LOCUS       NM_001206851            3922 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 44 (Usp44), transcript
            variant 2, mRNA.
ACCESSION   NM_001206851
VERSION     NM_001206851.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3922)
  AUTHORS   Liu,Y., Yuan,M., Xu,X., Yang,H., Yao,Y., Hou,P., Yu,W. and Ji,M.
  TITLE     USP44 inactivation accelerates the progression of thyroid cancer by
            inducing ubiquitylation and degradation of p21
  JOURNAL   Int J Biol Sci 20 (13), 5223-5238 (2024)
   PUBMED   39430240
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3922)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3922)
  AUTHORS   Zhang,Y., Mandemaker,I.K., Matsumoto,S., Foreman,O., Holland,C.P.,
            Lloyd,W.R., Sugasawa,K., Vermeulen,W., Marteijn,J.A. and
            Galardy,P.J.
  TITLE     USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and
            Prevent Tumors
  JOURNAL   Front Cell Dev Biol 9, 663411 (2021)
   PUBMED   33937266
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3922)
  AUTHORS   Yang,J., Wei,P., Barbi,J., Huang,Q., Yang,E., Bai,Y., Nie,J.,
            Gao,Y., Tao,J., Lu,Y., Xie,C., Hou,X., Ren,J., Wu,X., Meng,J.,
            Zhang,Y., Fu,J., Kou,W., Gao,Y., Chen,Z., Liang,R., Tsun,A., Li,D.,
            Guo,W., Zhang,S., Zheng,S.G., Niu,J., Galardy,P., Tong,X., Shi,G.,
            Li,H., Pan,F. and Li,B.
  TITLE     The deubiquitinase USP44 promotes Treg function during inflammation
            by preventing FOXP3 degradation
  JOURNAL   EMBO Rep 21 (9), e50308 (2020)
   PUBMED   32644293
REFERENCE   5  (bases 1 to 3922)
  AUTHORS   Lin,Y.H., Forster,M., Liang,Y., Yu,M., Wang,H., Robert,F.,
            Langlais,D., Pelletier,J., Clare,S. and Nijnik,A.
  TITLE     USP44 is dispensable for normal hematopoietic stem cell function,
            lymphocyte development, and B-cell-mediated immune response in a
            mouse model
  JOURNAL   Exp Hematol 72, 1-8 (2019)
   PUBMED   30639577
  REMARK    GeneRIF: USP44 is dispensable for the normal physiology of
            hematopoietic and immune systems, and its functions in these
            systems are likely redundant with other USP family proteins.
REFERENCE   6  (bases 1 to 3922)
  AUTHORS   Jahan,A.S., Lestra,M., Swee,L.K., Fan,Y., Lamers,M.M.,
            Tafesse,F.G., Theile,C.S., Spooner,E., Bruzzone,R., Ploegh,H.L. and
            Sanyal,S.
  TITLE     Usp12 stabilizes the T-cell receptor complex at the cell surface
            during signaling
  JOURNAL   Proc Natl Acad Sci U S A 113 (6), E705-E714 (2016)
   PUBMED   26811477
REFERENCE   7  (bases 1 to 3922)
  AUTHORS   Zhang,Y., Foreman,O., Wigle,D.A., Kosari,F., Vasmatzis,G.,
            Salisbury,J.L., van Deursen,J. and Galardy,P.J.
  TITLE     USP44 regulates centrosome positioning to prevent aneuploidy and
            suppress tumorigenesis
  JOURNAL   J Clin Invest 122 (12), 4362-4374 (2012)
   PUBMED   23187126
  REMARK    GeneRIF: USP44 inhibited chromosome segregation errors independent
            of its role in the mitotic checkpoint by regulating centrosome
            separation, positioning, and mitotic spindle geometry.
