LOCUS       NM_031388               4133 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 26 (Usp26), mRNA.
ACCESSION   NM_031388 XM_001474763
VERSION     NM_031388.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4133)
  AUTHORS   Ma,M., Yi,L., Pei,Y., Zhang,Q., Tong,C., Zhao,M., Chen,Y., Zhu,J.,
            Zhang,W., Yao,F., Yang,P. and Zhang,P.
  TITLE     USP26 as a hepatitis B virus-induced deubiquitinase primes
            hepatocellular carcinogenesis by epigenetic remodeling
  JOURNAL   Nat Commun 15 (1), 7856 (2024)
   PUBMED   39251623
  REMARK    GeneRIF: USP26 as a hepatitis B virus-induced deubiquitinase primes
            hepatocellular carcinogenesis by epigenetic remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4133)
  AUTHORS   Kazi,S., Castaneda,J.M., Savolainen,A., Xu,Y., Liu,N., Qiao,H.,
            Ramirez-Solis,R., Nozawa,K., Yu,Z., Matzuk,M.M. and
            Prunskaite-Hyyrylainen,R.
  TITLE     MRNIP interacts with sex body chromatin to support meiotic
            progression, spermatogenesis, and male fertility in mice
  JOURNAL   FASEB J 36 (9), e22479 (2022)
   PUBMED   35920200
REFERENCE   3  (bases 1 to 4133)
  AUTHORS   Segarra-Fas,A., Espejo-Serrano,C., Bustos,F., Zhou,H., Wang,F.,
            Toth,R., Macartney,T., Bach,I., Nardocci,G. and Findlay,G.M.
  TITLE     An RNF12-USP26 amplification loop drives germ cell specification
            and is disrupted by disease-associated mutations
  JOURNAL   Sci Signal 15 (742), eabm5995 (2022)
   PUBMED   35857630
  REMARK    GeneRIF: An RNF12-USP26 amplification loop drives germ cell
            specification and is disrupted by disease-associated mutations.
REFERENCE   4  (bases 1 to 4133)
  AUTHORS   Li,C., Qiu,M., Chang,L., Qi,J., Zhang,L., Ryffel,B. and Deng,L.
  TITLE     The osteoprotective role of USP26 in coordinating bone formation
            and resorption
  JOURNAL   Cell Death Differ 29 (6), 1123-1136 (2022)
   PUBMED   35091692
  REMARK    GeneRIF: The osteoprotective role of USP26 in coordinating bone
            formation and resorption.
REFERENCE   5  (bases 1 to 4133)
  AUTHORS   Hou,J.B., Shen,Q.N., Wan,X., Liu,X.K., Yu,Y., Li,M., Gao,W.W. and
            Zhao,B.
  TITLE     Ubiquitin-Specific Protease 29 Exacerbates Cerebral
            Ischemia-Reperfusion Injury in Mice
  JOURNAL   Oxid Med Cell Longev 2021, 6955628 (2021)
   PUBMED   34824671
  REMARK    GeneRIF: Ubiquitin-Specific Protease 29 Exacerbates Cerebral
            Ischemia-Reperfusion Injury in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4133)
  AUTHORS   Kogo,H., Tsutsumi,M., Ohye,T., Inagaki,H., Abe,T. and Kurahashi,H.
  TITLE     HORMAD1-dependent checkpoint/surveillance mechanism eliminates
            asynaptic oocytes
  JOURNAL   Genes Cells 17 (6), 439-454 (2012)
   PUBMED   22530760
REFERENCE   7  (bases 1 to 4133)
  AUTHORS   Lin,Y.W., Hsu,T.H. and Yen,P.H.
  TITLE     Localization of ubiquitin specific protease 26 at blood-testis
            barrier and near Sertoli cell-germ cell interface in mouse testes
  JOURNAL   Int J Androl 34 (5 Pt 2), e368-e377 (2011)
   PUBMED   21449984
  REMARK    GeneRIF: RT-PCR assays detected the expression of Usp26 in germ
            cells, but not in primary Sertoli cell lines
REFERENCE   8  (bases 1 to 4133)
  AUTHORS   Shin,Y.H., Choi,Y., Erdin,S.U., Yatsenko,S.A., Kloc,M., Yang,F.,
            Wang,P.J., Meistrich,M.L. and Rajkovic,A.
