LOCUS       NM_001403077            6666 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus ubiquitin specific peptidase 54 (Usp54), transcript
            variant 2, mRNA.
ACCESSION   NM_001403077 XM_006519703
VERSION     NM_001403077.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6666)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6666)
  AUTHORS   Fraile,J.M., Campos-Iglesias,D., Rodriguez,F., Espanol,Y. and
            Freije,J.M.
  TITLE     The deubiquitinase USP54 is overexpressed in colorectal cancer stem
            cells and promotes intestinal tumorigenesis
  JOURNAL   Oncotarget 7 (46), 74427-74434 (2016)
   PUBMED   27769071
REFERENCE   3  (bases 1 to 6666)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 6666)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC146594.3.
            
            On Mar 25, 2022 this sequence version replaced XM_006519703.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.2440975.1,
                                           SRR17784647.744404.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC146594.3         12788-12849
            63-886              AC146594.3         45861-46684
            887-979             AC146594.3         49622-49714
            980-1114            AC146594.3         62153-62287
            1115-1228           AC146594.3         64279-64392
            1229-1311           AC146594.3         64500-64582
            1312-1417           AC146594.3         65328-65433
            1418-1564           AC146594.3         65545-65691
            1565-1714           AC146594.3         67617-67766
            1715-1883           AC146594.3         70276-70444
            1884-2054           AC146594.3         72139-72309
            2055-2186           AC146594.3         76180-76311
            2187-2564           AC146594.3         76454-76831
            2565-2796           AC146594.3         77062-77293
            2797-2930           AC146594.3         79865-79998
            2931-3098           AC146594.3         83351-83518
            3099-3218           AC146594.3         87704-87823
            3219-3414           AC146594.3         88703-88898
            3415-4811           AC146594.3         91524-92920
            4812-4930           AC146594.3         97401-97519
            4931-5117           AC146594.3         101506-101692
            5118-6666           AC146594.3         103306-104854
FEATURES             Location/Qualifiers
     source          1..6666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..6666
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /note="ubiquitin specific peptidase 54"
                     /db_xref="GeneID:78787"
                     /db_xref="MGI:MGI:1926037"
     exon            1..62
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            63..886
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             740..5677
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin specific protease 54; inactive ubiquitin
                     carboxyl-terminal hydrolase 54; inactive
