LOCUS       NM_198421               8253 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 49 (Usp49), mRNA.
ACCESSION   NM_198421 XM_148792
VERSION     NM_198421.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8253)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8253)
  AUTHORS   Ye,L., Zhang,Q., Liuyu,T., Xu,Z., Zhang,M.X., Luo,M.H., Zeng,W.B.,
            Zhu,Q., Lin,D. and Zhong,B.
  TITLE     USP49 negatively regulates cellular antiviral responses via
            deconjugating K63-linked ubiquitination of MITA
  JOURNAL   PLoS Pathog 15 (4), e1007680 (2019)
   PUBMED   30943264
  REMARK    GeneRIF: Loss of Usp49 is associated with increased resistance to
            lethal HSV-1 infection.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060712.1 and AC139214.12.
            
            On Jul 17, 2018 this sequence version replaced NM_198421.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060712.1, SRR7652917.848917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5581              BC060712.1         1-5581
            5582-8253           AC139214.12        274444-277115
FEATURES             Location/Qualifiers
     source          1..8253
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.72 cM"
     gene            1..8253
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /note="ubiquitin specific peptidase 49"
                     /db_xref="GeneID:224836"
                     /db_xref="MGI:MGI:2685391"
     exon            1..226
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /inference="alignment:Splign:2.1.0"
     exon            227..300
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /inference="alignment:Splign:2.1.0"
     exon            301..1675
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..2386
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thioesterase 49; deubiquitinating enzyme
                     49; ubiquitin-specific-processing protease 49; ubiquitin
                     thiolesterase 49"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 49"
                     /protein_id="NP_940813.1"
                     /db_xref="CCDS:CCDS28852.1"
                     /db_xref="GeneID:224836"
                     /db_xref="MGI:MGI:2685391"
                     /translation="MDRCKHVGRLRLAQDHSILNPQKWCCLQCATTESAWACLKCSHV
                     ACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAV
                     RGQKQDLLARRGRTLRSTAAGEDVVPPQRTPQGQPQMLTALWYRRQRLLAKTLRLWFQ
                     KSSRGRAQLEQRRQEEALERKKEAARQRRREVKRRLLEELASAPPRKSARLLLHAPGP
                     VAVRPATLATSRRLSAAALNPRRQPAVAPGVTGLRNLGNTCYMNSILQVLSHLQKFRE
                     CFLNLDPSTSEHLFPQATNGKAQLSGRPASSSAAELSVRSVRAQGCEPQGLCWSSGAS
                     ISRSLELIQNKEPSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGY
                     DQQDAQEFLCELLHKVQQELESEGSTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQV
                     TCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEG
                     RIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGV
                     HVIFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCYNTEGGF
                     WVHCNDSKLDVCSVEEVCKTQAYILFYTRRTVQGSAKLSEPHLQAQVHSSSKDERRTY
                     TLP"
     exon            1676..1880
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1989
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2195
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..8253
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5581
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /note="major polyA site"
