LOCUS       NM_001411523            6222 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 53 (Usp53), transcript
            variant 1, mRNA.
ACCESSION   NM_001411523 XM_011240313
VERSION     NM_001411523.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6222)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6222)
  AUTHORS   Hariri,H., Kose,O., Bezdjian,A., Daniel,S.J. and St-Arnaud,R.
  TITLE     USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in
            Osteoblasts and Bone Marrow Adipocytes
  JOURNAL   J Bone Miner Res 38 (4), 578-596 (2023)
   PUBMED   36726200
  REMARK    GeneRIF: USP53 Regulates Bone Homeostasis by Controlling Rankl
            Expression in Osteoblasts and Bone Marrow Adipocytes.
REFERENCE   3  (bases 1 to 6222)
  AUTHORS   Kazmierczak,M., Harris,S.L., Kazmierczak,P., Shah,P.,
            Starovoytov,V., Ohlemiller,K.K. and Schwander,M.
  TITLE     Progressive Hearing Loss in Mice Carrying a Mutation in Usp53
  JOURNAL   J Neurosci 35 (47), 15582-15598 (2015)
   PUBMED   26609154
  REMARK    GeneRIF: A USP53 mutation is the cause of progressive hearing loss
            in the mambo mouse line.
REFERENCE   4  (bases 1 to 6222)
  AUTHORS   Schwander,M., Sczaniecka,A., Grillet,N., Bailey,J.S., Avenarius,M.,
            Najmabadi,H., Steffy,B.M., Federe,G.C., Lagler,E.A., Banan,R.,
            Hice,R., Grabowski-Boase,L., Keithley,E.M., Ryan,A.F.,
            Housley,G.D., Wiltshire,T., Smith,R.J., Tarantino,L.M. and
            Muller,U.
  TITLE     A forward genetics screen in mice identifies recessive deafness
            traits and reveals that pejvakin is essential for outer hair cell
            function
  JOURNAL   J Neurosci 27 (9), 2163-2175 (2007)
   PUBMED   17329413
REFERENCE   5  (bases 1 to 6222)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 6222)
  AUTHORS   Nishimatsu,S., Murakami,K., Mitsui,Y. and Ishida,N.
  TITLE     Mouse spleen derived cDNA clones containing per repeat sequence
  JOURNAL   Nucleic Acids Res 16 (24), 11831-11832 (1988)
   PUBMED   3267239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121540.14 and AC155158.15.
            
            On Aug 26, 2022 this sequence version replaced XM_011240313.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.2532929.1,
                                           SRR17253011.6267971.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC121540.14        179721-179905
            186-846             AC155158.15        952-1612
            847-939             AC155158.15        5854-5946
            940-1074            AC155158.15        7183-7317
            1075-1352           AC155158.15        8769-9046
            1353-1458           AC155158.15        11064-11169
            1459-1605           AC155158.15        12470-12616
            1606-1755           AC155158.15        13353-13502
            1756-1918           AC155158.15        16859-17021
            1919-2068           AC155158.15        17495-17644
            2069-2212           AC155158.15        18887-19030
            2213-2945           AC155158.15        20345-21077
            2946-3022           AC155158.15        22764-22840
            3023-3119           AC155158.15        34117-34213
            3120-6222           AC155158.15        35606-38708
FEATURES             Location/Qualifiers
     source          1..6222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 53.75 cM"
     gene            1..6222
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /note="ubiquitin specific peptidase 53"
                     /db_xref="GeneID:99526"
                     /db_xref="MGI:MGI:2139607"
     exon            1..185
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            186..846
