LOCUS       NM_011678               3686 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 4 (proto-oncogene)
            (Usp4), transcript variant 1, mRNA.
ACCESSION   NM_011678
VERSION     NM_011678.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3686)
  AUTHORS   Liu,B., Zhang,X., Zhou,Y., Liu,H., Wang,Z., Fu,Y., Gao,Q.,
            Cheng,X., Sun,Q. and Ju,Z.
  TITLE     USP4 regulates ribosome biogenesis and protein synthesis for
            hematopoietic stem cell regeneration and leukemia progression
  JOURNAL   Leukemia 38 (11), 2466-2478 (2024)
   PUBMED   39266638
  REMARK    GeneRIF: USP4 regulates ribosome biogenesis and protein synthesis
            for hematopoietic stem cell regeneration and leukemia progression.
REFERENCE   2  (bases 1 to 3686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3686)
  AUTHORS   Xu,J., Guo,R., Wen,N., Li,L., Yi,Y., Chen,J., He,Z., Yang,J.,
            Xiao,Z.J. and Niu,M.
  TITLE     FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast
            cancer metastasis
  JOURNAL   PLoS Biol 21 (12), e3002446 (2023)
   PUBMED   38134227
  REMARK    GeneRIF: FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated
            breast cancer metastasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3686)
  AUTHORS   Hou,X., Zhu,F., Ni,Y., Chen,T., Du,J., Liu,X., Han,Y., Liu,Y.,
            Du,W., Li,Y., Wang,X., Li,D., Liang,R., Li,B. and Shi,G.
  TITLE     USP4 is pathogenic in allergic airway inflammation by inhibiting
            regulatory T cell response
  JOURNAL   Life Sci 281, 119720 (2021)
   PUBMED   34144056
  REMARK    GeneRIF: USP4 is pathogenic in allergic airway inflammation by
            inhibiting regulatory T cell response.
REFERENCE   5  (bases 1 to 3686)
  AUTHORS   Lee,S., Sears,M.J., Zhang,Z., Li,H., Salhab,I., Krebs,P., Xing,Y.,
            Nah,H.D., Williams,T. and Carstens,R.P.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3686)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   7  (bases 1 to 3686)
  AUTHORS   Di Fruscio,M., Gilchrist,C.A., Baker,R.T. and Gray,D.A.
  TITLE     Genomic structure of Unp, a murine gene encoding a
            ubiquitin-specific protease
  JOURNAL   Biochim Biophys Acta 1398 (1), 9-17 (1998)
   PUBMED   9602026
REFERENCE   8  (bases 1 to 3686)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 3686)
  AUTHORS   Gupta,K., Chevrette,M. and Gray,D.A.
  TITLE     The Unp proto-oncogene encodes a nuclear protein
  JOURNAL   Oncogene 9 (6), 1729-1731 (1994)
   PUBMED   8183569
REFERENCE   10 (bases 1 to 3686)
  AUTHORS   Gupta,K., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Gray,D.A.
  TITLE     Unp, a mouse gene related to the tre oncogene
  JOURNAL   Oncogene 8 (8), 2307-2310 (1993)
   PUBMED   8336951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY322979.1, AK149964.1 and CD741063.1.
            
            On Jan 9, 2008 this sequence version replaced NM_011678.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.50608.1, L00681.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY322979.1         1-43
            44-3404             AK149964.1         2-3362
            3405-3686           CD741063.1         1-282               c
FEATURES             Location/Qualifiers
     source          1..3686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.25 cM"
     gene            1..3686
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /note="ubiquitin specific peptidase 4 (proto-oncogene)"
                     /db_xref="GeneID:22258"
                     /db_xref="MGI:MGI:98905"
     exon            1..188
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            189..316
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            317..447
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            448..574
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            575..720
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            721..782
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            783..923
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1041
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1215
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1374
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1599
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1683
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1778
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1970
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2059
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2284
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2355
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2474
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2624
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2728
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2817
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..3668
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3380..3385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /note="hexamer: AGTAAA"
