LOCUS       NM_013918               4432 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 25 (Usp25), mRNA.
ACCESSION   NM_013918
VERSION     NM_013918.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4432)
  AUTHORS   Xu,R., Huang,F., Liu,Q., Lv,Y., Hu,L. and Zhang,Q.
  TITLE     USP25 attenuates anti-GBM nephritis in mice by negative feedback
            regulation of Th17 cell differentiation
  JOURNAL   Ren Fail 46 (1), 2338932 (2024)
   PUBMED   38616174
  REMARK    GeneRIF: USP25 attenuates anti-GBM nephritis in mice by negative
            feedback regulation of Th17 cell differentiation.
REFERENCE   2  (bases 1 to 4432)
  AUTHORS   Jiang,P., Jing,Y., Zhao,S., Lan,C., Yang,L., Dai,X., Luo,L.,
            Cai,S., Zhu,Y., Miller,H., Lai,J., Zhang,X., Zhao,X., Wu,Y.,
            Yang,J., Zhang,W., Guan,F., Zhong,B., Umehara,H., Lei,J., Dong,L.
            and Liu,C.
  TITLE     Expression of USP25 associates with fibrosis, inflammation and
            metabolism changes in IgG4-related disease
  JOURNAL   Nat Commun 15 (1), 2627 (2024)
   PUBMED   38521787
  REMARK    GeneRIF: Expression of USP25 associates with fibrosis, inflammation
            and metabolism changes in IgG4-related disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4432)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4432)
  AUTHORS   Liu,B., Miao,X., Shen,J., Lou,L., Chen,K., Mei,F., Chen,M., Su,X.,
            Du,X., Zhu,Z., Song,W. and Wang,X.
  TITLE     USP25 ameliorates diabetic nephropathy by inhibiting TRAF6-mediated
            inflammatory responses
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110877 (2023)
   PUBMED   37657242
REFERENCE   5  (bases 1 to 4432)
  AUTHORS   Li,Z., Liu,B., Lambertsen,K.L., Clausen,B.H., Zhu,Z., Du,X., Xu,Y.,
            Poulsen,F.R., Halle,B., Bonde,C., Chen,M., Wang,X., Schluter,D.,
            Huang,J., Waisman,A., Song,W. and Wang,X.
  TITLE     USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic
            Stroke by Deubiquitinating TAB2
  JOURNAL   Adv Sci (Weinh) 10 (28), e2301641 (2023)
   PUBMED   37587766
REFERENCE   6  (bases 1 to 4432)
  AUTHORS   Zhong,B., Liu,X., Wang,X., Chang,S.H., Liu,X., Wang,A.,
            Reynolds,J.M. and Dong,C.
  TITLE     Negative regulation of IL-17-mediated signaling and inflammation by
            the ubiquitin-specific protease USP25
  JOURNAL   Nat Immunol 13 (11), 1110-1117 (2012)
   PUBMED   23042150
  REMARK    GeneRIF: USP25 is a deubiquitinating enzyme (DUB) that negatively
            regulates IL-17-triggered signaling.
REFERENCE   7  (bases 1 to 4432)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4432)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (bases 1 to 4432)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 4432)
  AUTHORS   Valero,R., Marfany,G., Gonzalez-Angulo,O., Gonzalez-Gonzalez,G.,
            Puelles,L. and Gonzalez-Duarte,R.
  TITLE     USP25, a novel gene encoding a deubiquitinating enzyme, is located
            in the gene-poor region 21q11.2
  JOURNAL   Genomics 62 (3), 395-405 (1999)
   PUBMED   10644437
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC048171.1.
