LOCUS       NM_001003918            5427 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus ubiquitin specific peptidase 7 (Usp7), mRNA.
ACCESSION   NM_001003918 XM_148584 XM_489507
VERSION     NM_001003918.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5427)
  AUTHORS   Yan,M., Mei,Y., Zhang,T., Liu,Z., Su,L., Xiao,Y., Zhong,X. and
            Lu,Y.
  TITLE     USP7 cardiomyocyte specific knockout causes disordered
            mitochondrial biogenesis and dynamics and early neonatal lethality
            in mice
  JOURNAL   Int J Cardiol 408, 132149 (2024)
   PUBMED   38723908
  REMARK    GeneRIF: USP7 cardiomyocyte specific knockout causes disordered
            mitochondrial biogenesis and dynamics and early neonatal lethality
            in mice.
REFERENCE   2  (bases 1 to 5427)
  AUTHORS   Tang,F., Gong,H., Ke,T., Yang,W., Yang,Y. and Liu,Z.
  TITLE     USP7 Promotes TGF-beta1 Signaling by De-Ubiquitinating Smad2/Smad3
            in Pulmonary Fibrosis
  JOURNAL   Discov Med 36 (187), 1616-1626 (2024)
   PUBMED   39190377
  REMARK    GeneRIF: USP7 Promotes TGF-beta1 Signaling by De-Ubiquitinating
            Smad2/Smad3 in Pulmonary Fibrosis.
REFERENCE   3  (bases 1 to 5427)
  AUTHORS   Yan,M., Su,L., Wu,K., Mei,Y., Liu,Z., Chen,Y., Zeng,W., Xiao,Y.,
            Zhang,J., Cai,G. and Bai,Y.
  TITLE     USP7 promotes cardiometabolic disorders and mitochondrial
            homeostasis dysfunction in diabetic mice via stabilizing PGC1beta
  JOURNAL   Pharmacol Res 205, 107235 (2024)
   PUBMED   38815879
  REMARK    GeneRIF: USP7 promotes cardiometabolic disorders and mitochondrial
            homeostasis dysfunction in diabetic mice via stabilizing PGC1beta.
REFERENCE   4  (bases 1 to 5427)
  AUTHORS   Zhao,B., Xia,Z., Yang,B., Guo,Y., Zhou,R., Gu,M., Liu,M., Li,Q.,
            Bai,W., Huang,J., Zhang,X., Zhu,C., Leung,K.T., Chen,C. and Dong,J.
  TITLE     USP7 promotes IgA class switching through stabilizing RUNX3 for
            germline transcription activation
  JOURNAL   Cell Rep 43 (5), 114194 (2024)
   PUBMED   38735043
  REMARK    GeneRIF: USP7 promotes IgA class switching through stabilizing
            RUNX3 for germline transcription activation.
            Erratum:[Cell Rep. 2024 Jun 25;43(6):114315. doi:
            10.1016/j.celrep.2024.114315.. PMID: 38795349]
REFERENCE   5  (bases 1 to 5427)
  AUTHORS   Migale,R., Neumann,M., Mitter,R., Rafiee,M.R., Wood,S., Olsen,J.
            and Lovell-Badge,R.
  TITLE     FOXL2 interaction with different binding partners regulates the
            dynamics of ovarian development
  JOURNAL   Sci Adv 10 (12), eadl0788 (2024)
   PUBMED   38517962
REFERENCE   6  (bases 1 to 5427)
  AUTHORS   Lim,S.K., Shin,J.M., Kim,Y.S. and Baek,K.H.
  TITLE     Identification and characterization of murine mHAUSP encoding a
            deubiquitinating enzyme that regulates the status of p53
            ubiquitination
  JOURNAL   Int J Oncol 24 (2), 357-364 (2004)
   PUBMED   14719112
  REMARK    GeneRIF: mHAUSP functions as a deubiquitinating enzyme for p53
REFERENCE   7  (bases 1 to 5427)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5427)
  AUTHORS   Vugmeyster,Y., Borodovsky,A., Maurice,M.M., Maehr,R., Furman,M.H.
            and Ploegh,H.L.
  TITLE     The ubiquitin-proteasome pathway in thymocyte apoptosis:
            caspase-dependent processing of the deubiquitinating enzyme USP7
            (HAUSP)
  JOURNAL   Mol Immunol 39 (7-8), 431-441 (2002)
   PUBMED   12413694
  REMARK    GeneRIF: USP7 (HAUSP) is proteolytically processed upon
            dexamethasone-, gamma-irradiation-, and antigen-induced cell death.
