LOCUS       NM_001177412            4325 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 35 (Usp35), mRNA.
ACCESSION   NM_001177412 XM_006507825 XM_886523
VERSION     NM_001177412.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4325)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155933.3.
            
            On or before Jun 17, 2019 this sequence version replaced
            XM_006507825.3, NM_001177412.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.115531.1,
                                           SRR14995048.1651419.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AC155933.3         189620-189892       c
            274-1042            AC155933.3         183075-183843       c
            1043-1175           AC155933.3         181991-182123       c
            1176-1305           AC155933.3         179832-179961       c
            1306-1407           AC155933.3         179343-179444       c
            1408-1566           AC155933.3         177750-177908       c
            1567-1760           AC155933.3         172517-172710       c
            1761-1854           AC155933.3         171282-171375       c
            1855-1961           AC155933.3         170839-170945       c
            1962-3234           AC155933.3         169136-170408       c
            3235-4325           AC155933.3         167189-168279       c
FEATURES             Location/Qualifiers
     source          1..4325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.47 cM"
     gene            1..4325
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /note="ubiquitin specific peptidase 35"
                     /db_xref="GeneID:244144"
                     /db_xref="MGI:MGI:2685339"
     exon            1..273
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     exon            274..1042
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..3399
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /note="ubiquitin specific protease 35"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 35"
                     /protein_id="NP_001170883.1"
                     /db_xref="CCDS:CCDS59734.1"
                     /db_xref="GeneID:244144"
                     /db_xref="MGI:MGI:2685339"
                     /translation="MDKILEAVVTSSYPASVKQGLVRRVLEAARQPLEREQCLALLAL
                     GARLYVGGTEELPRRVGCQLLHVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGARALA
                     CVQLGLQLLPDGPAADEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGAH
                     RLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELF
                     AVISCTEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSW
                     PLGKNIDKWIIALLKGLAAVKKFSILIEVSLAKIEKVFSKLLYPIVRGAALSVLKYML
                     LTFQHSHEAFHLLLPHIPAMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYE
                     PVMEAIKDLHIPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTC
                     YVNSVLQALFMASDFRHCVLRLTENNSQPLMTKLQWLFAFLEHSQRPAISPENFLSAS
                     WTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGMRICQKLKQSSLPSPQEELPSSNATSV
                     EKMFGGKIVTRICCLHCLNVSSREEAFTDLSLAFPPPERSRHRRLGSVMLPTEDVRVQ
                     ELTLAPRAPGAQRQRKRCITGDAPRTGLDSEGVDTIGTGGRSGQEKVEREQAGKEKEV
                     AEDREEEGTREEEKEEGEEKDKEKEKKEDEKEKEAENGKEKEGDSLGPGTHREAATPP