     regulatory      8239..8244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
                     /note="hexamer: AATAAA"
     polyA_site      8249
                     /gene="Usp49"
                     /gene_synonym="C330046L10Rik; Gm545"
ORIGIN      
        1 tgggccctgg gaattaaagg atggaatggg gagtggggaa agagaaagga gattaaggca
       61 agctagggaa gtcctggtgg gtatagaact ggggtgggct gcacaggagt gggaaacgaa
      121 tgttttgccc tgaagtgccc cagaaggtct ggaaggggca gggcacaaac gctgtagtga
      181 aggatctgaa gtagagagcc tttggtgcag aagataagga accatggtaa cagagaagag
      241 gaaacccagc cagtgataat gtgagaatat ggaaggcgat gggagcagct tgtttaatgg
      301 attaagacag tggcgactgc gctaaaacat ggatagatgc aaacatgtag ggcggttacg
      361 gctcgcccag gaccactcca tcctgaatcc ccagaagtgg tgctgtctgc agtgcgccac
      421 caccgagtct gcgtgggcct gcctcaagtg ctcccacgtg gcctgcggcc gctacattga
      481 agaccatgca ctaaaacact ttgaagagac aggacacccg ctggccatgg aggtccggga
      541 cctctacgtg ttctgctacc tgtgcaagga ctacgtgctc aatgacaacc cggaggggga
      601 cctgaagttg ctgagaagct ccctcctggc agttcgaggc cagaagcagg acctgctcgc
      661 caggcgtggg cggacgctgc ggtccacagc tgcgggcgag gacgtggtcc cgccacagcg
      721 cactcctcag ggacagccgc agatgctcac ggctctgtgg taccggcgcc agcgcctgct
      781 ggccaagacg ctgcggctct ggttccagaa gagctcccgc ggccgggcgc agctggagca
      841 gcggcggcag gaggaggcgc tggagcgcaa gaaggaggcg gcgcggcagc ggcgccgcga
      901 ggtcaagcgg cggctgctgg aggagctggc cagtgcgccg ccgcggaaga gtgcgcgcct
      961 gctcctgcac gctcccgggc ccgtggccgt gcgccctgcc accctcgcta cctcccggcg
     1021 cttgtccgca gctgccctca atccgcgccg ccagccggcg gtggccccag gtgtcaccgg
     1081 cctgcgcaac ctggggaata cctgctacat gaactccatc ctccaagtgc tcagccacct
     1141 ccagaagttc cgggaatgtt tcctgaacct cgacccttcc acctccgagc acctgtttcc
     1201 ccaagcaacc aacgggaagg cgcagctctc tggtaggcca gccagcagct ctgccgcaga
     1261 gttgtcagta aggagtgtcc gggcccaggg ctgcgaacct cagggcctct gctggagcag
     1321 cggagcctcc atcagcagga gcctggagct cattcagaac aaggaaccca gctcaaagca
     1381 catttccctc tgccacgaac tgcacaccct cttccgagtc atgtggtctg ggaagtgggc
     1441 gctggtatca ccctttgcca tgcttcactc cgtgtggagc ctgattcccg ccttccgtgg
     1501 ctacgaccag caggatgcgc aggaatttct ctgcgaactg ctgcacaagg tgcagcagga
     1561 acttgagtct gagggttcca cacgcaggat cctcatccca ttctcccaga ggaagctcac
     1621 caaacaggtc ttaaaggtgg tgaacaccat atttcatggg cagctgctca gtcaggtcac
     1681 atgtatatca tgcaattata aatccaatac cattgagccc ttttgggatc tgtccctgga
     1741 attccctgaa cgataccact gcatagaaaa ggggtttgtc cctttgaatc agacagagtg
     1801 cctgctcact gagatgctag ccaagttcac cgagacagag gccctggagg ggagaatcta
     1861 cgcttgtgac cagtgtaaca gcaaacgacg aaagtccaac cccaaacccc ttgttctgag
     1921 tgaagctagg aagcagttaa tgatctacag actacctcag gtcctccggc tacaccttaa
     1981 aagattcagg tggtctggcc gtaaccatcg tgagaagatt ggggtccatg tcatctttga
     2041 ccaggtatta accatggaac cttactgctg cagggacatg ctctcctctc ttgacaaaga
     2101 gacctttgcc tatgatctct ccgcagtggt catgcatcac gggaaagggt ttggctcagg
     2161 acactacaca gcctattgct acaacacaga gggaggtttt tgggtccact gcaatgactc
     2221 aaagctggat gtatgcagtg tcgaggaagt gtgcaaaacc caggcctaca ttctttttta
     2281 cactcgaaga acagttcagg gcagcgcaaa actctcagaa ccccatctcc aagctcaggt
     2341 gcactccagc agcaaggacg aacgcagaac atacacattg ccctgactgg gaggcaagca
     2401 tcaaaacggc ctccaggtct cctcttgggc ttgccaggaa cagatccctg ggtttgcctc
     2461 actggtctag gggagacaat gccctatgat tcctgctctg tcaaaaaatt ggtagtcact
     2521 ttcttgtgaa accatgcaaa tccccttctc tcataaaaac actataaagg agcagcttct
