LOCUS       NM_001405953            5190 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 48 (Usp48), transcript
            variant 13, mRNA.
ACCESSION   NM_001405953
VERSION     NM_001405953.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5190)
  AUTHORS   Yu,J., Hou,B., Huang,Y., Wang,X., Qian,Y., Liang,Y., Gu,X., Ma,Z.
            and Sun,Y.
  TITLE     USP48 alleviates bone cancer pain and regulates MrgC stabilization
            in spinal cord neurons of male mice
  JOURNAL   Eur J Pain 27 (6), 723-734 (2023)
   PUBMED   36864656
  REMARK    GeneRIF: USP48 alleviates bone cancer pain and regulates MrgC
            stabilization in spinal cord neurons of male mice.
REFERENCE   2  (bases 1 to 5190)
  AUTHORS   Ren,Y., Feng,M., Hao,X., Liu,X., Li,J., Li,P., Gao,J., Qi,Q.,
            Du,L., Wang,C., Wang,Q. and Wang,Y.
  TITLE     USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
  JOURNAL   Cancer Res 83 (7), 1074-1093 (2023)
   PUBMED   36607699
REFERENCE   3  (bases 1 to 5190)
  AUTHORS   Du,L., Li,Y., Kang,M., Feng,M., Ren,Y., Dai,H., Wang,Y., Wang,Y.
            and Tang,B.
  TITLE     USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular
            Carcinoma via Regulating SIRT6 Stabilization
  JOURNAL   Cancer Res 81 (14), 3822-3834 (2021)
   PUBMED   33903120
REFERENCE   4  (bases 1 to 5190)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   5  (bases 1 to 5190)
  AUTHORS   Ferrando,R.E., Newton,K., Chu,F., Webster,J.D. and French,D.M.
  TITLE     Immunohistochemical detection of FLAG-tagged endogenous proteins in
            knock-in mice
  JOURNAL   J Histochem Cytochem 63 (4), 244-255 (2015)
   PUBMED   25575566
REFERENCE   6  (bases 1 to 5190)
  AUTHORS   Armando,I., Villar,V.A., Jones,J.E., Lee,H., Wang,X., Asico,L.D.,
            Yu,P., Yang,J., Escano,C.S. Jr., Pascua-Crusan,A.M., Felder,R.A.
            and Jose,P.A.
  TITLE     Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48
            to promote NHE3 degradation
  JOURNAL   FASEB J 28 (3), 1422-1434 (2014)
   PUBMED   24308971
REFERENCE   7  (bases 1 to 5190)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX000694.9 and AL805954.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.5324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BX000694.9         25844-26191
            349-469             BX000694.9         36198-36318
            470-626             BX000694.9         37427-37583
            627-754             BX000694.9         38364-38491
            755-879             BX000694.9         39733-39857
            880-988             BX000694.9         40673-40781
            989-1122            BX000694.9         42365-42498
            1123-1205           BX000694.9         43381-43463
            1206-1385           BX000694.9         45357-45536
            1386-1511           BX000694.9         47391-47516
            1512-1661           BX000694.9         48033-48182
            1662-1859           BX000694.9         52737-52934
            1860-1956           BX000694.9         54949-55045
            1957-1974           AL805954.9         2001-2018
            1975-2102           AL805954.9         3790-3917
            2103-2174           AL805954.9         6804-6875
            2175-2299           AL805954.9         11744-11868
            2300-2422           AL805954.9         11973-12095
            2423-2578           AL805954.9         22973-23128
            2579-2704           AL805954.9         28923-29048
            2705-2753           AL805954.9         31588-31636
