMILRLLQISSFNGKMNALNEINKVLSSVSYYTHGHGNSEEEWLTVERMTEWIQQN
                     NILSIVLQDSLHQPQYVEKIEKILRFVIKEKALTLQDLNNIWAAQAGKHEAIVKNVHD
                     LLAKLAWNFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLN
                     LLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDCFIEEFRTNNKWVI
                     PALKQIKEICSLFGEAPQNLSQTHQSPRVFYRHDLISQLQHNHALVTLVAENLAAYMN
                     SIRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCVSQAKQIWNC
                     LAENAVYFSDREACFMWYSKLMGDEPDLHPDINKEFFESNVLQLDPSLLTENGMKCFE
                     RFFKTVNCREGKLMIKRKIYMMDDLDLIGLDYLWKVVIQSNDDISSRAIDLLKEIYTS
                     LGPKLQANQVVIHEDFIQSCFDRLKASYDTLCVLDSEKDNIFSCARQEAIRMVRILTV
                     LREYISEYDSDYHEERMILPMSRAFRGKHLSFTVRFPNQGKEVEDLDILSHTNATIGS
                     VRRCILNRMNVNVAHTKIELFIGGELVASEDDRKLVEQLNLKDKSLITAKFIQINSNM
                     PSSPDSSSDSSAGPPGNHSHNNYRDVSNPEMEKCLPGVIMSLQPRYISFLWQVADLGS
                     MLTVPTLRDGARILMKLMPPDSTTLEQLRALCSDHVNLGERRLGQSLHSLFFGSSASQ
                     VLYLTEVVYTLLMPAGAPLADISSDFQYHFLKSGGLPLVLSMLIQNNFLPNTDVETRR
                     DAYFSALKIAKLLLTIVGYGHVQAIAEACQPVADGTDPKTPINQVTHDQAVVLQNALQ
                     SIPNPSSECMLRNVSVHLAQQISGLASRYIPDICVIRAIQKIIWAAGCGSLELVFSPN
                     EDITETYKMTTSTRSNLEVKDEQVCCEALEVMTLCFALIPTAMDSLNKEKAWQSFVID
                     LLLYCPSKTVRQLAQEQFFLICTRCCMGHRPLLFFITLLFTILGGAANEKGKHSDVYF
                     TLLRRLLTYAYNSNIQVPNVDVLLNDEIDWLKRVRDYIKNTGETNVEDPILEGHLGVT
                     KELLSFQSPEKKYHIGCKTGGANLVKELIDYFIFPASKAYLQYMRSGELPIKQAIPVC
                     GSPATINAGFELLVALAFGCVRNLKQIVNCLTELFYIGTPVTTCEAVGEWEYLPPVGP
                     RPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIDSIWSDTDDDIFKGEKQDSE
                     NNVDPRDDVFRYPHQFEDKPTLSKVEDRKEYNIAVLKHLQITFGHLAASQLQYYVPKG
                     FWQQFRLWGEPVNLREQHDALEFFNSLVDSLDEAFKALGYPTVLSKVLGGSFADQKIC
                     QGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCDKKVDTVK
                     RLLIKKLPSVLTIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGATKLEGDSV
                     NPQTQLIKQNEQSESVIPGSTKYRLVGVLVHSGQANGGHYYSYIIQRNGKDSKRSHWF
                     KFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERM
                     DITDEDDEIITYISELTFTRPHQIMSPAIERSVWKQNVQFLHNQMQFSLEYFQFIKKL
                     LTCNAVYLSPAPGQDHLLPEAEDITMISIQLASRFLFTTGFHTKKIIRGPANDWYDAL
                     CILLRHSKNVRFWFVHNVLFNVSNRFSEYLLECPSAEIRGTFAKLIVFIAHFSLQDGS
                     SPSPFTSPFANPGPYSQIYDNLSLSDHLLKAVLSLLRREVSEHGRHLQQYFNLFIMYA
                     SLGLAEKTQLLKLNVPATFMLVSLDEGPGPPVKYQYAELSKLHSVVSQLIRCCSVSSR
                     MQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILFMRTTYMKKVIEDCSNSEDTVKL
                     LLFCCWENPQFSCSVLSELLWQVAHSHAYELQPYLDLLLQIILFEDSWQAHRIHNALK
                     GIPNDQDGLFDTIQHSKNHHQKRAYQCIKWMVTLFNSCPVAYQILQGNGDLKNKWTWA
                     MEWLGDELERKPYSGNPQYTYSNWSPPVQSNETANGYFLEKSHSAKMKLTKACDLYPE
                     EDPDDQDALDEHVSHAPQDRTFYLYSHRSHYQQNYVPEQPFSGPASHHLNNPQKNDKP
                     QETHESNEEISSCLIKDQ"
     exon            515..660
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..740