REFERENCE   8  (bases 1 to 3922)
  AUTHORS   Fuchs,G., Shema,E., Vesterman,R., Kotler,E., Wolchinsky,Z.,
            Wilder,S., Golomb,L., Pribluda,A., Zhang,F., Haj-Yahya,M.,
            Feldmesser,E., Brik,A., Yu,X., Hanna,J., Aberdam,D., Domany,E. and
            Oren,M.
  TITLE     RNF20 and USP44 regulate stem cell differentiation by modulating
            H2B monoubiquitylation
  JOURNAL   Mol Cell 46 (5), 662-673 (2012)
   PUBMED   22681888
  REMARK    Erratum:[Mol Cell. 2015 Oct 15;60(2):338]
REFERENCE   9  (bases 1 to 3922)
  AUTHORS   Zhang,Y., van Deursen,J. and Galardy,P.J.
  TITLE     Overexpression of ubiquitin specific protease 44 (USP44) induces
            chromosomal instability and is frequently observed in human T-cell
            leukemia
  JOURNAL   PLoS One 6 (8), e23389 (2011)
   PUBMED   21853124
  REMARK    GeneRIF: These data are consistent with an important role for USP44
            in regulating Cdc20-APC/C activity and suggest that high levels of
            this enzyme may contribute to the pathogenesis of T-cell leukemias.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124686.3.
            
            On Dec 6, 2019 this sequence version replaced NM_001206851.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR5189685.211579.1, SRR11927937.1697774.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849383, SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC124686.3         85947-86082
            137-210             AC124686.3         98421-98494
            211-1714            AC124686.3         100054-101557
            1715-1910           AC124686.3         104593-104788
            1911-2019           AC124686.3         107153-107261
            2020-2225           AC124686.3         110557-110762
            2226-3922           AC124686.3         112172-113868
FEATURES             Location/Qualifiers
     source          1..3922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.67 cM"
     gene            1..3922
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /note="ubiquitin specific peptidase 44"
                     /db_xref="GeneID:327799"
                     /db_xref="MGI:MGI:3045318"
     exon            1..136
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            137..210
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            211..1714
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..2425
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /EC_number="3.4.19.12"
                     /note="inactive ubiquitin carboxyl-terminal hydrolase 44;
                     inactive ubiquitin thioesterase 44; inactive
                     deubiquitinating enzyme 44; inactive
                     ubiquitin-specific-processing protease 44; ubiquitin
                     specific peptidase 49 pseudogene"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 44"
                     /protein_id="NP_001193780.1"
                     /db_xref="CCDS:CCDS88075.1"
                     /db_xref="GeneID:327799"
                     /db_xref="MGI:MGI:3045318"
                     /translation="MDRCKHVEQLQLAQGHSILDPQKWYCMVCNTTESIWACLSCSHV
                     ACGKYIQEHALKHFQESSHPVAFEVNDMYAFCYLCNDYVLNDNAAGDLKSLRSTLSTI
