LOCUS       NM_152825               6018 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ubiquitin specific petidase 45 (Usp45), transcript
            variant 1, mRNA.
ACCESSION   NM_152825 XM_907495 XM_920403 XM_920410 XM_920420 XM_920429
            XM_920449 XM_920458
VERSION     NM_152825.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6018)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6018)
  AUTHORS   Yi,Z., Ouyang,J., Sun,W., Xiao,X., Li,S., Jia,X., Wang,P. and
            Zhang,Q.
  TITLE     Biallelic mutations in USP45, encoding a deubiquitinating enzyme,
            are associated with Leber congenital amaurosis
  JOURNAL   J Med Genet 56 (5), 325-331 (2019)
   PUBMED   30573563
REFERENCE   3  (bases 1 to 6018)
  AUTHORS   Perez-Oliva,A.B., Lachaud,C., Szyniarowski,P., Munoz,I.,
            Macartney,T., Hickson,I., Rouse,J. and Alessi,D.R.
  TITLE     USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA
            damage responses
  JOURNAL   EMBO J 34 (3), 326-343 (2015)
   PUBMED   25538220
  REMARK    GeneRIF: these results establish USP45 as a new regulator of
            XPF-ERCC1 crucial for efficient DNA repair
REFERENCE   4  (bases 1 to 6018)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   5  (bases 1 to 6018)
  AUTHORS   Kambouris,M., Triarhou,L.C., Dlouhy,S.R., Sangameswaran,L., Luo,F.,
            Ghetti,B. and Hodes,M.E.
  TITLE     Novel cDNA clones obtained by antibody screening of a mouse
            cerebellar cDNA expression library
  JOURNAL   Brain Res Mol Brain Res 25 (3-4), 183-191 (1994)
   PUBMED   7808216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040660.1, AK019756.1, BM227454.2, AL772187.6 and AI465456.1.
            
            On Apr 11, 2007 this sequence version replaced NM_152825.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC027768.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849380, SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-536               AK040660.1         2-537
            537-2128            AK019756.1         652-2243
            2129-2639           BM227454.2         1-511               c
            2640-5912           AL772187.6         117574-120846
            5913-6018           AI465456.1         1-106               c
FEATURES             Location/Qualifiers
     source          1..6018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 8.93 cM"
     gene            1..6018
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /note="ubiquitin specific petidase 45"
                     /db_xref="GeneID:77593"
                     /db_xref="MGI:MGI:101850"
     exon            1..48
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            49..158
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            159..331
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            332..435
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            436..536
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            537..679
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            680..775
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            776..906
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            907..994
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1076
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1168
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1225
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1369
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..2030
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2128
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2215
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2369
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..6007
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5913..5918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /note="hexamer: AATAAA"
     polyA_site      5937
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /note="major polyA site"
