LOCUS       NP_001297591             957 aa            linear   ROD 30-APR-2024
DEFINITION  ubiquitin carboxyl-terminal hydrolase 37 isoform 2 [Mus musculus].
ACCESSION   NP_001297591 XP_006496121
VERSION     NP_001297591.1
DBSOURCE    REFSEQ: accession NM_001310662.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 957)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 957)
  AUTHORS   Qin,S., Yuan,Y., Huang,X., Tan,Z., Hu,X., Liu,H., Pu,Y., Ding,Y.Q.,
            Su,Z. and He,C.
  TITLE     Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by
            transcriptional activation of Usp37
  JOURNAL   Nucleic Acids Res 50 (16), 9319-9338 (2022)
   PUBMED   36029179
  REMARK    GeneRIF: Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis
            by transcriptional activation of Usp37.
REFERENCE   3  (residues 1 to 957)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 957)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   5  (residues 1 to 957)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB624535.1, AK035640.1, AK030013.1 and AC098570.7.
            
            On Jul 17, 2015 this sequence version replaced XP_006496121.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate in-frame exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.111153.1,
                                           SRR17784651.234197.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..957
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     Protein         1..957
                     /product="ubiquitin carboxyl-terminal hydrolase 37 isoform
                     2"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 37; ubiquitin
                     carboxyl-terminal hydrolase 37; ubiquitin thioesterase 37;
                     deubiquitinating enzyme 37; ubiquitin-specific-processing
                     protease 37; ubiquitin thiolesterase 37"
                     /calculated_mol_wt=107603
     Region          3..105
                     /region_name="UCH_N"
                     /note="N-terminal of ubiquitin carboxyl-terminal hydrolase
                     37; pfam16674"
                     /db_xref="CDD:465227"
     Region          342..>601
                     /region_name="UCH"
                     /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443"
                     /db_xref="CDD:425685"
     Region          <864..927
                     /region_name="Peptidase_C19"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; cd02257"
                     /db_xref="CDD:239072"
     CDS             1..957
                     /gene="Usp37"
                     /gene_synonym="4932415L06Rik; C330008N13Rik"
                     /coded_by="NM_001310662.1:376..3249"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS78616.1"
                     /db_xref="GeneID:319651"
                     /db_xref="MGI:MGI:2442483"
ORIGIN      
        1 msplkiygpi rirsmqtgit kwkegsfeiv ekdnrvsllv hyntggiprv fqlshniknv
       61 vlrpsgikqs rlmltlqdns flsidkvpsk daeemrlfld avhqnrlhaa mkasqgsgsf
      121 gtilgsrtsq ketnrqlsys dnqasskrgs letkdeipfr kvlgspgrgp iktvtgggma
      181 vtrtipsltl tstplrsgll enrtekrkrm lsgseltedy pkendsssnn kamtdpsrky
      241 ltscrekqls lkqaeenrts gllplqsssf ygsragskdy ssgvtnldrc nvssqtpsak
      301 rslgflpqpt plsvkklrcn qdyagwnrpr vplsshqqql qgfsnlgntc ymnailqslf
      361 slqsfandll kqsipwkkip fnalirrfan llikkdicns etkkellkkv knaisataer
      421 fsgyvqndah eflsqcldql kedmeklnkt wktepvlgee nlpdtsatkv ftcpvitnle
      481 fevqhsiick acgetipkre qfndlsidlp rrkkplpprs iqdsldlffr aeeleyscek
      541 cggkcalvrh kfnrlprvli lhlkrysfnv alslnnklgq qviiprfltl ashctestkp
      601 pvtlgwsapv amkftfksks svtscldsds edelkrsvvl sqrlcdlpgn eqyqedvekd
      661 lklcrlepgk aelensgfdr mseeevlaav leisrreasp vlspedddkp tsspdtgfae
      721 ddipempenp dameiekskt itepgpasft eitkdcdenk enktpegsqg evdwlqqydv
      781 drereeqelq qalaqslqeq eaweqkeddd lkratelslq efnnsfldsl gsdedsgned
      841 vfdmeyteae aeelkrnaet galphsyrli svvshigsts ssghyisdvy dikkqawfty
      901 ndlevskiqe aavqsdrdrs gyiffymhke ifdelletek tsqalsmevg raarqas
//