                     KSKKYPCVVPSDSVLHPVDAQDRVYSLLDGTQSLPGNEDPTCAALWHRRRVLMGKAFR
                     TWFEQSAIGRKGQEPTQERMVAKREAKRRQQQELEQQMKAELESTPPRKSLRLQGSSE
                     EAATIEIVPVRAPPPPPASPAKDKAALPTSEDRTFKKVSDSLIKRRPMVTPGVTGLRN
                     LGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAVAASDKARSYKHSAVTEAAAQQMN
                     EGQEKEKGFVCSRHSGLSSGLSGGASKGRNMELIQPREPSSPYSSLCHELHILFQVMW
                     SGEWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRELETTGTKLPALIP
                     TSQRRLIEQVLNVVNNIFHGQFLSQVTCLACDNKSDTIESFWDLSLEFPERYQCSGKD
                     AASQPCLVTDMLDKFTETEALEGKIYMCDHCNSKRRKFSSKSVVFTEAQKQLMICHLP
                     QVLRLHLKRFRWSGRNNREKIGVHVVFEETLNMEPYCCRETLNALRPECFLYNLSAVV
                     IHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKLSMCTMEEVRKAQAYILFYTQRVTENG
                     HSKLLPPELLSNSQHPSKETDASSNEVLS"
     exon            1715..1910
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2019
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2225
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..3922
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2481
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /note="major polyA site"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      2640
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
     regulatory      3897..3902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3922
                     /gene="Usp44"
                     /gene_synonym="E430004F17Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaaacaaaca tcatttaccc tggattcgaa ggccggaagc accgaaagcc tagcagacgg
       61 tatcgtccta gacgataaaa ggaccgacct cttagtctaa aggccaattc ggcgactgat
      121 tttaaggaca taatagaatt ctgtgctgac cttatattgc ccatagacaa gttgaggagt
      181 gatgcagacc gagaatcctc caagacccag ttttcagatg ctcccggtgt tgtgaagaga
      241 ggcccgtctg gattatgtgt ttcccagaca gactagctac ctgctaacaa tggataggtg
      301 caagcacgtt gagcagttgc agcttgctca aggccattcc atcttggacc ctcagaaatg
      361 gtactgtatg gtctgcaaca caaccgagtc catttgggct tgcctcagct gttcccacgt
      421 cgcctgtggg aagtacatcc aagagcacgc actgaagcac tttcaagaaa gcagccatcc
      481 cgttgccttc gaggtgaacg acatgtacgc tttttgttat ctttgtaacg attatgttct
      541 aaacgataac gcagccggag acctgaagtc actacggagt acactaagta caatcaaaag
      601 taaaaagtac ccctgtgtgg ttccgagtga ctcggtttta catcctgtgg atgcacagga
      661 ccgtgtttac tccttactcg acggcaccca atctctgccc ggaaacgagg atccaacgtg
      721 cgccgccctc tggcacagga gacgggtgct catggggaaa gcctttcgaa cttggttcga
      781 acagtcagca attggaagga aagggcaaga gccaactcag gagagaatgg tagcaaaacg
      841 agaggcgaag agaaggcagc agcaggagtt ggagcagcag atgaaagccg agctggaaag
      901 cacacctccg cggaagagtt tacgcttaca aggctcctcg gaggaggcgg ccacaatcga
      961 aatcgtgcca gtgcgggcac cgcccccacc tcccgcatcc ccagcaaagg acaaagccgc
     1021 gctacctact tcggaagaca ggacttttaa aaaagtaagt gactccttaa tcaaacgaag
     1081 gcccatggta actcctggtg taaccggact gagaaactta ggaaatactt gctatatgaa
     1141 ttctgttctt caagtgttga gtcatttact catttttcga caatgttttt taaagcttga
     1201 cctgaaccag tggctggctg tggctgccag cgataaggcc cgatcctata agcactcagc
     1261 cgtcacggag gcggcggcac agcagatgaa cgaagggcaa gagaaagaga aaggcttcgt
