LOCUS       NM_013919               2200 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 21 (Usp21), mRNA.
ACCESSION   NM_013919
VERSION     NM_013919.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2200)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2200)
  AUTHORS   Montauti,E., Weinberg,S.E., Chu,P., Chaudhuri,S., Mani,N.L.,
            Iyer,R., Zhou,Y., Zhang,Y., Liu,C., Xin,C., Gregory,S., Wei,J.,
            Zhang,Y., Chen,W., Sun,Z., Yan,M. and Fang,D.
  TITLE     A deubiquitination module essential for Treg fitness in the tumor
            microenvironment
  JOURNAL   Sci Adv 8 (47), eabo4116 (2022)
   PUBMED   36427305
REFERENCE   3  (bases 1 to 2200)
  AUTHORS   Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y.,
            Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
REFERENCE   4  (bases 1 to 2200)
  AUTHORS   Kim,A., Koo,J.H., Jin,X., Kim,W., Park,S.Y., Park,S., Rhee,E.P.,
            Choi,C.S. and Kim,S.G.
  TITLE     Ablation of USP21 in skeletal muscle promotes oxidative fibre
            phenotype, inhibiting obesity and type 2 diabetes
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (6), 1669-1689 (2021)
   PUBMED   34523817
  REMARK    GeneRIF: Ablation of USP21 in skeletal muscle promotes oxidative
            fibre phenotype, inhibiting obesity and type 2 diabetes.
REFERENCE   5  (bases 1 to 2200)
  AUTHORS   Hou,P., Ma,X., Yang,Z., Zhang,Q., Wu,C.J., Li,J., Tan,L., Yao,W.,
            Yan,L., Zhou,X., Kimmelman,A.C., Lorenzi,P.L., Zhang,J., Jiang,S.,
            Spring,D., Wang,Y.A. and DePinho,R.A.
  TITLE     USP21 deubiquitinase elevates macropinocytosis to enable oncogenic
            KRAS bypass in pancreatic cancer
  JOURNAL   Genes Dev 35 (19-20), 1327-1332 (2021)
   PUBMED   34531315
  REMARK    GeneRIF: USP21 deubiquitinase elevates macropinocytosis to enable
            oncogenic KRAS bypass in pancreatic cancer.
REFERENCE   6  (bases 1 to 2200)
  AUTHORS   Nakagawa,T., Kajitani,T., Togo,S., Masuko,N., Ohdan,H.,
            Hishikawa,Y., Koji,T., Matsuyama,T., Ikura,T., Muramatsu,M. and
            Ito,T.
  TITLE     Deubiquitylation of histone H2A activates transcriptional
            initiation via trans-histone cross-talk with H3K4 di- and
            trimethylation
  JOURNAL   Genes Dev 22 (1), 37-49 (2008)
   PUBMED   18172164
REFERENCE   7  (bases 1 to 2200)
  AUTHORS   Lionikas,A., Blizard,D.A., Gerhard,G.S., Vandenbergh,D.J.,
            Stout,J.T., Vogler,G.P., McClearn,G.E. and Larsson,L.
  TITLE     Genetic determinants of weight of fast- and slow-twitch skeletal
            muscle in 500-day-old mice of the C57BL/6J and DBA/2J lineage
  JOURNAL   Physiol Genomics 21 (2), 184-192 (2005)
   PUBMED   15687484
REFERENCE   8  (bases 1 to 2200)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 2200)
  AUTHORS   Smith,T.S. and Southan,C.
  TITLE     Sequencing, tissue distribution and chromosomal assignment of a
            novel ubiquitin-specific protease USP23
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 184-188 (2000)
   PUBMED   10786635
REFERENCE   10 (bases 1 to 2200)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY110597.1, AK011148.1, AF177759.1 and BP770216.1.