     polyA_site      3401
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
                     /note="major polyA site"
     polyA_site      3665
                     /gene="Usp4"
                     /gene_synonym="F730026I20Rik; mKIAA4155; Unp"
ORIGIN      
        1 gtggttacgt gcgtgcgtgg gcgcggccca tagcacgccg tgcgctaggc ggatgtccgg
       61 gccggctggg ccggggcggc ggacgagatg gcggaaggcc ggggcagccg tgagcgaccg
      121 gatgtggaga cccagaagac ggagctcgga gccttgatgg ggaccacgct ccaacgtggg
      181 gcgcagtggt atcttattga cagccggtgg ttcaagcagt ggaagaagta tgtgggcttt
      241 gacagctggg acatgtacaa tgtcggggag cataacctgt ttcctggacc tattgacaac
      301 tccggactct tctcagatcc tgagagtcag accttgaagg agcacttaat cgatgagctg
      361 gactatgtgc tggtcccagc cgaagcctgg aataaattgc tgaattggta tggctgtgtg
      421 gagggccagc agcctattgt cagaaaagtt gtggagcatg gcctgtttgt caagcactgc
      481 aaagtggaag tgtatttgct ggagctgaag ctctgtgaga acagtgaccc caccaatgtg
      541 ctaagttgcc attttagcaa agcagacacc attgcaacta ttgagaagga gatgaggaag
      601 ctcttcaaca tccctgcaga acgtgaaaca cggctttgga acaaatacat gagcaacacc
      661 tatgagcagt tgagcaagct agacaacact atccaggatg ctgggctgta ccagggtcag
      721 gtgctagtaa ttgagcccca aaatgaagat ggcacatggc cccggcagag cctgcagtca
      781 aaatcaagca ctgcacctag cagaaatttc actacctctt caaaaccatc cgcaagtccc
      841 tattgctcag tgtctgcctc tctcattgca aatggtgata gcactaacag ctctgggatg
      901 cacagctccg gtgtcagcag gggtggatct ggcttctctg cttcgtataa ttgccaggag
      961 cccccatcac ctcatataca gcctggcctc tgtggacttg gaaacctggg gaacacttgc
     1021 ttcatgaact ctgctctgca gtgcctgagc aacactgccc cactgactga gtactttctc
     1081 aaagatgagt atgaggccga gatcaaccga gacaaccctc tggggatgaa aggggagatt
     1141 gcagaggcct atgcagagct catcaagcag atgtggtctg gaagggacac tcacgtggca
     1201 ccacggatgt tcaagacgca agtgggacgt tttgcccctc agttttctgg ctaccaacag
     1261 caagactccc aggagctgct agcctttatt ctagacggac tgcacgagga cctgaaccgc
     1321 gtaaagaaga agccttacct ggagcccaag gacgccaatg ggcgaccaga tgcggtggta
     1381 gcaaaggaag cctgggaaaa ccacaggctg aggaatgatt ctgtgattgt ggatactttc
     1441 catggccttt tcaaatcgac tttggtttgc ccagaatgtg ctaaagtttc tgtgaccttt
     1501 gacccatttt gctatctaac tctcccactg cctttgaaga aggatcggat tatggaggtc
     1561 ttcctggttc ctgctgaccc tcagtgcaga cctatccagt accgtgtgac tgtgccattg
     1621 atgggggcca tttctgacct gtgtgaagca ctctccaagc tgtctggcat tgctgcagaa
     1681 aatatggtgg tcactgatgt atataatcac cgcttccaca aaattttcca aatggatgaa
     1741 ggtttaagcc acatcacgcc tcgagatgac atttttgtgt atgaggtctg caacacgtcc
     1801 atggatggct cagagtgtat cactcttcca gtctacttca gagagaagaa gtccaggccg
     1861 tcgagtgctt cctcgggggc tgtgctctat ggacagcccc ttcttgtctc tgtccctaag
     1921 cataagctaa ccctagagtc tttgtaccag gctgtttgtg atcgtatcag ccgctacata
     1981 aaacagcctt tgcctgatga gtttctcagc tcacccttag agcctggggc ctgcaatggc
     2041 tctaggagta gctatgaagg agatgaagag gaagaaatgg atcatcaaga ggaaggaaaa
     2101 gagcagcttt ccgaagtgga aggcagtggt gaggacgatc agggagatga ccatagcgag
     2161 agcgcccaaa aggtgaaagg ccagccgagg cacaagaggc tctttacctt cagcctcgtg
     2221 aactcctgtg gaactgctga tatcaattca ctggcaactg acgggaaact cctcaaactc
     2281 aactctcgat ccacactggc cattgactgg gacagtgaga cccgaagcct ttactttgat
     2341 gagcaagaat ctgaggcctg tgagaagcac ctgagcatgt cacagccgca gaagaagaag
     2401 aaggcggcag tagccctgcg agagtgcatc gagctcttca ccaccatgga gacccttggg
     2461 gagcatgacc cctggtactg tcccacctgt aagaagcacc agcaggcaac aaagaagttt
     2521 gacttgtggt ctttgcccaa gatcctggtg gttcacctca agcgtttctc ctataacaga
     2581 tactggcggg ataaacttga caccgtggtg gagttcccag tcagagctct gaacatgtcc
     2641 gagtttgtct gtgaccggtc agcaaggcct tatgtttatg acctaattgc tgtgtccaat
     2701 cactatggag ccatgggggt tggtcactac actgcatatg cgaagaacag actgaacggg
     2761 aaatggtatt actttgatga tagcagtgtg tccctggcct ctgaggacca gatagtgacg
     2821 aaagccgcct acgtgttgtt ctatcagcgt cgggatgacg aatgctccag cacatcttcg
     2881 ctcggcagtt tccccggttc tgatggaggg gtgaagctga gcagctcaca ccagggcatg
     2941 ggggatgagg aggcttacaa catggacacc aactgatgtg gcctctgtga ccctgccacc
     3001 ctcccaacac cagcatcctc ccccaggaga atatctgtgg cactcttgaa gactgctcat
     3061 atcaatctca aaccagatga ggacattacc tccttttatg agaagaggaa ggaaagagaa
     3121 accctgcttt ctgagaaggg ctctatgtta agaggctgga ttattttttc ttttaaacgg
     3181 gtggtgagag aaaaacctgt ggagctcaat tgtgggctgg ggtttggtgc acagtggcat
     3241 gtgtctcatg gattccaaag agtggagagg aagaccctgc aatgagcatg gtgcagccat
     3301 gaagacccac ctgcagggct gctccgaact gggttttgga ttctggtgcc cacactgctc
     3361 accccagtag tctggccaca gtaaaccaag cctccagcaa atttgatgtt gtcctctagt
     3421 tctttgctgt tcattgagat gggcttatag ttttctaaac tgtctctgaa acccgtttct
     3481 attctcttgt tctctcagaa ttttccagcc gccttcccgg ttatgaaatg aagttagtat
     3541 tgggctattg ttttcagttt ctcacagact cctagaagtt ctgttttgtc ccccactgcc
     3601 cttgataaag tgattctatg tggaactttc attagctctc ccttaaaaga agtctattca
     3661 taaaactgaa aaaaaaaaaa aaaaaa
//
