LOCUS       NM_001359739            4316 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 28 (Usp28), transcript
            variant 2, mRNA.
ACCESSION   NM_001359739 XM_006510262
VERSION     NM_001359739.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4316)
  AUTHORS   Le Menn,G., Pikkarainen,K., Mennerich,D., Miroszewska,D.,
            Kietzmann,T. and Chen,Z.
  TITLE     USP28 protects development of inflammation in mouse intestine by
            regulating STAT5 phosphorylation and IL22 production in T
            lymphocytes
  JOURNAL   Front Immunol 15, 1401949 (2024)
   PUBMED   39076972
  REMARK    GeneRIF: USP28 protects development of inflammation in mouse
            intestine by regulating STAT5 phosphorylation and IL22 production
            in T lymphocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4316)
  AUTHORS   Cai,C., Ma,H., Peng,J., Shen,X., Zhen,X., Yu,C., Zhang,P., Ji,F.
            and Wang,J.
  TITLE     USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation
            protects acetaminophen-induced liver injury in male mice
  JOURNAL   Nat Commun 14 (1), 3648 (2023)
   PUBMED   37339955
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4316)
  AUTHORS   Ren,Y., Zhu,X., Fu,K., Zhang,H., Zhao,W., Lin,Y., Fang,Q., Wang,J.,
            Chen,Y. and Guo,D.
  TITLE     Inhibition of deubiquitinase USP28 attenuates cyst growth in
            autosomal dominant polycystic kidney disease
  JOURNAL   Biochem Pharmacol 207, 115355 (2023)
   PUBMED   36442624
  REMARK    GeneRIF: Inhibition of deubiquitinase USP28 attenuates cyst growth
            in autosomal dominant polycystic kidney disease.
REFERENCE   4  (bases 1 to 4316)
  AUTHORS   LoMastro,G.M., Drown,C.G., Maryniak,A.L., Jewett,C.E., Strong,M.A.
            and Holland,A.J.
  TITLE     PLK4 drives centriole amplification and apical surface area
            expansion in multiciliated cells
  JOURNAL   Elife 11, e80643 (2022)
   PUBMED   35969030
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4316)
  AUTHORS   Ruiz,E.J., Pinto-Fernandez,A., Turnbull,A.P., Lan,L.,
            Charlton,T.M., Scott,H.C., Damianou,A., Vere,G., Riising,E.M., Da
            Costa,C., Krajewski,W.W., Guerin,D., Kearns,J.D., Ioannidis,S.,
            Katz,M., McKinnon,C., O'Connell,J., Moncaut,N., Rosewell,I.,
            Nye,E., Jones,N., Heride,C., Gersch,M., Wu,M., Dinsmore,C.J.,
            Hammonds,T.R., Kim,S., Komander,D., Urbe,S., Clague,M.J.,
            Kessler,B.M. and Behrens,A.
  TITLE     USP28 deletion and small-molecule inhibition destabilizes c-MYC and
            elicits regression of squamous cell lung carcinoma
  JOURNAL   Elife 10, e71596 (2021)
   PUBMED   34636321
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4316)
  AUTHORS   Schulein-Volk,C., Wolf,E., Zhu,J., Xu,W., Taranets,L., Hellmann,A.,
            Janicke,L.A., Diefenbacher,M.E., Behrens,A., Eilers,M. and Popov,N.
  TITLE     Dual regulation of Fbw7 function and oncogenic transformation by
            Usp28
  JOURNAL   Cell Rep 9 (3), 1099-1109 (2014)
   PUBMED   25437563
  REMARK    GeneRIF: Dual regulation of Fbw7 activity by Usp28 is a safeguard
            mechanism for maintaining physiological levels of proto-oncogenic
            Fbw7 substrates, which is equivalently disrupted by loss or
            overexpression of Usp28.
REFERENCE   7  (bases 1 to 4316)
  AUTHORS   Yang,J., Hung,L.H., Licht,T., Kostin,S., Looso,M., Khrameeva,E.,
            Bindereif,A., Schneider,A. and Braun,T.
  TITLE     RBM24 is a major regulator of muscle-specific alternative splicing
  JOURNAL   Dev Cell 31 (1), 87-99 (2014)
   PUBMED   25313962
REFERENCE   8  (bases 1 to 4316)
  AUTHORS   Diefenbacher,M.E., Popov,N., Blake,S.M., Schulein-Volk,C., Nye,E.,
            Spencer-Dene,B., Jaenicke,L.A., Eilers,M. and Behrens,A.
