LOCUS       NM_001355588            5706 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 48 (Usp48), transcript
            variant 3, mRNA.
ACCESSION   NM_001355588 XM_017320010
VERSION     NM_001355588.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5706)
  AUTHORS   Yu,J., Hou,B., Huang,Y., Wang,X., Qian,Y., Liang,Y., Gu,X., Ma,Z.
            and Sun,Y.
  TITLE     USP48 alleviates bone cancer pain and regulates MrgC stabilization
            in spinal cord neurons of male mice
  JOURNAL   Eur J Pain 27 (6), 723-734 (2023)
   PUBMED   36864656
  REMARK    GeneRIF: USP48 alleviates bone cancer pain and regulates MrgC
            stabilization in spinal cord neurons of male mice.
REFERENCE   2  (bases 1 to 5706)
  AUTHORS   Ren,Y., Feng,M., Hao,X., Liu,X., Li,J., Li,P., Gao,J., Qi,Q.,
            Du,L., Wang,C., Wang,Q. and Wang,Y.
  TITLE     USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
  JOURNAL   Cancer Res 83 (7), 1074-1093 (2023)
   PUBMED   36607699
REFERENCE   3  (bases 1 to 5706)
  AUTHORS   Du,L., Li,Y., Kang,M., Feng,M., Ren,Y., Dai,H., Wang,Y., Wang,Y.
            and Tang,B.
  TITLE     USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular
            Carcinoma via Regulating SIRT6 Stabilization
  JOURNAL   Cancer Res 81 (14), 3822-3834 (2021)
   PUBMED   33903120
REFERENCE   4  (bases 1 to 5706)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   5  (bases 1 to 5706)
  AUTHORS   Ferrando,R.E., Newton,K., Chu,F., Webster,J.D. and French,D.M.
  TITLE     Immunohistochemical detection of FLAG-tagged endogenous proteins in
            knock-in mice
  JOURNAL   J Histochem Cytochem 63 (4), 244-255 (2015)
   PUBMED   25575566
REFERENCE   6  (bases 1 to 5706)
  AUTHORS   Armando,I., Villar,V.A., Jones,J.E., Lee,H., Wang,X., Asico,L.D.,
            Yu,P., Yang,J., Escano,C.S. Jr., Pascua-Crusan,A.M., Felder,R.A.
            and Jose,P.A.
  TITLE     Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48
            to promote NHE3 degradation
  JOURNAL   FASEB J 28 (3), 1422-1434 (2014)
   PUBMED   24308971
REFERENCE   7  (bases 1 to 5706)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX000694.9 and AL805954.9.
            
            On May 6, 2022 this sequence version replaced NM_001355588.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.72994.1,
                                           SRR10223969.5019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BX000694.9         25844-26191
            349-469             BX000694.9         36198-36318
            470-626             BX000694.9         37427-37583
            627-754             BX000694.9         38364-38491
            755-879             BX000694.9         39733-39857
            880-988             BX000694.9         40673-40781
            989-1122            BX000694.9         42365-42498
            1123-1205           BX000694.9         43381-43463
            1206-1385           BX000694.9         45357-45536
            1386-1511           BX000694.9         47391-47516
            1512-1661           BX000694.9         48033-48182
            1662-1859           BX000694.9         52737-52934
            1860-1956           BX000694.9         54949-55045
            1957-1974           AL805954.9         2001-2018
            1975-2102           AL805954.9         3790-3917
            2103-2174           AL805954.9         6804-6875
            2175-2299           AL805954.9         11744-11868
            2300-2422           AL805954.9         11973-12095
            2423-2484           AL805954.9         12463-12524
            2485-2595           AL805954.9         13528-13638
            2596-2726           AL805954.9         16390-16520
            2727-2833           AL805954.9         16786-16892
            2834-2938           AL805954.9         17836-17940
            2939-3094           AL805954.9         22973-23128
            3095-3220           AL805954.9         28923-29048
