LOCUS       NM_027554               4711 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 38 (Usp38), mRNA.
ACCESSION   NM_027554 XM_904130
VERSION     NM_027554.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4711)
  AUTHORS   Pan,Y., Xiao,Z., Yang,H., Kong,B., Meng,H., Shuai,W. and Huang,H.
  TITLE     USP38 exacerbates pressure overload-induced left ventricular
            electrical remodeling
  JOURNAL   Mol Med 30 (1), 97 (2024)
   PUBMED   38937697
  REMARK    GeneRIF: USP38 exacerbates pressure overload-induced left
            ventricular electrical remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4711)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4711)
  AUTHORS   Xiao,Z., Dai,C., Yu,T., Zhu,J., Pan,Y., Shuai,W., Kong,B. and
            Huang,H.
  TITLE     Ubiquitin specific protease 38 aggravates pathological cardiac
            remodeling by stabilizing phospho-TBK1
  JOURNAL   Int J Biol Sci 20 (5), 1815-1832 (2024)
   PUBMED   38481817
  REMARK    GeneRIF: Ubiquitin specific protease 38 aggravates pathological
            cardiac remodeling by stabilizing phospho-TBK1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4711)
  AUTHORS   Xiao,Z., Pan,Y., Kong,B., Meng,H., Shuai,W. and Huang,H.
  TITLE     Ubiquitin-specific protease 38 promotes inflammatory atrial
            fibrillation induced by pressure overload
  JOURNAL   Europace 26 (1) (2023)
   PUBMED   38288617
  REMARK    GeneRIF: Ubiquitin-specific protease 38 promotes inflammatory
            atrial fibrillation induced by pressure overload.
REFERENCE   5  (bases 1 to 4711)
  AUTHORS   Gong,Y., Yu,T., Shuai,W., Chen,T., Zhang,J. and Huang,H.
  TITLE     USP38 exacerbates atrial inflammation, fibrosis, and susceptibility
            to atrial fibrillation after myocardial infarction in mice
  JOURNAL   Mol Med 29 (1), 157 (2023)
   PUBMED   37953295
  REMARK    GeneRIF: USP38 exacerbates atrial inflammation, fibrosis, and
            susceptibility to atrial fibrillation after myocardial infarction
            in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4711)
  AUTHORS   Probert,F., Rice,P., Scudamore,C.L., Wells,S., Williams,R.,
            Hough,T.A. and Cox,I.J.
  TITLE     (1)H NMR metabolic profiling of plasma reveals additional
            phenotypes in knockout mouse models
  JOURNAL   J Proteome Res 14 (5), 2036-2045 (2015)
   PUBMED   25849460
REFERENCE   7  (bases 1 to 4711)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 4711)
  AUTHORS   Ferron,M. and Vacher,J.