            2754-2780           AL805954.9         33853-33879
            2781-5190           AL805954.9         34752-37161
FEATURES             Location/Qualifiers
     source          1..5190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.0 cM"
     gene            1..5190
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="ubiquitin specific peptidase 48"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
     exon            1..348
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2803
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /EC_number="3.4.19.12"
                     /note="isoform 13 is encoded by transcript variant 13;
                     ubiquitin specific protease 48; ubiquitin specific
                     protease 31; ubiquitin carboxyl-terminal hydrolase 48;
                     ubiquitin thioesterase 48; deubiquitinating enzyme 48;
                     ubiquitin-specific-processing protease 48; ubiquitin
                     thiolesterase 48"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 48 isoform
                     13"
                     /protein_id="NP_001392882.1"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
                     /translation="MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVC
                     RRNCRGNPNCLVGIGEHIWLGEIDENSFHSIDDPNCERRKKNSFVGLTNLGATCYVNT
                     FLQVWFLNLELRQALYLCPSTCSDYTKGDGIHGGKDYEPQTICEHLQYLFALLQNSNR
                     RYIDPSGFVKALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNVVQQQFCGEYA
                     YVTVCNQCGRESKLVSKFYELELNIQGHKQLTDCISEFLKEERLEGDNRYFCENCQSK
                     QNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESLDMEPYVEHKGGSF
                     VYELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLEP
                     SKSQTRKPKCGKGTHCSRNAYMLVYRLQAQEKNHTMVQVPAFLQELVDRDNSKFEEWC
                     VEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPIDN
                     NACLCSHDKLHPDKISIMKRISEYAANIFYSRYGGGPRLTVKALCKDCVVERCRVLRL
                     KNQLNEDYKAVNNLLKSTMKGDGFWVGKSSLRSWRQLALEQLDEQDGEAEQSNGKING
                     STFNKDESKEEKKEEEEELNFNEDILCPHGELSISENERRLVSQEAWSKLQQYFPKAP
                     EFPSYRECCSQCKILEREGEENEALHKMIANEQKTSLPNLFQDKNRPCLSNWPESNGS
                     TKRQKTSQQGYVAYQKQVIRRSTRHRKVRGEKALLVSANQTLKELKIQIMHAFSVAPF
                     DQNLSIDGKILNDDCATLGTLGVIPESVILLKADEPIADYAAMDDVMQVCMPEEGFKG
                     TGLLGH"
     exon            349..469
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            470..626
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            627..754
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            755..879
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            880..988
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1122
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1205
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1385
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1511
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1661
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1859
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1974
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2102
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2174
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2299
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2422
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2578
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2704