                     ubiquitin-specific peptidase 54"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 54 isoform
                     2"
                     /protein_id="NP_001390006.1"
                     /db_xref="GeneID:78787"
                     /db_xref="MGI:MGI:1926037"
                     /translation="MSWKRNYFSGSRGSVQGMFAPRSSMSIAPSKGLSNEPGQNSCFL
                     NSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPSDTLRSA
                     LAKTFQDEQRFQLGIMDDAAECFENLLMRIHFHIADETKEDICTAQHCISHQKFAMTL
                     FEQCVCSSCGATSDPLPFIQMVHYISTTALCNQAICMLEKREKPSPSMFGELLQNAST
                     MGDLRNCPSNCGERIRIRRVLMNAPQIITIGLVWDSEHSDLAEDVIHSLGTCLKLGDL
                     FFRVTDDRAKQSELYLVGMICYYGKHYSTFFFQTKIRKWMYFDDAHVKEIGPKWKDVV
                     TKCIKGHYQPLLLLYADPQGTPVSAQDLPPHAQFLPYTKTCYDSEDSGREPSISSDTR
                     TDSSTESYPYKHFHLESVVSHFSSDSQGTVIYNVENDSVSQSSRDTGHLTDSECNQKH
                     TSKKGSLVERRRSSGRVRRKGDEPQASGYHSEGETLKEKQAPRNASKSSSSSRLKDFK
                     ETVSNMIHSRPSLASQTSAGSPCVGRAGDQLDKIPPRNFPLQARGWETESTSSEAKSS
                     SSSKYRPTWRPKRESLNIDSIFSKDRRKHCGYTQLRTFPEDAAKEFTPDEVSKPTAND
                     IKDGGSRSQHKLWGTARPGSHLLEQHPRLIQRMESGYESSERNSSSPVSLDAAPPDSV
                     NVYRDQSTKRPVGFVPSWRHIPKSHSSSILEVDCTAPMTSWTKTQPLSDGEVTSRSEL
                     DELQEEVVRRAQEQELRKKREKELEAAKGFNPHPSRYMDLDELQNQGRSDGFERSLQE
                     ANSIFEESLHLEQKGDCAAALALCNEAISKLRLTLHDASSSTHSRALVDKKLQISIRK
                     ARSLQDRMQQQASSQQPVQPSASLPSQGGALPQPTSEQPITLQVLLNQEAQLEPCKDT
                     ELGATSSFFHSPASCPELHSSLIPESPVSSVSQHSPPGTSSLKLLTSFEVDSVNRSAF
                     HRQGLPKATGRTEMNSQHECLPLDALEDRLQGHREDNSCCSKFPPREGRDIAQDQLFE
                     GKKNPADISMGMPWSYSTGEATSERVIYSLNSPSSSSAQPSIPPYSSCHPITSAASSP
                     VLHAADPMQKLNQHVQAQSLQTSLTSKVVRSSEEPYRLEFPSTKGLVRSLAEQFQKMQ
                     NTSTRDVIGSQDRSLPNGVRKSSSPSDFMPPLSQGPGREHCRWVKQPRSPDGRERPPC
                     WEDPAAHPPLSMGSGLPDGETSRTAQPRLAEPDMYQGKLPQVTDIRSKELGSSVNLGT
                     SLPLDSWVNVTRLCDSQVKPSAPGPGDKSSSHDSHPRATCLERSPILLHPHWDQDTEQ
                     ETSELESLYQASLQASSHTAYSDWRSQDVAWQPLSLAGSADGMGRRLHSAPGLDLSKP
                     LTAEMEHVLYEPSTVPVSQDSSNVRKKTLETGHHCSSSSSLPVIHDPPVFLLDPKLYP
                     PQPQFLSPDVLMPSMAGEPYRPPGTSRSVHQFLAMCDRDETPQGVKYTGRTLNYRSLP
                     HRSRTDASWGPGSETNQHIGARVLTMPACKPQLTYTATLPERHQGLQVPHAQSWGNLF
                     HSPSHPSAVHPGSPPSSNLHVPLRSTWNSGPVLGSRTPGPRRIDMPPDDDWRQSSYPS
                     QDRHRSPGEERIMFALSNAAGREQNRVRFLQHSRW"
     exon            887..979
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1114
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1228
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1311
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1417
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1564
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1714
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1883
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2054
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2186