  TITLE     Characterization of the murine Inpp4b gene and identification of a
            novel isoform
  JOURNAL   Gene 376 (1), 152-161 (2006)
   PUBMED   16631325
REFERENCE   9  (bases 1 to 4711)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 4711)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC054404.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_904130.1, NM_027554.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054404.1, AK142200.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 38.68 cM"
     gene            1..4711
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /note="ubiquitin specific peptidase 38"
                     /db_xref="GeneID:74841"
                     /db_xref="MGI:MGI:1922091"
     exon            1..1152
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..3599
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 38; ubiquitin
                     thioesterase 38; deubiquitinating enzyme 38;
                     ubiquitin-specific-processing protease 38; ubiquitin
                     thiolesterase 38"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 38"
                     /protein_id="NP_081830.2"
                     /db_xref="CCDS:CCDS22444.1"
                     /db_xref="GeneID:74841"
                     /db_xref="MGI:MGI:1922091"
                     /translation="MDKILEGLVSSSHPLPLKRMIVRKVVEFAEHWLDEAQCEAMFDL
                     TTRLILEGQDPFQRQVGHQVLEAYARYHRPEFESFFNKTFVLGLLQQGYHSVDRKDVA
                     ILDYIHNGLKLIMSCPSVLDLFSLLQVEVLRMVCERPEPVLCARLSDLLTDFVQCVPK
                     GKLSVTFCQQLVRTIGHFQCVSTQEKELREYVSQVTKVSTLLQNIWKAEPSTLLPSLQ
                     EVFASISSTDASFEPSVALASLVQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMID
                     WLSWPLAQHVDTWVIALLKGLAAVQKFTILIDVTLLKIELVFNRLWFPLVRPGALAVL
                     SHMLLSFQHSPEAFHVIVPHIVNLVHSFRSDGLPSSTAFLVQLTELVHCMMYHYSGFP
                     DLYEPILEAVKDFPKPSEEKIKLILNQSAWTSQSNALASCLSRLSGKSETGKTGLINL
                     GNTCYMNSVLQALFMATEFRRQVLSLNLNGCNSLMKKLQHLFAFLAHTQREAYAPRIF
                     FEASRPPWFTPRSQQDCSEYLRFLLDRLHEEEKILRVQSSHKPSEGLDCAETCLQEVT
                     SKVAVPTESPGTGDSEKTLIEKMFGGKLRTHICCLNCGSTSHKVEAFTDLSLAFCPSP
                     SVEDLSFQDTASLPSAQDDGLMQTSVADPEEEPVVYNPATAAFVCDSVVNQRVLGSPP
                     VEFHCAESSSVPEESAKILISKDVPQNPGGESTTSVTDLLNYFLAPEVLTGENQYYCE
                     SCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRTA
                     SFSSLSQSWSVDVDFTDINENLPKKLKPSGTEEAFCPKLVPYLLSSVVVHSGVSSESG
                     HYYSYARNITGTESSYQMCPQSESLALAPSQSCLLGVESPNTVIEQDLENKEMSQEWF
                     LFNDSRVTFTSFQSVQKITSRFPKDTAYVLLYKKQSRANGIDSDNPASGVWANGDPPL
                     QKELMDAITKDNKLYLQEQELNARARALQAASASCSFRPNGFDDNDPPGSCGPTGGGG
                     GGGFNTVGRLVF"
     exon            1153..1288
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1418
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1520
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1679
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1873
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1967
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2074
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..3437