            Such processing of HAUSP does not occur in caspase 3-/- thymocytes.
REFERENCE   9  (bases 1 to 5427)
  AUTHORS   Hong,S., Kim,S.J., Ka,S., Choi,I. and Kang,S.
  TITLE     USP7, a ubiquitin-specific protease, interacts with ataxin-1, the
            SCA1 gene product
  JOURNAL   Mol Cell Neurosci 20 (2), 298-306 (2002)
   PUBMED   12093161
REFERENCE   10 (bases 1 to 5427)
  AUTHORS   Orr,S.L., Gese,E. and Hood,L.
  TITLE     A new approach to understanding T cell development: the isolation
            and characterization of immature CD4-, CD8-, CD3- T cell cDNAs by
            subtraction cloning
  JOURNAL   Mol Biol Cell 3 (7), 761-773 (1992)
   PUBMED   1387565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156026.3, AF548565.1, AK135814.1 and AC115005.11.
            
            On Jul 28, 2007 this sequence version replaced NM_001003918.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF548565.1, SRR9219380.91350.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC156026.3         220162-220218
            58-540              AF548565.1         1-483
            541-1137            AK135814.1         733-1329
            1138-3369           AF548565.1         1081-3312
            3370-5427           AC115005.11        42241-44298
FEATURES             Location/Qualifiers
     source          1..5427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 4.28 cM"
     gene            1..5427
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /note="ubiquitin specific peptidase 7"
                     /db_xref="GeneID:252870"
                     /db_xref="MGI:MGI:2182061"
     exon            1..139
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..3369
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thiolesterase 7; herpesvirus-associated
                     ubiquitin-specific protease; mHAUSP; ubiquitin
                     thioesterase 7; deubiquitinating enzyme 7;
                     ubiquitin-specific-processing protease 7; ubiquitin
                     specific protease 7"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 7"
                     /protein_id="NP_001003918.2"
                     /db_xref="CCDS:CCDS49755.1"
                     /db_xref="GeneID:252870"
                     /db_xref="MGI:MGI:2182061"
                     /translation="MNHQQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVIN
                     GNVTLSDGHSNAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMV
                     MPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDDKSFSRRISHLFF
                     HKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLK
                     NQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVG
                     TKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQ
                     CKDVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEK
                     GVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYI
                     LHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSV
                     RHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYM
                     QVQIVAEDQFCGHQGNDMYDEEKVRYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLW
                     PMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDK
                     DHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVK
                     PNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVI
                     FCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRH
                     NYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPD
                     KHGCVRDLLEECKKAVELGDKASGRLRLLEIVSYKIIGVHQEDELLECLSPATSRTFR
                     IEEIPLDQVDIDKENEMLITVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLD
                     IQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPK
                     RSRYTYLEKAIKIHN"
     exon            140..244
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            245..443
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            444..582
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            583..671
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            672..780
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            781..911
