LOCUS       NM_001004143            4442 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 22 (Usp22), mRNA.
ACCESSION   NM_001004143
VERSION     NM_001004143.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4442)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4442)
  AUTHORS   Prokakis,E., Bamahmoud,H., Jansari,S., Fritsche,L., Dietz,A.,
            Boshnakovska,A., Rehling,P., Johnsen,S.A., Gallwas,J. and
            Wegwitz,F.
  TITLE     USP22 supports the aggressive behavior of basal-like breast cancer
            by stimulating cellular respiration
  JOURNAL   Cell Commun Signal 22 (1), 120 (2024)
   PUBMED   38347585
  REMARK    GeneRIF: USP22 supports the aggressive behavior of basal-like
            breast cancer by stimulating cellular respiration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4442)
  AUTHORS   Kuang,X., Salinger,A., Benavides,F., Muller,W.J., Dent,S.Y.R. and
            Koutelou,E.
  TITLE     USP22 overexpression fails to augment tumor formation in MMTV-ERBB2
            mice but loss of function impacts MMTV promoter activity
  JOURNAL   PLoS One 19 (1), e0290837 (2024)
   PUBMED   38236941
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4442)
  AUTHORS   Jiang,Y.N., Yang,S.X., Guan,X., Chen,Q., Zhao,L., Yu,X.Y.,
            Ren,F.F., Wu,S.J., Wu,L.P., Lai,T.F. and Li,L.
  TITLE     Loss of USP22 alleviates cardiac hypertrophy induced by pressure
            overload through HiF1-alpha-TAK1 signaling pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (8), 166813 (2023)
   PUBMED   37488049
  REMARK    GeneRIF: Loss of USP22 alleviates cardiac hypertrophy induced by
            pressure overload through HiF1-alpha-TAK1 signaling pathway.
REFERENCE   5  (bases 1 to 4442)
  AUTHORS   Li,Y., Gao,J., Liu,C., Bu,N., Zhan,S., Wu,H., Zhang,R., Sun,H. and
            Fan,H.
  TITLE     USP22 knockdown protects against cerebral ischemia/reperfusion
            injury via destabilizing PTEN protein and activating the mTOR/TFEB
            pathway
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 396 (11), 3163-3175 (2023)
   PUBMED   37191727
  REMARK    GeneRIF: USP22 knockdown protects against cerebral
            ischemia/reperfusion injury via destabilizing PTEN protein and
            activating the mTOR/TFEB pathway.
REFERENCE   6  (bases 1 to 4442)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   7  (bases 1 to 4442)
  AUTHORS   Lee,H.J., Kim,M.S., Shin,J.M., Park,T.J., Chung,H.M. and Baek,K.H.
  TITLE     The expression patterns of deubiquitinating enzymes, USP22 and
            Usp22
  JOURNAL   Gene Expr Patterns 6 (3), 277-284 (2006)
   PUBMED   16378762
REFERENCE   8  (bases 1 to 4442)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   9  (bases 1 to 4442)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   10 (bases 1 to 4442)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL646093.9 and AK160992.1.
            
            On Dec 16, 2009 this sequence version replaced NM_001004143.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155071.1, AK220368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AL646093.9         187486-187577       c
            93-403              AK160992.1         2-312
            404-404             AL646093.9         180852-180852       c
            405-4282            AK160992.1         314-4191
            4283-4442           AL646093.9         164299-164458       c
FEATURES             Location/Qualifiers
     source          1..4442
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..4442
                     /gene="Usp22"
                     /note="ubiquitin specific peptidase 22"
                     /db_xref="GeneID:216825"
                     /db_xref="MGI:MGI:2144157"
     exon            1..345
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1752
                     /gene="Usp22"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 22; ubiquitin
