LOCUS       NM_019461               3240 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 27, X chromosome
            (Usp27x), mRNA.
ACCESSION   NM_019461 XM_906471
VERSION     NM_019461.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3240)
  AUTHORS   Tao,X., Chu,B., Xin,D., Li,L. and Sun,Q.
  TITLE     USP27X negatively regulates antiviral signaling by deubiquitinating
            RIG-I
  JOURNAL   PLoS Pathog 16 (2), e1008293 (2020)
   PUBMED   32027733
  REMARK    GeneRIF: these studies uncover a novel negative regulatory role of
            USP27X in targeting RIG-I to balance innate immune responses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3240)
  AUTHORS   Weber,A., Heinlein,M., Dengjel,J., Alber,C., Singh,P.K. and
            Hacker,G.
  TITLE     The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and
            enhances apoptosis
  JOURNAL   EMBO Rep 17 (5), 724-738 (2016)
   PUBMED   27013495
  REMARK    GeneRIF: Usp27x can trigger via its proteolytic activity the
            deubiquitination of Bim and enhance its levels, counteracting the
            anti-apoptotic effects of ERK activity, and therefore acts as a
            tumour suppressor.
REFERENCE   3  (bases 1 to 3240)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663104.17.
            
            On Apr 28, 2010 this sequence version replaced NM_019461.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC137612.1, AK030383.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3240              AL663104.17        146274-149513       c
FEATURES             Location/Qualifiers
     source          1..3240
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.31 cM"
     gene            1..3240
                     /gene="Usp27x"
                     /gene_synonym="Sfc11; Usp27"
                     /note="ubiquitin specific peptidase 27, X chromosome"
                     /db_xref="GeneID:54651"
                     /db_xref="MGI:MGI:1859645"
     exon            1..3240
                     /gene="Usp27x"
                     /gene_synonym="Sfc11; Usp27"
                     /inference="alignment:Splign:2.1.0"
     CDS             970..2286
                     /gene="Usp27x"
                     /gene_synonym="Sfc11; Usp27"
                     /EC_number="3.4.19.12"
                     /note="X-linked ubiquitin thioesterase 27;
                     deubiquitinating enzyme 27; ubiquitin-specific-processing
                     protease 27; X-linked ubiquitin carboxyl-terminal
                     hydrolase 27; ubiquitin thiolesterase 27; ubiquitin
                     specific protease 27, X chromosome"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 27"
                     /protein_id="NP_062334.2"
                     /db_xref="CCDS:CCDS52983.1"
                     /db_xref="GeneID:54651"
                     /db_xref="MGI:MGI:1859645"
                     /translation="MCKDYVYDIDIEQIAKEEQGEALKLQASTSTEVSQQQCSVPGLG
                     EKYPTWETTKPELELLGHNPRRRRIASSFTIGLRGLINLGNTCFMNCIVQALTHTPIL
                     RDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGY
                     RQQDAHEFLIAALDVLHRHCKGDDVGKVASNPNHCNCIIDQIFTGGLQSDVTCQACHG
                     VSTTIDPCWDISLDLPGSCTSFWPMSPGRESSLNGESHIPGITTLTDCLRRFTRPEHL
                     GSSAKIKCGSCQSYQESTKQLTMKKLPVVACFHFKRFEHSAKQRRKITTYISFPLELD
                     MTPFMASSKETRVNGQLQLPTNSANNENKYSLFAVVNHQGTLESGHYTSFIRHHRDQW
                     FKCDDAVITKASIKDVLDSEGYLLFYHKQVLEPEPEKVKEMTPQAY"
     regulatory      3217..3222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp27x"
                     /gene_synonym="Sfc11; Usp27"
                     /note="hexamer: AGTAAA"
     polyA_site      3240
                     /gene="Usp27x"
                     /gene_synonym="Sfc11; Usp27"
                     /note="major polyA site"
ORIGIN      
        1 gagaaggcat agaggaaggt ggaggcggag aaggtggagg ggaaggtgga ggcggccggg
