LOCUS       NM_001405944            5553 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 48 (Usp48), transcript
            variant 10, mRNA.
ACCESSION   NM_001405944
VERSION     NM_001405944.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5553)
  AUTHORS   Yu,J., Hou,B., Huang,Y., Wang,X., Qian,Y., Liang,Y., Gu,X., Ma,Z.
            and Sun,Y.
  TITLE     USP48 alleviates bone cancer pain and regulates MrgC stabilization
            in spinal cord neurons of male mice
  JOURNAL   Eur J Pain 27 (6), 723-734 (2023)
   PUBMED   36864656
  REMARK    GeneRIF: USP48 alleviates bone cancer pain and regulates MrgC
            stabilization in spinal cord neurons of male mice.
REFERENCE   2  (bases 1 to 5553)
  AUTHORS   Ren,Y., Feng,M., Hao,X., Liu,X., Li,J., Li,P., Gao,J., Qi,Q.,
            Du,L., Wang,C., Wang,Q. and Wang,Y.
  TITLE     USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
  JOURNAL   Cancer Res 83 (7), 1074-1093 (2023)
   PUBMED   36607699
REFERENCE   3  (bases 1 to 5553)
  AUTHORS   Du,L., Li,Y., Kang,M., Feng,M., Ren,Y., Dai,H., Wang,Y., Wang,Y.
            and Tang,B.
  TITLE     USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular
            Carcinoma via Regulating SIRT6 Stabilization
  JOURNAL   Cancer Res 81 (14), 3822-3834 (2021)
   PUBMED   33903120
REFERENCE   4  (bases 1 to 5553)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   5  (bases 1 to 5553)
  AUTHORS   Ferrando,R.E., Newton,K., Chu,F., Webster,J.D. and French,D.M.
  TITLE     Immunohistochemical detection of FLAG-tagged endogenous proteins in
            knock-in mice
  JOURNAL   J Histochem Cytochem 63 (4), 244-255 (2015)
   PUBMED   25575566
REFERENCE   6  (bases 1 to 5553)
  AUTHORS   Armando,I., Villar,V.A., Jones,J.E., Lee,H., Wang,X., Asico,L.D.,
            Yu,P., Yang,J., Escano,C.S. Jr., Pascua-Crusan,A.M., Felder,R.A.
            and Jose,P.A.
  TITLE     Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48
            to promote NHE3 degradation
  JOURNAL   FASEB J 28 (3), 1422-1434 (2014)
   PUBMED   24308971
REFERENCE   7  (bases 1 to 5553)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX000694.9 and AL805954.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.2863931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BX000694.9         25844-26191
            349-469             BX000694.9         36198-36318
            470-626             BX000694.9         37427-37583
            627-754             BX000694.9         38364-38491
            755-879             BX000694.9         39733-39857
            880-988             BX000694.9         40673-40781
            989-1122            BX000694.9         42365-42498
            1123-1205           BX000694.9         43381-43463
            1206-1385           BX000694.9         45357-45536
            1386-1514           BX000694.9         47388-47516
            1515-1664           BX000694.9         48033-48182
            1665-1862           BX000694.9         52737-52934
            1863-1959           BX000694.9         54949-55045
            1960-1977           AL805954.9         2001-2018
            1978-2105           AL805954.9         3790-3917
            2106-2177           AL805954.9         6804-6875
            2178-2302           AL805954.9         11744-11868
            2303-2425           AL805954.9         11973-12095
            2426-2487           AL805954.9         12463-12524
            2488-2598           AL805954.9         13528-13638
            2599-2729           AL805954.9         16390-16520
            2730-2836           AL805954.9         16786-16892
            2837-2941           AL805954.9         17836-17940
            2942-3067           AL805954.9         28923-29048
            3068-3116           AL805954.9         31588-31636
