LOCUS       NM_001033528            5609 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ubiquitin specific peptidase 36 (Usp36), mRNA.
ACCESSION   NM_001033528 XM_126772 XM_916680
VERSION     NM_001033528.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5609)
  AUTHORS   Ryu,H., Sun,X.X., Chen,Y., Li,Y., Wang,X., Dai,R.S., Zhu,H.M.,
            Klimek,J., David,L., Fedorov,L.M., Azuma,Y., Sears,R.C. and
            Dai,M.S.
  TITLE     The deubiquitinase USP36 promotes snoRNP group SUMOylation and is
            essential for ribosome biogenesis
  JOURNAL   EMBO Rep 22 (6), e50684 (2021)
   PUBMED   33852194
REFERENCE   3  (bases 1 to 5609)
  AUTHORS   Fraile,J.M., Campos-Iglesias,D., Rodriguez,F., Astudillo,A.,
            Vilarrasa-Blasi,R., Verdaguer-Dot,N., Prado,M.A., Paulo,J.A.,
            Gygi,S.P., Martin-Subero,J.I., Freije,J.M.P. and Lopez-Otin,C.
  TITLE     Loss of the deubiquitinase USP36 destabilizes the RNA helicase
            DHX33 and causes preimplantation lethality in mice
  JOURNAL   J Biol Chem 293 (6), 2183-2194 (2018)
   PUBMED   29273634
  REMARK    GeneRIF: Usp36 is essential for cell and organism viability because
            of its role in ribosomal RNA processing and protein synthesis,
            which is mediated, at least in part, by regulating DHX33 stability.
REFERENCE   4  (bases 1 to 5609)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 5609)
  AUTHORS   Anta,B., Martin-Rodriguez,C., Gomis-Perez,C., Calvo,L.,
            Lopez-Benito,S., Calderon-Garcia,A.A., Vicente-Garcia,C.,
            Villarroel,A. and Arevalo,J.C.
  TITLE     Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor
            Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions
            over the Neurotrophin Receptor TrkA and Potassium Voltage-gated
            Channels 7.2/3 (Kv7.2/3)
  JOURNAL   J Biol Chem 291 (36), 19132-19145 (2016)
   PUBMED   27445338
  REMARK    GeneRIF: USP36 actions extend beyond TrkA because the presence of
            USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
REFERENCE   6  (bases 1 to 5609)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 5609)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591404.4.
            
            On or before Apr 10, 2009 this sequence version replaced
            XM_916680.2, XM_126772.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR13948564.502709.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMN00849374,
                                    SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AL591404.4         77364-77651         c
            289-388             AL591404.4         75074-75173         c
            389-650             AL591404.4         73145-73406         c
            651-872             AL591404.4         72266-72487         c
            873-983             AL591404.4         67223-67333         c
            984-1086            AL591404.4         66612-66714         c
            1087-1154           AL591404.4         64675-64742         c
            1155-1225           AL591404.4         64167-64237         c
            1226-1308           AL591404.4         63546-63628         c
            1309-1420           AL591404.4         62375-62486         c
            1421-1561           AL591404.4         60923-61063         c
            1562-1662           AL591404.4         60358-60458         c
            1663-1801           AL591404.4         59539-59677         c
            1802-2470           AL591404.4         55951-56619         c
            2471-2601           AL591404.4         55209-55339         c
            2602-3144           AL591404.4         52105-52647         c
            3145-3344           AL591404.4         51050-51249         c