     regulatory      5985..5990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /note="hexamer: AATAAA"
     polyA_site      6007
                     /gene="Usp45"
                     /gene_synonym="3110003C05Rik; 4930550B20Rik; Gcap7"
                     /note="major polyA site"
ORIGIN      
        1 acaggcgcag aagctcctgc gtgtggaagc tgcggcccgg cgggcgggta aataacagat
       61 gcgggtaaaa gatccatcaa aagatctacc tgaaaaaggc aaaagaaata aaagaccact
      121 gctgcctcat gatgaagatt cttccgatga cattgctgta ggtctaacgt gccagcacgt
      181 cagttatgct gtcagtgtga atcatgtgaa gaaagcagta gctgagagtc tgtggtcagt
      241 ttgttcagaa tgtttgaaag agagaagatt ctgcgatgga cagccagtac tgcctgctga
      301 tgtttggttg tgcctcaagt gtggtttgca gggatgcggt aaaaactcag aaagccagca
      361 ttcactgaga cacttcaaga gctctgggac agagtcccat tgtgttgtca tcagcctgag
      421 tacatgggtc atatggtgtt atgaatgcaa tgaaaagttg tcgacacatt gcaacaagaa
      481 agttttggct caaatagttg attttctcca gaaacatgct tttaaaacac aaacaggtgc
      541 attttctaga atcataaaac tttgtgaaga aaaacgtgaa gcaggtgaaa taaagaaggg
      601 gaagaaaggc tgcactgtgc catctgtcaa aggaattaca aacttaggga atacttgctt
      661 ttttaatgca gtcattcaga acttggctca gacttacatt ctttttgaac tgatgaacga
      721 gataaaagaa gatggcacca aattcaagat ttctctttcg tcagctccac agctggagcc
      781 gttagtggtg gaactctcga gcccaggacc actgacgtca gccttgttcc tgtttcttca
      841 cagcatgaag gaggctgaaa aaggaccact ttctcctaaa gttcttttca atcagctttg
      901 tcagaaggct cctcggttta aaggtttcca gcaacaggac agccaggagc ttctgcacca
      961 tctgttggat gcagtgagga cagaggagac caagaggata caagccagca ttctaaaagc
     1021 cttcaacaac ccaactacca agactgctga tgatgaaact agaaaaaagg tcaaagccta
     1081 tggaaaggaa ggtgtgaaga tgaacttcat agatcgcatc tttattggcg aattaactag
     1141 cacagtcatg tgtgaagaat gtgcgaacat ctctaccatg aaggatccct tcattgatat
     1201 ctcacttcct atcatagaag aaagggtttc aaaacctgta cttttgggga aaatgagtaa
     1261 atgcagaagt ttacaagaaa cagaccaaga tcataacaag ggcaccgtga ctgtaggaaa
     1321 tgcccatcaa cccagagctt ccaggaagca ctcctcacct aacgacaaga accaactaag
     1381 tcatgacaga aaacatttaa gaaaatggcc atctgaagaa gagaaaactg ttgttacaca
     1441 cccaaagaat gacaacttgg aagccagccc gcctgccagc accctcagca ctgaggcgtc
     1501 cctgaacgag agcctcactg acggcagcga gagggacgcc agcctagaga gcagcgtgga
     1561 tgccgacagc gaggcttcgg agcccgagat cgcttccaag cagcctgtgc tgctgcggtc
     1621 caggggtgat tcctgcggac acgcggagca gcacccacac ctcccactgg caagtgaatt
     1681 gccacaagcc aaggagacgc atggtggcga ggaggaaatg gcggaagcga ttgctgaact
     1741 tcatttgagt ggcactgtaa ctggcaatag agatttccac agggaaaaac agccactaaa
     1801 tgtcccaaat aatttgtgtt tttcagaggg aaaacatacg aggcttcaca gtgcccaaaa
     1861 tgcttttcag accctttctc agagttatgt aactacttct aaagaatgct cagtccagtc
     1921 ctgtctctac cagttcacat ccatggagtt attaatgggc aacaataagc tgctctgtga
     1981 ggactgtact gaaaagagac ggaagtgcca caaagaaacc agctccgcag aaaagaaagc
     2041 aggaggagtt tataccaatg ccaggaagca actcctcata tctgccgttc ctgctatcct
     2101 aatccttcat cttaaaagat tccaccaggc tggcttgagt cttcgtaaag taaacagaca
     2161 tgtagacttt ccgcttaccc ttgacttggc accgttctgt gcggctacct gtaagaatat
     2221 aagtgtgggg gagaaggttc tctacggtct ctacggtata gtggagcaca gcggctccat
     2281 gagaggaggc cactacactg cttacgtgaa agtgagagta ccctccagga agctgtccga
     2341 gtgcatcacc gggaggaaga ctgcagccgg tttgaaagaa cctgatggtg aattgggagg
     2401 ccactgggtc catgtcagcg acacctatgt gcaggtggtt ccagagtcaa gagccctgag
     2461 tgcacaagct tatcttcttt tttatgaaag aatattataa tatctgttca ttgttattta
     2521 gttcattttt attttaatgc tgaagtcgta accataatat gtaatgtgcc ttcttagtct
     2581 ttaggaatag tgcatccttc cagcgttatt taactctttc aacatgtggt gaatccttta
     2641 aaaaaaaatt aattaatttg acaggcagtt gtgcatgcct ttaattccag cacttgggag
     2701 gcagaggcag acagatctct gtttgaggcc aactagggct attcaataaa accttgtctt
     2761 gaaatattaa acaaaaagtt aattaatgct ttcaaatcta tattcttttt ttttcttttt
     2821 ttttgctttt gtgagacagg gtttctctgt gtagccctgg ctgtcctgga actcactttg