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            912..966
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1047
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1138
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1221
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1331
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1488
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1633
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1764
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1899
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2001
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2107
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2200
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2268
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2369
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2523
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2591
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2700
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2778
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2879
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..2979
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3099
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3171
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3262
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..5427
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4196
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /note="major polyA site"
     regulatory      4524..4529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /note="hexamer: AATAAA"
     polyA_site      4546
                     /gene="Usp7"
                     /gene_synonym="2210010O09Rik; Hausp"
                     /note="major polyA site"
ORIGIN      
        1 ccgccgggcc cgcagcccgg gcctccggcc gcaggcgagg cccaggccgc ggccgacatg
       61 aaccaccaac agcagcagca gcagcagcag aaagcgggcg agcagcagct gagcgagccc
      121 gaggacatgg agatggaagc tggagataca gatgacccac caagaattac tcagaaccct
      181 gtcatcaatg ggaatgtaac cctgagtgat gggcacagca acgcagaaga ggacatggag
      241 gatgacacca gttggcgctc cgaggcaacc tttcagttca ctgtcgagcg cttcagcaga
      301 ctgagtgagt cggtccttag ccctccgtgt tttgtgcgaa atctgccatg gaagattatg
      361 gtgatgccac gcttttatcc agacagacca caccaaaaaa gcgtaggatt ctttctccag
      421 tgcaatgctg aatctgactc cacgtcgtgg tcctgccacg cacaagcagt gctgaagata
      481 ataaattaca gggatgatga caaatcattc agccggcgaa tcagccactt gttcttccac
      541 aaggaaaacg actggggatt ctctaatttc atggcctgga gtgaagtgac tgatcctgag
      601 aaaggattca tcgatgatga caaagtcacc tttgaagttt ttgtacaggc agatgctccc
      661 catggagttg cgtgggactc aaagaagcat actggctatg tcggcttaaa gaatcaggga
      721 gcaacgtgtt acatgaatag cttgctgcag accttgtttt tcacaaatca gttacgaaag
      781 gctgtgtaca tgatgccaac agagggcgat gattcatcta aaagcgtccc tttagcatta
      841 caaagagtgt tctatgaatt acagcacagc gataagcccg taggaacaaa aaagctcaca
      901 aagtcatttg ggtgggaaac tttagatagc ttcatgcaac acgatgttca agagctttgt
      961 cgagtgttgc ttgataatgt ggaaaataag atgaaaggca cctgtgtaga gggcaccatt
     1021 ccaaagttat tccgaggcaa aatggtgtcc tatattcagt gcaaagacgt agactaccgt
     1081 tctgatagga gagaagatta ttatgatatc cagctaagta taaaaggaaa gaaaaacata
     1141 tttgaatcat ttgtggatta tgtggcagta gaacaactag acggtgacaa taaatacgat
     1201 gctggggagc atggcctgca ggaggcagag aaaggtgtga aattcctaac attgccccca
     1261 gtgttacacc tgcaacttat gaggttcatg tatgaccctc agacggacca aaacatcaag
     1321 atcaatgaca ggtttgagtt tccagaacag ttaccacttg atgaattttt gcaaaaaaca
     1381 gaccctaagg accctgcaaa ttatattctc catgcagtct tggttcacag tggagataat
     1441 catggtggac attacgtggt ttacctaaac cccaaagggg atggcaaatg gtgtaagttc
     1501 gatgatgacg tggtatccag gtgtactaaa gaagaagcca ttgagcacaa ttatgggggt
     1561 catgatgatg atctgtctgt tcgacactgc acaaatgcct atatgttagt gtacatcagg
     1621 gaatcaaagc taagtgaagt gttacaagct gtcaccgacc atgatattcc tcagcagttg
     1681 gtggaacgat tgcaagaaga gaaaaggatc gaggctcaga agcggaagga gcggcaggaa
     1741 gcccatctct acatgcaagt gcagatagtt gcagaggacc agttttgtgg ccaccaagga
     1801 aatgacatgt acgacgagga gaaagtgagg tacactgtgt tcaaggttct gaagaactcc
     1861 tccctggccg agtttgttca gagcctctcc cagaccatgg ggtttccaca agatcagatt
     1921 cgattatggc ctatgcaagc aagaagtaat ggaacaaagc ggcctgcaat gttagataat