            3117-3143           AL805954.9         33853-33879
            3144-5553           AL805954.9         34752-37161
FEATURES             Location/Qualifiers
     source          1..5553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.0 cM"
     gene            1..5553
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="ubiquitin specific peptidase 48"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
     exon            1..348
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..3166
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /EC_number="3.4.19.12"
                     /note="isoform 10 is encoded by transcript variant 10;
                     ubiquitin specific protease 48; ubiquitin specific
                     protease 31; ubiquitin carboxyl-terminal hydrolase 48;
                     ubiquitin thioesterase 48; deubiquitinating enzyme 48;
                     ubiquitin-specific-processing protease 48; ubiquitin
                     thiolesterase 48"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 48 isoform
                     10"
                     /protein_id="NP_001392873.1"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
                     /translation="MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVC
                     RRNCRGNPNCLVGIGEHIWLGEIDENSFHSIDDPNCERRKKNSFVGLTNLGATCYVNT
                     FLQVWFLNLELRQALYLCPSTCSDYTKGDGIHGGKDYEPQTICEHLQYLFALLQNSNR
                     RYIDPSGFVKALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNVVQQQFCGEYA
                     YVTVCNQCGRESKLVSKFYELELNIQGHKQLTDCISEFLKEERLEGDNRYFCENCQSK
                     QNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESLDMEPYVEHKGGSF
                     VYELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLAE
                     PSKSQTRKPKCGKGTHCSRNAYMLVYRLQAQEKNHTMVQVPAFLQELVDRDNSKFEEW
                     CVEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPID
                     NNACLCSHDKLHPDKISIMKRISEYAANIFYSRYGGGPRLTVKALCKDCVVERCRVLR
                     LKNQLNEDYKAVNNLLKSTMKGDGFWVGKSSLRSWRQLALEQLDEQDGEAEQSNGKIN
                     GSTFNKDESKEEKKEEEEELNFNEDILCPHGELSISENERRLVSQEAWSKLQQYFPKA
                     PEFPSYRECCSQCKILEREGEENEALHKMIANEQKTSLPNLFQDKNRPCLSNWPEDTD
                     ALYIVSHFFLDEWRKFVRKPARSAPVSSIGNAALLCPHGGLMFTFPSLTKEDSKLIAL
                     IWPSEWQMIQKLFVVDKVIKITRIEVGDVNPSQTQYISEPSLCPDCREGLLCQQQRDL
                     REYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKEEAKPDGEKDPDFNQIMHAF
                     SVAPFDQNLSIDGKILNDDCATLGTLGVIPESVILLKADEPIADYAAMDDVMQVCMPE
                     EGFKGTGLLGH"
     exon            349..469
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            470..626
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            627..754
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            755..879
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            880..988
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1122
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1205
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1385
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1514
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1664
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1862
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1977
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2105
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2177
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2302
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2425
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2487
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2598
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2729
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2836
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2941