            3221-3269           AL805954.9         31588-31636
            3270-3296           AL805954.9         33853-33879
            3297-5706           AL805954.9         34752-37161
FEATURES             Location/Qualifiers
     source          1..5706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.0 cM"
     gene            1..5706
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="ubiquitin specific peptidase 48"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
     exon            1..348
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..3319
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /EC_number="3.4.19.12"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ubiquitin specific protease 48; ubiquitin specific
                     protease 31; ubiquitin carboxyl-terminal hydrolase 48;
                     ubiquitin thioesterase 48; deubiquitinating enzyme 48;
                     ubiquitin-specific-processing protease 48; ubiquitin
                     thiolesterase 48"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 48 isoform
                     3"
                     /protein_id="NP_001342517.1"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
                     /translation="MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVC
                     RRNCRGNPNCLVGIGEHIWLGEIDENSFHSIDDPNCERRKKNSFVGLTNLGATCYVNT
                     FLQVWFLNLELRQALYLCPSTCSDYTKGDGIHGGKDYEPQTICEHLQYLFALLQNSNR
                     RYIDPSGFVKALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNVVQQQFCGEYA
                     YVTVCNQCGRESKLVSKFYELELNIQGHKQLTDCISEFLKEERLEGDNRYFCENCQSK
                     QNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESLDMEPYVEHKGGSF
                     VYELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLEP
                     SKSQTRKPKCGKGTHCSRNAYMLVYRLQAQEKNHTMVQVPAFLQELVDRDNSKFEEWC
                     VEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPIDN
                     NACLCSHDKLHPDKISIMKRISEYAANIFYSRYGGGPRLTVKALCKDCVVERCRVLRL
                     KNQLNEDYKAVNNLLKSTMKGDGFWVGKSSLRSWRQLALEQLDEQDGEAEQSNGKING
                     STFNKDESKEEKKEEEEELNFNEDILCPHGELSISENERRLVSQEAWSKLQQYFPKAP
                     EFPSYRECCSQCKILEREGEENEALHKMIANEQKTSLPNLFQDKNRPCLSNWPEDTDA
                     LYIVSHFFLDEWRKFVRKPARSAPVSSIGNAALLCPHGGLMFTFPSLTKEDSKLIALI
                     WPSEWQMIQKLFVVDKVIKITRIEVGDVNPSQTQYISEPSLCPDCREGLLCQQQRDLR
                     EYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKEEAKPDGEKDPDFNQSNGSTK
                     RQKTSQQGYVAYQKQVIRRSTRHRKVRGEKALLVSANQTLKELKIQIMHAFSVAPFDQ
                     NLSIDGKILNDDCATLGTLGVIPESVILLKADEPIADYAAMDDVMQVCMPEEGFKGTG
                     LLGH"
     exon            349..469
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            470..626
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            627..754
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            755..879
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            880..988
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1122
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1205
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1385
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1511
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1661
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1859
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1974
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2102
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2174
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2299
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2422
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2484
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2595
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2726
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2833
