LOCUS       NM_001033202            3373 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 30 (Usp30), transcript
            variant 1, mRNA.
ACCESSION   NM_001033202 XM_149655
VERSION     NM_001033202.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3373)
  AUTHORS   Ren,Y., Wu,X., Bai,T., Yang,N., Yuan,Y., Xu,L., Wen,Y., Wen,Y.,
            Wang,Z., Zhou,L., Zou,F. and Li,W.
  TITLE     CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation
            via suppressing mitophagy in MPTP/MPP+ PD model
  JOURNAL   Ecotoxicol Environ Saf 279, 116446 (2024)
   PUBMED   38772138
  REMARK    GeneRIF: CDK5-USP30 signaling pathway regulates MAVS-mediated
            inflammation via suppressing mitophagy in MPTP/MPP[+] PD model.
REFERENCE   2  (bases 1 to 3373)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   3  (bases 1 to 3373)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3373)
  AUTHORS   Jiang,Y., Bian,W., Chen,J., Cao,X., Dong,C., Xiao,Y., Xu,B. and
            Sun,X.
  TITLE     miRNA-137-5p improves spatial memory and cognition in Alzheimer's
            mice by targeting ubiquitin-specific peptidase 30
  JOURNAL   Animal Model Exp Med 6 (6), 526-536 (2023)
   PUBMED   38111333
  REMARK    GeneRIF: miRNA-137-5p improves spatial memory and cognition in
            Alzheimer's mice by targeting ubiquitin-specific peptidase 30.
REFERENCE   5  (bases 1 to 3373)
  AUTHORS   Fang,T.Z., Sun,Y., Pearce,A.C., Eleuteri,S., Kemp,M.,
            Luckhurst,C.A., Williams,R., Mills,R., Almond,S., Burzynski,L.,
            Markus,N.M., Lelliott,C.J., Karp,N.A., Adams,D.J., Jackson,S.P.,
            Zhao,J.F., Ganley,I.G., Thompson,P.W., Balmus,G. and Simon,D.K.
  TITLE     Knockout or inhibition of USP30 protects dopaminergic neurons in a
            Parkinson's disease mouse model
  JOURNAL   Nat Commun 14 (1), 7295 (2023)
   PUBMED   37957154
  REMARK    GeneRIF: Knockout or inhibition of USP30 protects dopaminergic
            neurons in a Parkinson's disease mouse model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3373)
  AUTHORS   Phu,L., Rose,C.M., Tea,J.S., Wall,C.E., Verschueren,E.,
            Cheung,T.K., Kirkpatrick,D.S. and Bingol,B.
  TITLE     Dynamic Regulation of Mitochondrial Import by the Ubiquitin System
  JOURNAL   Mol Cell 77 (5), 1107-1123 (2020)
   PUBMED   32142684
REFERENCE   7  (bases 1 to 3373)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3373)
  AUTHORS   Riccio,V., Demers,N., Hua,R., Vissa,M., Cheng,D.T., Strilchuk,A.W.,
            Wang,Y., McQuibban,G.A. and Kim,P.K.
  TITLE     Deubiquitinating enzyme USP30 maintains basal peroxisome abundance
            by regulating pexophagy
  JOURNAL   J Cell Biol 218 (3), 798-807 (2019)
   PUBMED   30700497
  REMARK    GeneRIF: USP30 can rescue the peroxisome loss observed in some
            disease-causing peroxisome mutations, pointing to a potential
            therapeutic target.
REFERENCE   9  (bases 1 to 3373)
  AUTHORS   Yue,W., Chen,Z., Liu,H., Yan,C., Chen,M., Feng,D., Yan,C., Wu,H.,
            Du,L., Wang,Y., Liu,J., Huang,X., Xia,L., Liu,L., Wang,X., Jin,H.,
            Wang,J., Song,Z., Hao,X. and Chen,Q.
  TITLE     A small natural molecule promotes mitochondrial fusion through
            inhibition of the deubiquitinase USP30
  JOURNAL   Cell Res 24 (4), 482-496 (2014)
   PUBMED   24513856
REFERENCE   10 (bases 1 to 3373)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129080.6.