                     thioesterase 22; deubiquitinating enzyme 22;
                     ubiquitin-specific-processing protease 22; ubiquitin
                     thiolesterase 22"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 22"
                     /protein_id="NP_001004143.2"
                     /db_xref="CCDS:CCDS24807.1"
                     /db_xref="GeneID:216825"
                     /db_xref="MGI:MGI:2144157"
                     /translation="MVARPEPEVEAMDAELAVPPPGCSHLGSFKVDNWKQNLRAIYQC
                     FVWSGTAEARKRKAKSCVCHVCGIHLNRLHSCLYCVFFGCFTKKHIHDHAKSKRHNLA
                     IDLMYGGIYCFLCQDYIYDKDIEIIAKEEQRKAWKMQGVGEKFSTWEPTKRELELLKH
                     NPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSS
                     CLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHR
                     HCKGDDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS
                     STPFWPLSPGSEGSVVNGESHASGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQES
                     TKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKESRMNGQY
                     QQPLDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVL
                     DSEGYLLFYHKQFLEYE"
     exon            346..478
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            479..592
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            593..694
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            695..864
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1012
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1118
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1277
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1404
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1496
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1559
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1709
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..4442
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4414..4419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp22"
                     /note="hexamer: AATAAA"
     polyA_site      4438
                     /gene="Usp22"
                     /note="major polyA site"
ORIGIN      
        1 gcccagcctc gccccgccct cctcgaagtc agagggtgct gcgcgtgcgg tgggtgctgc
       61 tgtagcctgc ctgagttctc aacgcggtct ttgtccccca gctttgttct cgccgccctg
      121 gcgtcgtcct cgcccccgtc gccgcctgcc ccgcgcgccc gggccttgcc cgccatggtg
      181 gccaggccgg agcctgaggt cgaggccatg gacgctgagc tggcggtacc gccgcctggc
      241 tgctcgcacc tgggcagctt caaggtggac aactggaagc aaaacctgcg ggccatctac
      301 cagtgcttcg tgtggagcgg aactgccgag gctcgcaagc gcaaggcaaa gtcctgtgtc
      361 tgccatgtct gcggcatcca cctgaaccgg ctgcactctt gcctctactg tgtcttcttt
      421 ggctgtttca cgaagaagca catccatgac catgccaagt caaagcgaca caacctggcc
      481 atcgacctga tgtacggagg tatttactgc ttcttgtgtc aggactacat ctatgacaaa
      541 gacatagaaa tcattgccaa agaggagcag cgcaaggctt ggaagatgca aggtgttgga
      601 gagaagtttt caacttggga accaactaaa cgggagctgg aactgctgaa gcataaccca
      661 aagaggcgga agatcacctc caattgtacc ataggtctgc gtggactgat caacctgggg
      721 aacacgtgtt tcatgaactg catcgtgcag gcgctgaccc acactccgct cctgagagac
      781 ttctttctgt cggataggca ccgctgtgag atgcagagcc ccagctcctg cttggtctgt
      841 gagatgtcct ctctcttcca ggagttttac tcagggcacc gctccccaca cattccatac
      901 aagctgctgc acctggtgtg gacgcacgcc cggcacctgg cgggttatga gcagcaggac
      961 gcacatgagt tcctcattgc agccctggac gtcctccacc ggcactgcaa aggtgatgac
     1021 aatgggaaga aagccaacaa tcctaaccac tgcaattgca tcattgacca gatctttacg
     1081 ggtgggctcc agtctgatgt tacatgccaa gtctgccacg gggtctccac caccatagac
     1141 cccttctggg acatcagttt agaccttccc ggttcttcta ccccattctg gcccttgagc
     1201 ccagggagcg agggcagtgt ggttaatggg gagagccatg catccgggac caccactctc
     1261 acagactgcc tgcgaagatt taccagacca gagcacttag gaagcagtgc caagatcaag