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             703..3993
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin specific protease 53; inactive ubiquitin
                     carboxyl-terminal hydrolase 53; per-hexamer repeat protein
                     3; inactive ubiquitin-specific peptidase 53; per-hexamer
                     repeat gene 3; protein mambo"
                     /codon_start=1
                     /product="inactive ubiquitin carboxyl-terminal hydrolase
                     53 isoform 1"
                     /protein_id="NP_001398452.1"
                     /db_xref="GeneID:99526"
                     /db_xref="MGI:MGI:2139607"
                     /translation="MAWVKFLRKPSGNLGKAYQAGSLLSLAPTVGLLNEPGQNSCFLN
                     SAVQVLWQLDIFRRSLRALTGHICQGDACIFCALKTIFAQFQHSREKALPSDNIRHAL
                     AESFKDEQRFQLGLMDDAAECFENILARIHFHLVPNRDADMCTSKSCVTHQKFAMTLY
                     EQVRCLGCLCRHWTAVSGAMDSAACVLPQCVCRSCGASSDPLPFTELVRYISTTALCN
                     EVERMMERHERVKPEMFAELLQAANTADDYRKCPSNCGQKIKIRRVLMNCPEIVTIGL
                     VWDSEHSDLTEDVVRSLATHLYLPGLFYRVTDENATDSELHLVGMICYTSRHYCAFAF
                     HTKSSKWVFFDDAHVKEMGTRWKDVVSKCIRCHLQPLLLFYANPDGTAVSTEDALRQV
                     VHWSHYRSGEENMGCGKPIIYKPDNSKENGFGGQTKQKENHKFQTDISSLNRSQMQTS
                     GRRAPVKLSHDQREKIKDISRECALKAIEQKNALSSQRKDLEKGQRKDTGRHRDLVDE
                     VLASFKSGSPPASDGFRQQGNPHLYHSQGKGPCKHDRATHESYTSGKVISSSKSQNLL
                     VPGEKTTGKAKSDSGTGYETDSSQDSRDKGGSYSSKTKSRHRGWKPMRETLNVDSVFS
                     ESEKRQHSPRRKSDIGSRPRCSKDQSFNNWPKANPKQKGLMTIYEDEMKQEAGSRSSL
                     ETNGKGAEKNLSAAESRGPGTSWQMQRTESGYESSDHVSNGSASLDSPGVEGSGAVMD
                     VGGGKAFSEHIKMNSHNMDSMEYISHHCKDHPEGFRKELQDLEADDKIHELHPESHVQ
                     IKSHLIKRSQIGETNDKLFPSASPQTLAREHVYQTNEHKVERPDRSKCSERHNTENSE
                     GTGLPFHVDESSVAGKRVDSNETVSPSSLPSSVRTAGLKPETGPLMFWSQQNITEQGY
                     SDNSLSRELTLLSACNADSCQMPKLHCHRSPPPLPPKKYSTASAPRLERVGLSPDVGV
                     TEAFNTNPSSLPKHSLSPASGPSLEGSPCMTQERDKETIQVKQLAANSYPSSCSTNSF
                     QPDQDSTSVCPNETISLTTYFSVDSCMTDTYRLKYHQRPKLYFPESSGHHSNNSLSQT
                     EQVEGSIT"
     exon            847..939
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1074
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1352
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1458
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1605
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1755
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1918
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2068
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2212
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2945
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3022
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3119
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..6222
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5915
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /note="major polyA site"
     regulatory      6202..6207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /note="hexamer: AATAAA"
     polyA_site      6222
                     /gene="Usp53"
                     /gene_synonym="mbo; mKIAA1350; Phxr3; Sp6"
                     /note="major polyA site"
ORIGIN      
        1 agaccggccc ctgggtcttg ggcgtgcgcg catgctctgc gcgggtctgg cggctgaaag
       61 cggcggtgtg gccgtctgtc cctgtgcgtg tcgctttgcc tgtcacgacg ttgtgggtgt
      121 cggcgcgagg cggagccggg ccagtgggac tggaagggct acggcgccgg gaggtagagc
      181 ttgggatttt ctttgaggtc atgctgatga aatatggagt cctctttgct aacttcacct
      241 gaatcagaga aaagctgctt cactaaagaa acaaaggaaa caagtggcca gaggaaccct