            
            On Mar 14, 2023 this sequence version replaced NM_001033202.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144578.1, BC038606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC129080.6         123340-123521
            183-292             AC129080.6         125389-125498
            293-475             AC129080.6         126650-126832
            476-579             AC129080.6         128754-128857
            580-678             AC129080.6         134123-134221
            679-724             AC129080.6         134875-134920
            725-819             AC129080.6         135893-135987
            820-879             AC129080.6         142045-142104
            880-966             AC129080.6         142569-142655
            967-1047            AC129080.6         143204-143284
            1048-1267           AC129080.6         143399-143618
            1268-1388           AC129080.6         144038-144158
            1389-3373           AC129080.6         144530-146514
FEATURES             Location/Qualifiers
     source          1..3373
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.96 cM"
     gene            1..3373
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /note="ubiquitin specific peptidase 30"
                     /db_xref="GeneID:100756"
                     /db_xref="MGI:MGI:2140991"
     exon            1..182
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            183..292
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            293..475
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            476..579
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            580..678
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            679..724
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            725..819
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            820..879
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            880..966
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1047
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1267
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1388
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..3373
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /note="hexamer: ATTAAA"
     polyA_site      2792
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /note="major polyA site"
     regulatory      3348..3353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
                     /note="hexamer: AATAAA"
     polyA_site      3373
                     /gene="Usp30"
                     /gene_synonym="6330590F17Rik; D5Ertd483e"
ORIGIN      
        1 actttgcgag cctcctgtct tgggctcctc attccgctgc ggcgggcggg cgagcggggg
       61 gcggcggcgg cagcggtagc ggcggcggca gcgagcgcga tgctaagttc ccgggcgcag
      121 gcggcgagga cggcggccga caaggccctg cagcgcttcc tgcgcaccgg ggcggccgtc
      181 agatacaaag tcatgaagaa ctggggagtg atcggtggga ttgccgctgc cctggcagca
      241 gggatctatg ttatttgggg tcccattaca gagaggaaga agcggagaaa agggcttgtg
      301 cctggccttg tcaatctggg gaatacctgc ttcatgaact cgctgctgca gggcctgtct
      361 gcctgccctg cgtttgtcaa gtggctggaa gagtttacca cccagtactc cagggaccag
      421 caggggccac acactcacca gtgcctgtcc ttaacactgc tgaacctcct gaaagctctg
      481 tcctgccaag aagtcaccga ggacgaggtc ttggacgcca gctgtctgct ggacgtcctg
      541 agaatgtaca gatggcagat ctcgtccttt gaggagcagg atgctcacga gctgtttcat
      601 gtcatcacct catcactgga ggacgagaga gaccgccagc ctcgagtcac ccacttgttt
