LOCUS       NM_001417952            3370 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 30 (Usp30), transcript
            variant 2, mRNA.
ACCESSION   NM_001417952 XM_017320581
VERSION     NM_001417952.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3370)
  AUTHORS   Ren,Y., Wu,X., Bai,T., Yang,N., Yuan,Y., Xu,L., Wen,Y., Wen,Y.,
            Wang,Z., Zhou,L., Zou,F. and Li,W.
  TITLE     CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation
            via suppressing mitophagy in MPTP/MPP+ PD model
  JOURNAL   Ecotoxicol Environ Saf 279, 116446 (2024)
   PUBMED   38772138
  REMARK    GeneRIF: CDK5-USP30 signaling pathway regulates MAVS-mediated
            inflammation via suppressing mitophagy in MPTP/MPP[+] PD model.
REFERENCE   2  (bases 1 to 3370)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   3  (bases 1 to 3370)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3370)
  AUTHORS   Jiang,Y., Bian,W., Chen,J., Cao,X., Dong,C., Xiao,Y., Xu,B. and
            Sun,X.
  TITLE     miRNA-137-5p improves spatial memory and cognition in Alzheimer's
            mice by targeting ubiquitin-specific peptidase 30
  JOURNAL   Animal Model Exp Med 6 (6), 526-536 (2023)
   PUBMED   38111333
  REMARK    GeneRIF: miRNA-137-5p improves spatial memory and cognition in
            Alzheimer's mice by targeting ubiquitin-specific peptidase 30.
REFERENCE   5  (bases 1 to 3370)
  AUTHORS   Fang,T.Z., Sun,Y., Pearce,A.C., Eleuteri,S., Kemp,M.,
            Luckhurst,C.A., Williams,R., Mills,R., Almond,S., Burzynski,L.,
            Markus,N.M., Lelliott,C.J., Karp,N.A., Adams,D.J., Jackson,S.P.,
            Zhao,J.F., Ganley,I.G., Thompson,P.W., Balmus,G. and Simon,D.K.
  TITLE     Knockout or inhibition of USP30 protects dopaminergic neurons in a
            Parkinson's disease mouse model
  JOURNAL   Nat Commun 14 (1), 7295 (2023)
   PUBMED   37957154
  REMARK    GeneRIF: Knockout or inhibition of USP30 protects dopaminergic
            neurons in a Parkinson's disease mouse model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3370)
  AUTHORS   Phu,L., Rose,C.M., Tea,J.S., Wall,C.E., Verschueren,E.,
            Cheung,T.K., Kirkpatrick,D.S. and Bingol,B.
  TITLE     Dynamic Regulation of Mitochondrial Import by the Ubiquitin System
  JOURNAL   Mol Cell 77 (5), 1107-1123 (2020)
   PUBMED   32142684
REFERENCE   7  (bases 1 to 3370)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3370)
  AUTHORS   Riccio,V., Demers,N., Hua,R., Vissa,M., Cheng,D.T., Strilchuk,A.W.,
            Wang,Y., McQuibban,G.A. and Kim,P.K.
  TITLE     Deubiquitinating enzyme USP30 maintains basal peroxisome abundance
            by regulating pexophagy
  JOURNAL   J Cell Biol 218 (3), 798-807 (2019)
   PUBMED   30700497
  REMARK    GeneRIF: USP30 can rescue the peroxisome loss observed in some
            disease-causing peroxisome mutations, pointing to a potential
            therapeutic target.
REFERENCE   9  (bases 1 to 3370)
  AUTHORS   Yue,W., Chen,Z., Liu,H., Yan,C., Chen,M., Feng,D., Yan,C., Wu,H.,
            Du,L., Wang,Y., Liu,J., Huang,X., Xia,L., Liu,L., Wang,X., Jin,H.,
            Wang,J., Song,Z., Hao,X. and Chen,Q.
  TITLE     A small natural molecule promotes mitochondrial fusion through
            inhibition of the deubiquitinase USP30
  JOURNAL   Cell Res 24 (4), 482-496 (2014)
   PUBMED   24513856
REFERENCE   10 (bases 1 to 3370)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129080.6.
