LOCUS       NM_001347227            5712 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 48 (Usp48), transcript
            variant 2, mRNA.
ACCESSION   NM_001347227 XM_017320008
VERSION     NM_001347227.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5712)
  AUTHORS   Yu,J., Hou,B., Huang,Y., Wang,X., Qian,Y., Liang,Y., Gu,X., Ma,Z.
            and Sun,Y.
  TITLE     USP48 alleviates bone cancer pain and regulates MrgC stabilization
            in spinal cord neurons of male mice
  JOURNAL   Eur J Pain 27 (6), 723-734 (2023)
   PUBMED   36864656
  REMARK    GeneRIF: USP48 alleviates bone cancer pain and regulates MrgC
            stabilization in spinal cord neurons of male mice.
REFERENCE   2  (bases 1 to 5712)
  AUTHORS   Ren,Y., Feng,M., Hao,X., Liu,X., Li,J., Li,P., Gao,J., Qi,Q.,
            Du,L., Wang,C., Wang,Q. and Wang,Y.
  TITLE     USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
  JOURNAL   Cancer Res 83 (7), 1074-1093 (2023)
   PUBMED   36607699
REFERENCE   3  (bases 1 to 5712)
  AUTHORS   Du,L., Li,Y., Kang,M., Feng,M., Ren,Y., Dai,H., Wang,Y., Wang,Y.
            and Tang,B.
  TITLE     USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular
            Carcinoma via Regulating SIRT6 Stabilization
  JOURNAL   Cancer Res 81 (14), 3822-3834 (2021)
   PUBMED   33903120
REFERENCE   4  (bases 1 to 5712)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   5  (bases 1 to 5712)
  AUTHORS   Ferrando,R.E., Newton,K., Chu,F., Webster,J.D. and French,D.M.
  TITLE     Immunohistochemical detection of FLAG-tagged endogenous proteins in
            knock-in mice
  JOURNAL   J Histochem Cytochem 63 (4), 244-255 (2015)
   PUBMED   25575566
REFERENCE   6  (bases 1 to 5712)
  AUTHORS   Armando,I., Villar,V.A., Jones,J.E., Lee,H., Wang,X., Asico,L.D.,
            Yu,P., Yang,J., Escano,C.S. Jr., Pascua-Crusan,A.M., Felder,R.A.
            and Jose,P.A.
  TITLE     Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48
            to promote NHE3 degradation
  JOURNAL   FASEB J 28 (3), 1422-1434 (2014)
   PUBMED   24308971
REFERENCE   7  (bases 1 to 5712)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX000694.9 and AL805954.9.
            
            On May 6, 2022 this sequence version replaced NM_001347227.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.15107.1,
                                           SRR9219382.66514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BX000694.9         25844-26191
            349-469             BX000694.9         36198-36318
            470-626             BX000694.9         37427-37583
            627-754             BX000694.9         38364-38491
            755-879             BX000694.9         39733-39857
            880-988             BX000694.9         40673-40781
            989-1122            BX000694.9         42365-42498
            1123-1205           BX000694.9         43381-43463
            1206-1385           BX000694.9         45357-45536
            1386-1514           BX000694.9         47388-47516
            1515-1664           BX000694.9         48033-48182
            1665-1862           BX000694.9         52737-52934
            1863-1959           BX000694.9         54949-55045
            1960-1977           AL805954.9         2001-2018
            1978-2108           AL805954.9         3787-3917
            2109-2180           AL805954.9         6804-6875
            2181-2305           AL805954.9         11744-11868
            2306-2428           AL805954.9         11973-12095
            2429-2490           AL805954.9         12463-12524
            2491-2601           AL805954.9         13528-13638
            2602-2732           AL805954.9         16390-16520
            2733-2839           AL805954.9         16786-16892
            2840-2944           AL805954.9         17836-17940
            2945-3100           AL805954.9         22973-23128
            3101-3226           AL805954.9         28923-29048