  TITLE     The deubiquitinase USP28 controls intestinal homeostasis and
            promotes colorectal cancer
  JOURNAL   J Clin Invest 124 (8), 3407-3418 (2014)
   PUBMED   24960159
  REMARK    GeneRIF: identified Usp28 as a c-MYC target gene highly expressed
            in colorectal cancers, which indicates that USP28 and c-MYC form a
            positive feedback loop that maintains high c-MYC protein levels in
            tumors
REFERENCE   9  (bases 1 to 4316)
  AUTHORS   Knobel,P.A., Belotserkovskaya,R., Galanty,Y., Schmidt,C.K.,
            Jackson,S.P. and Stracker,T.H.
  TITLE     USP28 is recruited to sites of DNA damage by the tandem BRCT
            domains of 53BP1 but plays a minor role in double-strand break
            metabolism
  JOURNAL   Mol Cell Biol 34 (11), 2062-2074 (2014)
   PUBMED   24687851
REFERENCE   10 (bases 1 to 4316)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160137.2.
            
            On Jan 13, 2018 this sequence version replaced XM_006510262.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.68152.1,
                                           SRR1660811.150732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC160137.2         113405-113557
            154-231             AC160137.2         128371-128448
            232-364             AC160137.2         129528-129660
            365-470             AC160137.2         131011-131116
            471-630             AC160137.2         131843-132002
            631-717             AC160137.2         136449-136535
            718-855             AC160137.2         137116-137253
            856-929             AC160137.2         138263-138336
            930-1009            AC160137.2         139283-139362
            1010-1158           AC160137.2         143122-143270
            1159-1286           AC160137.2         144702-144829
            1287-1382           AC160137.2         146392-146487
            1383-1562           AC160137.2         151926-152105
            1563-1783           AC160137.2         153788-154008
            1784-1854           AC160137.2         154839-154909
            1855-2083           AC160137.2         156093-156321
            2084-2278           AC160137.2         158747-158941
            2279-2418           AC160137.2         160234-160373
            2419-2514           AC160137.2         161597-161692
            2515-2693           AC160137.2         163613-163791
            2694-2772           AC160137.2         163902-163980
            2773-2852           AC160137.2         165197-165276
            2853-2976           AC160137.2         165788-165911
            2977-3172           AC160137.2         167002-167197
            3173-4316           AC160137.2         169394-170537
FEATURES             Location/Qualifiers
     source          1..4316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.56 cM"
     gene            1..4316
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /note="ubiquitin specific peptidase 28"
                     /db_xref="GeneID:235323"
                     /db_xref="MGI:MGI:2442293"
     exon            1..153
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3348
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin specific protease 28; ubiquitin
                     carboxyl-terminal hydrolase 28; ubiquitin thioesterase 28;
                     deubiquitinating enzyme 28; ubiquitin-specific-processing
                     protease 28; ubiquitin thiolesterase 28"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 28 isoform
                     2"
                     /protein_id="NP_001346668.1"
                     /db_xref="GeneID:235323"
                     /db_xref="MGI:MGI:2442293"
                     /translation="MTAELQQDDSAGAADGHGSSCQMLLNQLREITGIQDPSFLHEAL
                     KASNGDITQAVSLLTDQRVKEPSHDTTAAEPSEVEESATSKDLLAKVIDLTHDNKDDL
                     QAAIALSLLESPNIQADNRDLNRAHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGW
                     PVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYNLPQNILENCRSHTEKRNIMFMQEL
                     QYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVN
                     VNSHLRNKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYHNLDECLEGA
                     MVEGDIALLPSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQI
                     IYMDRYMYKSKELIRSKRESVRKLKEEIQVLQQKLERYVKYGSGPSRFPLPDMLKYVI
                     EFASTKPASESCLSGSAEHVTLPLPSVHCPISDLTPKESSSPESCSQNAGSTFSSPED
                     ALPSSEGMNGPFTSPHSSLETPAPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLKN
                     CISSSTKAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQTWLKYNDI
                     SVTESSWEELERDSYGGLRNVSAYCLMYINDNLPHFSAEASSNESDETAGEVEALSVE
                     LRQYIQEDNWRFQQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESPAVSSHEVRCL
                     SSEHAVIAKEQTAQAIANTAHAYEKSGVEAALSEVMLSPAMQGVILAIAKARQTFDRD
                     GSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQF
                     ADRNLSYDERSISIMKVAQAKLMEIGPDDMNMEEYKRWHEDYSLFRKVSVYLLTGLEL
                     FQKGKYQEALSYLVYAYQSNAGLLVKGPRRGVKESVIALYRRKCLLELNAKAASLFET
                     NDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENLQL
                     CLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCNRFAAVMESIQGVSTVTVK"
     exon            154..231
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            232..364
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            365..470
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            471..630
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            631..717
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            718..855
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            856..929
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1009
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1158
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1286
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1382
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1562
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1783
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1854
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2083
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2278
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2418
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2514
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2693
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2772
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2852
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2976
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3172
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..4316
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4286..4291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /note="hexamer: AATAAA"
     polyA_site      4309
                     /gene="Usp28"
                     /gene_synonym="9830148O20Rik; mKIAA1515"
                     /note="major polyA site"
ORIGIN      
        1 ggtgctcccg ggcttcgggg gcggtggtgg tggcggtggc gaccgcggcg aagacgacaa
       61 cgagagtggg gctacacgcg gagggacacc acggccatga ctgcggagct gcagcaggac
      121 gactcggcgg gggcggcgga cggccatggc tcgagctgcc agatgctgtt aaatcagctg
      181 cgagaaatca caggcatcca ggatccttcc tttcttcatg aagcattaaa ggccagtaat
      241 ggtgacatca cccaggctgt cagccttctc acagaccaaa gagttaagga gcccagtcac
      301 gacacaactg ctgcagaacc atctgaagta gaagagagtg ctaccagcaa agatctctta
      361 gcaaaagtga tagacctcac tcacgacaac aaagatgacc tgcaggcagc cattgccttg
      421 agtctcctgg agtctcctaa cattcaggct gacaacagag atcttaatag agcgcatgag
      481 gctaactctg cagaaactaa acgctcaaag agaaaacgct gtgaagtttg gggagaaaac
      541 cacaatccca ataactggag gagagtggat ggttggccag ttgggctgaa aaatgttggc
      601 aacacatgtt ggttcagtgc tgttattcag tctctctttc agttgcctga atttcgaaga
      661 cttgttctca gttataacct gccacagaac atccttgaaa attgtcgaag tcacactgaa
      721 aagagaaata tcatgtttat gcaagagctt cagtatttat ttgctctgtt gttgggatca
      781 aatcgaaaat ttgtagaccc ttctgcagcc ctggatctac tgaagggagc cttccgatca
      841 tccgaggagc agcagcaaga tgtgagtgaa ttcacacaca agctcctgga ttggctggag
      901 gatgcgttcc agctagctgt taatgttaac agccatctca ggaataaatc tgaaaatccc