                     REQTCGPEGSRSVLDLVNYFLSPERLTAENRYYCESCASLQDAEKVVELSQGPRYLIL
                     TLLRFSFDLRTMRRRKILDDVTIPLLLRLPLAGGQGQAYDLCSVVVHSGVSSESGHYY
                     CYAREGAARPAPVLGSTERPEPENQWYLFNDTRVSYSSFESVSNVTSFFPKDTAYVLF
                     YRQRPREDPAAEPGSPRVRAEPTLHKDLMEAISKDNVLYLQEQEKEARSRAAYISTLP
                     APPHWGRGFDEDKDEDEGSPGGCNPAGGNGDFHRLVF"
     exon            1043..1175
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1305
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1407
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1566
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1760
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1854
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1961
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..3234
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..4325
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4305..4310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /note="hexamer: AATAAA"
     polyA_site      4325
                     /gene="Usp35"
                     /gene_synonym="Gm1088; Gm493"
                     /note="major polyA site"
ORIGIN      
        1 gcagggtaac ccccgctgtg gctccgcccc gtttccccgc acctcacccc tctcccagtt
       61 ccgtcccgca gctctgagac cgcgcagttg cactgcccag gtccatctag ggttgtgcgg
      121 agcggggtgg gtggagttgg acatcacaaa gtagcagcag catccctgcg gtctgggacc
      181 cctcggtagg ggagcggagg acccgccctg acctcgactg gcccagccta gtctagtccg
      241 gcccatgcgc cccgcccagg agtgggttct aaggcaagaa aactgaggcc cttctacagt
      301 atcagcaccc aaggatctgg accgggttgt gggtggcgca gtccctgtcc ccagccccgt
      361 gcggccgtca tggacaagat cctggaggcc gtggtgactt cgtcctaccc tgcgagtgtg
      421 aagcaagggc tggtgcggcg cgtgctggag gccgcgcggc agcccttgga gcgggagcag
      481 tgcctggcgc tgctggccct gggcgcgcgc ctctacgtgg gtggcacgga ggagctgccg
      541 cgccgcgtgg gctgccagtt gctgcacgtg gcgggtcgcc accaccccga cgtcttcgcc
      601 gagttcttca gtgcgcgccg cgtgctgcgc ctgctgcagg gcggtgcagg gcccccgggg
      661 gcgcgcgcgc tggcctgtgt gcagctaggg ctgcagctgc tgcccgacgg gcccgcggcg
      721 gacgaggtgt tcgcgctgct gcggcgcgag gtcctgcgca ccgtgtgcga gcgcccgggc
      781 cccgccgcct gcgcgcaggt cgcccggctg ctggcgcgcc acccgcgctg cgtacccgac
      841 ggcgcgcacc gtctgctctt ctgccagcag ctggtgcgct gcctcggtcg cttccgctgc
      901 ccagccgagg gcgaggaggg cgcggtggag ttcctggagc aggcccagca ggtgagcggg
      961 ctcctggcgc agctgtggcg cgcgcagccc gccgccatcc ttccctgcct caaggagctg
     1021 ttcgctgtca tctcctgtac agaggaggag ccaccgtcca gcgccttggc cagcgtggtc
     1081 cagcacctcc cattggagct tatggatggt gtggtccgga acctcagcaa tgatgatagt
     1141 gtgacagact cccagatgct gactgccatt agcaggatga tcgactgggt gtcctggccc
     1201 ctggggaaga acattgacaa gtggatcatt gccctgctga agggcctggc tgctgttaag
     1261 aagttcagca tcttgatcga ggtttcgctc gccaaaattg agaaggtctt ctctaagctg
     1321 ctgtacccca tcgtgcgggg agctgcccta tctgtcctta agtacatgct cctgactttc
     1381 cagcactccc atgaggcctt ccacctgctt ctccctcaca ttcccgccat ggtggcctct
     1441 ctggtcaagg aggactcgaa ctctgggacc agctgcctgg agcagctggc agagctggtg
     1501 cactgcatgg tgtttcggtt cccgggcttc ccagacctgt atgagcctgt catggaagcc
     1561 atcaaggacc tccacattcc caatgaggac cgaatcaagc agctgctggg gcaggatgcc
     1621 tggacctcac agaagagtga actggctggc ttctatcccc ggctcatggc caagtcagac