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..853
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1072
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1188
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1440
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1576
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1729
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1834
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2041
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2178
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2312
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2400
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2743
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2839
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..3054
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3295
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3448
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3569
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3700
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3701..3979
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4105
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            4106..4231
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4401
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4510
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4657
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            4658..4804
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            4805..5027
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            5028..5248
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5439
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            5440..5613
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            5614..5755
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            5756..6503
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6504..6627
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6628..6865
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6866..6995
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6996..7181
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            7182..7402
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            7403..7491
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            7492..7648
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            7649..7861
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            7862..7957
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
     exon            7958..8094
                     /gene="Usp9y"
                     /gene_synonym="Dffry; Fafl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttcacttc ttagcgtcgt cgttggggcc gccatcttat ttttaagtga acaaacttta
       61 aatttctttt ctccctgatt gctgttgctg ggtgccactt tccttcacgt tggtggtcac
      121 tttgtggtgt cataaggatc agaacaggga tcaaagaaaa gtgaagctgt aactgccgga
      181 gaaatcagag gtgactccgg aaaaacggct cttagactga actctacgat tagagctccg
      241 tctcccaaga cagaaaaaag gttttcaata ttcctacaaa aacatgtctg agttgagaac
      301 tctgaaaata aatgatctat agtcctgtga ggaatccaga gttgacatac attgccttcc
