LOCUS       NM_177561               4535 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 46 (Usp46), transcript
            variant 1, mRNA.
ACCESSION   NM_177561
VERSION     NM_177561.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4535)
  AUTHORS   Kuno,A., Ikeda,Y., Ayabe,S., Kato,K., Sakamoto,K., Suzuki,S.R.,
            Morimoto,K., Wakimoto,A., Mikami,N., Ishida,M., Iki,N., Hamada,Y.,
            Takemura,M., Daitoku,Y., Tanimoto,Y., Dinh,T.T.H., Murata,K.,
            Hamada,M., Muratani,M., Yoshiki,A., Sugiyama,F., Takahashi,S. and
            Mizuno,S.
  TITLE     DAJIN enables multiplex genotyping to simultaneously validate
            intended and unintended target genome editing outcomes
  JOURNAL   PLoS Biol 20 (1), e3001507 (2022)
   PUBMED   35041655
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4535)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4535)
  AUTHORS   Jahan,A.S., Lestra,M., Swee,L.K., Fan,Y., Lamers,M.M.,
            Tafesse,F.G., Theile,C.S., Spooner,E., Bruzzone,R., Ploegh,H.L. and
            Sanyal,S.
  TITLE     Usp12 stabilizes the T-cell receptor complex at the cell surface
            during signaling
  JOURNAL   Proc Natl Acad Sci U S A 113 (6), E705-E714 (2016)
   PUBMED   26811477
REFERENCE   4  (bases 1 to 4535)
  AUTHORS   Umemura,S., Imai,S., Mimura,A., Fujiwara,M. and Ebihara,S.
  TITLE     Impaired Maternal Behavior in Usp46 Mutant Mice: A Model for
            Trans-Generational Transmission of Maternal Care
  JOURNAL   PLoS One 10 (8), e0136016 (2015)
   PUBMED   26284364
  REMARK    GeneRIF: Usp46 mutation is associated with Impaired Maternal
            Behavior.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4535)
  AUTHORS   Imai,S., Kano,M., Nonoyama,K. and Ebihara,S.
  TITLE     Behavioral characteristics of ubiquitin-specific peptidase
            46-deficient mice
  JOURNAL   PLoS One 8 (3), e58566 (2013)
   PUBMED   23472206
  REMARK    GeneRIF: Usp46 regulates a wide range of behavioral phenotypes that
            might be related to mental disorders
REFERENCE   6  (bases 1 to 4535)
  AUTHORS   Zhang,W., Tian,Q.B., Li,Q.K., Wang,J.M., Wang,C.N., Liu,T.,
            Liu,D.W. and Wang,M.W.
  TITLE     Lysine 92 amino acid residue of USP46, a gene associated with
            'behavioral despair' in mice, influences the deubiquitinating
            enzyme activity
  JOURNAL   PLoS One 6 (10), e26297 (2011)
   PUBMED   22043315
  REMARK    GeneRIF: results suggest that the Lys 92 deletion of USP46 could
            influence enzyme activity and thereby provide a molecular clue how
            the enzyme regulating the pathogenesis of mental illnesses.
REFERENCE   7  (bases 1 to 4535)
  AUTHORS   Tomida,S., Mamiya,T., Sakamaki,H., Miura,M., Aosaki,T., Masuda,M.,
            Niwa,M., Kameyama,T., Kobayashi,J., Iwaki,Y., Imai,S., Ishikawa,A.,
            Abe,K., Yoshimura,T., Nabeshima,T. and Ebihara,S.
  TITLE     Usp46 is a quantitative trait gene regulating mouse immobile
            behavior in the tail suspension and forced swimming tests
  JOURNAL   Nat Genet 41 (6), 688-695 (2009)
   PUBMED   19465912
REFERENCE   8  (bases 1 to 4535)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   9  (bases 1 to 4535)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   10 (bases 1 to 4535)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164570.3 and AC242530.3.