       61 aaggtggacg ccaccgggaa ggtggagaca gcagggaagg tggacgccac cgggaaggtg
      121 gagatcgcgg agggtccggg ccgcggggct gagctcaagc tggagctgga gcaggagccc
      181 gagccggagc ccgagccgga gcccgagcgg gagcccgagc gggagcccga gccggagccg
      241 gagcgggagc ccgagccgga gccccagcca gagcccgagc cggagcccga gcccgagccc
      301 cagccggagc cggaacccga acagaagccg gagcccgagc cggagcccga acccgagccc
      361 ttacaggagc ctgagcctga gcctgagcct gagcctgagc ctgagcctga gaggcagccc
      421 gagaaggagc cgaaggatga gaacccagcg cagagcggtg ttggcggcag cggcgacgag
      481 gttcctcccc ccacccttcc ctccgaccct ccgcggcccc ctgatccctc tccgcgtcgc
      541 agtcgtgccc cgcgccgccg accccggccc cggccccaga ctaggcttcg taccccgccg
      601 cagcctaggc cacggccccc accccggccc cggccccggc gtggtcctgg gggcggatgc
      661 ctggatgtgg attttgctgt ggggccacca ggttgttccc acgtgaacag ctttaaggtg
      721 ggagagaact ggaggcagga attgcgggtt atctaccagt gcttcgtgtg gtgtggaacc
      781 ccagagacca ggaaaagcaa ggcaaagtcg tgcgtctgcc atgtgtgtgg cacccattta
      841 aacagactcc actcttgcct ttcctgcgtc ttctttggct gcttcacaga gaaacacatc
      901 cacgagcacg ctgagacaaa acagcacaac ttagcggtag atctttatta tggaggcata
      961 tactgcttca tgtgtaaaga ctatgtgtat gacatagaca ttgagcaaat tgccaaagaa
     1021 gagcaaggag aagccttgaa attacaagcg tccacctcga cagaggtttc tcagcaacag
     1081 tgttcagtgc cgggacttgg ggagaaatat cccacctggg aaacgaccaa acctgaacta
     1141 gaacttctgg ggcacaaccc acggagaaga aggatcgcct ccagctttac catcggctta
     1201 cgaggactaa ttaatcttgg caacacgtgt tttatgaact gcattgtcca ggccttgacc
     1261 cacactccaa tactgagaga tttctttctc tctgacaggc accggtgtga aatgcccagc
     1321 cctgagttgt gtctggtctg tgagatgtcg tcgctctttc gggagctgta ttctggaaac
     1381 ccatctcctc atgtgcccta taagttactg cacctggtgt ggatacacgc tcgtcatcta
     1441 gcagggtaca ggcagcagga tgcccacgag ttcctcatcg ctgcgctaga tgtcctgcat
     1501 aggcactgca aaggtgacga tgttggcaag gtggccagca accccaacca ctgtaactgc
     1561 atcatagacc aaatcttcac aggtggcctg cagtccgatg tcacctgtca agcctgccat
     1621 ggtgtctcca ccactataga cccatgctgg gacattagtc tggacttgcc tggctcttgc
     1681 acatccttct ggcccatgag ccctgggagg gagagcagtt tgaatggcga aagccacatc
     1741 ccaggcatca ccactctcac ggactgcttg cgaaggttta caaggccaga gcacttagga
     1801 agtagtgcca aaatcaagtg tggtagttgc caaagctacc aagaatctac caaacagctc
     1861 actatgaaga agttaccagt agttgcctgc tttcatttca aacggtttga acactcagcg
     1921 aaacagaggc gcaagatcac tacgtacatt tcctttcctc tggagctgga tatgacacca
     1981 tttatggcgt caagtaaaga gacccgggtg aatggacagt tgcagctccc aaccaatagt
     2041 gcgaacaacg agaataagta ttccttgttt gctgtggtta atcaccaagg aaccttggag
     2101 agtggccact acaccagctt cattcggcac cacagggacc agtggttcaa gtgtgatgat
     2161 gccgtaatca ccaaggccag tattaaggat gtgctggaca gtgaagggta tttactgttc
     2221 tatcacaaac aggtcctgga acctgagcca gaaaaggtga aagaaatgac tccacaagcc
     2281 tactgaagca ccacacaggc ctacctagaa tggaagatga caccagtact acaccaggca
     2341 tcgagattta attgatctat gtgactgagg ccgatgggcc ttgctgagta agaattgaac
     2401 agtatccagt gtcccaaaaa gtcctgatca gaagagaaat aaataggagg ggagggagaa
     2461 gaggctctag cctaagcagt catgtgaagg aaattaagtg gcaggagtgt tctggatggg
     2521 gaagggtagg cagagcaggg aaattgtgac actggttcat atcctatatt cctccaaaag
     2581 attgtgtggg aaggtgtagg ggggaggggg gtggtgttgg ggtgtgtgtg tgcccttgta
     2641 actgtaaaac atctttctcc atgggtgtct cagcttcaat tgaccaatca tgtaacagcc
     2701 acatgtttgt ggggggaggg gaatgaaaaa gtttcttaaa atgtagccca ttgtgtacat
     2761 ggggatgaaa gcagagacat ggaggaggcg aggatatctc attgacaaac acctttgcca
     2821 gtttctttgt attcgtgatt tttgtgctat gaaatgcagt attaaaaaca agaaagctca
     2881 cctgggctag cgaaagaaga aataaccagg cttatggaag gggagcggca gatgctccaa
     2941 aagtagagag ggctagaaat gctgtaagat aagcaattaa caaggacagg cctcagctga
     3001 cagtgtaggt gtgtgtgtat gtgtgtgtgt ttatgtgtgt gtgtatgtgt gtattttttt
     3061 taaagctgta tgatgtactt gagcaaatca gtgaacctct ttgtgattct tttctcatct
     3121 gtatcatgca gataattcct accttaaagg gtcgctgtta aagataaatg atatacaatg
     3181 tgtcaaagtc aaaggcttgg aactttgtag agactcagta aactgtttgt tggctctgaa
//