      661 gatgtgcatt ccctggagca gcagtcagaa atggctccca gacaagtcac ttgccacacg
      721 agagggtccc ctcaccccac gaccaatcac tggaagtctc agcacccttt ccatggaaga
      781 ctcaccagta acatggtgtg caaacactgt gaacaccaga gtcctgttcg gtttgacacc
      841 tttgacagcc tttctctcag tattccagct gccacttggg ggcacccact gacactggac
      901 cactgccttc accacttcat ctcatcagag tccgtgcgag acgttgtgtg tgacaactgt
      961 acaaagattg aagcgagggg gacactgacc ggggagaagg tggagcatca gaggagcacc
     1021 tttgttaaac agttaaaact cggaaagctg ccacagtgcc tctgcatcca cctgcagcgg
     1081 ctcagctggt ccagccacgg cacgcccttg aagcggcacg agcacgtgca gtttaacgag
     1141 ttcctgatga tggacttcta caagtaccgc ctcctgggac acaagcccag ccagcatggc
     1201 cccaaagcca ccgagaaccc agggtctgcc ccagaagtac aggacgcaca ggcggcccca
     1261 aagccaggtc tgagtcagcc aggggccccc aagacacaga tttttctgaa tggcgcctgc
     1321 tccccgtctc tgttgccagc cctgccttcc ccggtggcct tccctctgcc agtggttcct
     1381 gactacagct cctccacata cctcttccgc ttgatggcag ttgtcgttca ccatggagac
     1441 atgcactctg gacactttgt cacctacaga cggtcaccac cttctgccaa gaaccctctc
     1501 tcaaccagca accaatggct gtggatttct gacgacaccg tccgcaaggc cagcctgcag
     1561 gaggtcctgt cctctagtgc ctacctgctg ttctatgagc gagttctgtc cagggtgcag
     1621 cagcaggggc gagagtatag gtctgaggag tgacaggcca gcccagagcc agggcccatg
     1681 gtgaggtcca cactgtccag gataaaagca aaggcatgcc acgtgtacac gtgcaagcca
     1741 gccctctaga gccctcagcc ttctgtgtat tctgagagca ggctccacaa gggagccaga
     1801 cccacacagc actgccaggg tgaactggaa gatgtcctgt gtgtctagag cgtcttacct
     1861 gacagaggca atgaaaagaa gcagatccca gaagccacct tttctctgct gtaatatgct
     1921 aggtgttctc agagggcagc ctttggctag cccctgacat ttcaccatag atatttattt
     1981 ttaataagga ggcccgtaaa tattattgac aagaattagt gaaattatta aaggcaacaa
     2041 ttgagaagaa aaagtgcctt tgtttcccat tgttgtgaga ccaagcgtga cctgagagtc
     2101 acagctgtga cgctgggaaa gccttgtcct tccaggctcc tcagaggcca aaagaatagt
     2161 tcaagaatgc ctaaaacagt gtggtggctc aacctggcat cccagcacgt ggagactgag
     2221 gcaggaggat cactgcaagt tctaggccag cctgggctcc atcattaaaa ccttatctcc
     2281 tcccaaagcc tcaagacacc tcccacctct ggggacgcct tttgtaatct cgagttccct
     2341 gtgccgccca cggaggacca ggagtgatca ctcttcctga gctgtgtcat ctgcacctct
     2401 gatccgcttc ggaagatggc tcgcttcctg ttagtagttg cccacgacag ggtttacagg
     2461 ccagaacctg ggcagggtga cctgacagct ggggtaggaa gagcaggccc taacccaggg
     2521 tggcagtctc tctggacctt gctttctcag tcagcctacg gtaaggacgg aagcagcatg
     2581 atacctgagc agaagtggag caaaatcctg cagtttggct ttagggccat gctctaagag
     2641 tgtgtgactc tcatggtttc aataagcaaa cggtacactg ggcctctccc ctttccagac
     2701 tagcctcatg gacagccagg gggggatcgt gacggcactg acgtacctag atgttagcta
     2761 agtgtgtaat taaaaatgat accaaattca aactgactct tctggtctaa ggtttggaac
     2821 ctgacctatc caaaggtcac tgaggtaagg ccaaggatgt gttttctctg ccgggggtga
     2881 gctggcagac attccagatg tgcctaggca tcagctatga gatcagatct cactgtgcat
     2941 actgaggact tgagactctg agactatgct gtgctggact ccacgacaca gcagccccac
     3001 agacctggct tccgggctga gatgaacaca aaagccggca gtcacttgtg accatagagc
     3061 accgtgcagg gctgtgggcc ccaggcacca gtcctgctgc tcctgaggtg gctgagagga
     3121 caattgtgtg cgtgagccgc tgtagatgtg tcaccctgac cgagcgctaa tgtccttcct
     3181 cattttgtaa attattacat taggtaatga ccaatgatgg ctcctagttt taagttcttc
     3241 acagtaggca cctacttccc ggagaaacgt aagctaagct agtacttccg ccgtaggctg
     3301 ccgagtgtgg acttgctgaa gcctttgtac ctgctgagca ctactgcaat aaagacggtt
     3361 ttgttaggaa aca
//
