LOCUS       NM_001405937            5766 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 48 (Usp48), transcript
            variant 4, mRNA.
ACCESSION   NM_001405937 XM_017320005
VERSION     NM_001405937.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5766)
  AUTHORS   Yu,J., Hou,B., Huang,Y., Wang,X., Qian,Y., Liang,Y., Gu,X., Ma,Z.
            and Sun,Y.
  TITLE     USP48 alleviates bone cancer pain and regulates MrgC stabilization
            in spinal cord neurons of male mice
  JOURNAL   Eur J Pain 27 (6), 723-734 (2023)
   PUBMED   36864656
  REMARK    GeneRIF: USP48 alleviates bone cancer pain and regulates MrgC
            stabilization in spinal cord neurons of male mice.
REFERENCE   2  (bases 1 to 5766)
  AUTHORS   Ren,Y., Feng,M., Hao,X., Liu,X., Li,J., Li,P., Gao,J., Qi,Q.,
            Du,L., Wang,C., Wang,Q. and Wang,Y.
  TITLE     USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
  JOURNAL   Cancer Res 83 (7), 1074-1093 (2023)
   PUBMED   36607699
REFERENCE   3  (bases 1 to 5766)
  AUTHORS   Du,L., Li,Y., Kang,M., Feng,M., Ren,Y., Dai,H., Wang,Y., Wang,Y.
            and Tang,B.
  TITLE     USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular
            Carcinoma via Regulating SIRT6 Stabilization
  JOURNAL   Cancer Res 81 (14), 3822-3834 (2021)
   PUBMED   33903120
REFERENCE   4  (bases 1 to 5766)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   5  (bases 1 to 5766)
  AUTHORS   Ferrando,R.E., Newton,K., Chu,F., Webster,J.D. and French,D.M.
  TITLE     Immunohistochemical detection of FLAG-tagged endogenous proteins in
            knock-in mice
  JOURNAL   J Histochem Cytochem 63 (4), 244-255 (2015)
   PUBMED   25575566
REFERENCE   6  (bases 1 to 5766)
  AUTHORS   Armando,I., Villar,V.A., Jones,J.E., Lee,H., Wang,X., Asico,L.D.,
            Yu,P., Yang,J., Escano,C.S. Jr., Pascua-Crusan,A.M., Felder,R.A.
            and Jose,P.A.
  TITLE     Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48
            to promote NHE3 degradation
  JOURNAL   FASEB J 28 (3), 1422-1434 (2014)
   PUBMED   24308971
REFERENCE   7  (bases 1 to 5766)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX000694.9 and AL805954.9.
            
            On May 6, 2022 this sequence version replaced XM_017320005.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.1186.1,
                                           SRR13422598.392275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BX000694.9         25844-26191
            349-469             BX000694.9         36198-36318
            470-626             BX000694.9         37427-37583
            627-754             BX000694.9         38364-38491
            755-879             BX000694.9         39733-39857
            880-988             BX000694.9         40673-40781
            989-1122            BX000694.9         42365-42498
            1123-1205           BX000694.9         43381-43463
            1206-1385           BX000694.9         45357-45536
            1386-1514           BX000694.9         47388-47516
            1515-1664           BX000694.9         48033-48182
            1665-1862           BX000694.9         52737-52934
            1863-1959           BX000694.9         54949-55045
            1960-1977           AL805954.9         2001-2018
            1978-2108           AL805954.9         3787-3917
            2109-2180           AL805954.9         6804-6875
            2181-2305           AL805954.9         11744-11868
            2306-2428           AL805954.9         11973-12095
            2429-2490           AL805954.9         12463-12524
            2491-2601           AL805954.9         13528-13638
            2602-2655           AL805954.9         15564-15617
            2656-2786           AL805954.9         16390-16520
            2787-2893           AL805954.9         16786-16892
            2894-2998           AL805954.9         17836-17940
            2999-3154           AL805954.9         22973-23128
            3155-3280           AL805954.9         28923-29048