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2564
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2796
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2930
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3098
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3218
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3414
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..4811
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4812..4930
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4931..5117
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5118..6666
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6639..6644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6666
                     /gene="Usp54"
                     /gene_synonym="4930429G18Rik; C030002J06Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggttgccttg gctccctgta gctatagcag ccgcggcggt tgaggatgcg acggcgggag
       61 cgctctctgg cacagctggc tattctcatc tcagaagaaa ggagaagaga ctttctgaag
      121 atctggtaga gaagatagaa gaaatttgga atacaaccaa aaggtacagc aaggaacatc
      181 aacagcagcc ctaccgagaa cgcagacaaa cttctcggct tgtggtgtct cctcagttgt
      241 tcagagcttg agttttgctc gaggatgatg agacaaggca ctaagagggc aaggaggagt
      301 gtgctaggtt cctgccactt cctccgggct tcagtccaca agaagcattg taagaagggc
      361 tgaagaacaa gctgtgcttg gtcctgaata ctgttgactt gaggattcca tctgtttcac
      421 caggcgtgta gggaggccgt tttagcaaca tagcttcctt agcagtactt aaagactttt
      481 ctctgcattg gtcatgtgcc aagttacatt ttgaacattg gggcaggtga aggaaggaca
      541 gctttggcac ctggatctaa ggagacacct gaattccccg agcttacaga tgtgatgttt
      601 gggaagatct aaactcagcc tttaattgga acaattttct ggattttttt tttttttaaa
      661 gacttcaaaa ggcacagttc cttgcctatc aaaaagacat aaagcccccc tttccccctt
      721 tgggctaatg tgaacaataa tgtcttggaa aagaaattac ttttctggaa gccgaggtag
      781 tgttcaaggg atgttcgcac ctcggagctc aatgtccatt gcccccagca aaggcctcag
      841 caatgagcca gggcaaaaca gctgcttcct caacagtgcc ctgcaggttt tgtggcactt
      901 ggacatcttc cgccgtagct ttcggcagct tacaactcac aagtgcatgg gtgattcctg
      961 catcttctgt gctctcaagg gcatctttaa ccagtttcag tgtagtagtg aaaaagtgct
     1021 tccttccgac actctccgca gtgctctggc aaagactttc caagatgaac aacgcttcca
     1081 gctggggatt atggatgatg ctgcagaatg ctttgaaaac ctcctgatga gaattcactt
     1141 ccatattgct gatgaaacca aagaggatat atgtactgct caacactgca tatcccacca
     1201 gaaatttgca atgacattgt ttgagcagtg tgtgtgcagc agctgtggcg ccacgtccga
     1261 cccgctgccc tttatccaga tggtgcacta catctccacc actgccctct gtaaccaggc
     1321 tatttgtatg ctggaaaagc gagagaaacc ctcaccaagt atgtttggtg agctgcttca
     1381 gaatgccagc accatggggg acctgcggaa ctgtccgagc aactgtgggg agagaatccg
     1441 gatccgccgt gtcttgatga atgcaccaca gattatcacg attggtctgg tttgggactc
     1501 agagcattca gacttggcag aggacgtcat ccacagcctg ggcacctgcc ttaagctggg
     1561 tgatctgttt ttcagagtga cagatgaccg ggccaagcag tctgaactat acttagtagg
     1621 aatgatctgt tactatggca agcattattc tacattcttt tttcaaacaa agatccgcaa
     1681 atggatgtat tttgatgatg ctcatgtcaa ggagattggt ccgaagtgga aggatgtggt