            3345-3446           AL591404.4         50442-50543         c
            3447-3562           AL591404.4         49796-49911         c
            3563-3714           AL591404.4         49386-49537         c
            3715-5609           AL591404.4         47060-48954         c
FEATURES             Location/Qualifiers
     source          1..5609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.06 cM"
     gene            1..5609
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /note="ubiquitin specific peptidase 36"
                     /db_xref="GeneID:72344"
                     /db_xref="MGI:MGI:1919594"
     exon            1..288
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            289..388
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            389..650
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..3694
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 36; deubiquitinating
                     enzyme 36; ubiquitin-specific-processing protease 36;
                     ubiquitin thioesterase 36"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 36"
                     /protein_id="NP_001028700.1"
                     /db_xref="CCDS:CCDS48998.1"
                     /db_xref="GeneID:72344"
                     /db_xref="MGI:MGI:1919594"
                     /translation="MPIVDKLKEALKPGRKDSAEDGDLGRLLAASAKKVLLQRIEFEP
                     ASKSFSYQLESLKSKYVLLSARAEGASRHRSGDELQARKPGTERVSGSGGDGVPAPQK
                     VLFPVERLSLRWERVFRVGAGLHNLGNTCFLNSTIQCLTYTPPLANYLLSKEHARSCH
                     QGGFCMLCLMQNHMVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTID
                     AMQKACLNGYAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDIALEIR
                     QAANIVRALELFVKSDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANF
                     SGGKITKDVGYPEFLNIRPYMSQSSGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNG
                     QWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGPVSRVGATLPSRPKVVPE
                     HSKKSPGNGVVPSPLMAKRQDSVMMRKLPAPEEVGVPVSRNGSLPGLKLQNGCAPAKT
                     PAGSPSPRLTPTPTHMPTILDEPGKKVKKSAPLQSLTTSPTTSQGSPGTGESRSQRPG
                     SWASRDTIFSTSPKLLARAITNGHRLKGEGSGVDLEKGDSSSSSPEHSASSDPAKAPQ
                     TAESRAAHACDSQGTNCPTAGHPKALLNGVDAKMVKLKSPALSSTTTEPTSLMSPPPA
                     KKLALSAKKASTLRRATGNDIGSPSPSAFCDLTSPMKATHPVVASTGPVSKTRTAAPA
                     PRPSTHPHSASLSSSSAKPLGTSEPQSCRPSAWTPLPQVNGHFTSHLHQLPEASEALH
                     SPSKKRKKTPNGDPQRLGIDTLLPQCLRGAPAAARRKRKKRCSEGEGATAPKQEGQFQ
                     DQSWSSGSQKEEGTQPQVNGHQVSHILDSYHVSSRKRRKRKRSEGLSQEATPSQDLIQ
                     HSCSPVDHSEPEARTELQKKKKKKRRKRKPEPQQDEESKHPGDQRSPRPSVTPVPALS
                     VNGHLPSDCLGLGQAPLVTWNRDQEPDVVQALLQDSSDKAYGKKVLTWDGEPSAISQD
                     AIKDSRLARTQTVVDDWDEEFDRGKEKKIKKFKREKKRNFNAFQKLQSRRNFWSVTHP
                     AKVASLSYRR"
     exon            651..872
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            873..983
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1086
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1154
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1225
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1308
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1420
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1561
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1662
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1801
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2470
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2601
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..3144
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3344
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3446