            3281-3329           AL805954.9         31588-31636
            3330-3356           AL805954.9         33853-33879
            3357-5766           AL805954.9         34752-37161
FEATURES             Location/Qualifiers
     source          1..5766
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.0 cM"
     gene            1..5766
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="ubiquitin specific peptidase 48"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
     exon            1..348
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..3379
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /EC_number="3.4.19.12"
                     /note="isoform 4 is encoded by transcript variant 4;
                     ubiquitin specific protease 48; ubiquitin specific
                     protease 31; ubiquitin carboxyl-terminal hydrolase 48;
                     ubiquitin thioesterase 48; deubiquitinating enzyme 48;
                     ubiquitin-specific-processing protease 48; ubiquitin
                     thiolesterase 48"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 48 isoform
                     4"
                     /protein_id="NP_001392866.1"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
                     /translation="MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVC
                     RRNCRGNPNCLVGIGEHIWLGEIDENSFHSIDDPNCERRKKNSFVGLTNLGATCYVNT
                     FLQVWFLNLELRQALYLCPSTCSDYTKGDGIHGGKDYEPQTICEHLQYLFALLQNSNR
                     RYIDPSGFVKALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNVVQQQFCGEYA
                     YVTVCNQCGRESKLVSKFYELELNIQGHKQLTDCISEFLKEERLEGDNRYFCENCQSK
                     QNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESLDMEPYVEHKGGSF
                     VYELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLAE
                     PSKSQTRKPKCGKGTHCSRNAYMLVYRLQAQEKNHTMVQVPAFLQELVDRDNSKFEEW
                     CVEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPID
                     NNACLCSHDKLHPDKISIMKRISEYAANIFYSRYGGGPRLTVKALCKDCVVERCRVLR
                     LKNQLNEDYKAVNNLLKSTMKGSDGFWVGKSSLRSWRQLALEQLDEQDGEAEQSNGKI
                     NGSTFNKDESKEEKKEEEEELNFNEDILCPHGELSISENERRLVSQEAWSKLQQYFPK
                     APEFPSYRECCSQCKILEREGEENEALHKMIANEQKTSLPNLFQDKNRPCLSNWPEDT
                     DALYIVSHFFLDEWRKFVRKPARSAPVSSIGNAALLCPHGGLMFTFPSLTKEDSKLCQ
                     PLERREGGWPTAAHNNIALIWPSEWQMIQKLFVVDKVIKITRIEVGDVNPSQTQYISE
                     PSLCPDCREGLLCQQQRDLREYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKE
                     EAKPDGEKDPDFNQSNGSTKRQKTSQQGYVAYQKQVIRRSTRHRKVRGEKALLVSANQ
                     TLKELKIQIMHAFSVAPFDQNLSIDGKILNDDCATLGTLGVIPESVILLKADEPIADY
                     AAMDDVMQVCMPEEGFKGTGLLGH"
     exon            349..469
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            470..626
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            627..754
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            755..879
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            880..988
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1122
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1205
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1385
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1514
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1664
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1862
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1977
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2108
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2180
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2305
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2428
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2490
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2601
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2655
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2786
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2893