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..4685
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4572..4577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /note="hexamer: ATTAAA"
     polyA_site      4602
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /note="major polyA site"
     regulatory      4667..4672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /note="hexamer: ATTAAA"
     polyA_site      4685
                     /gene="Usp38"
                     /gene_synonym="4631402N15Rik; 4833420O05Rik; mKIAA1891"
                     /note="major polyA site"
ORIGIN      
        1 gggtgttccg cgcctccggc tcctctcctt ggcagatcga ggtactcgca ttgacagtgc
       61 ctcctgactc aacccagggc gacttttaac tgcccacccg cgggagccgg ggctccgcac
      121 tgacccggga cacgaaggcg ctcctcacct tccagctcag cctggagggt ccctgcgccc
      181 ggaggctggg agaggtcgcg ggcccagcga ggcagcctta tgcggacctc cggcccctga
      241 ggcggaccgc ggggacccgc agcctttcgg cgtcccagaa tcgctcgctc ccgtcccggc
      301 tcggatgggc cttcccactc gataaatgtg gctgctgagg cggcggtggc ggtggccggt
      361 cctgctgctg gttggctcca agttcctccc cgccggggcg ctttgctgcc ccccggggct
      421 gccgctgcca gctctttatc cccagggcct ggccttgcag agtggcgacg atggacaaga
      481 ttctggaagg cctggtgagc tcctcgcacc cgctgcccct caagcggatg attgtgcgga
      541 aggtggtgga gttcgcggag cattggctcg acgaggcgca gtgcgaggcc atgtttgacc
      601 tgacgacccg cctcatcctg gagggccagg accctttcca gcgacaagtg ggccaccagg
      661 tgctggaggc ctacgcgcgg taccaccggc cggagttcga gtccttcttc aacaagactt
      721 tcgtgttggg cctccttcag cagggctacc actcagtgga caggaaggac gtcgccatcc
      781 tggactacat tcacaacggc ctgaagctga ttatgagctg cccgtcggtg ctggatctct
      841 tcagcctgct ccaggtggag gtcctgcgaa tggtttgcga gaggccggag ccagtgctct
      901 gtgcccggct gagcgacctc ctgaccgatt tcgtgcagtg cgtccccaaa gggaaactgt
      961 cagttacctt ctgtcaacag ctggttcgaa cgataggtca tttccagtgc gtgtccactc
     1021 aggagaagga actacgggag tatgtctccc aggtaacgaa agtgagtacc ttactacaga
     1081 atatttggaa ggctgagccc tccacgctgc taccttctct gcaagaagtt tttgcaagca
     1141 tctcttccac agatgcatcc tttgagccct cggttgcctt ggcaagcctg gtgcagcata
     1201 ttcctctgca gatgatcaca gtcctcatca ggagcctaac caccgaccca aatgtaaaag
     1261 atgcgagtat gacccaagct ctctgcagaa tgattgactg gctgtcctgg ccattggctc
     1321 agcatgtaga tacgtgggta attgctctcc tgaaaggact ggcagctgtt cagaagttta
     1381 ctattttgat agatgttact ttgctgaaaa tagaactggt ttttaaccga ctttggtttc
     1441 ctctcgtgag acctggtgct cttgcagtcc tctctcatat gctgcttagt tttcagcatt
     1501 ctcctgaggc attccatgtg attgtccctc atatagttaa cttggttcac tccttcagaa
     1561 gtgatggcct accttccagc acagccttcc tagtacagtt aacagagttg gttcactgta
     1621 tgatgtacca ttactccgga ttcccagatc tctatgagcc tattctggag gcagtaaagg
     1681 actttcctaa gcccagtgaa gaaaagatta agctgattct caatcaaagc gcctggactt
     1741 ctcaatccaa tgctttggca tcttgcttgt ctagactttc tggaaaatct gaaactggaa
     1801 aaactggtct tattaacctg ggaaacacgt gttacatgaa cagtgtttta caagcattgt
     1861 ttatggctac agagttcaga agacaagtat tatctttaaa tctaaatggg tgtaattcgt
     1921 taatgaaaaa attacaacat ctttttgctt ttttggctca tacacaaagg gaagcttacg
     1981 cacctcggat attttttgag gcttccagac ctccgtggtt tactcccagg tcacaacagg
     2041 actgctctga gtacctcagg tttctgctgg acagactcca tgaagaagaa aagatcttgc
     2101 gagttcagtc ctcacataag ccttcggaag gtctggactg tgctgaaact tgtttacaag