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2938
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3094
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3220
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3269
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3296
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..5706
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3482..3487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
     regulatory      5675..5680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: ATTAAA"
     polyA_site      5706
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="major polyA site"
ORIGIN      
        1 atcggcggcg gcggcggcgc tttgcggctg gtcgtgcgag ctgggcgcgg gcgggcgggc
       61 gcggcggccg tggcgcgcgc aggtgattga ctgctctcct gtctgagggc agcgctgggt
      121 tctttcggct ggcaggggcc cgtgcccatt cgggcggaga cggaggcggc gccggaggcc
      181 accgggctcg gcgagtgcta cctcggtcaa ggctatggct ccgcggctgc agctggagaa
      241 ggcggcctgg cgctgggcgg agacggtgcg gcccgaggag gtgtcgcagg agcacatcga
      301 gaccgcctac cgcatctggc tggagccttg tatccgaggc gtgtgcagaa gaaactgcag
      361 aggaaacccg aattgcttgg ttggcattgg cgagcacatt tggttaggag agatagatga
      421 gaatagtttt catagcattg atgatcccaa ctgtgagagg aggaaaaaga attcctttgt
      481 gggcttgact aacctgggag ccacctgcta cgtcaacacc tttctccagg tgtggttcct
      541 caacttggag cttcggcagg cgctgtactt atgccccagc acctgcagtg attacacgaa
      601 gggagatggg atccatgggg gaaaagatta tgagcctcag acaatttgtg agcatcttca
      661 gtacttgttt gctttgttgc aaaacagtaa cagacgatac atcgatcctt caggatttgt
      721 taaagccttg ggcttagata ctgggcagca gcaggatgca caagagtttt ccaagctctt
      781 tatgtcgctg ttggaagaca ctttgtctaa acagaagaac ccggatgttc ggaatgttgt
      841 gcagcagcag ttctgtggag aatatgccta tgtgactgtg tgcaatcagt gtggccgaga
      901 gtctaagctt gtatcgaagt tctatgaact ggagttaaac atccaaggcc acaagcagtt
      961 aacagactgc atctcagagt tcctgaagga agaacgatta gaaggagaca atcgatactt
     1021 ctgtgaaaac tgtcagagca aacagaatgc tacacggaaa atccggcttc tgagcctccc
     1081 ttgcactctg aacttgcagc tgatgcgttt cgtgtttgac aggcaaactg gacacaagaa
     1141 gaagctcaat gcatacatcg gcttctcaga gagtctagat atggagcctt acgtggagca
     1201 caaaggcggg tccttcgtgt acgagctcag tgccgtcctc atccacagag gagtcagcgc
     1261 ctattctggc cactacatcg cacacgtgaa agaccctcag tctggagaat ggtacaagtt
     1321 caatgacgag gacatagaga agatggaggg caagaagcta cagctaggga ttgaggaaga
     1381 tctagaacct tctaaatccc agacccgtaa acccaagtgt ggcaaaggaa ctcactgctc
     1441 ccgaaatgca tacatgctgg tttataggct gcaagcccag gaaaagaacc acacaatggt
     1501 tcaagtccca gcctttcttc aagagctggt agatcgtgat aattccaaat tcgaggagtg
     1561 gtgtgtagaa atggccgaga tgcgcaagca gagtgtggac aaaggcaaag cgaagcacga
     1621 ggaggtgaag gagctgtacc aaaggttgcc tgctggagct gagccctatg agtttgtctc
     1681 tcttgaatgg ctgcagaagt ggttggacga gtcaacaccc accaaaccga ttgataataa
     1741 tgcttgcctg tgttcccacg acaagcttca tcctgataaa atatcaatta tgaagagaat
     1801 atcggaatat gcggctaaca ttttctatag tcgatatgga ggaggtccaa gactaactgt
     1861 gaaagccctt tgtaaggact gcgtcgtgga acgctgccgt gtcctgcgcc tgaagaatca
     1921 gctgaatgaa gattacaaag ctgtcaacaa tttgctgaaa tcgacaatga agggtgatgg
     1981 attttgggta ggaaagtctt ccttgcgtag ctggcgccag ctggctcttg aacaactaga
     2041 tgagcaagat ggtgaggcgg agcaaagcaa cgggaagata aacgggagca ccttcaataa
     2101 agatgaatca aaggaagaaa agaaagaaga ggaggaggaa ttaaatttta atgaagacat
     2161 tctgtgtcct catggagagt taagcatatc tgaaaatgaa agaaggctgg tttctcagga
     2221 ggcttggagc aagctgcagc agtacttccc aaaggctccc gagttcccaa gttacagaga
     2281 gtgctgctcg cagtgcaaga tactagaacg agaaggtgaa gaaaacgaag ccttgcataa
     2341 gatgatagca aacgagcaga agacctcact tccaaacttg ttccaggaca aaaacagacc
     2401 atgtctcagt aactggccag aggacacgga tgctctctat attgtgtcgc acttcttttt
     2461 agatgaatgg cggaaatttg ttagaaagcc tgcaaggtct gctcctgtgt cgtcaattgg
     2521 gaatgctgcc cttctgtgtc cacatggagg actcatgttt acatttcctt ccctcaccaa