            3227-3275           AL805954.9         31588-31636
            3276-3302           AL805954.9         33853-33879
            3303-5712           AL805954.9         34752-37161
FEATURES             Location/Qualifiers
     source          1..5712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.0 cM"
     gene            1..5712
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="ubiquitin specific peptidase 48"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
     exon            1..348
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..3325
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin specific protease 48; ubiquitin specific
                     protease 31; ubiquitin carboxyl-terminal hydrolase 48;
                     ubiquitin thioesterase 48; deubiquitinating enzyme 48;
                     ubiquitin-specific-processing protease 48; ubiquitin
                     thiolesterase 48"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 48 isoform
                     2"
                     /protein_id="NP_001334156.1"
                     /db_xref="CCDS:CCDS84808.1"
                     /db_xref="GeneID:170707"
                     /db_xref="MGI:MGI:2158502"
                     /translation="MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVC
                     RRNCRGNPNCLVGIGEHIWLGEIDENSFHSIDDPNCERRKKNSFVGLTNLGATCYVNT
                     FLQVWFLNLELRQALYLCPSTCSDYTKGDGIHGGKDYEPQTICEHLQYLFALLQNSNR
                     RYIDPSGFVKALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNVVQQQFCGEYA
                     YVTVCNQCGRESKLVSKFYELELNIQGHKQLTDCISEFLKEERLEGDNRYFCENCQSK
                     QNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESLDMEPYVEHKGGSF
                     VYELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLAE
                     PSKSQTRKPKCGKGTHCSRNAYMLVYRLQAQEKNHTMVQVPAFLQELVDRDNSKFEEW
                     CVEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPID
                     NNACLCSHDKLHPDKISIMKRISEYAANIFYSRYGGGPRLTVKALCKDCVVERCRVLR
                     LKNQLNEDYKAVNNLLKSTMKGSDGFWVGKSSLRSWRQLALEQLDEQDGEAEQSNGKI
                     NGSTFNKDESKEEKKEEEEELNFNEDILCPHGELSISENERRLVSQEAWSKLQQYFPK
                     APEFPSYRECCSQCKILEREGEENEALHKMIANEQKTSLPNLFQDKNRPCLSNWPEDT
                     DALYIVSHFFLDEWRKFVRKPARSAPVSSIGNAALLCPHGGLMFTFPSLTKEDSKLIA
                     LIWPSEWQMIQKLFVVDKVIKITRIEVGDVNPSQTQYISEPSLCPDCREGLLCQQQRD
                     LREYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKEEAKPDGEKDPDFNQSNGS
                     TKRQKTSQQGYVAYQKQVIRRSTRHRKVRGEKALLVSANQTLKELKIQIMHAFSVAPF
                     DQNLSIDGKILNDDCATLGTLGVIPESVILLKADEPIADYAAMDDVMQVCMPEEGFKG
                     TGLLGH"
     exon            349..469
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            470..626
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            627..754
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            755..879
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            880..988
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1122
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1205
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1385
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1514
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1664
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1862
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1977
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2108
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2180
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2305
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2428
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2490
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2601
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2732
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2839
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2944