      361 acttaagaac tggacaaatg cataaacaga caaactagaa aaggtctgct ctttgatcat
      421 gacaatcaca actcgtggct ctccagtagg agagaatgag agccagggtc agacttctga
      481 tggacaacct cagccttctt tccaacagaa ccagatctca tcatctgatt cttccaatga
      541 gacttctcca acaactcctc catatgaaca aggccaaggt gatgctccac cacagcatga
      601 agaagaggat ccttcatttc ctcatactga cctggcaaag ttagaagaca tgatcaacag
      661 gtcccgatgg gtggttcctg ttttgccaaa gggagaatta gaagtacttt tagaagcttc
      721 tattgatctt actaaaaaag gtctggatgt taaaagtgaa gcatgccagc gtttttttcg
      781 cgatgtttta actgtgtctt tttccaaaat ccttatggat gaggctgtga gtggatggaa
      841 gtttgaaatt cataggtgta ttattaacaa tacccatcgc ctggtggagc tttgtgtggc
      901 caaattgtct caggactggt ttccatttct agaacttcta gcaattgcat taaatcctca
      961 ttgcaaattt catgtctata atggtgcacg tccatgtgaa tcagtgtcct caagtgttca
     1021 gtttcctgaa gatgaactct ttgcctgttc tccagaccta cattcaccaa aaggttggtt
     1081 agtggacctc attaacacat ttggcacact aaatggtttc cagattttgc atgatcgttt
     1141 cactagtgga tcagcattaa atgttcaaac aattgcagct cttattaagc cgtttggaca
     1201 gtgctatgag tttctcactc aacatacatt aagaaagtac ttcattccag ttatagaagt
     1261 agttccacaa atattacaaa aattaactaa tgaagaactg aaaaaagaaa caaagactga
     1321 agtgaaaaat gataccattt caatgattat taaatttcta aaaaatttag cttcaagaat
     1381 tccaggacaa gaggaaactg ttaaaaattt agaaactttt aggttaaaaa tgatactcag
     1441 attgctacag atttcttctt ttaatggaaa gatgaatgca ctgaatgaaa ttaacaaagt
     1501 gctttcaagt gtgtcatatt atacgcatgg acatggtaat tctgaagaag agtggctaac
     1561 cgttgagcga atgacagagt ggatacagca gaacaatatc ttatccattg tcttgcaaga
     1621 tagcctacat caaccacagt atgtggaaaa aatagagaag attcttcgtt ttgtaattaa
     1681 agaaaaggct cttactttac aggatcttaa taatatctgg gcagcacagg ctggaaaaca
     1741 tgaagctatt gtgaagaatg ttcatgattt actagcaaaa ttggcttgga atttttctcc
     1801 tgaacaactt gatcatctct ttgattgctt taaggcaagc tggacaaatg caagtaaaaa
     1861 acaacgtgaa aaactacttg aattgatacg tcgtcttgca gaagatgata aagatggtgt
     1921 aatggcacac aaagtgttga atcttctttg gaatctagct cacagtgatg acgtgcctgt
     1981 agatatcatg gatctggctc tcagtgccca cataaaaata ctggattata gttgttccca
     2041 ggatcgagat acacaaaaaa tccagtggat agactgcttt atagaagaat ttcgaacaaa
     2101 taataaatgg gtcatccctg cattaaaaca aattaaagaa atttgtagtt tgtttggtga
     2161 agcacctcaa aatttaagtc aaactcatca aagtccccgt gtattttatc gtcatgactt
     2221 aatcagccaa cttcagcata atcatgcttt agttactttg gtagcagaaa accttgcagc
     2281 ttacatgaac agcataagat tgtatgctag agatcatgaa gattatgacc cacaaactgt
     2341 aagactagga agtagataca gtcatgttca agaagtccaa gaacggctta atttcctcag
     2401 attcttactg aaggatggtc aactctggct ctgtgtttcc caggcaaaac aaatatggaa
     2461 ctgtttagca gagaatgccg tttactttag tgatcgagaa gcctgtttta tgtggtattc
     2521 caaattaatg ggagatgaac ctgacttaca tcctgatatt aataaggagt ttttcgaaag
     2581 taatgtgctt cagcttgatc cttctctatt aactgaaaat gggatgaaat gttttgaaag
     2641 atttttcaaa actgttaatt gtcgagaagg gaaactaatg ataaaaagaa aaatctatat
     2701 gatggatgat ttggacttaa taggattaga ctacctttgg aaggttgtga ttcagagtaa
     2761 tgatgatatt tcaagcagag caatagatct tcttaaagag atatacacaa gccttggtcc
     2821 caaattgcaa gctaatcagg tagtaattca tgaagacttt attcaatctt gctttgatcg
     2881 cttgaaagcc tcatatgata cattgtgtgt tttggatagt gaaaaagaca atatttttag