     2581 atgaagatcc ttttgtcagt tgcttctgga taacagggat ctgggtagag gagacagggt
     2641 aagtcatcag ccaaccagga gagcaagcat gtctgtctct gttgtgagtc ccctactaat
     2701 gaggcccttc ccaaagcact gcacagagta catgaggccc tgggctgaca gctggcggga
     2761 aagaccggtt ctgactcagg tgaagtcaca ggagttactc acactaaaaa ggtaatatac
     2821 catccagggg catagcttgc agactttctt ttttaggaga gagcagctga agggtgaggg
     2881 gcaaggagca gacttcctcc atgccaatgg gaaggctgtc tgtcatggct cagtttctcc
     2941 tgaactgctg tcacctcatc actccacaca gcgaggccga ggcttgagcc accccttcct
     3001 tcagaagagg cagtcagaag gacacagacc tgtgtgtgca tggtctatac gtgttatgcc
     3061 gtggacactc ctgacttccc cagtcctgta gcaaggcctg ggctcaaagt catggtttgg
     3121 tttagattgg tttttggatc agttgtcaga agccttctca gaatgcagtg aagatgagat
     3181 gagcttgtct gaatgcctgc tgtccctaag gctgccccta aggtcccgcc cacctgtgtg
     3241 gcatgaagct tcgttcttgc ccctagaaca tcagtgccca caggcttcag gagcttttac
     3301 tgccctagtg tgtgagcagt gcttagggac tgactggatc gtttgcttgt ggcccttgcc
     3361 tgctgtatcc cagcgctgtt tatccacctc tgctgctttg tccgtgagga atagagcaag
     3421 actcgtctgt tactctggta ttagtgaaaa cacatctcta aaattgactc catctctatg
     3481 ggattcaggt gctcagagcc ttcctcccta tcaggcacag taagcttctt tctctttgca
     3541 gtggctactg cagtgcccca cagcctcccg tgaatgctct cttttggtta agtagctcgg
     3601 gttaacgttt gagctcaggc agagcagtta tcactcaatg gggggaggca acggaggcat
     3661 ggccacactt caggcacatc tgtggtattt actgctgttc tcctttgagg tgagctctca
     3721 gtgggcctgc cagacatcag acatggaaga aatcagagtg gctcatcctg atagggacga
     3781 cgtgctggat tcaaacaaca ctgtgaggtt tctgtagtat ttagcttttc tttggaagcg
     3841 ataccgtaag gcatttttgt gctgtttggt ttttactgtc tgtggcaggc ttttctgtga
     3901 gctttgctca ggctcctcct ctcctggaca ctgttgtcag gtgtcccagt tgcccacact
     3961 gcctgaggct ctgacgtaaa gctgtacccc ttcagggagg ccgacattac tagcacagca
     4021 tgacggtgat gatttgttac cactgtagga aagcccattc aaaaagaaag ccatgtgtgc
     4081 tggaacactc ctgtaaggcc agcacttgtc aggctgaggc aggaggatca tgagtttgaa
     4141 gctacactgt gaggccctgt ttgaaaaaca aaactagcaa actagtgaaa aggactggat
     4201 tgcacctcac ctgaaaccct gtgttgttta ttccagaaag agaatttgca ggcagagaat
     4261 acagatctgc ctgtctagag gggaaacaca ttaatcacta taaacaccta caggaacatt
     4321 aaaggattct tacccaactt ttaagaagag ttttatagca gctatcagca ggactggtaa
     4381 gcagattagg gacctaataa aaaaaatgct taactgacct gaacacctac atatgagatt
     4441 agtaaaatta cttagtcaga agtgaaacca actgtcccca ctgagccacc cacatgaagg
     4501 tgccactgca accacagatg acacctcagc tccaggagca gcagctcgag ttaggggtgt
     4561 ggtgcttaag gagagctctg ctgcagaagg gcagggcagg gcagggcagg gcagggctgc
     4621 tgcggtacta catagccaaa gcagagcgct gtgtcagatg catcacagtg aaacatccta
     4681 aaaacaaagg acagacagac agaccctgac tagctgactc caggacatac ccccagtgct
     4741 gctctcccgg ctgcagtctc ctgaacgctg tgattggctg gtgtgtttac ttactgctgt
     4801 aaccagccaa gatgaattca ccccagccct caaaaatgac ttcttacctc agtctagcct
     4861 ggccctcatg cttgtggtcg cctctaagag cagcacccat tactagtgca aaaccagcag
     4921 ggctagcctt ggcaccagga actgtagctc tcatcccatg gcaggcagag ctcttgccag
     4981 ctttaaccca gcccctctgg ctgagatggg agggcaatgc cacatagtga agaactttta
     5041 gatgtctctt aaaacgtcaa gaataagact ggaaactgta gaagagttaa tgtgtcctat
     5101 ggactcaata gcagagttta tttttgttca cagtggcaag gcctctcgag tccatgattg
     5161 tatgaggtcc ctgctctggc tatgccttca gctccatcca cattcagggg acgaaccaat
     5221 gaggtggact ggccggcagt gcccgagtaa gccgagaggt ccatggtgaa gaatgaaaac
     5281 tttgggggcg gggggtggga ggatatctga tatttgtttt actgataaag ctttgtgaac
     5341 taattttcta caattcataa aatttggtgc cttgtacttg attgtggttt gcatgagagt
