LOCUS       NM_001403494            5679 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus ubiquitin specific peptidase 47 (Usp47), transcript
            variant 4, mRNA.
ACCESSION   NM_001403494 XM_006508273
VERSION     NM_001403494.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5679)
  AUTHORS   Wang,Q.L., Lu,S.Y., Xu,D.D., Ma,J.X., Guo,R., Zhang,L., Tang,L.Y.,
            Shen,Y., Shen,C.L., Wang,J.J., Wu,Y.L., Lu,L.M., Wang,Z.G. and
            Zhang,H.X.
  TITLE     USP47 deficiency in mice modulates tumor infiltrating immune cells
            and enhances antitumor immune responses in prostate cancer
  JOURNAL   Cancer Immunol Immunother 73 (8), 143 (2024)
   PUBMED   38832955
  REMARK    GeneRIF: USP47 deficiency in mice modulates tumor infiltrating
            immune cells and enhances antitumor immune responses in prostate
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5679)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5679)
  AUTHORS   Li,X., Qian,K., Zhang,Y., Zhang,Y., Liu,Y., Sun,C., Jiao,Y., Yu,D.,
            Geng,F., Cao,J. and Zhang,S.
  TITLE     Ubiquitin-specific peptidase 47 (USP47) regulates cutaneous
            oxidative injury through nicotinamide nucleotide transhydrogenase
            (NNT)
  JOURNAL   Toxicol Appl Pharmacol 480, 116734 (2023)
   PUBMED   37924851
  REMARK    GeneRIF: Ubiquitin-specific peptidase 47 (USP47) regulates
            cutaneous oxidative injury through nicotinamide nucleotide
            transhydrogenase (NNT).
REFERENCE   4  (bases 1 to 5679)
  AUTHORS   Wang,A., Huang,H., Shi,J.H., Yu,X., Ding,R., Zhang,Y., Han,Q.,
            Ni,Z.Y., Li,X., Zhao,R. and Zou,Q.
  TITLE     USP47 inhibits m6A-dependent c-Myc translation to maintain
            regulatory T cell metabolic and functional homeostasis
  JOURNAL   J Clin Invest 133 (23), e169365 (2023)
   PUBMED   37788092
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5679)
  AUTHORS   Zhu,Y., Guo,Y., Liu,H., Zhou,A., Fan,Z., Zhu,X. and Miao,X.
  TITLE     Ubiquitin specific peptidase 47 contributes to liver regeneration
  JOURNAL   Life Sci 329, 121967 (2023)
   PUBMED   37487274
  REMARK    GeneRIF: Ubiquitin specific peptidase 47 contributes to liver
            regeneration.
REFERENCE   6  (bases 1 to 5679)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 5679)
  AUTHORS   Peschiaroli,A., Skaar,J.R., Pagano,M. and Melino,G.
  TITLE     The ubiquitin-specific protease USP47 is a novel beta-TRCP
            interactor regulating cell survival
  JOURNAL   Oncogene 29 (9), 1384-1393 (2010)
   PUBMED   19966869
REFERENCE   8  (bases 1 to 5679)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 5679)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   10 (bases 1 to 5679)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122343.4.
            
            On Mar 31, 2022 this sequence version replaced XM_006508273.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.9930.1,
                                           SRR10223971.8018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AC122343.4         107228-107489
            263-322             AC122343.4         130670-130729
            323-526             AC122343.4         136960-137163
            527-640             AC122343.4         138585-138698
            641-779             AC122343.4         140218-140356
            780-876             AC122343.4         142715-142811
            877-1022            AC122343.4         146989-147134
            1023-1102           AC122343.4         148108-148187
            1103-1252           AC122343.4         150828-150977
            1253-1348           AC122343.4         158215-158310
            1349-1501           AC122343.4         158400-158552
            1502-1669           AC122343.4         161535-161702
            1670-1729           AC122343.4         163915-163974
            1730-1861           AC122343.4         166173-166304
            1862-1938           AC122343.4         166831-166907
            1939-1994           AC122343.4         167600-167655
            1995-2107           AC122343.4         169738-169850
            2108-2212           AC122343.4         170744-170848
            2213-2420           AC122343.4         171509-171716
            2421-2536           AC122343.4         173268-173383
            2537-2656           AC122343.4         175148-175267