            
            On Mar 14, 2023 this sequence version replaced XM_017320581.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4855035.1,
                                           SRR13422598.1247608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC129080.6         123340-123521
            183-292             AC129080.6         125389-125498
            293-475             AC129080.6         126650-126832
            476-579             AC129080.6         128754-128857
            580-678             AC129080.6         134123-134221
            679-721             AC129080.6         134878-134920
            722-816             AC129080.6         135893-135987
            817-876             AC129080.6         142045-142104
            877-963             AC129080.6         142569-142655
            964-1044            AC129080.6         143204-143284
            1045-1264           AC129080.6         143399-143618
            1265-1385           AC129080.6         144038-144158
            1386-3370           AC129080.6         144530-146514
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.96 cM"
     gene            1..3370
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /note="ubiquitin specific peptidase 30"
                     /db_xref="GeneID:100756"
                     /db_xref="MGI:MGI:2140991"
     exon            1..182
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1650
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin specific protease 30; ubiquitin
                     carboxyl-terminal hydrolase 30; ub-specific protease 30;
                     ubiquitin thioesterase 30; deubiquitinating enzyme 30;
                     ubiquitin-specific-processing protease 30; ubiquitin
                     thiolesterase 30"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 30 isoform
                     2"
                     /protein_id="NP_001404881.1"
                     /db_xref="GeneID:100756"
                     /db_xref="MGI:MGI:2140991"
                     /translation="MLSSRAQAARTAADKALQRFLRTGAAVRYKVMKNWGVIGGIAAA
                     LAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFVKWLEEFTTQ
                     YSRDQQGPHTHQCLSLTLLNLLKALSCQEVTEDEVLDASCLLDVLRMYRWQISSFEEQ
                     DAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQSEMAPRQVTCHTRGSPHPTTNHWK
                     SQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSE
                     SVRDVVCDNCTKIEARGTLTGEKVEHQRSTFVKQLKLGKLPQCLCIHLQRLSWSSHGT
                     PLKRHEHVQFNEFLMMDFYKYRLLGHKPSQHGPKATENPGSAPEVQDAQAAPKPGLSQ
                     PGAPKTQIFLNGACSPSLLPALPSPVAFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSG
                     HFVTYRRSPPSAKNPLSTSNQWLWISDDTVRKASLQEVLSSSAYLLFYERVLSRVQQQ
                     GREYRSEE"
     exon            183..292
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            293..475
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            476..579
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            580..678
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            679..721
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            722..816
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            817..876
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            877..963
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1044
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1264
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1385
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..3370
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2766..2771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /note="hexamer: ATTAAA"
     polyA_site      2789
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /note="major polyA site"
     regulatory      3345..3350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /note="hexamer: AATAAA"
     polyA_site      3370
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
ORIGIN      
        1 actttgcgag cctcctgtct tgggctcctc attccgctgc ggcgggcggg cgagcggggg