     1681 acgggcaaga ttggcttaat taacttgggc aacacatgct acgtgaacag tgtccttcag
     1741 gccttattca tggcttctga ctttcgacac tgtgtgctcc gcttgactga gaacaactcc
     1801 cagcccttga tgaccaagct gcagtggctc tttgccttcc tggagcacag tcagaggcct
     1861 gccatctctc ctgagaactt cctctctgcg tcctggacgc cctggttcag ccctggcacc
     1921 cagcaagact gttcagagta tctgaagtac ctgctggatc ggcttcatga agaagagaaa
     1981 actgggatga ggatctgcca gaagctcaag cagtccagct tgccatcccc acaggaagag
     2041 ctccccagct ccaatgcaac gtcggtggag aagatgttcg gaggcaagat tgtgacccgg
     2101 atatgctgtc tccactgcct caatgtttcc tcaagggagg aagccttcac agacctctct
     2161 ttggccttcc ctcctcctga gagaagtcgc caccgccgcc tcggctccgt gatgctcccc
     2221 acggaggatg tgcgagtcca ggagttgaca ctggctccca gagcccccgg ggcgcagagg
     2281 cagaggaagc gctgcatcac aggggacgct cctcgcactg ggctggacag tgaaggtgtg
     2341 gacaccatag gcactggtgg acggagtggg caggagaagg tggagaggga gcaggctggg
     2401 aaggagaagg aggtggcaga ggacagggaa gaggaaggaa caagggaaga ggagaaagaa
     2461 gagggggaag agaaagacaa agagaaagag aagaaggaag atgaaaagga aaaggaagct
     2521 gagaatggca aggagaagga aggggacagc ttaggaccag ggacccatag ggaggctgcc
     2581 actccaccca gggagcagac atgcggccct gagggttccc gctctgtact ggacttggtc
     2641 aactacttcc tgtcccctga gaggctgaca gctgagaacc gctactactg tgagtcctgt
     2701 gcctccctgc aggatgcgga gaaggtggtg gagctgagcc agggtccacg ctacctcatc
     2761 ctcacactac tgcgcttctc ctttgacctg cgtaccatgc ggcggcgtaa gatcctggac
     2821 gatgtcacca tccccctttt gctgcgcctg ccactggctg ggggtcaggg ccaggcctat
     2881 gacctctgta gtgtggtggt gcactctgga gtgtcctcag agagtggcca ctattactgc
     2941 tatgctcgtg agggtgctgc tcggccagct cctgtcctgg gatccacaga gaggcctgag
     3001 cctgagaacc agtggtacct gtttaatgat acccgggtgt cttactcatc ctttgagtct
     3061 gtcagcaatg tcacctcctt cttccctaag gacactgcct atgtgctctt ctaccgccag
     3121 aggcccaggg aggaccctgc ggctgagccc ggctctccta gagtccgagc agagcctacc
     3181 ctccacaagg acctgatgga ggccatttcc aaagacaatg tcctctacct gcaggagcag
     3241 gagaaggagg cccggagcag ggcagcttat atctctacac tccctgcccc tccacactgg
     3301 ggtaggggct tcgatgaaga caaagatgag gatgaaggct caccaggggg ctgcaaccct
     3361 gcaggtggca atggtgactt ccacagactg gtcttctaat gggagttccc acttgttggg
     3421 gctatcacag ccaacctcag agtgggccag gtggagctca gggcccaggt agaacactct
     3481 gccatctggg gttttaggga gctgtggagg caagcccagg gtgaagcagg tctttctgag
     3541 ggcaaggagg atgaagaggg accatttggg atatcagtct gtagcttgaa gtgcacagag
     3601 aaactgaaac ccaaagctcc ttaggcattc atcctcttac gatgttatag actactgtcc
     3661 cgactaacaa ggagcatcca ctctgggctt tgcctccctg cagggccaat cctggaaagg
     3721 ccagccagct cgggagccag ggtggtgtca gcttggtgtc ctgtgtccag tagcacttct
     3781 ttctagatcc ttcactcagc tctttctcaa taggagaaaa gtcacagttg aagtcaagcc
     3841 cttgggacaa gaaggggtgg ctatgtcccc aatgcccacc ctcttgtttt ttaagggggt
     3901 ccttaaaata aggtatatga gtgtctgcac ctgctgtgtt ttacaggcat gtggatggaa
     3961 ggcagcatag cacaggatca gagacaagaa tcttaccaca tgcccctccc ctaccccaag
     4021 tgacactgtg ggagagcccc ttgtcctccc tagcctgcct cagtgcctga gatgctgcca
     4081 ttgcatccct gtctagttaa ggtccagagt ccttatttta ctgaagacat tagtctgtca
     4141 gaaagccatt gtctcatctg aggaagctag ctggcttggc tcctctgatg gaatgtgagg
     4201 gctgggtagg tatgaactgt gtataatgca cctgacctca tcgtgccctg agactactat
     4261 agccccttct cagtgaagag aagaaacctg tgttcttaaa taggaataaa attctcttct
     4321 ctgaa
//