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2753
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2780
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..5190
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2966..2971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: AATAAA"
     polyA_site      3002
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
     regulatory      5159..5164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: ATTAAA"
     polyA_site      5190
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="major polyA site"
ORIGIN      
        1 atcggcggcg gcggcggcgc tttgcggctg gtcgtgcgag ctgggcgcgg gcgggcgggc
       61 gcggcggccg tggcgcgcgc aggtgattga ctgctctcct gtctgagggc agcgctgggt
      121 tctttcggct ggcaggggcc cgtgcccatt cgggcggaga cggaggcggc gccggaggcc
      181 accgggctcg gcgagtgcta cctcggtcaa ggctatggct ccgcggctgc agctggagaa
      241 ggcggcctgg cgctgggcgg agacggtgcg gcccgaggag gtgtcgcagg agcacatcga
      301 gaccgcctac cgcatctggc tggagccttg tatccgaggc gtgtgcagaa gaaactgcag
      361 aggaaacccg aattgcttgg ttggcattgg cgagcacatt tggttaggag agatagatga
      421 gaatagtttt catagcattg atgatcccaa ctgtgagagg aggaaaaaga attcctttgt
      481 gggcttgact aacctgggag ccacctgcta cgtcaacacc tttctccagg tgtggttcct
      541 caacttggag cttcggcagg cgctgtactt atgccccagc acctgcagtg attacacgaa
      601 gggagatggg atccatgggg gaaaagatta tgagcctcag acaatttgtg agcatcttca
      661 gtacttgttt gctttgttgc aaaacagtaa cagacgatac atcgatcctt caggatttgt
      721 taaagccttg ggcttagata ctgggcagca gcaggatgca caagagtttt ccaagctctt
      781 tatgtcgctg ttggaagaca ctttgtctaa acagaagaac ccggatgttc ggaatgttgt
      841 gcagcagcag ttctgtggag aatatgccta tgtgactgtg tgcaatcagt gtggccgaga
      901 gtctaagctt gtatcgaagt tctatgaact ggagttaaac atccaaggcc acaagcagtt
      961 aacagactgc atctcagagt tcctgaagga agaacgatta gaaggagaca atcgatactt
     1021 ctgtgaaaac tgtcagagca aacagaatgc tacacggaaa atccggcttc tgagcctccc
     1081 ttgcactctg aacttgcagc tgatgcgttt cgtgtttgac aggcaaactg gacacaagaa
     1141 gaagctcaat gcatacatcg gcttctcaga gagtctagat atggagcctt acgtggagca
     1201 caaaggcggg tccttcgtgt acgagctcag tgccgtcctc atccacagag gagtcagcgc
     1261 ctattctggc cactacatcg cacacgtgaa agaccctcag tctggagaat ggtacaagtt
     1321 caatgacgag gacatagaga agatggaggg caagaagcta cagctaggga ttgaggaaga
     1381 tctagaacct tctaaatccc agacccgtaa acccaagtgt ggcaaaggaa ctcactgctc
     1441 ccgaaatgca tacatgctgg tttataggct gcaagcccag gaaaagaacc acacaatggt
     1501 tcaagtccca gcctttcttc aagagctggt agatcgtgat aattccaaat tcgaggagtg
     1561 gtgtgtagaa atggccgaga tgcgcaagca gagtgtggac aaaggcaaag cgaagcacga
     1621 ggaggtgaag gagctgtacc aaaggttgcc tgctggagct gagccctatg agtttgtctc
     1681 tcttgaatgg ctgcagaagt ggttggacga gtcaacaccc accaaaccga ttgataataa
     1741 tgcttgcctg tgttcccacg acaagcttca tcctgataaa atatcaatta tgaagagaat
     1801 atcggaatat gcggctaaca ttttctatag tcgatatgga ggaggtccaa gactaactgt
     1861 gaaagccctt tgtaaggact gcgtcgtgga acgctgccgt gtcctgcgcc tgaagaatca
     1921 gctgaatgaa gattacaaag ctgtcaacaa tttgctgaaa tcgacaatga agggtgatgg
     1981 attttgggta ggaaagtctt ccttgcgtag ctggcgccag ctggctcttg aacaactaga
     2041 tgagcaagat ggtgaggcgg agcaaagcaa cgggaagata aacgggagca ccttcaataa
     2101 agatgaatca aaggaagaaa agaaagaaga ggaggaggaa ttaaatttta atgaagacat
     2161 tctgtgtcct catggagagt taagcatatc tgaaaatgaa agaaggctgg tttctcagga
     2221 ggcttggagc aagctgcagc agtacttccc aaaggctccc gagttcccaa gttacagaga
     2281 gtgctgctcg cagtgcaaga tactagaacg agaaggtgaa gaaaacgaag ccttgcataa
     2341 gatgatagca aacgagcaga agacctcact tccaaacttg ttccaggaca aaaacagacc