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2998
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3154
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3280
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3329
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3356
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..5766
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3542..3547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: AATAAA"
     polyA_site      3578
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
     regulatory      5735..5740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: ATTAAA"
     polyA_site      5766
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="major polyA site"
ORIGIN      
        1 atcggcggcg gcggcggcgc tttgcggctg gtcgtgcgag ctgggcgcgg gcgggcgggc
       61 gcggcggccg tggcgcgcgc aggtgattga ctgctctcct gtctgagggc agcgctgggt
      121 tctttcggct ggcaggggcc cgtgcccatt cgggcggaga cggaggcggc gccggaggcc
      181 accgggctcg gcgagtgcta cctcggtcaa ggctatggct ccgcggctgc agctggagaa
      241 ggcggcctgg cgctgggcgg agacggtgcg gcccgaggag gtgtcgcagg agcacatcga
      301 gaccgcctac cgcatctggc tggagccttg tatccgaggc gtgtgcagaa gaaactgcag
      361 aggaaacccg aattgcttgg ttggcattgg cgagcacatt tggttaggag agatagatga
      421 gaatagtttt catagcattg atgatcccaa ctgtgagagg aggaaaaaga attcctttgt
      481 gggcttgact aacctgggag ccacctgcta cgtcaacacc tttctccagg tgtggttcct
      541 caacttggag cttcggcagg cgctgtactt atgccccagc acctgcagtg attacacgaa
      601 gggagatggg atccatgggg gaaaagatta tgagcctcag acaatttgtg agcatcttca
      661 gtacttgttt gctttgttgc aaaacagtaa cagacgatac atcgatcctt caggatttgt
      721 taaagccttg ggcttagata ctgggcagca gcaggatgca caagagtttt ccaagctctt
      781 tatgtcgctg ttggaagaca ctttgtctaa acagaagaac ccggatgttc ggaatgttgt
      841 gcagcagcag ttctgtggag aatatgccta tgtgactgtg tgcaatcagt gtggccgaga
      901 gtctaagctt gtatcgaagt tctatgaact ggagttaaac atccaaggcc acaagcagtt
      961 aacagactgc atctcagagt tcctgaagga agaacgatta gaaggagaca atcgatactt
     1021 ctgtgaaaac tgtcagagca aacagaatgc tacacggaaa atccggcttc tgagcctccc
     1081 ttgcactctg aacttgcagc tgatgcgttt cgtgtttgac aggcaaactg gacacaagaa
     1141 gaagctcaat gcatacatcg gcttctcaga gagtctagat atggagcctt acgtggagca
     1201 caaaggcggg tccttcgtgt acgagctcag tgccgtcctc atccacagag gagtcagcgc
     1261 ctattctggc cactacatcg cacacgtgaa agaccctcag tctggagaat ggtacaagtt
     1321 caatgacgag gacatagaga agatggaggg caagaagcta cagctaggga ttgaggaaga
     1381 tctagcagaa ccttctaaat cccagacccg taaacccaag tgtggcaaag gaactcactg
     1441 ctcccgaaat gcatacatgc tggtttatag gctgcaagcc caggaaaaga accacacaat
     1501 ggttcaagtc ccagcctttc ttcaagagct ggtagatcgt gataattcca aattcgagga
     1561 gtggtgtgta gaaatggccg agatgcgcaa gcagagtgtg gacaaaggca aagcgaagca
     1621 cgaggaggtg aaggagctgt accaaaggtt gcctgctgga gctgagccct atgagtttgt
     1681 ctctcttgaa tggctgcaga agtggttgga cgagtcaaca cccaccaaac cgattgataa
     1741 taatgcttgc ctgtgttccc acgacaagct tcatcctgat aaaatatcaa ttatgaagag
     1801 aatatcggaa tatgcggcta acattttcta tagtcgatat ggaggaggtc caagactaac
     1861 tgtgaaagcc ctttgtaagg actgcgtcgt ggaacgctgc cgtgtcctgc gcctgaagaa
     1921 tcagctgaat gaagattaca aagctgtcaa caatttgctg aaatcgacaa tgaagggcag
     1981 tgatggattt tgggtaggaa agtcttcctt gcgtagctgg cgccagctgg ctcttgaaca
     2041 actagatgag caagatggtg aggcggagca aagcaacggg aagataaacg ggagcacctt
     2101 caataaagat gaatcaaagg aagaaaagaa agaagaggag gaggaattaa attttaatga
     2161 agacattctg tgtcctcatg gagagttaag catatctgaa aatgaaagaa ggctggtttc
     2221 tcaggaggct tggagcaagc tgcagcagta cttcccaaag gctcccgagt tcccaagtta
     2281 cagagagtgc tgctcgcagt gcaagatact agaacgagaa ggtgaagaaa acgaagcctt
     2341 gcataagatg atagcaaacg agcagaagac ctcacttcca aacttgttcc aggacaaaaa
     2401 cagaccatgt ctcagtaact ggccagagga cacggatgct ctctatattg tgtcgcactt
     2461 ctttttagat gaatggcgga aatttgttag aaagcctgca aggtctgctc ctgtgtcgtc
     2521 aattgggaat gctgcccttc tgtgtccaca tggaggactc atgtttacat ttccttccct