     2881 tatcactttg tagaccaggc tggcctcgaa ctcagaaatc cacctacctc tgcctcccaa
     2941 gtgctggcat taaaggcgtg cgccaccact gcctggctca aatctatatt tttaaatgta
     3001 aaaacatgtt ttatgttaat tttcatgtcc atggaaattg cccctacaca cacacacaca
     3061 gagttgatag taaagcaacc ccctctatga tatgactcat ccttacatgc attcaaagat
     3121 gatgctaaat tggatcttta gtatactatt tcctaatgta atacaacctt cctgagtgga
     3181 tccaatatat cttatgctac aatttgctta ctttttgttg aagccttttt taagcttggc
     3241 tgttttgaat catacttcac atttttatgt gctagttatt tttctagtaa acattgatgt
     3301 gagtttataa ctatgaaagg aaaatcatac atccttgcac caccccactt taaatcatct
     3361 cagggctctg cagtggtgtg tgtgttagtc tataggaaaa gtttctagaa cagtctgaac
     3421 tagtgcctaa tgtaacataa ttaatttttc atattttatg tgagtcagta gtataaaaag
     3481 gagccattgt aattttggta gtgtgagttt acaagtaatg aattgattcg cttattgctt
     3541 tgaatatttg aaggtattga aacatttcat aaactaatca tttgcagtct ttgaaagata
     3601 atttacaaca cataaaactg gtaaatagaa gttatagtct atataggaat atagaatact
     3661 ttaaagttta aggatatctt tgaactgtaa accaccaaat tatatttata aatggtagag
     3721 atcatattct tataaccaac aatgaatata taatactttt ttacttctat acattaatac
     3781 atgttaagca tagttttgtc ttcataagca tttatttaaa acttcaggtg gatagttagg
     3841 gttgtagttc aatggcaaag cacttgcctg gttccatccc tagcaaaaca aagaaaatat
     3901 tcaggtgggc ttggctactt tcatgggaca cagacttgcc acttctgttc cccttaaata
     3961 agcagtaaca cagaatagtt tcttctagca ttcaaaggat tgaactgtga aaacttagca
     4021 tgaaaaatat tactaccaag attttcaata atcaatgaag tggctcactg atacatagta
     4081 ttgaatcaag atgtaaggga acaggttcaa tgtcttagtc atcagtgcct gtgtttgatt
     4141 ctatgggcaa atgtgaggga gagaggctgt aaactgtcca gacctttagc caggatggaa
     4201 ccttcttaac atgtgtaaca taaagtcccc agtgttgcct cttgatatgt ggctgggtga
     4261 aactgattgt ctaatggaga cattttaaga ttgtggagaa attttcaatg gtatttgaat
     4321 ttttttaatt gaaggtgaag aaatatattt tatctgtaga gcccagttgt gtcctctaaa
     4381 aagaactttc cagtgtcttc tgtttcatca gacattcagt gttattaatc tattgacacg
     4441 gaagagtcta gcaccagagc aatgaatgag aaaaataatt tatttgttca agctagcctg
     4501 tcatagcagt tgcacccaca cccccaaaca aatgcaagcg gtcagccttt ttcccccctc
     4561 tctcctggaa aagatactat taagacatgt acaatctaag caggttccaa taccgggcat
     4621 atgatagtat tttatgagcc tttaaaacag aaaaacctgc tgagtgatgg tggcccatgc
     4681 ctttagattc agcacttggg aggcagaggc aggtggattt gagttcaagg acaccctggt
     4741 ccacagagca ggttccagga aagccaagac aacacagaga aaccttgcct gaaaaacctt
     4801 ggggaaaaaa aaaacaccct aaaatctata tgattttata cattattcta gtagtgatgt
     4861 acaaataaaa tgttcattta ttacctagtt ctgaggagat tctggaatgt attttttttt
     4921 aatgacctaa agtttgagtg tttttcttgt cacctgaaaa tgtaggaaaa tggtttgatt
     4981 tgatatctag gaatttctta tcaagcttat gtaatataga aaaatcaccc agatctacac
     5041 ttaaattttt gttcttactt tgaagttttc caaagcacat ttgtagaaat tttaaattgt
     5101 gaggccactg tactaacaga ttacctcagg aaaccgtgca aacaaacaag aatgtttaca
     5161 gatccgcaca actagtcagt gctttggcac cgtgaatttg aaaggtaaaa gagagaagtt
     5221 tttatctaga aactggttta cagggtacct ctagccccag ttctcccctg actttcccat
     5281 atttaaaata ataaaattct gatgatgtgc caattatgtg aatgcttgtg acataaacaa
     5341 atatacatct gtatttaaga tttgttgttt aatgttttaa aaaataatat gaagactgct
     5401 tatgtaggtg gtcaagggga tgatcatata tcaacagagc tattttacca tagttcttag
     5461 cttgcatgtg tgattaatta gtgattttta tgtaatactt gaataagata tcctgaagat
     5521 atgaaatgtc ttcgtgaaat gtagctgtga aatgtcaccg cacatcaaat ttttatagta
     5581 caaaataaca tcctgcctac tttcatgaac tttatactca gcttattttt ctgcatgaca
     5641 tctggtcata taaacctaaa ccaaatatgt gcgataaaat caagctttca gctagcatcc
     5701 attgcagtat tagagaaatg atttctgcat taaaatgttt ttgttcatgc agaaatcatc
     5761 aattgaaatg tgtttaaaag atgattattt ttaggtatca gtaatacatt catggtatca
     5821 ttccttctct ttcatccagt tttacagtat tttaaaaata tctgtgtaac ttattgagca
     5881 ttatttgatc attgctgtat gtaaaagatc acaataaata ttagattctt atgttaattg
     5941 attaggccta gagtttttgc attatacatt gttagcagaa tgttaataaa cattgtgtca
     6001 ttgcctaaaa aaaaaaaa
//