     2161 aggtgaccag taaggtagca gtgcccacag agtctcctgg tacaggtgac agtgagaaga
     2221 ctctaataga gaaaatgttt ggagggaagc tacggactca catctgctgc ctaaactgtg
     2281 ggagtacctc acacaaagtt gaagccttca cagatctttc gctagccttt tgtcctagcc
     2341 cttctgtgga agacctgtct ttccaagata cagcttcgtt acccagtgct caagatgatg
     2401 ggctaatgca aaccagtgtc gctgacccag aagaagagcc agtagtttat aatccagcaa
     2461 cagctgcctt tgtctgcgac tcagttgtga atcaaagagt attaggcagt cctcctgttg
     2521 agtttcactg tgctgaaagc tcttctgtcc ctgaagaatc tgcaaagatt ctcatcagta
     2581 aagatgtacc tcagaaccca ggaggtgaaa gcacaacttc agtgactgac ttactaaact
     2641 actttctggc tccagaggtt cttactgggg agaaccaata ctactgtgaa agctgtgcct
     2701 ctctacagaa cgcagagaaa actatgcaaa tcacggagga gcctgagtat cttatcctta
     2761 cgctcctgag attctcctac gatcagaagt accatgtgag aagaaaaatt ttagacaatg
     2821 tgtcactgcc tctggttttg gagttgccag ttaaaagaac tgcttccttc tcttccttgt
     2881 cccagagttg gtctgtagat gttgacttca ctgatattaa tgagaaccta cctaaaaaat
     2941 taaaaccttc tgggactgaa gaagctttct gccccaaatt agtgccctac ctattaagtt
     3001 ctgttgttgt gcactctggt gtgtcctctg agagtggcca ttactactct tatgccagaa
     3061 acatcacagg tacagagtct tcataccaga tgtgccccca gtctgaaagt ctggcattag
     3121 caccctccca gagttgttta ctaggggtag aaagccccaa tacagtcatt gaacaggact
     3181 tggaaaataa ggaaatgtca caagagtggt ttttatttaa tgacagcagg gtgacattta
     3241 cttcatttca gtcagttcag aaaatcacaa gtaggtttcc aaaagacaca gcttatgtgc
     3301 ttttgtacaa aaaacaaagc agagctaatg gcatagacag tgacaatcca gccagtggtg
     3361 tctgggccaa tggagatcca cccctacaga aagagctgat ggatgccata acaaaggaca
     3421 acaagctgta tttgcaggaa caagaattga atgctcgagc ccgggccctg caagctgcat
     3481 ctgcttcctg ttcgttccga cccaatggat ttgatgacaa tgacccacca ggaagctgtg
     3541 ggccaactgg tgggggcggt ggaggaggct tcaatacagt tggcagactc gtattttgac
     3601 cctgagagaa ctgaaaatgt atctggtcac aaaacatcca atactgtggc tgttaaaatg
     3661 tcaggctgta acctatagca tatctatctt ttatttttct tttcattaga cccgaatact
     3721 ttaagaaaat atactcagtg gttgttttta ttttcttgac aaaaattcat catggaaaaa
     3781 aaaaatctac ctcttaaact catttgcagt tacagttaga catgtttggc cacaagtatt
     3841 tagaggaaaa ggcatacctg ctccctaatt aagctgcatt aaatttggta gaaggattta
     3901 aatggtgtat tttcagttgt actgaacaaa ataattcact tatcattctt tgtacaaaaa
     3961 ttgatgctag atatatctta agaaaaatga aattcttatt tctggtataa ttaccccaat
     4021 attaaattca agtctttgaa aatagtagag atggtgagtc tctggaggcg atagcacctt
     4081 ccaccccagc tgccagtctc tgggctgctg tctccgctgt cctcggcgtt gcactccaga
     4141 ttcaggaaca agtgtcattt acacacgtgg caagtgaatt cacacaaggt gcatgacgcc
     4201 agagggcagg ggttttaact gaactttgta ggatttccag ttgtccaagg actttaaaat
     4261 cctgtttcag ggagtgtatc tcctatgtgt tttaaaggag gtgagtctct gaatgtgcct
     4321 tgcagtactg taattcaaaa ataggttctc tttggctgcg gcggaaagtt ttctaaaaca
     4381 aagcgttagg aaggaatttt gtgctaacat taaaattata attttttaag gtattagata
     4441 tttcagaagt aagatctggt ggttctaaac tagtaagtgt aatggtaaat ttctaactct
     4501 tagaaaaatt cggaggaaat gaagctagtt taagtaaaaa atctttaatt gatttgttac
     4561 ttaatcttca cattaaacat tgataacatt tttagagttg tatatttgga tttttttcct
     4621 ttgagacaca tgccttacac ataaaatata atctgcttca tgaaatatta aaatgccaca
     4681 cctcaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