            
            On Mar 9, 2023 this sequence version replaced NM_177561.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039916.1, SRR1660825.36393.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC164570.3         79029-79188         c
            161-241             AC164570.3         47812-47892         c
            242-455             AC164570.3         43083-43296         c
            456-685             AC164570.3         39920-40149         c
            686-762             AC242530.3         35926-36002         c
            763-846             AC242530.3         25090-25173         c
            847-1044            AC242530.3         22421-22618         c
            1045-1123           AC242530.3         21951-22029         c
            1124-4535           AC242530.3         17992-21403         c
FEATURES             Location/Qualifiers
     source          1..4535
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.33 cM"
     gene            1..4535
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /note="ubiquitin specific peptidase 46"
                     /db_xref="GeneID:69727"
                     /db_xref="MGI:MGI:1916977"
     exon            1..160
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1225
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin specific protease 46; ubiquitin
                     carboxyl-terminal hydrolase 46; ubiquitin thioesterase 46;
                     deubiquitinating enzyme 46; ubiquitin-specific-processing
                     protease 46; ubiquitin thiolesterase 46"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 46 isoform
                     1"
                     /protein_id="NP_808229.1"
                     /db_xref="CCDS:CCDS39112.1"
                     /db_xref="GeneID:69727"
                     /db_xref="MGI:MGI:1916977"
                     /translation="MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTC
                     YCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKF
                     ISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAEN
                     NKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNT
                     ETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVF
                     PLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEK
                     IDAQAIEEFYGLTSDISKNSESGYILFYQSRE"
     exon            161..241
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            242..455
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            456..685
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            686..762
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            763..846
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1044
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1123
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..4535
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3202..3207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3223
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /note="major polyA site"
     regulatory      3591..3596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3610
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
     regulatory      4505..4510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4535
                     /gene="Usp46"
                     /gene_synonym="1190009E20Rik; 2410018I08Rik"
ORIGIN      
        1 aaccccactg caagccggcc ccaggccgcc tcgccgccac ccggcctcgc tgcgcgccac
       61 catggacagt cccgttttcc cctggtaaag atggcggtgc gcgatcgctg caacctttag
      121 actaatgact gtccgaaaca tcgcctccat ctgtaatatg ggcaccaatg cctctgctct
      181 ggaaaaagac attggaccag agcagtttcc gatcaatgaa cactacttcg gattggtcaa
      241 ttttggaaac acatgctact gtaactccgt gcttcaagcg ctgtacttct gccggccgtt
      301 ccgggagaat gtgttggcat acaaggccca gcaaaaaaag aaggaaaacc tgttgacatg
      361 cctggcagac cttttccaca gcattgccac gcagaagaag aaggttggcg tcatcccacc
      421 aaagaagttc atttcaaggc tgaggaaaga gaacgatctc tttgataact acatgcagca
      481 ggatgctcac gagttcttaa attatttgct aaacactatt gcggacatcc tgcaggaaga
      541 gaagaaacag gaaaaacaaa acgggaagtt aaaaaacggc aacatgaacg aaccagccga
      601 gaacaataag ccagaactca cctgggtcca cgagattttt cagggaacac tcactaacga
      661 aactcgatgc ttgaactgtg aaactgtgag tagcaaagat gaagattttc ttgacctctc
      721 tgtcgatgtg gaacagaaca cctccatcac ccactgtctg agagacttca gcaacacaga
      781 aacgctgtgt agtgaacaaa aatattattg tgaaacatgt tgcagcaaac aggaggctca
      841 gaagaggatg agggtaaaaa agctgcccat gattttggcc ctgcacctca agaggttcaa