            2657-3437           AC122343.4         176449-177229
            3438-3613           AC122343.4         185481-185656
            3614-3694           AC122343.4         186182-186262
            3695-3810           AC122343.4         187693-187808
            3811-3929           AC122343.4         188093-188211
            3930-4060           AC122343.4         190522-190652
            4061-4108           AC122343.4         192179-192226
            4109-4239           AC122343.4         192317-192447
            4240-5679           AC122343.4         193688-195127
FEATURES             Location/Qualifiers
     source          1..5679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.74 cM"
     gene            1..5679
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /note="ubiquitin specific peptidase 47"
                     /db_xref="GeneID:74996"
                     /db_xref="MGI:MGI:1922246"
     exon            1..262
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..4414
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /EC_number="3.4.19.12"
                     /note="isoform 4 is encoded by transcript variant 4;
                     ubiquitin specific protease 47; ubiquitin
                     carboxyl-terminal hydrolase 47; ubiquitin thioesterase 47;
                     deubiquitinating enzyme 47; ubiquitin-specific-processing
                     protease 47; ubiquitin thiolesterase 47"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 47 isoform
                     4"
                     /protein_id="NP_001390423.1"
                     /db_xref="GeneID:74996"
                     /db_xref="MGI:MGI:1922246"
                     /translation="MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVL
                     CIIQDTTNSKTVSERITLNLPASTPVRKLFEDVANKVGYINGTFDLTRENGVTTADMA
                     PLDHTSDKSLLDANFEPGKKNFLHLTDKDGEPPQMLLEDSNNVDDSVHDRFIGPLPRE
                     GSVASTNDYVSQNYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYK
                     WEFEDSEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQEL
                     CRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPY
                     GSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKR
                     FDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQM
                     SNDFSTDDAVDEGICLESSSGSEKISKPGLEKVEMAETDQRKDPIQFQLGEPNSLMYE
                     LFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYY
                     SSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIER
                     NTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYD
                     EFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHV
                     VDLKAETVAAPVTVRAYLNQTVTEFKQLISKATHLPADSMRIVLERCYNDLRLLSMPS
                     KTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRHANTIRLFVLLPEQSPGSY
                     SKRTAYQKAGGDSGNVDDDCERVKGPAGNLKSVDAILEESTEKLKSLSLQQQQQDGDN
                     GDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNND
                     RSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTA
                     EEDSGTDSEYDESGKSRGDMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQ
                     HLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDNKITIRLGRALKKGEYRV
                     KVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLDLSIDRFRLRKKTW
                     KNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAILTRRWRPAEMKLDP
                     FQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCDISVLDIHQDLDWNPKVS
                     TLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKESSRLQKTGHRVTYSPRKE
                     KALKIYLDGAPNKDVAQD"
     exon            263..322
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            323..526
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            527..640
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            641..779
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            780..876
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1022
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1102
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1252
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1348