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3100
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3226
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3275
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3302
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..5712
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3488..3493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: AATAAA"
     polyA_site      3524
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
     regulatory      5681..5686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="hexamer: ATTAAA"
     polyA_site      5712
                     /gene="Usp48"
                     /gene_synonym="2810449C13Rik; D330022K21Rik; Usp31"
                     /note="major polyA site"
ORIGIN      
        1 atcggcggcg gcggcggcgc tttgcggctg gtcgtgcgag ctgggcgcgg gcgggcgggc
       61 gcggcggccg tggcgcgcgc aggtgattga ctgctctcct gtctgagggc agcgctgggt
      121 tctttcggct ggcaggggcc cgtgcccatt cgggcggaga cggaggcggc gccggaggcc
      181 accgggctcg gcgagtgcta cctcggtcaa ggctatggct ccgcggctgc agctggagaa
      241 ggcggcctgg cgctgggcgg agacggtgcg gcccgaggag gtgtcgcagg agcacatcga
      301 gaccgcctac cgcatctggc tggagccttg tatccgaggc gtgtgcagaa gaaactgcag
      361 aggaaacccg aattgcttgg ttggcattgg cgagcacatt tggttaggag agatagatga
      421 gaatagtttt catagcattg atgatcccaa ctgtgagagg aggaaaaaga attcctttgt
      481 gggcttgact aacctgggag ccacctgcta cgtcaacacc tttctccagg tgtggttcct
      541 caacttggag cttcggcagg cgctgtactt atgccccagc acctgcagtg attacacgaa
      601 gggagatggg atccatgggg gaaaagatta tgagcctcag acaatttgtg agcatcttca
      661 gtacttgttt gctttgttgc aaaacagtaa cagacgatac atcgatcctt caggatttgt
      721 taaagccttg ggcttagata ctgggcagca gcaggatgca caagagtttt ccaagctctt
      781 tatgtcgctg ttggaagaca ctttgtctaa acagaagaac ccggatgttc ggaatgttgt
      841 gcagcagcag ttctgtggag aatatgccta tgtgactgtg tgcaatcagt gtggccgaga
      901 gtctaagctt gtatcgaagt tctatgaact ggagttaaac atccaaggcc acaagcagtt
      961 aacagactgc atctcagagt tcctgaagga agaacgatta gaaggagaca atcgatactt
     1021 ctgtgaaaac tgtcagagca aacagaatgc tacacggaaa atccggcttc tgagcctccc
     1081 ttgcactctg aacttgcagc tgatgcgttt cgtgtttgac aggcaaactg gacacaagaa
     1141 gaagctcaat gcatacatcg gcttctcaga gagtctagat atggagcctt acgtggagca
     1201 caaaggcggg tccttcgtgt acgagctcag tgccgtcctc atccacagag gagtcagcgc
     1261 ctattctggc cactacatcg cacacgtgaa agaccctcag tctggagaat ggtacaagtt
     1321 caatgacgag gacatagaga agatggaggg caagaagcta cagctaggga ttgaggaaga
     1381 tctagcagaa ccttctaaat cccagacccg taaacccaag tgtggcaaag gaactcactg
     1441 ctcccgaaat gcatacatgc tggtttatag gctgcaagcc caggaaaaga accacacaat
     1501 ggttcaagtc ccagcctttc ttcaagagct ggtagatcgt gataattcca aattcgagga
     1561 gtggtgtgta gaaatggccg agatgcgcaa gcagagtgtg gacaaaggca aagcgaagca
     1621 cgaggaggtg aaggagctgt accaaaggtt gcctgctgga gctgagccct atgagtttgt
     1681 ctctcttgaa tggctgcaga agtggttgga cgagtcaaca cccaccaaac cgattgataa
     1741 taatgcttgc ctgtgttccc acgacaagct tcatcctgat aaaatatcaa ttatgaagag
     1801 aatatcggaa tatgcggcta acattttcta tagtcgatat ggaggaggtc caagactaac
     1861 tgtgaaagcc ctttgtaagg actgcgtcgt ggaacgctgc cgtgtcctgc gcctgaagaa
     1921 tcagctgaat gaagattaca aagctgtcaa caatttgctg aaatcgacaa tgaagggcag
     1981 tgatggattt tgggtaggaa agtcttcctt gcgtagctgg cgccagctgg ctcttgaaca
     2041 actagatgag caagatggtg aggcggagca aagcaacggg aagataaacg ggagcacctt
     2101 caataaagat gaatcaaagg aagaaaagaa agaagaggag gaggaattaa attttaatga
     2161 agacattctg tgtcctcatg gagagttaag catatctgaa aatgaaagaa ggctggtttc
     2221 tcaggaggct tggagcaagc tgcagcagta cttcccaaag gctcccgagt tcccaagtta
     2281 cagagagtgc tgctcgcagt gcaagatact agaacgagaa ggtgaagaaa acgaagcctt
     2341 gcataagatg atagcaaacg agcagaagac ctcacttcca aacttgttcc aggacaaaaa
     2401 cagaccatgt ctcagtaact ggccagagga cacggatgct ctctatattg tgtcgcactt
     2461 ctttttagat gaatggcgga aatttgttag aaagcctgca aggtctgctc ctgtgtcgtc
     2521 aattgggaat gctgcccttc tgtgtccaca tggaggactc atgtttacat ttccttccct