     2581 caccaaagaa gactcgaaac tctgtcaacc tttagagaga agagaaggag gctggcccac
     2641 tgcagcacat aataatatag ctctcatatg gcccagcgaa tggcaaatga ttcaaaagct
     2701 ctttgttgtg gataaagtaa ttaaaatcac aagaattgaa gtgggagacg tgaatccttc
     2761 tcaaacacag tatatttctg aacctagtct ctgtccagat tgcagagaag gtctgctgtg
     2821 ccagcagcag agggaccttc gagagtatac ccaagccacc atctatgtcc acaaggttgt
     2881 ggataacaaa aaggtgatga aggactcggc ccccgagttg aatgtgagta gttctgagac
     2941 ggaagaagac aaggaggagg ctaagccaga tggggagaag gatcctgact ttaatcaaag
     3001 caatggaagt accaagcgac agaagacatc ccaacagggc tatgtggcct accagaagca
     3061 ggtcatccgg aggagcacga ggcacaggaa ggttcgggga gagaaggcac tgttggtgtc
     3121 tgccaaccag acgttaaaag aattgaagat tcagatcatg cacgcatttt cagttgctcc
     3181 atttgaccag aatttgtcaa ttgatggaaa gattttaaac gacgactgtg ccacccttgg
     3241 taccctcggc gtcattcctg agtctgtcat tttgttaaag gctgatgaac caattgcaga
     3301 ctacgctgca atggatgatg tcatgcaagt ttgtatgccg gaagagggct ttaaaggtac
     3361 gggcctgctc ggacattaat ctttgactac tcgctgactg ccaaggagtg accagaaagg
     3421 aagacgaaat tgacatgttt gggcattaaa gaaaacgtgg ttttaagaat gaaactctta
     3481 cctggctctt ccaaaagaca aaaatccatt caaaagagac tgtcccactt gccttatgtc
     3541 aaataaagca gattgcactg atgggcatca gacttgaagg acgtgtttca gattttctat
     3601 ttaaggtggg agggagaggg cgagcgagga ctgagcaggc agagcaagag taggagtgaa
     3661 tcatgtttac actgagggag tgaagccctg gtcagtccac acagatgccc tgctcactag
     3721 cggatctgtg tcccaggaca tgggctagca tcctgctcca aactccaagt gaccgtctag
     3781 agacaagatc tgctaaccca gcctttattt aacctatact catctttcaa taaagcatga
     3841 acgtgaagga cttgccaacg aggaacgtgt cttcagagca ccacgcctgc agggcagcca
     3901 cagccctgcc acctccctgc tcactgtctg tcagtgctga gtagtagggt caagccagtg
     3961 actgtctcag ttttcctcca tcatctcaga gggataggaa atgttcagtg ttcggtggca
     4021 gcaaagagag tatccctgaa cgtttgaaaa gccgaaccgg agctccgtag gatagcacgg
     4081 gttttcatag acagccctcc cgctctccag ttctgccttc ctcggacctc actgcttttt
     4141 gaaaaccctt aagactatac agggtgtgct gcctcaccaa ctcaggatca ctgttgacgg
     4201 tagtttaagc agcatcagga tctgctcgaa cagaaaaagg ttttagggga gcacggacgg
     4261 ggctgggcag cgatttgcat tttctctatc aagtggattg ttggtatgtt tgtggcccag
     4321 ttgctgatac agattttttt ttttttttaa aaacctagtt ggttgaaaaa ctttaaatga
     4381 tgtatacatg ctgatctcaa cattggcagc atcttttggt agctttctgc tgctgggtag
     4441 aactcccaac atggcattta tgtttgcaat gaagaaagag tgttctgaga tggtgagaag
     4501 cgcggggcag agccaggaga gctgcacacc taccttcctg gaagactgac ttctcaagga
     4561 gctcctgcct ttggggacac agggactcac gggaccctgg ctttcagatc tgtcctttac
     4621 cgagcaccac agaaatggga ccaagcctca ctcaccaaga gcccactctt tcccaaggcc
     4681 aagacatttg aaagtcacca gatatttgac aaatggtctt tactgtcctt agaaagaaac
     4741 ccagagtttg tggctttgta acaaagcatt ggcagggcct cagcacccct gaaaggtggt
     4801 ggggctaggt ggcaagaagc agctgttcct ccccctttct cttggcattg gctgtgcaca
     4861 agccagaagt tagcactgtg aggttggttg cataggcatc ctttgtttcc tttacgaaat
     4921 gttagcaagg taatagccat taactcctgt caggcaaata cagtggggca gacccagttc
     4981 cagcgagctg aagtgtgctg cttccgcctc acagccggtg cccgccactg cagagcctta
     5041 ctggagcttc agctcagacc cccgcaccca ctgaacaagg ccactcccga aaagcttggg
     5101 atccctgggc tgcggcttcc tcacagcttg aagcagacat atttcaaaga gtctgcattt
     5161 ggacttacca gctgccatgt tcctgctcac taatccatgc tgtttggttg tcctctgagc
     5221 tggggtggct gtatacagca caggctagct attctgctgg gttctaaagc tacattcagg
     5281 aaccacatta aaccagatta tgaatctcca ggcttcttta tgtttccttt ttctttccca
     5341 ggcagggttt cctgtaaccc aggctggcct tggactcact atgtaaccag gataacctta
     5401 acttctgatc ttcctacttc ctcctcccag gtgctgggat tgcaggcatg tggccactgt
     5461 gacaggtttc ctgtgctgtg ccgaggcccg ggcccagcgc ctcgtgcaca ctagagaaaa
     5521 ttctgcatac tgacccacat ccccagctct acccgtgtat atttctagtc attctttaaa
     5581 cccaagcaaa tgtgtagagt ctcctatgct gagatgtttt ttgccactac cagacatgta
     5641 ggctatcatt tgacgtcttt attccctgag agaaaacttc ttttctgtat ttatgaactt
     5701 tattattgag aatcactgtt aacctttctg ccaaattaaa gacacttgtg tctctgtttc
     5761 cacgga
//