       61 gcggcggcgg cagcggtagc ggcggcggca gcgagcgcga tgctaagttc ccgggcgcag
      121 gcggcgagga cggcggccga caaggccctg cagcgcttcc tgcgcaccgg ggcggccgtc
      181 agatacaaag tcatgaagaa ctggggagtg atcggtggga ttgccgctgc cctggcagca
      241 gggatctatg ttatttgggg tcccattaca gagaggaaga agcggagaaa agggcttgtg
      301 cctggccttg tcaatctggg gaatacctgc ttcatgaact cgctgctgca gggcctgtct
      361 gcctgccctg cgtttgtcaa gtggctggaa gagtttacca cccagtactc cagggaccag
      421 caggggccac acactcacca gtgcctgtcc ttaacactgc tgaacctcct gaaagctctg
      481 tcctgccaag aagtcaccga ggacgaggtc ttggacgcca gctgtctgct ggacgtcctg
      541 agaatgtaca gatggcagat ctcgtccttt gaggagcagg atgctcacga gctgtttcat
      601 gtcatcacct catcactgga ggacgagaga gaccgccagc ctcgagtcac ccacttgttt
      661 gatgtgcatt ccctggagca gtcagaaatg gctcccagac aagtcacttg ccacacgaga
      721 gggtcccctc accccacgac caatcactgg aagtctcagc accctttcca tggaagactc
      781 accagtaaca tggtgtgcaa acactgtgaa caccagagtc ctgttcggtt tgacaccttt
      841 gacagccttt ctctcagtat tccagctgcc acttgggggc acccactgac actggaccac
      901 tgccttcacc acttcatctc atcagagtcc gtgcgagacg ttgtgtgtga caactgtaca
      961 aagattgaag cgagggggac actgaccggg gagaaggtgg agcatcagag gagcaccttt
     1021 gttaaacagt taaaactcgg aaagctgcca cagtgcctct gcatccacct gcagcggctc
     1081 agctggtcca gccacggcac gcccttgaag cggcacgagc acgtgcagtt taacgagttc
     1141 ctgatgatgg acttctacaa gtaccgcctc ctgggacaca agcccagcca gcatggcccc
     1201 aaagccaccg agaacccagg gtctgcccca gaagtacagg acgcacaggc ggccccaaag
     1261 ccaggtctga gtcagccagg ggcccccaag acacagattt ttctgaatgg cgcctgctcc
     1321 ccgtctctgt tgccagccct gccttccccg gtggccttcc ctctgccagt ggttcctgac
     1381 tacagctcct ccacatacct cttccgcttg atggcagttg tcgttcacca tggagacatg
     1441 cactctggac actttgtcac ctacagacgg tcaccacctt ctgccaagaa ccctctctca
     1501 accagcaacc aatggctgtg gatttctgac gacaccgtcc gcaaggccag cctgcaggag
     1561 gtcctgtcct ctagtgccta cctgctgttc tatgagcgag ttctgtccag ggtgcagcag
     1621 caggggcgag agtataggtc tgaggagtga caggccagcc cagagccagg gcccatggtg
     1681 aggtccacac tgtccaggat aaaagcaaag gcatgccacg tgtacacgtg caagccagcc
     1741 ctctagagcc ctcagccttc tgtgtattct gagagcaggc tccacaaggg agccagaccc
     1801 acacagcact gccagggtga actggaagat gtcctgtgtg tctagagcgt cttacctgac
     1861 agaggcaatg aaaagaagca gatcccagaa gccacctttt ctctgctgta atatgctagg
     1921 tgttctcaga gggcagcctt tggctagccc ctgacatttc accatagata tttattttta
     1981 ataaggaggc ccgtaaatat tattgacaag aattagtgaa attattaaag gcaacaattg
     2041 agaagaaaaa gtgcctttgt ttcccattgt tgtgagacca agcgtgacct gagagtcaca
     2101 gctgtgacgc tgggaaagcc ttgtccttcc aggctcctca gaggccaaaa gaatagttca
     2161 agaatgccta aaacagtgtg gtggctcaac ctggcatccc agcacgtgga gactgaggca
     2221 ggaggatcac tgcaagttct aggccagcct gggctccatc attaaaacct tatctcctcc
     2281 caaagcctca agacacctcc cacctctggg gacgcctttt gtaatctcga gttccctgtg
     2341 ccgcccacgg aggaccagga gtgatcactc ttcctgagct gtgtcatctg cacctctgat
     2401 ccgcttcgga agatggctcg cttcctgtta gtagttgccc acgacagggt ttacaggcca
     2461 gaacctgggc agggtgacct gacagctggg gtaggaagag caggccctaa cccagggtgg
     2521 cagtctctct ggaccttgct ttctcagtca gcctacggta aggacggaag cagcatgata
     2581 cctgagcaga agtggagcaa aatcctgcag tttggcttta gggccatgct ctaagagtgt
     2641 gtgactctca tggtttcaat aagcaaacgg tacactgggc ctctcccctt tccagactag
     2701 cctcatggac agccaggggg ggatcgtgac ggcactgacg tacctagatg ttagctaagt
     2761 gtgtaattaa aaatgatacc aaattcaaac tgactcttct ggtctaaggt ttggaacctg
     2821 acctatccaa aggtcactga ggtaaggcca aggatgtgtt ttctctgccg ggggtgagct
     2881 ggcagacatt ccagatgtgc ctaggcatca gctatgagat cagatctcac tgtgcatact
     2941 gaggacttga gactctgaga ctatgctgtg ctggactcca cgacacagca gccccacaga
     3001 cctggcttcc gggctgagat gaacacaaaa gccggcagtc acttgtgacc atagagcacc
     3061 gtgcagggct gtgggcccca ggcaccagtc ctgctgctcc tgaggtggct gagaggacaa
     3121 ttgtgtgcgt gagccgctgt agatgtgtca ccctgaccga gcgctaatgt ccttcctcat
     3181 tttgtaaatt attacattag gtaatgacca atgatggctc ctagttttaa gttcttcaca
     3241 gtaggcacct acttcccgga gaaacgtaag ctaagctagt acttccgccg taggctgccg
     3301 agtgtggact tgctgaagcc tttgtacctg ctgagcacta ctgcaataaa gacggttttg
     3361 ttaggaaaca
//