     2941 ctgtgcaaga caagaagcca tccgaatggt tcgcatatta acggtcttaa gggaatacat
     3001 aagtgaatat gacagtgatt atcatgagga aaggatgatt ctacctatgt caagagcatt
     3061 tcgtggaaaa cacttgtctt ttacagtacg atttccaaac cagggcaaag aggttgagga
     3121 tttggacata ttgtctcata caaacgctac cattggttct gtgcgacgct gcattctcaa
     3181 tcgtatgaat gtcaatgtag cccatacaaa aattgaactg tttataggtg gagagttagt
     3241 agcgtctgaa gatgacagaa agctagttga acagttaaat ttgaaagata aatcactaat
     3301 tactgctaaa tttatacaaa taaattccaa catgccttca agtcctgata gctcatctga
     3361 ttcgtcagct ggacctcctg gaaaccatag tcataataac tacagagatg tttccaatcc
     3421 agaaatggaa aagtgtttac ctggggtgat aatgtcactg cagcccagat acatatcttt
     3481 cctttggcaa gttgcagact taggtagcat gttgactgtg ccaactctta gagatggagc
     3541 aagaatactt atgaaactta tgccaccaga tagcacaact ctagaacaat taagagctct
     3601 atgttcagac catgtaaatc ttggagaaag acgacttggt caatctcttc actcactttt
     3661 ctttggttct tctgcctccc aagtgctata tttaacagag gtagtttaca ccttgttaat
     3721 gcctgctggt gcacctctgg ctgatatttc ctctgacttt cagtatcact tcttgaaaag
     3781 tggtggctta cctcttgtac taagtatgct gatacaaaat aacttcttac caaatacaga
     3841 tgttgaaact cgtagagatg cttacttcag tgcccttaaa atagccaaac tgttgttaac
     3901 tatcgttggc tatggccatg ttcaggccat agcagaagct tgtcagcctg ttgcagatgg
     3961 cacagatcct aaaacaccga ttaaccaggt tactcatgat caagctgtgg tgctacaaaa
     4021 tgcccttcaa agcattccta atccttcttc tgagtgcatg cttagaaatg tatcagttca
     4081 tcttgctcaa caaatatcag ggttggcctc aagatatata cctgatattt gtgttattag
     4141 agctatacaa aaaatcatct gggcagcagg atgtggatca ttagagctag tttttagtcc
     4201 aaatgaagat atcacagaaa cttacaagat gaccaccagt acaaggagta atctagaagt
     4261 gaaagatgaa caagtttgct gtgaagccct ggaagtgatg acattatgtt ttgctttaat
     4321 tccaactgct atggattcac tcaataaaga aaaggcctgg cagtcatttg tcattgactt
     4381 actattgtac tgtcctagca aaactgtacg gcagttggca caggagcagt tctttttaat
     4441 atgtaccaga tgttgcatgg gacatagacc tttgctgttc ttcattactc tactctttac
     4501 cattttgggg ggtgcagcta acgagaaggg taaacattca gatgtctact tcacactttt
     4561 aaggcgtctt ctcacttatg cttacaacag caacattcaa gttcccaatg ttgatgttct
     4621 tctcaatgac gaaattgatt ggcttaaaag ggttagggat tacattaaaa atacaggaga
     4681 aacaaatgta gaagacccaa tcttagaagg ccatctggga gtaacaaaag agttactgtc
     4741 ttttcagtct cctgaaaaaa agtatcatat tggttgtaaa acaggaggtg ctaatcttgt
     4801 taaagaatta attgattatt tcatctttcc tgcatccaaa gcttacctgc aatatatgag
     4861 aagtggggaa ttgccaatca agcaagctat tccagtctgt ggttcaccag ctacaattaa
     4921 tgctggtttt gaactacttg tagctttggc ttttggttgt gtaaggaatc ttaaacagat
     4981 agtaaactgt ttgactgaac tgttttacat aggcacacca gtaactactt gtgaagccgt
     5041 tggtgaatgg gaatatttac cccctgttgg gccccgccca ccaaaaggat ttgtgggact
     5101 gaaaaatgct ggtgctactt gttatatgaa ctctgtgatc caacagctat acatgattcc
     5161 ttcaatcagg aacagtattc ttgcaattga tagcatatgg agtgatacag atgatgatat
     5221 attcaaaggt gaaaagcagg acagtgagaa taatgttgat cccagagatg atgtattcag
     5281 atatcctcat caatttgaag ataaaccaac attaagtaaa gtagaagatc ggaaagagta
     5341 caacattgct gttttaaaac accttcagat aacctttgga catttagctg cttctcaact
     5401 acaatactat gtgccaaaag gattttggca acaattcagg ctttggggtg aacctgttaa
     5461 tctccgtgag caacatgatg cattagagtt ttttaattct ttggtggata gtttagatga