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1501
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1669
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1729
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1861
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1938
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..1994
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2107
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2212
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2420
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2536
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2656
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..3437
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..3613
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3694
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3810
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..3929
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..4060
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4108
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4239
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4240..5679
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4758..4763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4783
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /note="major polyA site"
     regulatory      5659..5664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5679
                     /gene="Usp47"
                     /gene_synonym="4930502N04Rik; A630020C16Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcg gcagcggcgg cggcagcagc ggcgacggcg gcggcgccct gggtcggtgt
       61 ctgcgcgctg gtgtctaagg cctgagcgga ggcctcctca gttgctggag cgcaggcggc
      121 tgggaggatg actgtcgctg ccgttctctc ctgagacaca gccgccgcca cctccaccag
      181 gcccccgcag gcagggcgga gacgagcggt cggagtctga gcgatggtgc ccggcgagga
      241 gaaccaactg gtcccgaagg aggatgtgtt ttggagatgc agacaaaata tctttgatga
      301 aatgaagaag aaatttttac agatagaaaa tgctgctgaa gaacctagag tcttatgtat
      361 aatacaagac actactaact cgaagacagt gagtgaacgg atcacattaa atttaccagc
      421 atctacccca gtccgaaagc tctttgaaga tgtggccaac aaagtaggct acataaatgg
      481 aacctttgat ttgaccaggg aaaatggagt cactactgct gacatggcac cactggatca
      541 caccagtgac aagtctcttc ttgatgctaa ttttgagcca ggaaagaaga actttctgca
      601 tttgacagat aaagatggtg aaccgcctca gatgttgttg gaggactcca ataacgtgga
      661 tgacagcgtg catgacaggt tcataggtcc actgccaaga gaaggttctg tggcctctac
      721 caatgattat gtcagccaga actactccta ttcatcaatt ttgaacaagt cagaaactgg
      781 ttatgtggga ttagtaaacc aggcgatgac gtgctatttg aatagccttt tgcaaacact
      841 ttttatgact cctgaattta ggaatgcatt atataagtgg gaatttgaag actctgaaga
      901 agatcctgta acgagtatcc cataccagct tcaaaggctt tttgttttgt tacaaaccag
      961 caaaaagaga gcaattgaga ccacagatgt tacaaggagc tttggatggg atagcagtga
     1021 ggcttggcaa cagcatgatg tacaagaact gtgccgtgtt atgtttgatg ctttggaaca
     1081 gaaatggaag caaacagaac aggctgatct tataaatgag ctgtaccaag gcaagctgaa
     1141 agattatgtg aggtgtctgg aatgcggtta tgaaggctgg agaattgaca cgtatcttga
     1201 tattccactg gtcatccgac cttatgggtc cagccaagcg tttgctagtg tggaagaagc
     1261 gttgcatgca tttattcaac cagagatctt ggatggccca aatcaatatt tttgtgaacg
     1321 ttgtaagaag aagtgtgatg ctcggaaggg ccttcggttt ttgcatttcc cctatctgct
     1381 gaccttacag ttgaaaaggt ttgattttga ttatacaacc atgcatagaa ttaaactgaa
     1441 tgatcgaatg tcatttccgg aggagctgga tatgagcaca tttattgata ttgaagatga
     1501 gaaatctcct cagactgaaa gttgcactga tagtggagca gaaaatgaag gcagttgcca
     1561 cagcgaccag atgagtaatg atttctccac ggatgatgct gttgatgaag ggatatgcct
     1621 ggagagcagt agtgggagtg agaagatttc aaaacctggc ctggaaaagg tagagatggc
     1681 ggagacagac cagagaaagg atcccatcca attccagctt ggtgaaccaa actccctgat
     1741 gtatgagctc ttctcagtga tggtgcattc agggagtgct gctggaggac actattatgc
     1801 ttgcataaag tctttcagtg acgatcaatg gtacagtttc aatgaccaac atgtgagcag
     1861 gataacacaa gaagacatta agaagacaca tggtgggtct tcaggaagca gaggctacta
     1921 ctccagtgct tttgcaagct caacaaatgc atatatgctg atatacagac tgaaggatcc
     1981 aacaagaaat gcaaagtttc tagaagtgga cgagtaccca gaacacatta agaatctggt
     2041 gcagaaggag agagagctgg aagagcagga aaagaggcaa cgagagattg aacgcaacac
     2101 gtgcaagata aaattatttt gtttgcatcc tgtgaaacaa gtaatgatgg aaaacaagct
     2161 ggaggttcat aaggataaga cgctaaagga agccgttgaa atggcttata agatgatgga