     1981 gaagctgacg gcaataaaac aatgattgaa ctgagtgata atgaaaaccc ttggacaata
     2041 ttcctggaaa cagttgatcc tgagctggct gctagtggag caacattgcc caagtttgat
     2101 aaagatcatg atgtaatgtt atttttgaag atgtatgatc ctaaaacccg gagcttgaat
     2161 tactgtggac atatctacac acccatatcc tgtaaaatac gtgacttgct cccggttatg
     2221 tgtgacagag caggatttat ccaggatact agccttatcc tctatgagga agttaagccg
     2281 aatttaacag agagaattca ggactatgat gtgtctcttg ataaagccct tgatgagctg
     2341 atggatggtg acatcatagt gtttcagaag gatgacccag aaaacgataa cagtgagctg
     2401 cccactgcta aagagtattt cagagatctc taccaccggg tcgacgtcat cttctgtgac
     2461 aaaacgatcc ccaatgaccc tggatttgtg gtcacattat caaataggat gaactatttt
     2521 caggttgcaa agacagttgc acagaggctc aacacagacc ccatgctgct gcagtttttc
     2581 aagtctcaag gttataggga cggccccggt aatcctctta ggcataatta cgaaggtact
     2641 ttaagagatc ttctacaatt cttcaagcca agacaaccta agaaacttta ctatcagcaa
     2701 cttaagatga aaatcacaga ctttgagaac aggagaagtt ttaagtgtat atggttaaac
     2761 agccaattta gggaagagga aataacacta tacccagaca agcatggctg tgtccgggac
     2821 ctgttagaag aatgtaaaaa agccgtggag ctcggtgaca aagcatcagg gagacttagg
     2881 ctgctagaaa ttgtgagcta caaaattatt ggtgtgcatc aagaagatga actattagaa
     2941 tgcttatctc ctgcaacgag tcggactttt agaatagagg aaataccttt ggaccaggta
     3001 gacatagata aggaaaacga gatgctaatc acagtggcac atttccacaa agaggtgttt
     3061 gggacgtttg gaattccatt tttgctaagg atacaccagg gtgagcattt ccgagaggtg
     3121 atgaagcgga tacagagcct gctggacatc caggagaagg agtttgaaaa gtttaaattt
     3181 gcaattgtca tgatgggccg gcaccagtac atcaatgaag atgagtatga agtaaatttg
     3241 aaggactttg agccacaacc tggtaacatg tctcatcctc ggccttggct agggcttgac
     3301 cacttcaaca aagccccaaa gaggagtcgc tacacttacc tagaaaaggc aattaaaatc
     3361 cacaactgac ttccttcccg tgtccaaggc gagggacagt gcgtgggtgt gtgccctttt
     3421 taacagccgt agacctctgg tgcacgtgca ctctccccga agtctccagc aagaggattt
     3481 gctgctgatg ttttattttg ttgaggctgt tcagtttggc ttctctgtat ctattgactg
     3541 ccctttttga gcaaaatgaa ggtgttttta taaagcttgg atgccaatga gagttctttt
     3601 atggtaacca caatgcaagg cagccatccg cagcatggga gaagaggttc ctagggggtg
     3661 agtccctggc agaagtccct ggttggcgca ggcagcctgg ccacctgccc aggtcctgcc
     3721 accagccctg cagctagtca ggctgatgag taggctcgtc caatttcttc cttcagttag
     3781 actttcagtg atctgtgtgc atctgtaaag gcaaaccaga gaaaacagcc ctagtcaata
     3841 gtgttctcct caccatgtcc gatgctggcc cttcctgggg ctcctctcct cagctgcctg
     3901 gaggcttttt aataaccgtc tctctttgtc agctagtact gtagcagcct gttcacgaag
     3961 tggaagtgga tgcactgagt gcggtcctgg cagttagggg tcttttatac actgagaaca
     4021 ttgtcagata caattaaggt ttactctgtt gcccattggc aaatgtaatg atctgagcag
     4081 gtgaaaagtc actctaggct tctgtgagga cagagtggac gagcgacaaa ggagagagcc
     4141 ttttagcaag ggcgcatgct cgctaatggt tagtacgctg ttgactttgt aaaaaagata
     4201 aaataaaaaa ggaaaaatgg aaaatgaaat tgtatattta atgaatgaaa cctgtacaat
     4261 ttgccctggg aggaggccgt tttctattgg gtgagtgcga gtgaccctgg ccgacttgga
     4321 cactctgcgt agctttattt gagtcttctc cttgtttccc tttttgttgg agctaatgcc
     4381 agctgcgtgt ctagtttgga gtgcagatag aaggagcaag ccacacttct ttcccacccc
     4441 cagtacttct gtttgtttct gtagcagcag tgtacaccaa ttctcctgta tattgccttt
     4501 ttgctggaaa atgttgtatg ttgaataaaa ttttctataa aaattataat ccgatgactg
     4561 ctgtggaagc cgagggtgac tgctcccctg ggagctttgc gttgagccag gctttcagcc
     4621 gccacatgct ttctcacctg gccttttcct ttgggtggca gtttttattt tctttttgag
     4681 acatggtttt gccctacagg cctgaagctt gctgtgtaga ccaggctgat cttgaacgca
     4741 cagaggtcca cctgcctccg cttcccaagt gttgggttta aaggtgtgag ctcggctcct
     4801 ggcttcccat ttggagcttg aggggtaagg gtttgtaagg tgtggtggca gttaggaggc
     4861 tgggggagga gcggcaagtc agcctgtgct acgcagacag accctgacaa gaagttggaa
     4921 tgtagctggc gccacagaac ttgtctagta tgtgcaaggc cctgggcttc atccccagta
     4981 tctaaagaaa atgcaagcat cctcaggtgg aattccttgg agtctgtatt cagactgagg
     5041 aagtgtaggg cctctgcatg aggcgtctgg gggaggccac tggtgtgctg tgggttacct
     5101 cgggcctcct ggttctgagc cagtctgtaa cccgacttcc tttctctgtt gcactatgaa
     5161 ttgtgtgcct tctgataact tattgtatcc agatgagtgg ggaaagcagc acatcgtggg
     5221 gggccaggtg ggcctcgatc ctgctgggcc ctttggcctg taaatgagaa gttacaggta
     5281 gtaacaggca agacaatgag gactgctcac ccaatgttgg cctttgaacc ccaaggtgtt
     5341 cctgtttcag ggtttgttgg ggttgctcag acttagatac ccacaatttt tattctccct
     5401 taaatattaa atgactattt ttcaaat
//