            
            On Jun 19, 2003 this sequence version replaced NM_013918.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048171.1, AF170563.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4432
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 44.4 cM"
     gene            1..4432
                     /gene="Usp25"
                     /note="ubiquitin specific peptidase 25"
                     /db_xref="GeneID:30940"
                     /db_xref="MGI:MGI:1353655"
     exon            1..72
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..3195
                     /gene="Usp25"
                     /EC_number="3.4.19.12"
                     /note="mUSP25; ubiquitin thioesterase 25; deubiquitinating
                     enzyme 25; ubiquitin-specific-processing protease 25;
                     ubiquitin thiolesterase 25; ubiquitin specific protease
                     25"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 25"
                     /protein_id="NP_038946.2"
                     /db_xref="CCDS:CCDS28275.1"
                     /db_xref="GeneID:30940"
                     /db_xref="MGI:MGI:1353655"
                     /translation="MTVEQNVLQQSAAQKHQQTFLNQLREITGINDAQILQQALKDSN
                     GNLELAVAFLTAKNAKTPPQEETGYYQTALPGNDRYISVGSQADANVIDLTGDDKDDL
                     QRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPIEVWRDSRNPYD
                     RKRQEKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRN
                     LPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLED
                     AFQMKAEEETDEEKPKNPMVELFYGRFLAMGVLEGKKFENTEMFGQYPLQVNGFKDLH
                     ECLEAAMIEGEIESLHSDNSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNK
                     LEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVD
                     VLQYALEFASSKPVCTSPVDDIDASSSASGPLPSQSLPSTTEQQGPCASDLPGSSSPA
                     SGAALPLRSVIHKPFTQSRIPPDLPMHPAPRHITEEELCVLESCLHRWRTEIENDTRD
                     LQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKY
                     NDIAVTKSSWEELVRDSFGGYRNASAYCLMYIDDKAQFLIQEEFNKETGQALVGMETL
                     PPDLRDFVEEDNQRFEKELEEWDTQLAQRSLQEKLLAAPKLREAEASATTAQAGGADY
                     LEQPSRSDLSKHWKEETLRVIAKASHDLEDKGPETVLQSAIKLEYSRLVKLAQEDTPP
                     ETDYRLHHVLVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKP
                     EEVNLEEYEEWHADYKKFRETTMYLITGLENFQRESYIDSLLFLLCAYQNNKELLSKG
                     PYRGHDGELISHYRRECLLKLNEQAAELFESGEDGDVNNGLIIMNEFIVPFLPLLLVD
                     DMEEKDILAVEDMRNRWCSYLGQEMEANLQEKLTDFLPKLLDCSTEIKGFHEPPKLPS
                     YSAHELCERFARIMLSLSRTPADGR"
     exon            73..150
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            151..295
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            296..419
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            420..582
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            583..669
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            670..807
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            808..884
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            885..958
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1107
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1235
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1331
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1493
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1723
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1794
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..2023
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2224
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2364
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2543
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2622
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2702
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2826
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..3022
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..4413
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgacaggcg gggccgccgc gggggccatg accgtggagc agaatgtgct gcagcagagc
       61 gcggcgcaga agcaccagca gacatttttg aatcagctga gagaaattac tgggattaat
      121 gacgcccaga tactccaaca agccctgaag gatagtaacg gaaacttgga attagcagta
      181 gccttcctca ctgcaaagaa tgccaagacc cccccacagg aggagacagg ctattaccag
      241 acagcgcttc caggcaacga caggtacatc agcgtgggaa gccaggcaga tgcaaatgta
      301 attgatctca ctggagatga caaagatgat cttcagagag cgattgcctt gagtttggcg
      361 gagtcaaaca gggcattcag ggagacgggc ataaccgatg aagagcaggc catcagtaga
      421 gttcttgaag ccagcatagc agaaaataaa gcatgcttga agagaacacc tatagaagtt
      481 tggagggatt ctcgaaaccc ctatgacaga aaaagacaag agaaagctcc agtcggtctg
      541 aagaatgtcg gcaacacctg ctggtttagt gcagttattc agtcattatt caatcttttg