      301 gcagatgcca gctctgtacc ttgaatcttc tgttttcagc ccaacagact aatgactcac
      361 atgttaacga aaatggtcta ttcatcatag atttttagca gttaaagtta tttttatcag
      421 tgtgtccaac ttaacagatt ttaagaatta ttaaacctgg aaggccttgt ttaaaatcag
      481 ttgcttttta gctctcagca attgaacgtt tactttgctt ttacatatga aagtcctcag
      541 aactgtagcc catcaggaac aagatggact tggaagcata cagctttatt gtggactgca
      601 gtggaattaa gtggacagct cgacatcacc cattttcttg tccagaatac cacataaact
      661 aagcatatta cttaacttta atgcaaaaga agtggcttga aaatggcctg ggtaaaattt
      721 ttacggaagc ctagcggcaa tcttggcaaa gcttatcaag ctggaagcct gctgtcccta
      781 gcccctactg tgggcttgtt aaacgagcca gggcagaaca gctgctttct aaacagtgct
      841 gtacaggttt tatggcaatt agatatattc cgaagaagct tgagagctct gactggacac
      901 atatgtcagg gagatgcctg tatattttgt gcattgaaga caatatttgc acaatttcaa
      961 cacagtcgag aaaaagcact tccctcagat aacataaggc atgctcttgc agaaagcttc
     1021 aaagatgagc agagatttca gcttggcctc atggatgatg ctgccgagtg ctttgaaaat
     1081 atattggcaa gaattcattt tcacctggtg ccaaacaggg acgcagacat gtgcacctct
     1141 aagtcttgtg tgactcatca gaagtttgcc atgactctgt atgagcaggt gaggtgcctg
     1201 ggttgtctgt gtagacactg gactgctgtc tcgggagcga tggactcagc agcttgtgtt
     1261 cttccgcagt gtgtgtgccg gagctgtggc gcttcctcag accctctgcc ctttaccgaa
     1321 ctcgtgaggt acatttctac aacagccctg tgcaatgaag ttgaaagaat gatggaaagg
     1381 catgagcgag ttaaaccaga gatgtttgcg gaactgttgc aagctgcaaa cacagcagat
     1441 gactatcgga agtgtcctag taactgtggc caaaaaataa aaatccgccg tgttttaatg
     1501 aattgcccag agattgttac aattggatta gtgtgggact ccgagcactc agacttgact
     1561 gaagatgttg ttcgaagtct agccacgcat ctctaccttc ctgggctttt ttatagggtc
     1621 actgatgaga atgccacaga cagcgagctg caccttgtgg gtatgatctg ttacaccagc
     1681 cgacactact gtgcctttgc ttttcacacc aagagctcca agtgggtgtt ttttgatgat
     1741 gcacacgtga aggagatggg aaccagatgg aaagatgtgg tctccaagtg catacgatgc
     1801 cacttacagc cccttttgct gttttatgca aacccggatg gtacagcggt ctctactgag
     1861 gatgcactca ggcaggttgt ccactggtca cattacagat cgggtgaaga aaacatggga
     1921 tgtggaaagc ctatcattta taaaccagat aattcaaagg aaaatggatt tggtggtcag
     1981 acgaaacaga aagaaaatca caaatttcaa actgatattt cctcacttaa tcggagccaa
     2041 atgcagacaa gtgggaggag agcaccagtt aagttaagcc atgatcaaag agaaaagata
     2101 aaagacattt ccagagaatg tgctctgaaa gccattgaac agaaaaatgc actttcttct
     2161 caacggaaag atttagaaaa gggacagagg aaagatacag gccgacacag ggatttggtt
     2221 gatgaagtct tggcatcttt caagtccgga tcacctcctg cctcggatgg ctttagacag
     2281 caagggaatc cccatctcta ccacagccaa ggcaaaggac cttgtaaaca tgaccgagcc
     2341 acccatgaga gctacacctc tggaaaagtg ataagttcaa gcaaatccca gaatcttctt
     2401 gttcctggag agaaaacaac cggcaaagct aagagtgaca gtggcactgg atatgaaaca
     2461 gacagcagcc aagattcaag ggacaaagga ggcagctaca gtagtaagac taaaagccgc
     2521 caccgtggct ggaaacccat gagagaaacc ctaaacgtcg atagcgtttt tagtgagagc
     2581 gagaagaggc agcacagtcc gaggcggaag tcggatatcg gtagcaggcc taggtgtagc
     2641 aaggaccaga gttttaataa ctggccaaag gcaaacccaa agcaaaaagg cttaatgacc
     2701 atatacgaag atgaaatgaa gcaagaggca ggaagcagaa gttcccttga aactaatgga
     2761 aaaggagcag agaaaaatct aagtgctgca gagagcagag gtcctggtac cagctggcag
     2821 atgcaaagga cagagtctgg gtatgagagc agcgatcatg tcagtaacgg atctgccagc
     2881 ttggactctc ctggtgtgga gggaagtggg gcagtcatgg atgtcggtgg tgggaaagcc
     2941 ttcagtgaac atattaagat gaacagccat aatatggaca gtatggagta tatatctcat
     3001 cattgcaaag accacccaga aggctttagg aaagaactcc aggacttgga agcagatgat
     3061 aaaattcatg agctccaccc agaatcacat gtgcaaataa aaagccattt gataaaaagg
     3121 tcacagattg gtgaaaccaa tgacaagttg tttccttcag ccagcccaca aacacttgca
     3181 agagagcatg tttaccagac aaatgaacac aaagtagaaa gaccagatag gagcaaatgt