  TITLE     Hormad1 mutation disrupts synaptonemal complex formation,
            recombination, and chromosome segregation in mammalian meiosis
  JOURNAL   PLoS Genet 6 (11), e1001190 (2010)
   PUBMED   21079677
  REMARK    Erratum:[PLoS Genet. 2011;7(2). doi:
            10.1371/annotation/8aa656b6-55f7-4795-a441-cf243ea62175]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4133)
  AUTHORS   Wang,P.J., Page,D.C. and McCarrey,J.R.
  TITLE     Differential expression of sex-linked and autosomal
            germ-cell-specific genes during spermatogenesis in the mouse
  JOURNAL   Hum Mol Genet 14 (19), 2911-2918 (2005)
   PUBMED   16118233
  REMARK    GeneRIF: Germ-cell-specific sex-linked genes, like Usp26, are
            subject to meiotic sex-chromosome inactivation (MSCI) during
            spermatogenesis.
REFERENCE   10 (bases 1 to 4133)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
  REMARK    GeneRIF: Usp26 is a testis-specific gene identified in a
            genome-wide cDNA subtraction screen.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133417.1 and AL662931.10.
            
            On Oct 24, 2009 this sequence version replaced NM_031388.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1610              AK133417.1         5-1614
            1611-4133           AL662931.10        19483-22005         c
FEATURES             Location/Qualifiers
     source          1..4133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 28.31 cM"
     gene            1..4133
                     /gene="Usp26"
                     /note="ubiquitin specific peptidase 26"
                     /db_xref="GeneID:83563"
                     /db_xref="MGI:MGI:1933247"
     exon            1..13
                     /gene="Usp26"
                     /inference="alignment:Splign:2.1.0"
     exon            14..156
                     /gene="Usp26"
                     /inference="alignment:Splign:2.1.0"
     exon            157..272
                     /gene="Usp26"
                     /inference="alignment:Splign:2.1.0"
     exon            273..331
                     /gene="Usp26"
                     /inference="alignment:Splign:2.1.0"
     exon            332..435
                     /gene="Usp26"
                     /inference="alignment:Splign:2.1.0"
     exon            436..481
                     /gene="Usp26"
                     /inference="alignment:Splign:2.1.0"
     exon            482..537
                     /gene="Usp26"
                     /inference="alignment:Splign:2.1.0"
     exon            538..618
                     /gene="Usp26"
                     /inference="alignment:Splign:2.1.0"
     exon            619..4133
                     /gene="Usp26"
                     /inference="alignment:Splign:2.1.0"
     CDS             696..3203
                     /gene="Usp26"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thioesterase 26; deubiquitinating enzyme
                     26; ubiquitin-specific-processing protease 26; ubiquitin
                     thiolesterase 26; ubiquitin specific protease 26"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 26"
                     /protein_id="NP_113565.2"
                     /db_xref="CCDS:CCDS30122.1"
                     /db_xref="GeneID:83563"
                     /db_xref="MGI:MGI:1933247"
                     /translation="MEPILINAQVQMWSAKAGMSKSRNALIETCVGKREVKLILYFST