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3067
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3116
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3143
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..5553
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3329..3334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: AATAAA"
     polyA_site      3365
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
     regulatory      5522..5527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: ATTAAA"
     polyA_site      5553
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="major polyA site"
ORIGIN      
        1 atcggcggcg gcggcggcgc tttgcggctg gtcgtgcgag ctgggcgcgg gcgggcgggc
       61 gcggcggccg tggcgcgcgc aggtgattga ctgctctcct gtctgagggc agcgctgggt
      121 tctttcggct ggcaggggcc cgtgcccatt cgggcggaga cggaggcggc gccggaggcc
      181 accgggctcg gcgagtgcta cctcggtcaa ggctatggct ccgcggctgc agctggagaa
      241 ggcggcctgg cgctgggcgg agacggtgcg gcccgaggag gtgtcgcagg agcacatcga
      301 gaccgcctac cgcatctggc tggagccttg tatccgaggc gtgtgcagaa gaaactgcag
      361 aggaaacccg aattgcttgg ttggcattgg cgagcacatt tggttaggag agatagatga
      421 gaatagtttt catagcattg atgatcccaa ctgtgagagg aggaaaaaga attcctttgt
      481 gggcttgact aacctgggag ccacctgcta cgtcaacacc tttctccagg tgtggttcct
      541 caacttggag cttcggcagg cgctgtactt atgccccagc acctgcagtg attacacgaa
      601 gggagatggg atccatgggg gaaaagatta tgagcctcag acaatttgtg agcatcttca
      661 gtacttgttt gctttgttgc aaaacagtaa cagacgatac atcgatcctt caggatttgt
      721 taaagccttg ggcttagata ctgggcagca gcaggatgca caagagtttt ccaagctctt
      781 tatgtcgctg ttggaagaca ctttgtctaa acagaagaac ccggatgttc ggaatgttgt
      841 gcagcagcag ttctgtggag aatatgccta tgtgactgtg tgcaatcagt gtggccgaga
      901 gtctaagctt gtatcgaagt tctatgaact ggagttaaac atccaaggcc acaagcagtt
      961 aacagactgc atctcagagt tcctgaagga agaacgatta gaaggagaca atcgatactt
     1021 ctgtgaaaac tgtcagagca aacagaatgc tacacggaaa atccggcttc tgagcctccc
     1081 ttgcactctg aacttgcagc tgatgcgttt cgtgtttgac aggcaaactg gacacaagaa
     1141 gaagctcaat gcatacatcg gcttctcaga gagtctagat atggagcctt acgtggagca
     1201 caaaggcggg tccttcgtgt acgagctcag tgccgtcctc atccacagag gagtcagcgc
     1261 ctattctggc cactacatcg cacacgtgaa agaccctcag tctggagaat ggtacaagtt
     1321 caatgacgag gacatagaga agatggaggg caagaagcta cagctaggga ttgaggaaga
     1381 tctagcagaa ccttctaaat cccagacccg taaacccaag tgtggcaaag gaactcactg
     1441 ctcccgaaat gcatacatgc tggtttatag gctgcaagcc caggaaaaga accacacaat
     1501 ggttcaagtc ccagcctttc ttcaagagct ggtagatcgt gataattcca aattcgagga
     1561 gtggtgtgta gaaatggccg agatgcgcaa gcagagtgtg gacaaaggca aagcgaagca
     1621 cgaggaggtg aaggagctgt accaaaggtt gcctgctgga gctgagccct atgagtttgt
     1681 ctctcttgaa tggctgcaga agtggttgga cgagtcaaca cccaccaaac cgattgataa
     1741 taatgcttgc ctgtgttccc acgacaagct tcatcctgat aaaatatcaa ttatgaagag
     1801 aatatcggaa tatgcggcta acattttcta tagtcgatat ggaggaggtc caagactaac
     1861 tgtgaaagcc ctttgtaagg actgcgtcgt ggaacgctgc cgtgtcctgc gcctgaagaa
     1921 tcagctgaat gaagattaca aagctgtcaa caatttgctg aaatcgacaa tgaagggtga
     1981 tggattttgg gtaggaaagt cttccttgcg tagctggcgc cagctggctc ttgaacaact
     2041 agatgagcaa gatggtgagg cggagcaaag caacgggaag ataaacggga gcaccttcaa
     2101 taaagatgaa tcaaaggaag aaaagaaaga agaggaggag gaattaaatt ttaatgaaga
     2161 cattctgtgt cctcatggag agttaagcat atctgaaaat gaaagaaggc tggtttctca
     2221 ggaggcttgg agcaagctgc agcagtactt cccaaaggct cccgagttcc caagttacag
     2281 agagtgctgc tcgcagtgca agatactaga acgagaaggt gaagaaaacg aagccttgca
     2341 taagatgata gcaaacgagc agaagacctc acttccaaac ttgttccagg acaaaaacag
     2401 accatgtctc agtaactggc cagaggacac ggatgctctc tatattgtgt cgcacttctt
     2461 tttagatgaa tggcggaaat ttgttagaaa gcctgcaagg tctgctcctg tgtcgtcaat