     1321 atgctccaga cattcgggtt tatcctcagg cctgagcgga ggggcctcaa aaggtcggaa
     1381 catggagctt attcagccaa gggagcccag ttccccgtac agttctctct gccatgaatt
     1441 gcatatcctg ttccaagtca tgtggtctgg agagtgggcc ttggtctcac cgtttgccat
     1501 gcttcactcc gtgtggaggc tgatccctgc tttccgcggt tacgcccagc aggatgctca
     1561 ggaatttctt tgtgaacttc tggataagat acaacgtgaa ctagagacaa ccggaaccaa
     1621 gttaccagcc ctcatcccca cttcccaaag gagacttatt gagcaagttc tgaatgtggt
     1681 gaataacatt tttcacggac aatttcttag tcaggttaca tgtcttgctt gtgacaacaa
     1741 atcagatacc atagaatcct tctgggactt gtccctggag tttccagaga gataccagtg
     1801 cagtgggaaa gatgctgcct cccagccgtg cctggttact gacatgttgg acaaatttac
     1861 agaaacagaa gctttagaag ggaaaatcta catgtgtgac cattgtaact caaagcgtag
     1921 aaagttttcg tcaaaatcag ttgtattcac agaagcccag aagcagctta tgatatgcca
     1981 tctacctcag gttctcagac tgcacctcaa acggttcaga tggtcaggac gtaataaccg
     2041 agagaagatt ggtgttcatg ttgtctttga ggaaacctta aacatggagc cttattgctg
     2101 cagggagacc ctgaacgctc tcagaccaga gtgctttctc tataatttat ctgctgtcgt
     2161 aattcaccat ggaaaaggat ttggctcagg acactacact gcctactgct acaattccga
     2221 aggagggttc tgggtccact gcaacgattc caagctgagc atgtgcacga tggaagaagt
     2281 acgcaaggcc caagcttata tcttatttta tactcagcga gttactgaga atggacattc
     2341 gaaactcttg cctcccgagc tcctgtccaa tagccagcac cccagtaagg agactgatgc
     2401 ctcttctaat gaagtcctta gctgatccag acagtgggct ctcgttatct gtatatatcc
     2461 tttttaaatg ggctgaccta cgctgctgtg cttcattgtt tttattctgg aattatgatc
     2521 agtgcctgct atgtttagac attgtgtatt taactaccaa gtttttcttt tcttttttta
     2581 cagagacaaa ctataaatat atgtatatca actataggcc aactaaactt ttttcaaata
     2641 ttttgagttt tatactttta gtgtttacct cagactgtta cctcttatat tctgatgtct
     2701 taattgcctc aaatcatgaa tttgtgcaat ctactaaaga aattcaggtg gcatcattat
     2761 atatattatt attatttaac ttctgtagct gttttctata cagattctaa ctccacgggg
     2821 aaggagacgc tcgtcacaga ttgtcttgct gactccagct cttccccgtt ggaggtaaac
     2881 agattggaag tgagatactg aagcatcacc tagctccagt cactcctgag gcttctacag
     2941 ggctcggagt agatttaatg cagatactgg tctttcactc caaaatttat tgcttccata
     3001 actgtccttt attgagcaca aattcaaaat gaaaatagca gatttacaca tggtatatac
     3061 ttcaatgaac tttggaacta tgggcaatga aaaaatagtt ctaataaggc agtcacaaaa
     3121 ttttgaattt agcaaaccaa tatattatga tacacaaatg tagtttatct tgagaatgag
     3181 tttttacgtt taattttaga tatcttaagt agttgagatt tatttcttta ttttttattt
     3241 ttagttcaaa ggagtaagac aaatgcatag gggcaaatgc ataggggcag atgtttaagg
     3301 cagagagaag acagttcgag catggcacct gggctgttac atctaagatc ttgtttttct
     3361 cgaagtaccc taagcctgac tcttgctagg attatgtgac cactgggaat ttctcagggc
     3421 cctggcccct ttttaaaaac actagaagtg gtctaaactt gaattaacta aaagcaagag
     3481 agattccttt cgctgtgttc taaagaaagc tttccaggtc ttatggatgg agctctgctg
     3541 ctgccatggc catggccatg gccaccgcca cccaacctgc tcagaaatgg ggctccacca
     3601 acccacagat cccaaggaac ctgtgagcca ctgggagagg tttttttttc ccccttcttc
     3661 ctaaagaaag tgacttaatt tacagcttat atctaagcca ggaagagtta tctttagcac
     3721 agacttctga aaggagtgtc gcctggggca gcttattaac aaaccgcaac aaaaacacat
     3781 caaccgaaga cagaatccta tgtgccaaaa atacagctgg agtaatattt ggagtgatat
     3841 taggtcactt acccaaagcg tatacaaatt gttgcatcag ctgttaaata tacctcatta
     3901 aagattcatg tgataaaagt ta
//