                     GKIKTLQLHDNIKSVVLQTYGEDQNYLHLTFKNNDFLFVEKLTTTDARRLKRFLDKTS
                     QGSIRPARSDERCGEPSTSAQELNGSGSSCETNSECFESPKESEMCMFRELSLLPSSS
                     TFLHNVGLLENQFIKRKRFFSDLAKNEKQSNLKDSIRDFEANLVVCISNEKGKERNVR
                     EVDISKPGFGFPFETNYPEDSGVDVRDLNDLITKLFSPVLLETHCIENGLEWHEYMKT
                     YLLYPEKLWQGLPNVGNTCYINVVLQSLCSIPLFINDLFNQGFPWIKAPKDDFNMLLM
                     QLLVLKDIYNARFRQKLLIGITKALPIFGEIFAVDRQNDAHEFLSLCLVQLKETFQRV
                     TMMWQSENDSGDFYLLKDIFADYATINKMPVCPVTNNFEFELLSSIFCKACGLTLFKG
                     EPSRYLSINIPQGGKDMSIQSTLDLFFSAEELEHRCEKCLYNKSVSFHRFGRLPRVII
                     VHLKRYHFNESWVMKKDERPILVSKYLRLSCHCSKSTKPPPPLRPGEHVKNLDLLKPL
                     EVLGSEILKLPFNSVRTSRSKGFETINITSNRESEAQSGKRVSEVLSGKVQQENSGKG
                     DTAHIVGSELTKETEKLKKHEEEHRPSDLDSGSIREAQKYQQAEKCNEGRSDKQISLE
                     ALTQSRPKPISQEQTENLGKTTLSHTQDSSQSSQSSSDSSKSSRCSDDLDKKAKPTRK
                     VDPTKLNKKEDNVYRLVNIINHIGNSPNGGHYINDAFDFKRQSWFTYSDLHVTRTQED
                     FVYRGRSSTGYVFFYMHNDIFEELLAKETQSTSTSKG"
     regulatory      3503..3508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp26"
                     /note="hexamer: ATTAAA"
     polyA_site      3533
                     /gene="Usp26"
                     /note="major polyA site"
     regulatory      3926..3931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp26"
                     /note="hexamer: TATAAA"
     polyA_site      3945
                     /gene="Usp26"
ORIGIN      
        1 tcaccaatga ggaccacaac caatctagat ccgtgggggt ctgcctataa aaggaggctc
       61 accggggtgc ccagcctcca ttttgtctca gcttttggag tgtacagtgc tagacacttt
      121 acactctggt aaacaggaca gcaaggagac aaaaaggggt gtgaaccaga gtgaggaccg
      181 gaccagctca gaccagcgca gacaggacca gaccggaagt accacagacg gcgcagcagc
      241 ggcagctgtg gcctcgaccg ggaactttag cgttcttctg agcaagaaca cctgtgttcc
      301 agccagggag tgctttactg cctcctcaca gaaaatctag ttgacggtgg aagaattacc
      361 tggagtggac tgcaaaaaaa aaaaaaaaaa aaaaaaacag aactgcaaga gtcaagagag
      421 tgttggtgtg ttcaggccag agtctctgtt ctatacagca gcaaatccta ggacttgatt
      481 gctctccatt cactgtttct acctgtgctg agtgcctgtc ctaagattct gatagaggtt
      541 gttttccctt ggcatataca cacactgctg agttgggaag ctgcttcatt tgcatttagc
      601 atccagtgcc agtctctggt aaacttggga aacaaataga aactccgaga ttgttaatca
      661 gtatacgtga gtttacttgc aaagaaaaaa gaagtatgga gcccatattg ataaatgctc
      721 aagtccagat gtggagtgca aaggcaggaa tgtccaagtc aagaaatgca ctcattgaaa
      781 catgtgtagg aaaacgagaa gttaaactta ttctctattt cagcactgga aagattaaga
      841 ctttgcaact acacgataat attaaaagtg tggtccttca aacctatggc gaagaccaga
      901 attacctaca tttgactttt aaaaataatg atttcttgtt tgttgagaaa ctcaccacca
      961 cagatgccag aagactgaag agatttctag acaaaacctc tcaaggtagt attcggccag
     1021 ccagaagtga tgagagatgt ggtgagccta gcacaagtgc acaggagttg aatggctctg
     1081 gaagttcatg tgaaacaaat agtgagtgct ttgaatcacc caaagaaagt gaaatgtgca
     1141 tgtttcgtga gttgtctttg cttccatcct catcaacctt tcttcacaat gtaggattat
     1201 tagaaaacca attcataaag aggaaaagat ttttctctga tttagcaaaa aatgaaaaac
     1261 agagcaacct gaaggacagt atcagggact ttgaggcaaa tttagtggtg tgtatctcta
     1321 atgaaaaggg aaaagaaagg aatgtaagag aagtagacat cagtaagcca gggtttggat
     1381 ttccatttga gaccaactat cctgaagata gtggtgtgga tgttcgtgat cttaatgatc
