LOCUS       NP_573510                909 aa            linear   ROD 09-FEB-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 33 isoform 1 [Mus musculus].
ACCESSION   NP_573510
VERSION     NP_573510.2
DBSOURCE    REFSEQ: accession NM_133247.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 909)
  AUTHORS   Dong,W., Chen,J., Wang,Y., Weng,J., Du,X., Fang,X., Liu,W.,
            Long,T., You,J., Wang,W. and Peng,X.
  TITLE     miR-206 alleviates LPS-induced inflammatory injury in
            cardiomyocytes via directly targeting USP33 to inhibit the
            JAK2/STAT3 signaling pathway
  JOURNAL   Mol Cell Biochem 479 (4), 929-940 (2024)
   PUBMED   37256445
  REMARK    GeneRIF: miR-206 alleviates LPS-induced inflammatory injury in
            cardiomyocytes via directly targeting USP33 to inhibit the
            JAK2/STAT3 signaling pathway.
            Erratum:[Mol Cell Biochem. 2024 Feb;479(2):445. doi:
            10.1007/s11010-023-04803-2.. PMID: 37432634]
REFERENCE   2  (residues 1 to 909)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 909)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 909)
  AUTHORS   Cubillos-Rojas,M., Schneider,T., Hadjebi,O., Pedrazza,L., de
            Oliveira,J.R., Langa,F., Guenet,J.L., Duran,J., de Anta,J.M.,
            Alcantara,S., Ruiz,R., Perez-Villegas,E.M., Aguilar-Montilla,F.J.,
            Carrion,A.M., Armengol,J.A., Baple,E., Crosby,A.H., Bartrons,R.,
            Ventura,F. and Rosa,J.L.
  TITLE     The HERC2 ubiquitin ligase is essential for embryonic development
            and regulates motor coordination
  JOURNAL   Oncotarget 7 (35), 56083-56106 (2016)
   PUBMED   27528230
REFERENCE   5  (residues 1 to 909)
  AUTHORS   Chan,N.C., den Besten,W., Sweredoski,M.J., Hess,S., Deshaies,R.J.
            and Chan,D.C.
  TITLE     Degradation of the deubiquitinating enzyme USP33 is mediated by p97
            and the ubiquitin ligase HERC2
  JOURNAL   J Biol Chem 289 (28), 19789-19798 (2014)
   PUBMED   24855649
  REMARK    GeneRIF: Knockdown or chemical inhibition of p97 causes robust
            accumulation of USP33 due to inhibition of its degradation
REFERENCE   6  (residues 1 to 909)
  AUTHORS   Yuasa-Kawada,J., Kinoshita-Kawada,M., Wu,G., Rao,Y. and Wu,J.Y.
  TITLE     Midline crossing and Slit responsiveness of commissural axons
            require USP33
  JOURNAL   Nat Neurosci 12 (9), 1087-1089 (2009)
   PUBMED   19684588
  REMARK    GeneRIF: Our results reveal a previously unknown role for USP33 in
            vertebrate commissural axon guidance and in Slit signaling
REFERENCE   7  (residues 1 to 909)
  AUTHORS   Yuasa-Kawada,J., Kinoshita-Kawada,M., Rao,Y. and Wu,J.Y.
  TITLE     Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling
            in inhibiting breast cancer cell migration
  JOURNAL   Proc Natl Acad Sci U S A 106 (34), 14530-14535 (2009)
   PUBMED   19706539
REFERENCE   8  (residues 1 to 909)
  AUTHORS   Li,Z., Na,X., Wang,D., Schoen,S.R., Messing,E.M. and Wu,G.
  TITLE     Ubiquitination of a novel deubiquitinating enzyme requires direct
            binding to von Hippel-Lindau tumor suppressor protein
  JOURNAL   J Biol Chem 277 (7), 4656-4662 (2002)
   PUBMED   11739384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087467.1, AK143844.1, BC089315.1 and AA210301.1.
            
            On Oct 10, 2006 this sequence version replaced NP_573510.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF383174.1, SRR1660817.16866.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..909
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 77.15 cM"
     Protein         1..909
                     /product="ubiquitin carboxyl-terminal hydrolase 33 isoform
                     1"
                     /EC_number="3.4.19.12"
                     /note="Vhlh-interacting deubiquitinating enzyme 1;
                     ubiquitin specific protease 33; ubiquitin
                     carboxyl-terminal hydrolase 33; pVHL-interacting
                     deubiquitinating enzyme 1; ubiquitin thioesterase 33;
                     deubiquitinating enzyme 33; VHL-interacting
                     deubiquitinating enzyme 1; ubiquitin-specific-processing
                     protease 33; ubiquitin thiolesterase 33"
                     /calculated_mol_wt=102597
     Region          30..90
                     /region_name="zf-UBP"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; pfam02148"
                     /db_xref="CDD:460464"
     Region          154..679
                     /region_name="UCH"
                     /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443"
                     /db_xref="CDD:425685"
     Region          261..315
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R5K2.2)"
     Region          397..436
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R5K2.2)"
     Site            407
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TEY7; propagated from
                     UniProtKB/Swiss-Prot (Q8R5K2.2)"
     Region          701..770
                     /region_name="DUSP"
                     /note="DUSP domain; cl12116"
                     /db_xref="CDD:416436"
     Region          807..891
                     /region_name="DUSP"
                     /note="Domain in ubiquitin-specific proteases; smart00695"
                     /db_xref="CDD:197831"
     CDS             1..909
                     /gene="Usp33"
                     /gene_synonym="9830169D19Rik; Vdu1"
                     /coded_by="NM_133247.3:214..2943"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17918.1"
                     /db_xref="GeneID:170822"
                     /db_xref="MGI:MGI:2159711"
ORIGIN      
        1 mttfrnhcph ldsvgeitke dliqkslgac qdckvrgpnl waclenrcsy vgcgesqvdh
       61 stihsqetkh yltvnlttlr vwcyacskev fldrklgtpp slphvrqpqq tqensvqdfk
      121 ipsnpalktp mvavsedldi eveeedelka rgltglknig ntcymnaalq alsncppltq
      181 ffldcgglar tdkkpaicks ylklmtelwh ksrpgsvvpa nlfqgiktvn ptfrgysqqd
      241 aqeflrclmd llheelkeqv memeeepqtl tseetveeek sqsdvdfqsc escsssekae
      301 nesgskgfpe dsnettmliq deddlemakd wqkekvcnki nkanadveld kdrdtvcetv
      361 dlnsqetvkv qihgrasesi tdvhlndlat sqilpsnesv sprlsasppk lgslwpglsp
      421 phkkaqstsa krkkqhkkyr svisdifdgt vissvqcltc drvsitletf qdlslpipgk
      481 edlaklhsss hptivkagsc geayapqgwi affmeyvkrf vvscvpswfw gpvvtlqdcl
      541 aaffardelk gdnmyscekc kklrngvkfc kvqkfpeilc ihlkrfrhel mfstkisthv
      601 sfplegldlq pflakdspaq ivtydllsvi chhgtassgh yiaycrnnln nlwyefddqs
      661 vtevsestvq naeayvlfyr ksseeaqker rrisnllnim epsllqfyis rqwlnkfktf
      721 aepgpisnnd flcihggipp rkasyiedlv lmlpqniwdn lysrygggpa vnhlyichtc
      781 qielekiekr rkteleifir lnrafqeeds patfycismq wfrewesfvk gkdgdppgpi
      841 dntkiavtkc gsvmlkqgad sgqiseetwn flqsiygggp evilrppvvh vdpdvlqaee
      901 kievetrsl
//