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3562
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            3563..3714
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..5609
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4384..4389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /note="hexamer: GATAAA"
     polyA_site      4408
                     /gene="Usp36"
                     /gene_synonym="2700002L06Rik; mKIAA1453"
                     /note="major polyA site"
ORIGIN      
        1 cgcctcttaa ggcgaacgtg cccttcacgc ggactcaggg agcacattgc agtgcggctc
       61 ctttaaacgt cgtggtgaca cgtgtgtgag gctctggagg cccggatggt gcgcatgctg
      121 gcccggcccg gatcggacgc tggtgctgcg cgggccttcc gcgggttccc gagaggccta
      181 ggaggtcgag gtcgggcgcg gcggagcgca ggagcttccg cggggcttgg gacgaggagg
      241 gtgcgcgttc tacccgcggg ttttggggac tccagcgaag gctgacagtc caggggagcg
      301 ccttcccggt cagttccgtt cctcccttga gaacctggtt cccttacctg ctgcagagag
      361 aagcagcagc caggcacggg caccccagga atgcaccatg cctatagtcg ataagctgaa
      421 ggaggctctc aagcctggcc gcaaggactc ggccgaggat ggggacctgg gcaggctgct
      481 ggcagcctct gccaagaagg tgcttctgca gaggattgag tttgagccgg ccagcaagag
      541 cttctcctac cagctggagt ccttgaagag caaatacgta ctgttgagcg ccagggctga
      601 gggagccagt cgccacagga gcggagatga actccaggcc aggaaaccag gcaccgagcg
      661 tgtgtctgga agtggaggcg acggagtccc tgccccgcag aaagtgctct tccctgtgga
      721 gcgtctgtcc ctgaggtggg aacgtgtttt ccgagttggc gcagggctgc acaacctggg
      781 taacacctgc ttcctcaact ccaccatcca gtgcttgacc tacacaccac ctctggccaa
      841 ctacttgctc tccaaggagc acgcacggag ctgtcaccaa gggggcttct gcatgctgtg
      901 tctcatgcaa aaccacatgg tccaggcctt tgccaacagc ggcaatgcta tcaagcccgt
      961 ctccttcatc agagacctga aaaagattgc ccggcacttc cggttcggga accaagagga
     1021 tgcacacgaa ttcctgcggt acaccattga tgcgatgcag aaggcctgct tgaatggcta
     1081 cgctaagttg gatcggcaga cacaggctac taccctggtg catcagatct ttggaggcta
     1141 tctcaggtcc cgagtgaagt gctctgtgtg caagagtgtc tcagacacat acgatcccta
     1201 cttggacata gcactggaga tccggcaagc tgcaaatatt gtgcgcgctc tggaactttt
     1261 tgtgaagtca gatgtcctga gtggagagaa cgcctatatg tgtgctaagt gtaagaagaa
     1321 ggttccagcc agcaagcgct tcaccatcca tagaacatcc aatgtcctga ctctgtccct
     1381 caagcgcttc gccaacttta gtggggggaa gatcaccaag gatgttggct atccagagtt
     1441 cctgaacatc cgtccataca tgtcgcagag cagcggtgat cctgtcatgt atgggctcta
     1501 tgctgtcctg gtgcactcag gctacagctg tcacgctggg cactactact gctatgtgaa
     1561 ggccagcaat ggacagtggt accagatgaa cgactccttg gtccattcca gcaatgtcaa
     1621 ggtggttctg aaccagcagg cctacgtgct cttctatctg cggattccag gctctaagaa
     1681 aagtcctgag ggccctgtct ccagagtggg cgccactctc cctagccgtc ccaaagttgt
     1741 tccagagcac tccaagaaga gccctggcaa tggggttgtt ccctccccgc tgatggcaaa
     1801 gcgacaagac tctgtaatga tgagaaagct cccagcccct gaggaggttg gcgtacctgt
     1861 gtccagaaat ggctcccttc ctggcctgaa gttacagaac ggatgtgctc ctgccaagac
     1921 acctgccggg tccccgtccc caagactcac gcccacgccc actcatatgc ccaccattct
     1981 ggatgagccc ggaaagaagg tgaagaagtc agccccactg cagtctctca ccacatctcc
     2041 aaccacttct cagggctctc ctgggaccgg cgagtcccgg agccagcggc ccggctcctg
     2101 ggcaagcaga gacaccatct tctctacctc cccgaagctc ctggccagag ccattactaa
     2161 cgggcacagg ctgaagggcg aaggcagtgg tgtggacctg gagaaggggg attcaagcag
     2221 ctccagcccc gagcactctg ccagcagtga ccctgccaag gccccgcaga ccgcagagag
     2281 cagagctgcg catgcctgtg attctcaggg aacaaactgt cccaccgctg gccatcccaa
     2341 agcgctgttg aatggagtag atgccaagat ggtgaagttg aagtccccgg ccctgagcag
     2401 caccacaacc gagcccacaa gcctcatgtc tcctccacca gccaaaaaac tggccctgtc
     2461 agccaagaag gccagcaccc tgcggagggc gaccggcaat gacatcggtt caccttcccc
     2521 ctcagcattc tgcgacctca cctcccccat gaaagccacc caccccgtcg ttgcctccac
     2581 tgggcctgtc agtaagacca ggactgctgc acctgccccc cgaccgtcca cccaccccca