     1441 tcattacaaa attattttct ccagttctgt tggaaacaca ctgtattgag aacggcctag
     1501 agtggcatga atatatgaag acatacttgc tttacccaga gaaattgtgg caaggcctgc
     1561 ctaatgtggg aaacacctgc tatataaatg ttgtattaca gtctctatgc tcaataccac
     1621 tgtttattaa tgatttattc aaccagggtt tcccatggat taaagctccc aaagatgatt
     1681 ttaacatgct cttgatgcaa ctgcttgttt tgaaagatat ttacaacgca agatttagac
     1741 agaagttact tataggtatt acaaaagccc tccccatatt tggagagata tttgctgttg
     1801 acaggcagaa tgatgctcat gagtttttaa gtctctgttt agttcagttg aaggagactt
     1861 tccaaagagt aaccatgatg tggcagtctg aaaatgattc gggggatttt tacttactta
     1921 aagacatttt tgctgattat gctactatca acaaaatgcc cgtttgtcct gttaccaata
     1981 attttgaatt tgagttgcta agctccattt tttgtaaagc ttgtggcctg actcttttta
     2041 agggagaacc aagtagatac ctttctatca acattcccca aggagggaaa gacatgtcca
     2101 tccagtccac tttagatctt ttctttagtg cagaggagct tgagcatagg tgtgaaaagt
     2161 gtttgtacaa caaatctgtt tcatttcaca ggtttggccg gctacccagg gtaattattg
     2221 ttcatctgaa acgctatcac tttaatgagt catgggtaat gaagaaggat gagcggccca
     2281 tccttgtttc caaatactta aggctgtctt gtcactgtag caaaagcaca aaaccgcccc
     2341 caccccttcg cccaggtgaa catgttaaga atcttgactt attaaaaccc cttgaagtgt
     2401 tgggttccga aatactcaaa ttgcctttta attcagtgag gacctctaga tccaagggtt
     2461 tcgaaactat aaacatcaca tcaaacaggg agtcagaagc acaaagtggg aaaagagtct
     2521 ctgaagtgtt gagtggaaaa gtgcagcagg aaaattcagg gaaaggtgac acagcacata
     2581 tagttgggtc agaacttaca aaggagactg agaaactcaa gaaacatgag gaagagcata
     2641 gacccagtga tttagattct ggtagtatca gggaggccca aaagtaccaa caggctgaga
     2701 aatgtaacga agggagaagt gataagcaga tttccctaga ggcacttact caaagccgtc
     2761 caaaaccaat ctcccaggaa cagacagaaa accttgggaa aactacactg tcacataccc
     2821 aggatagtag tcagagttca cagagctcat cagattccag taagagctcc cgatgcagtg
     2881 atgatctcga taagaaggca aagcctacac gcaaggtgga tccaacaaag ttaaataaaa
     2941 aagaagataa tgtttacagg cttgttaata ttatcaacca tattgggaac agtcccaatg
     3001 gaggccacta catcaatgat gcctttgact tcaagaggca gagttggttc acttatagtg
     3061 atctacatgt aacaagaacc caagaggact ttgtatatag gggtcggagt tctactgggt
     3121 atgtcttctt ttacatgcat aatgatatat ttgaagagct cttggcaaag gaaactcagt
     3181 ctaccagcac atccaagggt tagtaagagg agtgtatgct tcacagtaca tgtctatcca
     3241 aatgcctcac ttatctaaat tggatagaga aggacagata attagcccag gaccaacagc
     3301 tcaacgaaca tttatagaga aacgtttgtt ccaaccctga ccacatcagt cttataatta
     3361 cagctcatgc taatgagtgt tctcttatac aagtttggaa ctgtaacttt tgtatagtat
     3421 tttgtcataa attttattat tgacagtaag gtttttcagt attttggtgg aagttatata
     3481 atccaaagtt gcctttatac cgattaaaat gacttatttt gcttccagta aaaggtatgt
     3541 tttctctcat ttctgctttc tttcttgcat ggcagcataa taagttctaa tgaaaaagct
     3601 tttatatatc agaaggaaaa ccacacatgc ccagacacag cacagttcag acgagtctat
     3661 ccagcgctgt taccccagcc tgctgctctc ttgctctttc tacatttgga atggttcggt
     3721 gtcatcctcc cctcctggct ttctcacagt ggatgccaat taatggtgat gcttaagtga
     3781 agagagaaga gaacatttta tggctgcaca tgttggaaaa aatacaaaaa tggggagagg
     3841 gctgcattta gcttttgttg atttttagga gttttcatta acactgaaca atgttcttac
     3901 tgttctctga tttaggcctt ggttttataa actgttttca aaatagtttg attttgttaa
     3961 gtctgttttc cagtgtctgt ctttagttgt cttgtcttta atggggttat tttcttatta
     4021 ggaaaaaaac aatttccact tctagaatta acgttgaagg agctctgcat gtgctcggga
     4081 cctactgtgt gctcctttct ccagaattct ctgtttggga tggttgacac cgt
//