     2581 agaagactcg aaacttatag ctctcatatg gcccagcgaa tggcaaatga ttcaaaagct
     2641 ctttgttgtg gataaagtaa ttaaaatcac aagaattgaa gtgggagacg tgaatccttc
     2701 tcaaacacag tatatttctg aacctagtct ctgtccagat tgcagagaag gtctgctgtg
     2761 ccagcagcag agggaccttc gagagtatac ccaagccacc atctatgtcc acaaggttgt
     2821 ggataacaaa aaggtgatga aggactcggc ccccgagttg aatgtgagta gttctgagac
     2881 ggaagaagac aaggaggagg ctaagccaga tggggagaag gatcctgact ttaatcaaag
     2941 caatggaagt accaagcgac agaagacatc ccaacagggc tatgtggcct accagaagca
     3001 ggtcatccgg aggagcacga ggcacaggaa ggttcgggga gagaaggcac tgttggtgtc
     3061 tgccaaccag acgttaaaag aattgaagat tcagatcatg cacgcatttt cagttgctcc
     3121 atttgaccag aatttgtcaa ttgatggaaa gattttaaac gacgactgtg ccacccttgg
     3181 taccctcggc gtcattcctg agtctgtcat tttgttaaag gctgatgaac caattgcaga
     3241 ctacgctgca atggatgatg tcatgcaagt ttgtatgccg gaagagggct ttaaaggtac
     3301 gggcctgctc ggacattaat ctttgactac tcgctgactg ccaaggagtg accagaaagg
     3361 aagacgaaat tgacatgttt gggcattaaa gaaaacgtgg ttttaagaat gaaactctta
     3421 cctggctctt ccaaaagaca aaaatccatt caaaagagac tgtcccactt gccttatgtc
     3481 aaataaagca gattgcactg atgggcatca gacttgaagg acgtgtttca gattttctat
     3541 ttaaggtggg agggagaggg cgagcgagga ctgagcaggc agagcaagag taggagtgaa
     3601 tcatgtttac actgagggag tgaagccctg gtcagtccac acagatgccc tgctcactag
     3661 cggatctgtg tcccaggaca tgggctagca tcctgctcca aactccaagt gaccgtctag
     3721 agacaagatc tgctaaccca gcctttattt aacctatact catctttcaa taaagcatga
     3781 acgtgaagga cttgccaacg aggaacgtgt cttcagagca ccacgcctgc agggcagcca
     3841 cagccctgcc acctccctgc tcactgtctg tcagtgctga gtagtagggt caagccagtg
     3901 actgtctcag ttttcctcca tcatctcaga gggataggaa atgttcagtg ttcggtggca
     3961 gcaaagagag tatccctgaa cgtttgaaaa gccgaaccgg agctccgtag gatagcacgg
     4021 gttttcatag acagccctcc cgctctccag ttctgccttc ctcggacctc actgcttttt
     4081 gaaaaccctt aagactatac agggtgtgct gcctcaccaa ctcaggatca ctgttgacgg
     4141 tagtttaagc agcatcagga tctgctcgaa cagaaaaagg ttttagggga gcacggacgg
     4201 ggctgggcag cgatttgcat tttctctatc aagtggattg ttggtatgtt tgtggcccag
     4261 ttgctgatac agattttttt ttttttttaa aaacctagtt ggttgaaaaa ctttaaatga
     4321 tgtatacatg ctgatctcaa cattggcagc atcttttggt agctttctgc tgctgggtag
     4381 aactcccaac atggcattta tgtttgcaat gaagaaagag tgttctgaga tggtgagaag
     4441 cgcggggcag agccaggaga gctgcacacc taccttcctg gaagactgac ttctcaagga
     4501 gctcctgcct ttggggacac agggactcac gggaccctgg ctttcagatc tgtcctttac
     4561 cgagcaccac agaaatggga ccaagcctca ctcaccaaga gcccactctt tcccaaggcc
     4621 aagacatttg aaagtcacca gatatttgac aaatggtctt tactgtcctt agaaagaaac
     4681 ccagagtttg tggctttgta acaaagcatt ggcagggcct cagcacccct gaaaggtggt
     4741 ggggctaggt ggcaagaagc agctgttcct ccccctttct cttggcattg gctgtgcaca
     4801 agccagaagt tagcactgtg aggttggttg cataggcatc ctttgtttcc tttacgaaat
     4861 gttagcaagg taatagccat taactcctgt caggcaaata cagtggggca gacccagttc
     4921 cagcgagctg aagtgtgctg cttccgcctc acagccggtg cccgccactg cagagcctta
     4981 ctggagcttc agctcagacc cccgcaccca ctgaacaagg ccactcccga aaagcttggg
     5041 atccctgggc tgcggcttcc tcacagcttg aagcagacat atttcaaaga gtctgcattt
     5101 ggacttacca gctgccatgt tcctgctcac taatccatgc tgtttggttg tcctctgagc
     5161 tggggtggct gtatacagca caggctagct attctgctgg gttctaaagc tacattcagg
     5221 aaccacatta aaccagatta tgaatctcca ggcttcttta tgtttccttt ttctttccca
     5281 ggcagggttt cctgtaaccc aggctggcct tggactcact atgtaaccag gataacctta
     5341 acttctgatc ttcctacttc ctcctcccag gtgctgggat tgcaggcatg tggccactgt
     5401 gacaggtttc ctgtgctgtg ccgaggcccg ggcccagcgc ctcgtgcaca ctagagaaaa
     5461 ttctgcatac tgacccacat ccccagctct acccgtgtat atttctagtc attctttaaa
     5521 cccaagcaaa tgtgtagagt ctcctatgct gagatgtttt ttgccactac cagacatgta
     5581 ggctatcatt tgacgtcttt attccctgag agaaaacttc ttttctgtat ttatgaactt
     5641 tattattgag aatcactgtt aacctttctg ccaaattaaa gacacttgtg tctctgtttc
     5701 cacgga
//