     1321 tgtagcggtt gccatagcta ccaagagtcc acaaagcagc tcaccatgaa gaagctgccc
     1381 attgtggcct gtttccatct caaacgattt gaacactcag ccaaacttcg gcggaagatc
     1441 accacatatg tgtcttttcc cctggaactg gacatgacgc ccttcatggc ctccagcaaa
     1501 gagagcagga tgaatgggca ataccagcag cccctggaca gtctcaacaa tgacaacaaa
     1561 tactccctgt ttgctgtcgt taaccatcaa gggaccttgg agagtggcca ctacaccagc
     1621 ttcatccggc agcacaaaga ccagtggttc aagtgtgatg acgccattat caccaaggcc
     1681 agcatcaaag atgtactgga cagtgaaggg tacctactct tctatcacaa acagttcctg
     1741 gaatacgagt agcctcctgc cttgctggcc agagaaagag agagagagag aaagagagag
     1801 agagcaagtt ggcaaacttc ccgacatgat ccctgctccc cccaaatcag aacaccatgg
     1861 cattcctcct atgcaggcaa gcctccctca tggcctgcac taggagatgt gtcaggtggg
     1921 atgagcagag tggagtgcgc ccttggtgga aaggagctgc ctccccagca cctgtccttt
     1981 gagccttgta ggcaggggat ggatgtcttc agagcagacc aaccactctg cctgctgctt
     2041 caccctgcca tcccacctgc ctccttgaaa atgagcccgt caaagctgta gagtgggcag
     2101 agatgatgcc agagggcaga gtgcttgcag cagcagccct ctggcatgaa gggcagaggg
     2161 tatgtctctt ctttctaaaa ttgtaagata gccccaggcc caggttgagg ccacccacag
     2221 gctacaaata catctgtcct acagataact tagcatcaac tgcatgtgga aacatcggct
     2281 cagacgttcc ctttgttttc tagaaatagg tgtcgtctta cctctacccc atttgctctt
     2341 tttccacggt ggtgagtttc ctaaacgtga tagtagtgaa gtgaatgatt atcaagttat
     2401 acggaattct agatgattct ctcccctctg agagcgtgtc ttgctctttt gatcagtgtt
     2461 gtttccttgc cctgtgccct gccttccttc tcaaacggct ggtggccagg cagatatcag
     2521 agtccctggt atcttgatct ttgcagtaga ttccttggtg gctccattga cccaatcctc
     2581 ccatgtttct tcttggtctt tttgcctgcc cagggaggtt tagtgactgt gtgagatttg
     2641 aagctgaggt ccagttggag actgcattgc atagtgtcac ccgcttgcct ccattctgtg
     2701 ttcactatag tttcagttac agccagaata ggaaggctcc attaccagtt ctcctggcag
     2761 ggtcattcat gaagtttatt gtaagatatt ttgcatgtat ctctggacaa gcctaggctg
     2821 tccacttctg agcaactgga atctagggtc ttggtgtttc tcctcatacc actgcctttc
     2881 cagtggtgct tacccaggag cctgttggca cccacccagg agttgcccat cagaacaggc
     2941 aactatttcc taagagccag gctctgagcc gtagacccat agcaggtaac acgtgcatcg
     3001 tgtttgcata acaagtacgg ctgtgattta aattacatat aattatgtgt acagatactt
     3061 tttttttttt tttttttact atttgaaaat aagattttgt tttttcactt acaggctata
     3121 aaagagcagt acagggccca gcccagctcc ttagctagcg aattgcgatg gaatgacata
     3181 gctgtggcaa aactaagcgg ccgctgctca atcggtgtga aaatcactcg aggtcagggg
     3241 cagcagaaac tttgtcacgt ggtaacagtt gccctgttct tctctagtgt gtttctattt
     3301 ctgcatttaa gtaaagaaca gacttgaagc atgttttaga aaaatcctct tttgagtaca
     3361 gctgagccta gattctcaga catggaccat gtttgtggga ctctactgtg gagatgcccc
     3421 agggtcagca tgttgtattt gtgaacaagt ccacatgaaa aacttcactg cagttgccac
     3481 gggaaccaga gctccaagct tcctgaaggt ctgcctcctt gacactccag tgaatggggc
     3541 atccagaaca ggggagatga gcaggtgtgc tggccaggcc tgcctcctct gtccccacag
     3601 aacacgaccc atttcttcct atatttgggg cactaaggag gacagcagct gttttctgtc
     3661 aatgtgactt taacctttta tatccgaaag cattctcctt caccatggtt ttaacattct
     3721 aaacacttca ctctgtacct gtagcaaggt ctgccaactc tatggctgcc gcacatgcat
     3781 ctggccctcc ctctctgtcc tggggtcctc agcgtgctgt ctccactgga caggcatgtg
     3841 tggatggcta aggaacagtt tatttgagca atgggcttgg ttctttcagt tgcccctctg
     3901 gatagcaagg caggaaaagg gttcctcatc ctagaaccac ctagtatatg tgctcagatg
     3961 gtcacagaag tgcatctcac cacagggctg cattgcctac ccctctcttc catacactgc
     4021 tggcgccagc ttgacaggag actaaagtcc tcttcaaatg gcctcagtga gagagtaggg
     4081 cattgggatg gattctgcag ttcctctctt taccccagaa gtcccctcaa gctgggcact
     4141 acctgagtgt cctacaccat gtgaacctga gtgctgttgt attcggctca gtgtgtatgc
     4201 ttttccttgt gtaaaatcat tgttcttttt gacaagtggt ttgtttcatt tattatagct
     4261 ttgaaataaa aaatcgtgag ggaaaaaaaa tccaatgatt gtactgtggt taggagtttt
     4321 attaccaaga catttatgtc acttttcttt cccttgtcat tttgaggggc tatttgactc
     4381 ctccctaatg gcttttagtc tttcctatat cataataaag ctgcatttta ttctgaaacc
     4441 tg
//