     2581 caccaaagaa gactcgaaac ttatagctct catatggccc agcgaatggc aaatgattca
     2641 aaagctcttt gttgtggata aagtaattaa aatcacaaga attgaagtgg gagacgtgaa
     2701 tccttctcaa acacagtata tttctgaacc tagtctctgt ccagattgca gagaaggtct
     2761 gctgtgccag cagcagaggg accttcgaga gtatacccaa gccaccatct atgtccacaa
     2821 ggttgtggat aacaaaaagg tgatgaagga ctcggccccc gagttgaatg tgagtagttc
     2881 tgagacggaa gaagacaagg aggaggctaa gccagatggg gagaaggatc ctgactttaa
     2941 tcaaagcaat ggaagtacca agcgacagaa gacatcccaa cagggctatg tggcctacca
     3001 gaagcaggtc atccggagga gcacgaggca caggaaggtt cggggagaga aggcactgtt
     3061 ggtgtctgcc aaccagacgt taaaagaatt gaagattcag atcatgcacg cattttcagt
     3121 tgctccattt gaccagaatt tgtcaattga tggaaagatt ttaaacgacg actgtgccac
     3181 ccttggtacc ctcggcgtca ttcctgagtc tgtcattttg ttaaaggctg atgaaccaat
     3241 tgcagactac gctgcaatgg atgatgtcat gcaagtttgt atgccggaag agggctttaa
     3301 aggtacgggc ctgctcggac attaatcttt gactactcgc tgactgccaa ggagtgacca
     3361 gaaaggaaga cgaaattgac atgtttgggc attaaagaaa acgtggtttt aagaatgaaa
     3421 ctcttacctg gctcttccaa aagacaaaaa tccattcaaa agagactgtc ccacttgcct
     3481 tatgtcaaat aaagcagatt gcactgatgg gcatcagact tgaaggacgt gtttcagatt
     3541 ttctatttaa ggtgggaggg agagggcgag cgaggactga gcaggcagag caagagtagg
     3601 agtgaatcat gtttacactg agggagtgaa gccctggtca gtccacacag atgccctgct
     3661 cactagcgga tctgtgtccc aggacatggg ctagcatcct gctccaaact ccaagtgacc
     3721 gtctagagac aagatctgct aacccagcct ttatttaacc tatactcatc tttcaataaa
     3781 gcatgaacgt gaaggacttg ccaacgagga acgtgtcttc agagcaccac gcctgcaggg
     3841 cagccacagc cctgccacct ccctgctcac tgtctgtcag tgctgagtag tagggtcaag
     3901 ccagtgactg tctcagtttt cctccatcat ctcagaggga taggaaatgt tcagtgttcg
     3961 gtggcagcaa agagagtatc cctgaacgtt tgaaaagccg aaccggagct ccgtaggata
     4021 gcacgggttt tcatagacag ccctcccgct ctccagttct gccttcctcg gacctcactg
     4081 ctttttgaaa acccttaaga ctatacaggg tgtgctgcct caccaactca ggatcactgt
     4141 tgacggtagt ttaagcagca tcaggatctg ctcgaacaga aaaaggtttt aggggagcac
     4201 ggacggggct gggcagcgat ttgcattttc tctatcaagt ggattgttgg tatgtttgtg
     4261 gcccagttgc tgatacagat tttttttttt ttttaaaaac ctagttggtt gaaaaacttt
     4321 aaatgatgta tacatgctga tctcaacatt ggcagcatct tttggtagct ttctgctgct
     4381 gggtagaact cccaacatgg catttatgtt tgcaatgaag aaagagtgtt ctgagatggt
     4441 gagaagcgcg gggcagagcc aggagagctg cacacctacc ttcctggaag actgacttct
     4501 caaggagctc ctgcctttgg ggacacaggg actcacggga ccctggcttt cagatctgtc
     4561 ctttaccgag caccacagaa atgggaccaa gcctcactca ccaagagccc actctttccc
     4621 aaggccaaga catttgaaag tcaccagata tttgacaaat ggtctttact gtccttagaa
     4681 agaaacccag agtttgtggc tttgtaacaa agcattggca gggcctcagc acccctgaaa
     4741 ggtggtgggg ctaggtggca agaagcagct gttcctcccc ctttctcttg gcattggctg
     4801 tgcacaagcc agaagttagc actgtgaggt tggttgcata ggcatccttt gtttccttta
     4861 cgaaatgtta gcaaggtaat agccattaac tcctgtcagg caaatacagt ggggcagacc
     4921 cagttccagc gagctgaagt gtgctgcttc cgcctcacag ccggtgcccg ccactgcaga
     4981 gccttactgg agcttcagct cagacccccg cacccactga acaaggccac tcccgaaaag
     5041 cttgggatcc ctgggctgcg gcttcctcac agcttgaagc agacatattt caaagagtct
     5101 gcatttggac ttaccagctg ccatgttcct gctcactaat ccatgctgtt tggttgtcct
     5161 ctgagctggg gtggctgtat acagcacagg ctagctattc tgctgggttc taaagctaca
     5221 ttcaggaacc acattaaacc agattatgaa tctccaggct tctttatgtt tcctttttct
     5281 ttcccaggca gggtttcctg taacccaggc tggccttgga ctcactatgt aaccaggata
     5341 accttaactt ctgatcttcc tacttcctcc tcccaggtgc tgggattgca ggcatgtggc
     5401 cactgtgaca ggtttcctgt gctgtgccga ggcccgggcc cagcgcctcg tgcacactag
     5461 agaaaattct gcatactgac ccacatcccc agctctaccc gtgtatattt ctagtcattc
     5521 tttaaaccca agcaaatgtg tagagtctcc tatgctgaga tgttttttgc cactaccaga
     5581 catgtaggct atcatttgac gtctttattc cctgagagaa aacttctttt ctgtatttat
     5641 gaactttatt attgagaatc actgttaacc tttctgccaa attaaagaca cttgtgtctc
     5701 tgtttccacg ga
//