     1741 caccaaatgc attaaagggc actatcaacc cttgctgctg ctctatgcag acccccaggg
     1801 tactccagtg tctgcccagg acctgcctcc ccacgctcag ttcctgccat acaccaagac
     1861 atgctacgat agtgaagact cagggaggga gccttccatc tcaagtgaca ctcgaacaga
     1921 ttcctcaacg gagagctatc cctacaaaca ttttcacctt gagtctgtgg tcagtcactt
     1981 ctcttcagat tctcagggga cagtcatcta taatgtggag aatgattccg tgtctcagag
     2041 cagtcgggac acaggacacc tgactgatag tgaatgtaat cagaaacaca catcgaagaa
     2101 agggtccctg gtggagcgca ggaggagcag tggccgtgtt cggagaaaag gcgatgagcc
     2161 acaggcctca gggtaccaca gcgaaggaga aacactgaaa gagaagcagg ctcctaggaa
     2221 tgcctctaaa tccagcagca gcagcaggct aaaggatttc aaagagacag tcagcaacat
     2281 gatccacagc aggccttccc tggcttctca gaccagtgca ggatctccct gtgtaggtag
     2341 ggcaggagac cagctagaca agataccacc aaggaacttc cctttacagg ctcggggctg
     2401 ggaaacggag agtaccagta gtgaggcaaa atccagttct tccagcaagt accgcccaac
     2461 atggagacct aaacgagaat ctctaaatat tgacagcatt tttagtaagg acagaaggaa
     2521 gcattgtggc tacacccagc ttaggacctt tcctgaagat gcagctaaag aatttacacc
     2581 ggatgaagta agcaagccaa ctgctaatga cattaaagat ggcggatcaa ggtcacagca
     2641 taaactctgg ggaacagctc ggccaggctc tcatctttta gagcagcatc ctcgcctaat
     2701 ccagcggatg gaatctggct atgagagcag tgagaggaac agcagcagcc ctgtcagttt
     2761 ggatgctgcc ccgcctgaca gcgtgaatgt ctacagggat caaagcacaa agaggcctgt
     2821 tgggtttgtc ccttcttggc gtcatattcc aaagtctcac agcagtagca tcctggaggt
     2881 agactgtaca gcacccatga ccagctggac aaagactcaa cctctctcag atggggaggt
     2941 cacctctaga agtgaattgg atgaactaca ggaagaagtg gtcaggcgag cccaggaaca
     3001 ggagctgcgg aagaaacggg agaaggaatt agaggctgct aaaggcttta accctcatcc
     3061 cagccgctac atggatttgg atgaactgca gaatcagggg aggagtgacg gctttgaaag
     3121 gtccttgcaa gaggcaaatt caatatttga agagtcgctg catctggaac aaaagggaga
     3181 ctgtgctgca gctctggctc tgtgtaacga agctatctct aaactaagac ttaccctgca
     3241 tgatgccagc tctagcacgc acagcagagc cctagtcgat aagaagttgc aaatcagtat
     3301 tcgaaaagca cgaagccttc aggatcgcat gcagcaacaa gcatcatcgc agcagccggt
     3361 gcagccctca gcctctctcc catcacaggg gggcgccctc cctcagccga caagtgaaca
     3421 gcctatcacg ctccaagtat tgttaaacca ggaggcacag ctggaacctt gcaaggatac
     3481 agagcttggg gccacttcct ctttcttcca ctcacctgct tcctgccctg agttacactc
     3541 atcactcatc ccagagtcac ctgtttcatc tgtttcacag cacagtcccc ctgggacatc
     3601 ttccttgaag cttctgacgt cttttgaggt ggacagcgtc aatcgctctg cattccacag
     3661 gcagggttta cctaaagcaa caggtagaac tgagatgaac tctcaacatg aatgcctgcc
     3721 attagatgcc cttgaagata ggctccaagg ccacagggag gacaacagct gttgcagcaa
     3781 attcccacca cgagaaggaa gagacatagc tcaagatcag ctgtttgaag gaaaaaagaa
     3841 tcctgctgat atatccatgg ggatgccttg gtcatattca acaggagaag ccacttctga
     3901 gagagttata tatagcctaa atagtccttc aagttcatca gctcagccta gtattccccc
     3961 ttacagttcc tgccacccca tcacgtctgc tgcttcttca cctgtgcttc atgctgctga
     4021 ccccatgcag aaacttaacc aacacgttca agcccaaagt ctccagactt cattgacttc
     4081 aaaagtggtc agaagcagtg aggagcccta taggctagag ttccccagta caaaaggact
     4141 tgtccgctca ttggcagagc aattccagaa gatgcagaat acttccacga gagatgttat