     2641 ctctgcatct ctgtccagta gtagtgccaa gcccttaggg acatcagagc cacagagctg
     2701 ccgcccctct gcctggacac ccctgcctca ggtcaatgga cacttcacgt cccacttaca
     2761 ccaactgcca gaggccagcg aggccctaca cagcccctcc aaaaagagga aaaagacccc
     2821 taatggagat ccccagagac tgggcatcga cacgctcctc ccacagtgcc tcaggggagc
     2881 acctgcagca gcacgcagga agagaaagaa gaggtgctcg gagggtgagg gtgccacagc
     2941 tcccaagcag gaaggccaat ttcaggacca gtcttggagt tccgggagcc agaaggaaga
     3001 gggtacgcag ccccaggtaa atggccatca agtgagtcac attctggaca gttaccatgt
     3061 gagcagcagg aaaaggagga agaggaaaag atcggaagga ctcagccagg aagccacccc
     3121 gtcgcaggac ctaattcagc acagctgctc ccctgtagac cacagtgagc ctgaggccag
     3181 gacagagttg cagaagaaga agaagaagaa aagaaggaaa agaaagcccg agccacagca
     3241 ggatgaagag agcaagcacc caggagacca gaggagccca aggcccagtg tcaccccagt
     3301 ccctgcgttg agtgtgaatg gccatcttcc tagtgactgc ttggggctgg gacaagcacc
     3361 tctcgttacc tggaacagag atcaggaacc cgatgtggtc caggcgttgc ttcaggactc
     3421 atctgataag gcttatggga aaaaagtttt gacctgggat ggcgagcctt cagccatcag
     3481 tcaggacgcc atcaaagaca gcagactagc ccggacccag accgtggttg acgactggga
     3541 tgaagagttt gatcgaggga aggaaaagaa aattaaaaag ttcaagagag aaaagaagag
     3601 aaacttcaat gccttccaga agcttcagag taggcgcaac ttttggtctg tgacgcatcc
     3661 tgctaaggtg gccagcctca gctatcgccg ctgagcttgc tgtggccatt agaggaagag
     3721 cagtgtgcct gtgccacagc atccagagct gtcacatcac atccttggag ctgtctgctt
     3781 ggatctgagg atcgcatcgt gcatggtcat ggtggaggct cctggtccca ctgttcacag
     3841 atgatccggt gcaagtgctc agctcagggc ctctggtggt ttcacgttga acctcacaag
     3901 agaaaacctg gcctgtggtg tcatgctgac agtaaccttg gagacctctg gaaaggttga
     3961 gcatcttcct catagacctg tggtccagta ggaacaccgt tcctggcctg gggctgtcag
     4021 ataaggaaca gaggccaggg tggcatttgg tggtgccttt tctggtgagc tgtcctttgc
     4081 tctctgaagc tggagctgtc tcgtggctct cctctcagag gggcctctgt atgactgact
     4141 atcagctgca acaagaacaa gccctgctga ctgcactgcc cccatcccca cccccaaagt
     4201 gcatctcctt gaaagaccac cacttcttcc agaaagctgc agctgctggg cagggagagc
     4261 ctctgcttcc gtggctgcca gccctgcggg gagactggca agctcccgca tctgccacaa
     4321 cctgtggatc tctgtcaagg tggtggtctt tagagacgaa ttctccgtta ttttactact
     4381 tacgataaag cctttatttt tgaccaggcc tgtggctacc agtagcaata tgtttctcta
     4441 atatgcagac actggctttg tttgctcaat tttgtgagtg ctttgacatt gacatgatct
     4501 ccttccctgt cttgctcaag ctgcccctat ggacttaggg ttaacaaaca agactcctca
     4561 cccaggagac agaaggtgcc agaaggttcc tcctcatggg gtgcatctct tcgttcccca
     4621 agccccagcc tgctctgggc tgggctccta gtctgggcct cttgggagcg ctggagctgc
     4681 ctctcatttc catgtgtagc gttctgttca gctgcaggct cagggtctta cttgctgcag
     4741 atgtgggaag aaagggttgt gttctccgtg ggccggagtt gaggtcctgt ttctgtgtgg
     4801 gtgtttcctt cctgtctgtt tctttccctt tagagaaaag gcgagaacag tgcccctcga
     4861 tgggtctgct ggtgagtgag tcttccagct gtatgcgatg gtccttgtgt ggctgctgtc
     4921 tggatattgt gtctgggagt gctgtgggct ccgtgttctc tcagaggggg gcagggaccg
     4981 tccttctgag gtactgccat ccttcctgta gcagctgctt cctgggtaca ttggttttct
     5041 ttacagcctt ctctagtaga aaggtgtaaa gctgccagca cagaactgat ctgtcttccg
     5101 tgtctcctca gattggttcc ttcctttgtg ctctagatta cgcagtgtaa agtctcctcc
     5161 aggggcacgt agtccactgc ctcttaggca gtcatgatcc cccatctact gtcctgactt
     5221 ctggcagcgt gtgttgctgt cagtgatggc aagtcctttt cttccttaga agccattagg
     5281 aacaggtcat gggtggaatg agttcttggt ggcgtactga cataaataat tgaagctttc
     5341 ctaaaagtag tcattttgtt gggtcaaatc aaatcagttt gaactttgtg cttggcagta
     5401 gacatgtttt aggcccattt gcagagggcc acctccctgg tgtttctgtt cttgctcacc
     5461 tgcctgttag gggctgtttc catccaacat cctgtgtggc tgcgtctgta tgtgtgcagg
     5521 aatccccgta ctcttccact tcctcttcag gggtccccag atattgccaa gatcttggtg
     5581 caataaagta atgcattttt tttttgtga
//