      961 atggtgcagc tattctacgg tacttttctg acagaagggg tccgagaagg aaagcccttt
     1021 tgtaacaatg agaccttcgg ccagtatcct cttcaggtaa acggttacca caacttagac
     1081 gaatgtttgg aaggggccat ggtggaaggt gacatcgcgc tgcttccttc ggatcgttcc
     1141 gtgaagtatg ggcaggagcg ttggtttaca aagctgcctc cagtgttgac ctttgaactc
     1201 tccagatttg agtttaatca gtctcttggg cagcctgaaa aaattcataa taagctggaa
     1261 tttcctcaga ttatctatat ggataggtac atgtataaga gcaaagagct tatccgaagt
     1321 aagagagaga gcgttcggaa gttgaaggag gaaatacaag ttctgcagca gaagttagaa
     1381 aggtatgtga agtacggctc gggcccatct cggttcccac ttcccgacat gttgaaatac
     1441 gttattgaat ttgccagtac aaaacctgcc tctgaaagct gtctgtctgg aagtgctgag
     1501 catgtgacat taccacttcc ctcggtgcac tgcccgattt ctgacctcac acccaaggaa
     1561 agttcaagtc cagaaagctg ctctcagaat gctggaagta ccttttcctc tccagaagat
     1621 gctcttccca gctctgaggg gatgaatggg ccatttacct ctcctcactc gtctctggaa
     1681 acgcctgcac ccccagctcc tcggacagtc acagatgaag aaatgaactt cgttaagacc
     1741 tgtcttcaga ggtggcggag tgaaattgaa caggatatac aagacctaaa gaactgtatc
     1801 tcgagcagca cgaaggcgat tgagcagatg tactgtgacc ctcttcttcg tcaggtgcct
     1861 tatcgcttac atgcagttct tgttcacgaa ggacaagcca gtgcaggaca ctactgggca
     1921 tacatctaca accagccccg gcagacctgg ctcaaataca acgacatctc tgttactgag
     1981 tcttcctggg aggaacttga aagagattct tacgggggcc tgagaaatgt cagcgcctac
     2041 tgcttgatgt atatcaatga caacttgccc cacttcagtg cagaggcatc ttctaatgaa
     2101 tctgatgaga ctgcaggaga agtggaagcc ctgtctgtgg aactcaggca gtacattcag
     2161 gaagataact ggaggtttca gcaagaggtg gaggaatggg aggaagaaca gtcctgtaag
     2221 atcccacaga tggagtcctc cccgaactct tcctcacagg atttctccac atcacaagag
     2281 tctccagcag tgtcctctca tgaggtccga tgcttgtctt ctgagcatgc tgtgattgca
     2341 aaagaacaga ctgcccaggc aattgccaac acagctcatg cctacgagaa gagtggtgta
     2401 gaagcagcct tgagtgaggt gatgctgagc cctgccatgc aaggggtcat cctggccata
     2461 gctaaagcac gccagacctt tgaccgagat gggtctgaag cagggcttat taaggcattt
     2521 catgaggagt actccaggct ctatcagctt gccaaagaga cacccacctc tcacagtgac
     2581 cctcgccttc agcatgttct tgtctacttt ttccaaaatg aagcacccaa gagggtagta
     2641 gaacggaccc ttctggaaca gtttgcggat agaaacctta gctatgatga gagatctatc
     2701 agtatcatga aggtggctca ggccaaattg atggaaattg gtccagatga catgaacatg
     2761 gaagagtata agaggtggca tgaagattat agtctgttcc gaaaggtgtc tgtgtacctt
     2821 ctaacgggcc tggaactctt ccaaaaagga aagtaccagg aagcattgtc ctacctggtg
     2881 tacgcatacc agagcaacgc tggcctgctg gtgaaggggc cccgaagggg cgtgaaggag
     2941 tctgtgattg ccttataccg cagaaaatgc cttctggagc tgaatgccaa ggctgcttct
     3001 ctttttgaaa caaatgacga ccattctgta acagagggca ttaatgtaat gaatgagttg
     3061 atcattccct gcatccacct gatcattaat aacgacatct ccaaggacga cctcgatgcc
     3121 atcgaggtca tgaggaacca ctggtgctct tacctgggga aggatattgc agagaatctg
     3181 cagctgtgct taggagagtt cctacccagg cttctagatc cttctgcaga aatcatcgtc
     3241 ctaaaggagc ctccaactat tcgaccgaat tctccctatg atctttgcaa ccggtttgca
     3301 gctgtcatgg agtccattca aggagtttca acagtaaccg tgaaataagc cgctcatgga
     3361 cagtcaagac tcagtctggt ctccggtccc ctgcctgtta tgtggcagtc tgttgtgaca
     3421 gatttccctg gacagaggga ttgggtgtct gagcgagatt cagaccctcc cccctctcgt
     3481 gatgtgtgtt taagggatta aggataaagt tgcacatttt aggtacagaa ccacaagagc
     3541 tatttcactg aagaaggcag gagccagtgc attaaggttt tgaattatcc tagaagacct
     3601 gaactgcctt tgtaaatctc ccataacact tgggtttgtc taaacctcgt gccactttta
     3661 aattaccctt caggcaccag tctttgacag caaaagggtg actcatcaga actgagccag
     3721 gggagcagtt tctagttatt ttgtcaagtt caggtgacat ttaaaagtcc tcagctacca
     3781 gagattggta gtaggggtct tgcctggctc ttgccagtga tgaaaagagg tgctggtgag
     3841 cccttccttc cacataaggc tgcgccatga agccgccaag ggaaagctgc atcccccttt
     3901 ggtctgttta tactttagat aaaccagaaa acctcacatt cagtcttgag tgaaagaaaa
     3961 gaaagcatcc tgggcttcca gccctgtgct ggtgtgacag atgccacaca aggaacactt
     4021 aatagttaat aatcatcaga agcaggtgtc taaggctacc cggcctaaga gaattttgat
     4081 cctttctctc cctttttttt ttttaaagaa aataagggat gtgaatttgt ataaaaaata
     4141 acatctatct gtgtatatgt agaaagaagc tgctttttaa agaacttcta attggaaact
     4201 catgttttaa ccaaatttta aggattaatg gagcaatcat gggagggaag aacacaatac
     4261 aactatgcag gttttataaa tgtgcaataa aagtatttgt tttacctttg gtatgt
//