      901 gtacatggaa cagctccaca ggtacaccaa gctgtcttac cgggtggtct tccctctgga
      961 actccggctc ttcaacacct ccagcgatgc tgtgaacctg gaccgcatgt atgacctggt
     1021 tgctgtggtc gttcactgtg gaagtggtcc taaccgtggg cattacatca ccatcgtaaa
     1081 aagtcatggc ttctggctgt tgtttgatga cgacattgta gagaaaatag acgctcaagc
     1141 cattgaggaa ttctatggtc taacgtcaga tatatcaaaa aattcagaat ctggatatat
     1201 tttattctat caatcaagag aataacttgg tggagtgcga gactcattca agcagggaaa
     1261 tactccaagc actagagccg tggtttctct gcagacctct cctcccccac aatggcccgc
     1321 tgatgtcatc actatgatgg gcactggtcc ggcagtgtta aacttccttc ctttgtgttt
     1381 tttacatgca gcactactcc tgactctgtt ttggtctgag gtagagttaa ctgcagtcgg
     1441 attatatagt cagatttaca tgaataactg ttgctaattt taagattgga gttgaatggt
     1501 taatgccgct tgtcacgtct ggctaaacta gagtgatatt tcctgtaaat gtcacggtcc
     1561 atactgagtg tttggtaggc ttcctgaatg gtttctgggg gcccccttcc catgcattcc
     1621 tttgacaggt ccctggaagc attgctaccc gttgttagca tgcctgcctc ctctgatggg
     1681 aggagttggg tagatagata ttcatctgtt agggctgcaa ccatagcttt aagtttgtgc
     1741 aagtgaaaat gtttaaaagt gagtggccta gatgccaaaa tcctcctcca cattggagca
     1801 aggtgaggta aggctgtcat tggtagatgg cgtttgcacc caactgtgct tacctagctg
     1861 gtagaatccc aggggctaag acattttgga gctcagggca ggcaaagcca aaaggaagat
     1921 gtttttgtgg tcagtgagaa gttacttacc tttctaccaa aagccacgtt tctggaaaat
     1981 agctcgatgc tgttcatttt ttaggaatga ttttcttcca tcaggtcctg tagttgtctt
     2041 cttctcatgt ttggtaccgc taagcttttc aaactgtctt ttcaaccctg ctgatggttt
     2101 ttagtcagtg gcaccagggc tgagacggta gctgaccgcc tctggcaggg ttctcgatag
     2161 ccagtcaaca tcagcatcgt tcctagatga ggaagacgag gaatcaagaa ctctgttcac
     2221 ctggacaacc atcagcagat tgaacagctt cttcttcttc ttcttcttct tcttcttctt
     2281 cttcttcttc ttcttcttct aacattcagt ctatttatgg aggcactggt gagttttgct
     2341 ggagttagtg cagtgtgagg tgggtcacag gaagtgttag gaggtgggtg gagaggtaag
     2401 atggtggctc agattcctag aatgcttgac aagacagttt ccaggaagaa ccttatctca
     2461 ccgtttcccc cttttgtttt gtgtgtattt attagagcat ttgcatactg gtacctttta
     2521 ttaaaagggt tgatttggtg ttttaccatt gaatgggtct tggttttcct acaaatacta
     2581 tgggtcatag tccttggctt ccttttggga tgtcagttga cttctacaca cgttaatata
     2641 ctgtgaatgt gttacgttgc gacgtactac gtcagcgaat gaacatgcaa actcgtggtg
     2701 taatgtgaac tcaaactgca gttgaaatca tcagtggcca tcgtgcagca gtgaagagga
     2761 tagcacttta tctaggtgaa aactggactc cttatttctg aaatatcttg aattgtttgt
     2821 gactcggaac ttcagcatgc caacgcttca tttgttcacg cttcaaggga catgtctcat
     2881 tcttcactgg agcagacaaa acagggttat gtcatgttac tctcttatgc aagtgacaaa
     2941 aatggacctt gccttggtta gaggcaatgc atatttataa atattttttc tttatttccc
     3001 cctccatgaa gcatatttat taatcactta catggatggt gaaccttcat tctttaagga
     3061 gaggcacttt tccaagtgta agggattgat ggcctgagat atttgtatac atacagccat
     3121 atacttcact gtgggttaca aaggttaaaa aaatggctac tggtctctaa tatatttgga
     3181 actcatcata gaacaaaaac tattaaaact atctttgaaa caactcttgc agctaattta
     3241 ttagacaaaa aatgtttcaa atggaagccc aaatgctatt gtaaggtttg gcacattttt
     3301 cttgtctttc tttttcttcc tttcttttgt tcctgtgagc atgtaaagta ttctccagca
     3361 acgtaaccaa agtcattgct tttaatggaa aaaagtaagt aaaaattcag tatttgtgaa
     3421 gaggttttgg aaccgaagga gatgagcgat cgctgaaact attgtactga cattcatttg
     3481 gttgtatggt gctggagaag aagaccggag aagaccaaac acggctctcc atcaacactc
     3541 catcagttta tccagtatgg aactatctgg tagtgactta cctcttcctc aataaagaaa
     3601 acacaaggca gctctgtccc atgccccatc cttttttttc cccacagaga agtcatgttc
     3661 taacttactg tccctggttc ctagcattaa gcaggcgatg acagtggctg tgaggcacgt
     3721 gagaccaatc ccaggtcaca gagatagcac aaagacccag caacagtccc caatgggggt
     3781 ttgtatgtcc tttcccccag caggagtgag taagcctgct gaatttttct taatttctgt
     3841 aaaagctggg tatttaaaaa gaaattaaag tgtctttcaa gagattttaa catttttttt
     3901 tttaaaatga aatgtttctt ttatcggtta tttgctactt taacatctag agtatggtgc
     3961 agtatgctga atcttttgtt tcaaagcaaa tgttagtaaa aagctggtgt gcatagtctt
     4021 gttacattga tgcagttttt cccattccaa ggtctcatca ggtagactgg cttgaagaga
     4081 gcctggaaga atgccatcag ggtgtcagtc tgaataggaa gccatttccc acacggtttc
     4141 ctgtcccgtt tatattttgg acgtaacaga aaatggaaaa tgacagcagt ggcccctgtg
     4201 catggttttc atgggtgccc ttaatctcat gggcatgcct aacttgaaag tctgttctaa
     4261 ctggcgctta aggcttattt tagatactgg agtgtagctt tattatggat ggacttttat
     4321 cttttaaaca tttcattttg atcaactttg tatattcatg tgtattaaaa tatcgtggca
     4381 ctaaatgtcg ttcccccccc ccccctcgtt tgctgtacct ggtcaaggca tttgctggca
     4441 ccatcgtggt tggctcatgc aaatggcatg ggccagagac aattattgcc tatttttctg
     4501 cctaattaaa tttctgtttt ctagtattac attaa
//