     3241 tcagagaggc ataatacaga aaactctgag ggaacaggct tgccatttca cgttgatgag
     3301 agttctgtgg ctgggaagag agtcgacagt aacgaaacag tctcgccatc ttcactgcct
     3361 tcatctgtga gaactgctgg gctaaagccc gaaactggac ccctcatgtt ttggtcacag
     3421 caaaatatca cagaacaggg ttactctgac aactctctgt ccagagaact tacacttctg
     3481 tctgcctgca atgctgatag ttgtcagatg ccaaaactcc actgccaccg ttcaccaccc
     3541 cctttgccac caaagaaata ctctacagcc agtgcaccaa ggttagagag agttggactt
     3601 agccctgatg tcggggttac cgaggcgttt aacactaatc cctccagcct tccaaaacac
     3661 agcttgagtc cagcctcagg accaagttta gaagggagtc catgcatgac ccaggaaaga
     3721 gataaagaaa ctattcaagt gaagcaactt gctgccaaca gctacccgtc cagttgttca
     3781 actaacagtt ttcagccaga tcaagactct acttctgtgt gtccaaatga aacaatttca
     3841 ttaactacct atttctcagt tgatagttgc atgactgata cctacagatt gaaataccat
     3901 caaagaccta agctctattt tccagagagc agtggccatc atagtaataa ttcactctct
     3961 caaactgagc aagtagaggg atccattaca taatggtcat ctttcgtcaa ctgtccttct
     4021 gaacaaagac ctttatccat gtaagataaa tgaaccagcc attaaaaata ccaactgata
     4081 aaatctaact gtataaaata aaaatcagga taacatattt tatgataaac ttactaaata
     4141 ttttagaaat ttcctttgtg tgatcttggc gtgccttgaa aaataaggaa gtctataatt
     4201 actttgctat ataacagtta agtaagcacc gtgtctccta tttggttagt aaatgtgtaa
     4261 ctattgtact tccagtattc atatgtaggc tggtgtattt tgctaattaa gaaatacaaa
     4321 gtgtctagga aagcaatatt tgcttttgca gagcactttc tagtgggtaa ccaaagatgg
     4381 ctatacccac atgcttttga cttctgtgat agtctaatac atgtgatcct tcaagtgtct
     4441 taaaaatacc catggattta cgtgatcatc tggaaagcct ttgccttaat gatgaacaat
     4501 ttttaataat ctcaaagtca tataaaattt actttattcc tagaactttt cagaatatct
     4561 atttatcttt ataacttgta tctaaaaata tttcagtcat gtaagttaaa aataaaaatt
     4621 tggtagtata ttatttatta aattattttc tagctttata tgaaatgtga aaggtcttcc
     4681 ctctggttta atttacttta ggctgctaat aaccaatgtt acaagttaac attgggcctc
     4741 ttattgggat ggtcactgct gctttgatca cttaaagatt gctagattgt cagagctttt
     4801 actattgagg cttccaggtt aaatttctgc ctttatataa aggtttattc ctaatgaaat
     4861 gtccttttat ttattttttt cacttaaaca gtgatttttg tatccacaac catcatggag
     4921 tagagtttat ttatttaata tttttcatta ttttgaaagt aagctgaatt gccttattag
     4981 ttttgatttt attttgtaac aggctgaaaa actaactagt tgtagaatag tttcaaaatg
     5041 actactccag agaattgaaa gctacaaaat tagttgtctt tatcatctct ctaaatggag
     5101 gagactcaca atcattactt taaaacttgt aacttgacga gtcccacaaa ttagtaaaac
     5161 ccaaacccaa catttgttta agaaaaagca cttttagcta aactgaacat tgcttataaa
     5221 agtgttgtca attcttagcc aaaccctgtt tttgttcttt tccagcataa ttgatgatca
     5281 ttactttcta ttctcttaag gaacacttga atataaaatt aaaattcatc cttaaagatt
     5341 atttttaaca gcttttagta cggagagttt gtaaatagtg taaactttgt aaattgtatt
     5401 gagttatcag tgttgataat tcttgctttt ataacattgt aaaatactag caaagatctt
     5461 gttattttta atagttttta aaagattttt aagtttaaaa aaaaattcct atttggtcta
     5521 tattccctgt tgggaatgta tcatttgaaa cactaactaa tttctgtatt ttacagcagt
     5581 ttcatagatg taccttttca actcagtgga gtttgcaaag agaaatgtca tttctccttt
     5641 taattgatgc acttctcagt tatgtaagac tgactgaaat agaaactgat catttgttga
     5701 ttcaacacag aatagattca gtatgtattg gctaattaat tatatgtatt tcttttctgg
     5761 tgcctgtttt taaccaatgt ttctgtgtta aaagcttgta acttcttaaa taatgtaatc
     5821 atgtttcaaa tagttatctt cagaatgtta tattttcatg tgaaatcaat ttcttttggc
     5881 tcaaaacaat gagagaaact caattttaag cagtatagct ggtcttttct ttgcatttat
     5941 gaactgtggt ccccttctcc acattactca atttatggga aacattttaa aaaaaaaatt
     6001 aaagctcaca aatattagcc taggatgttc ctgagattta catcccggag tcagaaccat
     6061 agctcttggc agccactcta tagagggcaa gacgtcaatg gtttgactgt ggacaggcga
     6121 tccctggaac agagttatgg attgaaaaca gccataagca aattgtaatg ggtgttaggg
     6181 ctgtttttct tttcttttta aaataaacat caatactatt ta
//