     5521 agcttttaaa gctttaggat atccaactgt gcttagtaaa gtccttggag gatcctttgc
     5581 tgatcagaag atttgccaag gctgcccaca taggtatgaa tgtgaagaat cttttacaac
     5641 attaaatgta gacattagaa atcaccaaaa tcttcttgat tctttggagc agtatgttaa
     5701 aggagattta ttagagggtg caaatgcata tcactgtgaa aaatgtgata aaaaggttga
     5761 tacagtaaaa cgcttattga ttaaaaaact accttctgtt cttactatcc aactgaaacg
     5821 atttgactat gattgggaaa gagaatgtgc aatcaaattc aatgattact ttgaatttcc
     5881 aagagaattg gatatggaac cttacacagt agcaggtgcc acaaagctgg aaggtgacag
     5941 tgtaaatcca cagactcaat tgattaaaca gaatgagcag tctgaaagtg tcataccagg
     6001 aagcacaaaa tatcgacttg ttggtgtgct tgtacacagt ggtcaagcaa atggtggaca
     6061 ttattattct tacatcattc aaagaaatgg taaagacagt aagagaagtc actggttcaa
     6121 atttgatgat ggagatgtaa cagaatgtaa aatggatgat gatgaagaaa tgaaaaatca
     6181 gtgctttggt ggagagtata tgggagaagt ttttgatcat atgatgaagc gtatgtcata
     6241 caggcgtcag aaaagatggt ggaatgctta cattcttttt tatgaacgga tggatataac
     6301 tgatgaagat gatgagataa taacatatat atcagagcta acatttacca gacctcatca
     6361 gattatgtca ccagccattg agagaagtgt atggaaacag aatgtgcaat tcctgcataa
     6421 ccaaatgcag tttagcttag aatattttca gtttattaaa aaactgctta catgtaatgc
     6481 tgtgtactta agccctgctc caggacaaga tcacttgcta ccagaagcag aagatatcac
     6541 aatgatcagc attcagcttg cttctagatt cctctttact actggatttc atactaagaa
     6601 aataatccgt ggacctgcca atgactggta tgacgcactt tgtattctcc tccgtcacag
     6661 caagaatgta cgtttttggt ttgttcataa tgtcctcttt aatgtatcaa atcgtttctc
     6721 tgagtacctt ctggaatgtc caagtgcaga aatcagaggt acatttgcaa agcttatagt
     6781 atttattgca catttttctt tgcaagatgg atcttctcct tcacctttta catcaccttt
     6841 tgcaaatcca ggaccttata gtcagatcta tgacaattta agcttgagtg atcatttact
     6901 aaaagcagta ttaagtctct tgagaaggga agtttctgaa catgggcgac atttacaaca
     6961 atatttcaat ttatttataa tgtatgccag cttaggtttg gcagaaaaga cccagcttct
     7021 aaaactgaat gttcctgcaa cctttatgct tgtgtctttg gatgaaggac caggccctcc
     7081 agttaaatat caatatgctg agttgagcaa gttacattca gtagtgtctc agctgatcag
     7141 atgttgcagt gtctcatcaa gaatgcagtc ttctatcaat ggtaaccccc ctcttccaaa
     7201 tccatttggt gacccaaatt tatcacaacc gataatgcca attcagcaaa atgtggctga
     7261 cattttattt atgagaacca cttacatgaa gaaagttatt gaagactgca gtaactcaga
     7321 ggatacagtc aaattacttc tcttctgctg ctgggagaat ccccagtttt catgttctgt
     7381 tcttagcgaa ctgctatggc aggttgcaca ttcacatgca tatgaacttc aaccatattt
     7441 ggatctactt ttgcaaatta ttctgtttga ggactcctgg caagctcaca gaattcataa
     7501 tgcacttaaa ggaattccaa atgatcaaga tggactgttt gatacaatcc agcactctaa
     7561 aaatcaccat caaaaaagag cctatcaatg tataaaatgg atggtaactc tctttaacag
     7621 ttgtcctgtt gcctaccaga tcttgcaggg taatggagac cttaaaaata agtggacttg
     7681 ggctatggaa tggcttggag atgaacttga aagaaaacca tattctggca atcctcaata
     7741 cacttacagc aactggtctc ctccagtaca aagcaatgaa acagcaaatg gttatttttt
     7801 agagaaatct catagtgcaa aaatgaaact tacaaaagct tgtgatctgt atccagaaga
     7861 ggaccctgat gaccaagatg ccctcgatga acatgtgtca catgcaccac aagatagaac
     7921 attttatctt tattcacaca gatctcacta tcaacagaat tatgtacctg aacagccgtt
     7981 ttcaggtcca gcatcacatc acttgaataa ccctcagaaa aatgataaac cacaagaaac
     8041 tcatgaaagc aatgaagaaa tatcttcatg tctaataaaa gatcagtaac acaa
//
