LOCUS       NP_001131019             661 aa            linear   ROD 28-APR-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 51 [Mus musculus].
ACCESSION   NP_001131019 XP_001473788
VERSION     NP_001131019.1
DBSOURCE    REFSEQ: accession NM_001137547.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 661)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132077.1, AL840632.7 and BY671610.1.
            
            On Nov 13, 2008 this sequence version replaced XP_001473788.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132077.1, BB618927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     Protein         1..661
                     /product="ubiquitin carboxyl-terminal hydrolase 51"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific peptidase 51; deubiquitinating
                     enzyme 51"
                     /calculated_mol_wt=74652
     Region          1..144
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B1AY15.1)"
     Region          192..252
                     /region_name="zf-UBP"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; pfam02148"
                     /db_xref="CDD:460464"
     Region          320..654
                     /region_name="Peptidase_C19D"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; cd02660"
                     /db_xref="CDD:239125"
     Site            order(324,329,615,632)
                     /site_type="active"
                     /db_xref="CDD:239125"
     CDS             1..661
                     /gene="Usp51"
                     /coded_by="NM_001137547.1:200..2185"
                     /db_xref="CCDS:CCDS53226.1"
                     /db_xref="GeneID:635253"
                     /db_xref="MGI:MGI:3588217"
ORIGIN      
        1 mrgtqgaqem kpelwpepkp tsenltsrgs gsyekvlpsi paachtssss vcprrkprpr
       61 pqprsrsrgg rglkappppp akppppppap pppplpkqrs vawrnsrrrs rpgprpqtrk
      121 syssdhgssr dsdgsensll evgsnkgptg cchvesfkva knwqrnlrmi yqrfiwsgtp
      181 etrkrkaksc icqicsthkn rlhsclscvf fgcftdkhih ihaettqhnl avdlchgviy
      241 cfmcrdyvyd kdiekiaket kekilgllss ptgdasyqql maseveenql tceskdqets
      301 lvkpkkkrrk ktmyytvgfr glinlgntcf mncivqvlth ipllkeffls nkhkcmmtsp
      361 slclvcemsl lfqamysgnq sphipykllh liwihaehla gyrqqdaqef liaildvlhr
      421 hsrddgidqe gnsnccncii dhiftgslqs dltcqvchgv sttidpcwdi sldlpgpytp
      481 grassstssr dgqkprvisl tdclkwftrp edlgssakik csqcqsyqes tkqltmkklp
      541 ivacfhlkrf ehlgkqrrki nsfisfplel dmtpflastk esimkgqplt ecvpsenkys
      601 lfavinhhgt lesghytsfv rqekdqwfsc ddavvtkatm eellnsegyl lfyhrqdiek
      661 e
//