     5401 taaggggagg gctccttttc gttatgggtc tgtagtgttt aaaggatacg tgctatcaga
     5461 tttttagagc attcctttct ttgtcttatt acgaatgtaa attgttctta ccagcaagtt
     5521 ctagagtttt actgtccaaa ctgtatttgt aatcaatcat tcatcaaatg tctgactact
     5581 accactgttg ttcactgcct tttgttcatg cctaacattt atgctggcct tttctggagg
     5641 gtgacccttt cttgaatgtc tatcacatcc tatatggcgt tgcagcttat gtgagcaagg
     5701 gtttccggtt agttgggaga gcacaaatga tgagaaaagg ctttctctaa atcacgatga
     5761 agctaggtga ccaatggcag tagagtctgc gttaacactg gggtccttct gcatgaacca
     5821 tcaggaagca gtgtcaaaac aatgcgcaca tgtgaacctt cagactgtaa gacaagccac
     5881 tgtgtactat gcagtgaatc atggagaaat gacccgtctc caccatcctc aacacttctc
     5941 gggcagatga caacctggac agtgctgact ggctgaggaa ggtagtgaga ctcaagtgtg
     6001 ttcgtcaggg ccagtcccag ccagttcttt cactccaagc ttgaagtttc tgttgaactt
     6061 gtgagacttc accaagtgtt catgaattta ccatgcaaag catacgcggt aactgggtcc
     6121 ctcgcttcgt tcctagagta attaggtgaa gagttttatc tttggggtga aattttctag
     6181 ggtcacttga ttttttgtca gctaagtgtg ggtctcacag gtgggtcatt tttgtcaata
     6241 ctaaagctga aaagcacctt ctcagaactg tgagcttcgc ctctcttcta cattcctctg
     6301 ctctccatcc agtctgtcac tgtaactatg atgtaccgtc aacccatgct ccactctaca
     6361 ccaaggctca gtagctatga gtcagggggg tcactttgtg agacctgccc atgcttaagt
     6421 tggcatcttt cacttaaaaa tacaactagc agctggggaa atgctcattg ctagagcact
     6481 tagcactcga ggccctgggt ttcacccagc tccactaagc cagcttaaat gaaactgccc
     6541 aaccagcatc atggcgtcaa agaacaacag taaagttact tggaattaaa tcttaggttc
     6601 tgaatgaagc ttcagttaag ctctgaaagc tgtcatgtct taagtttttg tctcatctgg
     6661 cttttaactt aaatcttgtc attaactgct caattatggg atcatggcac actttaaggt
     6721 tttattcctc cagaaatcag ttgctctttc ctagtgtagc caaaatcatg tgggttctaa
     6781 gtctcacaca ctgtttacaa ggctgcttcc tggtcacctt ttggggctct gcaagtaatg
     6841 gcttcaaacc caagctttgt cctcgagttc atactcatga ccctggctcc ccagccctat
     6901 tgtttttttt taaaaaagga agtctcagtg tgtagccctg gctaacctgg aactcactat
     6961 gtaggacagg ctggccttag agatacatag cttctgggat taagtgtgtg ccaccaggcc
     7021 tccagcctgc ctcttcagag tatctgtaat cccagggtaa attctaggcc tgagttccct
     7081 catagggtgt ttctcctagc catccccact caggtcctac ctgctaaaga ttcacaagag
     7141 aatggcaacc cccgtcctat gcatgactag gcacgtggct cagtagggtg cttgcctagc
     7201 aagcataaag cccagagtct gatgctagca ccacataaaa tcaggcatag taaagccttg
     7261 aatcctaacc tgtacctgtg atcctaagag tcggttcatg gaaacagcaa aataagcagt
     7321 tcatgaccat cttcaactat gtagctaagt ttgaggccag cctggactac agaccagcac
     7381 aagaaccaga tatctccccc tccccccccc ccccccgcaa aagaacaaaa aacaaacact
     7441 tttaattatg cctcccccaa ccccaattat tttctggagg tcaaattgaa gccttttctg
     7501 caatgagcta tactggtagg cctcagagaa ctgactggat gagctatgtg ccagcaggtc
     7561 caggaaagct gctttgtctt tttccttttt taagtaacat ctgtaacagt catgcagcta
     7621 tgacccagac acactaatcc tttccgacgc atgctgtgac ccacaaccag ttccaaagcg
     7681 gctggtgcat aaaaaaagtt ttaaaatacc cagtcaattg actacatgaa actatggaga
     7741 ccccgtctct accgccacct ggttccctgg tacaggagtc tttctgtgct ggtttctgcg
     7801 tgcctggaag aacaccagac agcagcacca gtgtgaattt cagggtaggg agcacctttg
     7861 tttgtgaagg aagctgcttc cttgtgctcc ctgacacgtt tgtctccacc cacacatcac
     7921 tgtccactcc tgccaccagg tctcactcta tcccaacaat gcctccctgg tccctggaga
     7981 acccacctgg caaactaaaa cgacaaccac caccttcttc ctacaggaag actcagcagt
     8041 aggaactgct caagaatcag ctttgcggca cgtgtgcatc cctgggaagt gggtggtccc
     8101 attcccattt catctccact gcagatcatg tttggggctc atgcctgtct cttgagtgtg
     8161 aaatacaagt catgtttatt tgatttttgt aagcggactt tttacacctt gtttttgtaa
     8221 taagtttctt attaaaagaa taaaatacct gtc
//