     2401 atgtctcagt aactggccag agagcaatgg aagtaccaag cgacagaaga catcccaaca
     2461 gggctatgtg gcctaccaga agcaggtcat ccggaggagc acgaggcaca ggaaggttcg
     2521 gggagagaag gcactgttgg tgtctgccaa ccagacgtta aaagaattga agattcagat
     2581 catgcacgca ttttcagttg ctccatttga ccagaatttg tcaattgatg gaaagatttt
     2641 aaacgacgac tgtgccaccc ttggtaccct cggcgtcatt cctgagtctg tcattttgtt
     2701 aaaggctgat gaaccaattg cagactacgc tgcaatggat gatgtcatgc aagtttgtat
     2761 gccggaagag ggctttaaag gtacgggcct gctcggacat taatctttga ctactcgctg
     2821 actgccaagg agtgaccaga aaggaagacg aaattgacat gtttgggcat taaagaaaac
     2881 gtggttttaa gaatgaaact cttacctggc tcttccaaaa gacaaaaatc cattcaaaag
     2941 agactgtccc acttgcctta tgtcaaataa agcagattgc actgatgggc atcagacttg
     3001 aaggacgtgt ttcagatttt ctatttaagg tgggagggag agggcgagcg aggactgagc
     3061 aggcagagca agagtaggag tgaatcatgt ttacactgag ggagtgaagc cctggtcagt
     3121 ccacacagat gccctgctca ctagcggatc tgtgtcccag gacatgggct agcatcctgc
     3181 tccaaactcc aagtgaccgt ctagagacaa gatctgctaa cccagccttt atttaaccta
     3241 tactcatctt tcaataaagc atgaacgtga aggacttgcc aacgaggaac gtgtcttcag
     3301 agcaccacgc ctgcagggca gccacagccc tgccacctcc ctgctcactg tctgtcagtg
     3361 ctgagtagta gggtcaagcc agtgactgtc tcagttttcc tccatcatct cagagggata
     3421 ggaaatgttc agtgttcggt ggcagcaaag agagtatccc tgaacgtttg aaaagccgaa
     3481 ccggagctcc gtaggatagc acgggttttc atagacagcc ctcccgctct ccagttctgc
     3541 cttcctcgga cctcactgct ttttgaaaac ccttaagact atacagggtg tgctgcctca
     3601 ccaactcagg atcactgttg acggtagttt aagcagcatc aggatctgct cgaacagaaa
     3661 aaggttttag gggagcacgg acggggctgg gcagcgattt gcattttctc tatcaagtgg
     3721 attgttggta tgtttgtggc ccagttgctg atacagattt tttttttttt ttaaaaacct
     3781 agttggttga aaaactttaa atgatgtata catgctgatc tcaacattgg cagcatcttt
     3841 tggtagcttt ctgctgctgg gtagaactcc caacatggca tttatgtttg caatgaagaa
     3901 agagtgttct gagatggtga gaagcgcggg gcagagccag gagagctgca cacctacctt
     3961 cctggaagac tgacttctca aggagctcct gcctttgggg acacagggac tcacgggacc
     4021 ctggctttca gatctgtcct ttaccgagca ccacagaaat gggaccaagc ctcactcacc
     4081 aagagcccac tctttcccaa ggccaagaca tttgaaagtc accagatatt tgacaaatgg
     4141 tctttactgt ccttagaaag aaacccagag tttgtggctt tgtaacaaag cattggcagg
     4201 gcctcagcac ccctgaaagg tggtggggct aggtggcaag aagcagctgt tcctccccct
     4261 ttctcttggc attggctgtg cacaagccag aagttagcac tgtgaggttg gttgcatagg
     4321 catcctttgt ttcctttacg aaatgttagc aaggtaatag ccattaactc ctgtcaggca
     4381 aatacagtgg ggcagaccca gttccagcga gctgaagtgt gctgcttccg cctcacagcc
     4441 ggtgcccgcc actgcagagc cttactggag cttcagctca gacccccgca cccactgaac
     4501 aaggccactc ccgaaaagct tgggatccct gggctgcggc ttcctcacag cttgaagcag
     4561 acatatttca aagagtctgc atttggactt accagctgcc atgttcctgc tcactaatcc
     4621 atgctgtttg gttgtcctct gagctggggt ggctgtatac agcacaggct agctattctg
     4681 ctgggttcta aagctacatt caggaaccac attaaaccag attatgaatc tccaggcttc
     4741 tttatgtttc ctttttcttt cccaggcagg gtttcctgta acccaggctg gccttggact
     4801 cactatgtaa ccaggataac cttaacttct gatcttccta cttcctcctc ccaggtgctg
     4861 ggattgcagg catgtggcca ctgtgacagg tttcctgtgc tgtgccgagg cccgggccca
     4921 gcgcctcgtg cacactagag aaaattctgc atactgaccc acatccccag ctctacccgt
     4981 gtatatttct agtcattctt taaacccaag caaatgtgta gagtctccta tgctgagatg
     5041 ttttttgcca ctaccagaca tgtaggctat catttgacgt ctttattccc tgagagaaaa
     5101 cttcttttct gtatttatga actttattat tgagaatcac tgttaacctt tctgccaaat
     5161 taaagacact tgtgtctctg tttccacgga
//