      601 gagtttagaa gattagttct gaattacaag cctccatcaa atgctcaaga tttaccccga
      661 aaccaaaagg aacatcggaa tttgcctttt atgcgggaac tgaggtatct gtttgcactt
      721 cttgttggta ccaagaggaa gtatgttgat ccgtccagag cagttgagat tctgaaggat
      781 gccttcaaat ccaatgactc acagcagcaa gatgtgagtg agtttacaca caagttattg
      841 gactggttgg aagatgcctt ccaaatgaaa gctgaagagg aaacggatga agagaagcca
      901 aagaacccta tggtagagct gttctatgga agattcctag ccatgggagt gcttgaagga
      961 aaaaaatttg agaacactga aatgttcggt cagtatccac ttcaggtgaa cgggttcaaa
     1021 gacctgcatg agtgcctgga ggccgccatg atcgaagggg agatcgaatc cttacactcc
     1081 gataactcag gaaagtcagg ccaggagcat tggttcactg aattgccgcc ggtattaaca
     1141 tttgaactgt caagatttga atttaaccag gcattgggaa gaccagaaaa aattcacaat
     1201 aaactagaat ttccccaagt tttatatctg gacaggtata tgcacagaaa tagagaaata
     1261 acaagaatta aacgtgaaga gatcaagaga cttaaagatt acctcacagt attacaacaa
     1321 agattagaga gatatttaag ctatggttcc ggtcccaaaa gattcccatt ggtagatgtt
     1381 ctacagtatg cattggagtt tgcctccagt aaacctgtgt gcacttcccc cgttgatgac
     1441 atcgatgcta gttcctcagc aagtggcccc ctaccatcac agtccttacc aagcacaaca
     1501 gaacagcagg gaccctgtgc ttcagatctg cccggctcct cctcacccgc atcaggtgcc
     1561 gccctgccct tgaggtcagt gattcacaaa cccttcactc agtctcggat acctccagat
     1621 ttgcccatgc atccggcacc aaggcacatc acagaggaag aactgtgcgt gctggagagc
     1681 tgtttacatc gctggaggac ggaaatagaa aatgacacgc gagatctgca ggaaagcata
     1741 tccagaatcc atcgaacaat tgaactcatg tactcggaca aatccatgat ccaagtccct
     1801 taccgcctcc atgccgtcct agttcatgag ggccaggcta atgccggcca ctactgggcg
     1861 tacatctttg accaccggga gagccggtgg atgaagtata atgatattgc tgtgaccaag
     1921 tcttcatggg aagagctagt gagggactct ttcggtggtt atcgaaatgc cagtgcatac
     1981 tgcttaatgt acatagacga caaggcacag ttcctaatac aagaggagtt taataaagag
     2041 actgggcagg cccttgttgg aatggaaacc ttacctccag acttgagaga ctttgttgag
     2101 gaggacaacc agcgctttga gaaggaactg gaagaatggg acacgcagct tgcccaacga
     2161 tcactgcaag aaaagctgct agctgcgccg aaactgcggg aagcagaggc ttcggccacc
     2221 acagcacaag caggaggcgc agactatcta gagcagccat caagaagtga cttgtcaaag
     2281 cactggaaag aagaaacgct ccgagtgatt gccaaggcgt cacatgatct tgaagataaa
     2341 gggccagaga cagttttgca gtcggcaatt aaattagagt attctaggct ggttaagttg
     2401 gcccaagaag atactccacc agaaacagat tatcgtttac atcatgtcct ggtctacttt
     2461 atccagaacc aggcaccaaa gaaaatcatt gagaaaacat tactcgaaca atttggagat
     2521 agaaatttga gttttgatga aaggtgtcac aacataatga aagttgccca agccaaactg
     2581 gaaatgatca aacctgaaga agtgaacttg gaagaatatg aggagtggca tgcagattat
     2641 aagaaattcc gagaaacaac tatgtatctc ataactggac tagaaaactt tcagagagaa
     2701 agttatatag actccttgct gttccttctc tgtgcttatc agaataacaa agagctcttg
     2761 tctaagggtc cgtacagagg ccacgatggg gagctgatat cacattacag aagagagtgc
     2821 ttactgaaat taaacgagca agcggccgag ctgtttgagt ctggagagga cggagacgtg
     2881 aacaatggct taattattat gaatgagttt atcgttccct ttctgccctt gttgctggtg
     2941 gatgacatgg aagagaaaga tatccttgct gtggaagaca tgaggaatcg ctggtgttca
     3001 tacctggggc aagaaatgga agcaaacctc caagaaaagc tcacggattt tctgccaaaa
     3061 ctgcttgatt gttctacaga gattaaaggt ttccacgagc caccaaagtt accttcctac
     3121 tctgcgcacg aactctgtga gcgattcgcc cggatcatgt tgtccctcag tcgtacgcct
     3181 gctgatggaa gataaactgc ccggacttcc cagggtcacc atagaaactc tgttctcacc
     3241 ccggctacct gccgcgggga ttgcttgctg ctgctagagt ttttaacttt ttattttaat
     3301 aactgcaaaa gacaaaacga ctatgccgac cttagccaag actgcaaaca ataaacccga
     3361 gaatcgcatg gcactcacct tgttttatcc gaaaccaatg tataattaca aatgaattga
     3421 tttcttgtgg caaaagtatg cttttgctgc cttctattgc agtattgcct ctcagttttc
     3481 tttacaaaca gctttccatt tagtctggga cctccaagac taagccatta agtgtttagc
     3541 actgtctatg atacataata tttggtagct tgtaaatgaa atcaaagaat aaagttttat
     3601 ttatggctac ctaagtgttt gtaagcaggt atattgtata atggtgtgta ttttagttat
     3661 atacatgagt ttagccatgg ggtggacatt ggatgatgca tacaataata gcccttttgt
     3721 gttagtataa tggaaccata ttggaaatgt actgagtgtt tagcacttca ctgtgtctat
     3781 atccactgag ttcttggacc taaacatgtt atgttcagtc agatttcact aaagtgagcg
     3841 actgggtttt aagtcaaact gcactgaaac ttttaacctt tacttagatt aaacgtttgt
     3901 tcttttctgt atgtataaat aatacaaggt gattatttca agagaaacct gaaaaagtac
     3961 ttgaataagg gctattgtga aatttaaaaa gaaaaaaaat gtgcacatat acacacacat
     4021 acatgcacat acatgtattc ttcataatgg agggcaatgt ttttcattat ataattattc
     4081 tatttttgta aattatatac tactttaatt gagaaatgtc ctctactaat caatgctgtg
     4141 aaatgaaatt gatactgttc aactaggaat tataagaatc ttaacttttt atttgcctcc
     4201 tttttttttt ccaaaaaaaa aaaaaaaaaa aaaccgtaaa agacgtagac tattttatga
     4261 atggaactac tgttttaaga tcaatgaagt gatgttgtga atgaaaattt agattcatgc
     4321 tttaaaggta atcatgttac caccgatcta tttttgaatt tataaaaatt ctttataact
     4381 gatactttgt tagcatagta aaatatatcc ttaaaaaaaa aaaaaaaaaa aa
//