     4201 aggttcccag gatagaagtt tgccaaatgg tgtcaggaag agctcttctc cttctgactt
     4261 tatgcctcca ttatcccagg gtccaggaag agagcactgt cgctgggtaa aacaaccccg
     4321 ttcccccgat ggcagggaaa gaccgccctg ctgggaagac cctgcagctc atcctcctct
     4381 ttccatgggc tcggggcttc ctgatggtga aacctcgagg acagcacagc ccaggctggc
     4441 tgagccagat atgtaccaag gaaagctacc ccaagtgaca gatattaggt ccaaggagct
     4501 gggtagtagt gtcaatttgg ggacttcttt gcctttggat tcttgggtaa atgtcacaag
     4561 gctctgtgat tctcaggtta aacccagtgc ccctgggccc ggagacaagt cctcctccca
     4621 tgattcccac ccacgtgcaa cctgcctaga aagaagtcct atccttttgc atccacactg
     4681 ggaccaagac acagagcagg agacctctga actggagtct ctctaccaag ccagccttca
     4741 ggcctcttct cacactgcct attctgattg gagatcacag gatgtggcct ggcagccact
     4801 tagcctagca ggctctgcag atggcatggg aaggagactg cactcagccc ctgggcttga
     4861 tctctcaaag cctctgacag cagagatgga gcatgtcctt tatgaaccga gcacagtgcc
     4921 tgtctctcag gattcatcaa acgtgaggaa aaagactttg gaaaccgggc accattgttc
     4981 cagctcctct tccctccctg tcatccatga tcctcctgta tttctccttg atcctaaact
     5041 ctaccctccc caaccacagt tcctgtcccc agatgtcctg atgcccagca tggcagggga
     5101 gccctataga cccccaggaa cttcaaggag tgtccaccag tttctggcta tgtgtgacag
     5161 ggatgaaact ccccaagggg tcaagtacac aggaaggact ttgaactacc gaagtctacc
     5221 tcatcgttcc agaactgatg cttcctgggg accagggtca gagaccaacc agcacattgg
     5281 ggccagagtc ctaactatgc cagcatgcaa gcctcagcta acctacactg ccacactacc
     5341 agaaagacac cagggccttc aggttccaca tgctcagtcc tgggggaatc ttttccactc
     5401 accctcccat ccttctgctg ttcacccagg gtccccacca tccagcaatc ttcatgtacc
     5461 ccttaggtca acttggaatt ctggtcctgt tctggggtcc cgaacacctg gtccacgaag
     5521 aatagacatg cccccagatg atgactggag acagagcagt tacccctccc aggacagaca
     5581 caggagccca ggagaggaaa gaattatgtt tgctctatca aatgctgctg gaagagagca
     5641 gaacagggtg agatttctac agcacagcag gtggtaaggg ccaccctaac ctgccctgga
     5701 gctacacctt catccataaa actgtacggc ggcgcagtga caccttgttt cctgccagtt
     5761 atgccagtct catctcaaca gacttggcca tttcattcca ggcaccatat gcctgtaatc
     5821 ccagtagttg ggaggtagag attggggaat cagcatttca aggccagaga ctggggtaaa
     5881 aagagactgt ttgttgttgt tgttgttttg ttttaaagaa cagaaccaca acaacaaaga
     5941 agacattgat ttttttttcc cctaagggtg tttgctgctt tgagagggaa tatttgaaat
     6001 tccagcttta gagttgggga tgtagctcaa ttggtagcgt gtttttgtaa catgcacatc
     6061 agccatggtt ctatccttag aagtgtgtga aactgaccat ggtggtgcac aactgtcatc
     6121 ctagcacttg ggagacagag ggaggaggat cagaagttca gggttatcct tggctacata
     6181 acaagttcta gactagtctg gactacttta gttctggttc ttttggcccc atctccatca
     6241 gagccctcat cttctggtcc tactatactc ccaacttaca ctctttgttt atccacctgt
     6301 ccatattact taacattctt tcttccctat ttcgtatcaa tggaaaaggg gtatttatcc
     6361 ccatagtcag gattctgacc acgtccttaa gggaagccca actgcccagg tattatggcc
     6421 tgtcagcctt ccttgtgact cagactttag gcctagaatg tggagctgcc aatacactgt
     6481 ttgcccttct gaacagatgg agttgggcac actaacaccc ctcctgtcct tagcagcaga
     6541 gccattacta ccactgctca ctcacccttg taaactctca agagtcagct aaagtatttt
     6601 agggcaaagc atactggttt tgtaaagtat ttttcattaa taaatctata agatagttgt
     6661 atttaa
//