     2221 tttagaagat gtgattccct tggattgctg tcgcctggta aaatatgacg agtttcatga
     2281 ttacctggaa cgatcgtatg agggagaaga agatacacca atggggttgc ttctaggagg
     2341 agtcaagtcc acatacatgt ttgatctgct gttggaaacg agaaagcctg atcaaatttt
     2401 tcagtcttac aaacctggag aagtgatggt gaaagttcat gttgttgatc tgaaagcaga
     2461 gactgtcgct gctcctgtaa cagtgcgtgc gtatttaaat cagacagtta cagagtttaa
     2521 acagctgatc tcaaaggcca cgcacttacc tgcagactcc atgaggatag tgctggagcg
     2581 ctgctacaat gacctgcgcc ttctcagcat gcccagcaag accctgaagg ctgagggctt
     2641 cttcagaagt aacaaggtgt ttgttgaaag ctctgagaca gtggatcacc aggcagcctt
     2701 tacagactcc cacttgtgga aactcctgga tcgacatgca aatacaatcc ggttatttgt
     2761 tttgctgcct gaacaatctc caggatcata ttcgaaaagg acagcatacc agaaagctgg
     2821 aggtgattct ggtaatgtgg acgatgattg tgaaagagtc aaaggacctg cagggaattt
     2881 aaagtctgtg gatgctattc tagaagagag cactgaaaaa ctgaaaagct tgtcactgca
     2941 gcagcagcag caagatgggg acaacggaga cagcagcaaa agcactgaga caagtgactt
     3001 tgaaaatatt gaatcccctc tcaatgagag gggctcttcc acctctgtgg ataatcgaga
     3061 acttgaacag cacattcaga cttctgaccc agaaaacttt cagtctgagg aacgctcgga
     3121 ctcagatgtg aataatgacc ggagtacaag ttcggtagac agtgatattc ttagctccag
     3181 tcacagcagt gacactttgt gcaatgcaga cagcgctcag attcctctgg ccaatggact
     3241 tgactctcac agtatcacaa gtagtagaag aactaaagca aacgagggga aaaaggagac
     3301 ctgggacaca gctgaagaag actctgggac tgacagtgaa tatgacgaga gtggcaagag
     3361 caggggggac atgcagtaca tgtacttcaa agctgacccc tacactgcgg atgaaggctc
     3421 tggggaagga cacaaatggt tgatggtgca tgttgataag agaatcaccc tggcagcttt
     3481 caaacagcat ttagaacctt ttgttggagt cctctcctct cacttcaagg tttttcgagt
     3541 gtacaccagc aatcaagagt ttgagaccgt ccggttgaat gagacccttt catcattttc
     3601 agatgacaat aagatcacaa tccgactggg gagagcactg aagaagggag agtacagagt
     3661 taaagtgtgc cagctcttag tcaatgagca agagccatgc aagtttctgc tagacgctgt
     3721 gtttgctaaa ggcatgactg tgcggcaatc aaaagaggag ctgattcctc aactcaggga
     3781 gcagtgtggc ttagacctca gcatcgacag gtttcgtcta aggaagaaaa catggaagaa
     3841 tcctggcact gtctttttgg attatcatat ttatgaagaa gatattaata tttccagcaa
     3901 ctgggaagtt ttcctggaag ttcttgatgg tgtggagaag atgaagtcca tgtcacagct
     3961 tgccatctta acaagacgct ggaggcctgc agagatgaag ttggacccct tccaggagct
     4021 tgtgttggaa agcaatagtg ttgatgaact ccgagagaag ctaagtgaaa tcagtgggat
     4081 tcctttggaa gacattgaat ttgccaaggg taggggaacc ttcccctgtg atatttctgt
     4141 ccttgatatt catcaagatt tggactggaa tcctaaagtc tctaccctga atgtttggcc
     4201 tctttatatc tgtgatgatg gtgccgtcat attttatagg gatagaacag aagaagtgat
     4261 ggaattgaca gatgagcaaa gaaatgaatt gatgaaaaag gaaagcagcc gactgcagaa
     4321 gacgggacat cgtgtgacat actcccctcg caaagagaaa gcactcaaga tctacctgga
     4381 tggggcgcca aataaagatg tggctcaaga ctgactgcca gtgtagcctt tcccctgagg
     4441 gcttgtttaa gtagatggtt cactactgct gggtagtgcc attttggccg gacatggttt
     4501 gggtaatccc atgacaccag cactgattgg actgcccttc accaatcaga agctcagtgc
     4561 ccagtgggcc actgtcttga cttggaatca tgttgtgcac tatggtcaga tgtactgtaa
     4621 agccaaggat gtgcaaagag aaacaagcaa agcctgctac tatgaaggga gggggacaag
     4681 tagattcatt gattgcggac aaatgtgcac atagccgcta gtaaaactag cctcaaacag
     4741 gatgctcata gcttaataat aaaagctgtg caaaggccat gaatgaatga atcttctgtt
     4801 tatttcattg atacacacat tacctcattg acagttctga agcaaatgca actgtgttga
     4861 cttttgaaaa gcagcaaaga ggagctgaag gagttcttag agccagtgta gccctcagag
     4921 gaattaggaa ggtgtgttat tttatttgac ttttttgcaa agtattaaga accttaggga
     4981 gacagcccaa catctgtttc ctcgggccac gcccagtagg tgtgctcagc tgctacaggt
     5041 ttgtgattag agccaactgt ctgtaagcta tggatgtaga gaatgtctcc ctccttcact
     5101 cgggccggcc ggcatgtaaa tacagcggtc ctgttgagtt ctcccagctg cagcttcgat
     5161 gtctgccaag gttctttgcc tctcattgtc atgtacattt gtgtacacta aagcttagcg
     5221 gtcggtctgt ctgtgtactc ctcggtaaga ctccatagga tgtatttgct cgttaatgag
     5281 ggttctctgt tcagtagctt caagatcttt tctctgtaca tttattttcc aaaaattgct
     5341 tcaagtttga gtcttctaga atgcttgtaa agtcccgttt taattttaag agtcgatttg
     5401 tagttctgta gtgtaacttt gggaaccatc tgcccatcta tggaataaag tttctcgggg
     5461 gccttggcgt agactcggtg ccacatgatt cattgcagag cgtgctagcg tcagcaggcc
     5521 tcttctgctc tgctaagtac agtttcaaag aatacgattc tacataaact ttgaaatact
     5581 atctaattta taaaagtcaa taaaaggttt tggtaaaact ttttcatgca agatgctgtt
     5641 tacaacaatg aacatgccaa taaaacattt gttcatgtt
//