     2521 tgggaatgct gcccttctgt gtccacatgg aggactcatg tttacatttc cttccctcac
     2581 caaagaagac tcgaaactta tagctctcat atggcccagc gaatggcaaa tgattcaaaa
     2641 gctctttgtt gtggataaag taattaaaat cacaagaatt gaagtgggag acgtgaatcc
     2701 ttctcaaaca cagtatattt ctgaacctag tctctgtcca gattgcagag aaggtctgct
     2761 gtgccagcag cagagggacc ttcgagagta tacccaagcc accatctatg tccacaaggt
     2821 tgtggataac aaaaaggtga tgaaggactc ggcccccgag ttgaatgtga gtagttctga
     2881 gacggaagaa gacaaggagg aggctaagcc agatggggag aaggatcctg actttaatca
     2941 aatcatgcac gcattttcag ttgctccatt tgaccagaat ttgtcaattg atggaaagat
     3001 tttaaacgac gactgtgcca cccttggtac cctcggcgtc attcctgagt ctgtcatttt
     3061 gttaaaggct gatgaaccaa ttgcagacta cgctgcaatg gatgatgtca tgcaagtttg
     3121 tatgccggaa gagggcttta aaggtacggg cctgctcgga cattaatctt tgactactcg
     3181 ctgactgcca aggagtgacc agaaaggaag acgaaattga catgtttggg cattaaagaa
     3241 aacgtggttt taagaatgaa actcttacct ggctcttcca aaagacaaaa atccattcaa
     3301 aagagactgt cccacttgcc ttatgtcaaa taaagcagat tgcactgatg ggcatcagac
     3361 ttgaaggacg tgtttcagat tttctattta aggtgggagg gagagggcga gcgaggactg
     3421 agcaggcaga gcaagagtag gagtgaatca tgtttacact gagggagtga agccctggtc
     3481 agtccacaca gatgccctgc tcactagcgg atctgtgtcc caggacatgg gctagcatcc
     3541 tgctccaaac tccaagtgac cgtctagaga caagatctgc taacccagcc tttatttaac
     3601 ctatactcat ctttcaataa agcatgaacg tgaaggactt gccaacgagg aacgtgtctt
     3661 cagagcacca cgcctgcagg gcagccacag ccctgccacc tccctgctca ctgtctgtca
     3721 gtgctgagta gtagggtcaa gccagtgact gtctcagttt tcctccatca tctcagaggg
     3781 ataggaaatg ttcagtgttc ggtggcagca aagagagtat ccctgaacgt ttgaaaagcc
     3841 gaaccggagc tccgtaggat agcacgggtt ttcatagaca gccctcccgc tctccagttc
     3901 tgccttcctc ggacctcact gctttttgaa aacccttaag actatacagg gtgtgctgcc
     3961 tcaccaactc aggatcactg ttgacggtag tttaagcagc atcaggatct gctcgaacag
     4021 aaaaaggttt taggggagca cggacggggc tgggcagcga tttgcatttt ctctatcaag
     4081 tggattgttg gtatgtttgt ggcccagttg ctgatacaga tttttttttt tttttaaaaa
     4141 cctagttggt tgaaaaactt taaatgatgt atacatgctg atctcaacat tggcagcatc
     4201 ttttggtagc tttctgctgc tgggtagaac tcccaacatg gcatttatgt ttgcaatgaa
     4261 gaaagagtgt tctgagatgg tgagaagcgc ggggcagagc caggagagct gcacacctac
     4321 cttcctggaa gactgacttc tcaaggagct cctgcctttg gggacacagg gactcacggg
     4381 accctggctt tcagatctgt cctttaccga gcaccacaga aatgggacca agcctcactc
     4441 accaagagcc cactctttcc caaggccaag acatttgaaa gtcaccagat atttgacaaa
     4501 tggtctttac tgtccttaga aagaaaccca gagtttgtgg ctttgtaaca aagcattggc
     4561 agggcctcag cacccctgaa aggtggtggg gctaggtggc aagaagcagc tgttcctccc
     4621 cctttctctt ggcattggct gtgcacaagc cagaagttag cactgtgagg ttggttgcat
     4681 aggcatcctt tgtttccttt acgaaatgtt agcaaggtaa tagccattaa ctcctgtcag
     4741 gcaaatacag tggggcagac ccagttccag cgagctgaag tgtgctgctt ccgcctcaca
     4801 gccggtgccc gccactgcag agccttactg gagcttcagc tcagaccccc gcacccactg
     4861 aacaaggcca ctcccgaaaa gcttgggatc cctgggctgc ggcttcctca cagcttgaag
     4921 cagacatatt tcaaagagtc tgcatttgga cttaccagct gccatgttcc tgctcactaa
     4981 tccatgctgt ttggttgtcc tctgagctgg ggtggctgta tacagcacag gctagctatt
     5041 ctgctgggtt ctaaagctac attcaggaac cacattaaac cagattatga atctccaggc
     5101 ttctttatgt ttcctttttc tttcccaggc agggtttcct gtaacccagg ctggccttgg
     5161 actcactatg taaccaggat aaccttaact tctgatcttc ctacttcctc ctcccaggtg
     5221 ctgggattgc aggcatgtgg ccactgtgac aggtttcctg tgctgtgccg aggcccgggc
     5281 ccagcgcctc gtgcacacta gagaaaattc tgcatactga cccacatccc cagctctacc
     5341 cgtgtatatt tctagtcatt ctttaaaccc aagcaaatgt gtagagtctc ctatgctgag
     5401 atgttttttg ccactaccag acatgtaggc tatcatttga cgtctttatt ccctgagaga
     5461 aaacttcttt tctgtattta tgaactttat tattgagaat cactgttaac ctttctgcca
     5521 aattaaagac acttgtgtct ctgtttccac gga
//