            
            On Mar 11, 2009 this sequence version replaced NM_013919.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.873822.1,
                                           SRR7652917.793265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               BY110597.1         1-343
            344-881             AK011148.1         345-882
            882-1213            AF177759.1         681-1012
            1214-2176           AK011148.1         1224-2186
            2177-2200           BP770216.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.3 cM"
     gene            1..2200
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /note="ubiquitin specific peptidase 21"
                     /db_xref="GeneID:30941"
                     /db_xref="MGI:MGI:1353665"
     exon            1..200
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            201..821
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1922
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 21; ubiquitin specific
                     protease 23; ubiquitin thioesterase 21; deubiquitinating
                     enzyme 21; ubiquitin-specific-processing protease 21;
                     ubiquitin thiolesterase 21"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 21"
                     /protein_id="NP_038947.2"
                     /db_xref="CCDS:CCDS35774.1"
                     /db_xref="GeneID:30941"
                     /db_xref="MGI:MGI:1353665"
                     /translation="MPQASEHRLGRTREPPVNVQPRVGAKIPFPPRARSKERRNPVPG
                     PNSMLRPLPPRPGPPDERLKKLELGRGRTSGSRPRGPLRADHGVPLPGSPPPAVALPL
                     PSRTNLARSKSVSSGDLRPMGIALGGHRGAGELGAALSRLALRPEPPTLRRSTSLRRL
                     GGFPGPPTLLSIRTEPPTSHGSFHMISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLG
                     NTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCE
                     AVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASGPVP
                     SPPCRGGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRS
                     TTFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKK
                     LTVQRFPRILVLHLNRFSTSRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYAL
                     CNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPLRCL
                     "
     exon            822..881
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1002
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1114
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1273
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1338
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1442
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1529
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1608
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1716
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1831
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2185
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2165..2170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /note="hexamer: AATAAA"
     polyA_site      2185
                     /gene="Usp21"
                     /gene_synonym="ESTM28; Usp16; Usp23"
                     /note="major polyA site"
ORIGIN      
        1 gagactgtga agccggtggc cggtggccgg gcggcaccaa caaagatggc ggcggccctt
       61 gcggcgggag caagctgggc aacagctgcg gctaaagctg cagcccggcc tgtggggagg
      121 ctgtttgggg ataagagggg gtggccctga gctggagctg gaccccggct ggcctccccc
      181 gccgcctcac cgggggacag gtccagcctg tggtgcccac aatgccccag gcttctgagc
      241 accgcctggg ccggactcga gagccacctg tcaatgtaca gccccgagtg ggagccaaga
      301 taccatttcc tccccgggca cgcagcaagg agcgccgaaa cccagttcct gggccaaact
      361 ccatgttacg acctttgcct cccaggccag gtcccccaga tgaaaggctc aagaaactgg
      421 agctgggtcg gggtcggacc tcaggctctc gtcctagagg tccccttcga gcagatcatg
      481 gggttcccct gcctggctca ccgcccccag ctgtggctct gcctctccca tcccggacca
      541 acttagcccg ttccaagtct gtgagcagtg gggacttgcg tccaatgggg attgccttgg
      601 gagggcaccg tggcgctggc gagctagggg ctgcactgag ccgcttggca ctccggcctg
      661 agccacccac tttgagacgt agtacttctc tccggcgtct tgggggcttc cctggccccc
      721 ctaccctgct cagcatacgg acagagcccc ctacttccca tggctccttc cacatgatat
      781 ctgcccggcc ttctgagcct ttctactctg atgacaagat ggctcaccac acactgcttc
      841 tgggctctgg tcatgttggc ctccgaaatc taggaaatac atgcttcctg aatgccgtgc
      901 tacagtgttt gagcagcaca aggcctcttc gagacttctg tctgcgaagg gacttccggc
      961 aagaggtgcc cggaggaggc cgagcccagg aactcacaga agcctttgca gatgtgattg
     1021 gtgccctctg gcaccctgac tcctgtgaag ctgtgaatcc cacccgattc cgggctgtct
     1081 tccagaaata cgtcccttcc ttctctggat acagccagca ggatgcccaa gagttcctga
     1141 agctcctcat ggagcggttg caccttgaga tcaaccgacg agggcgccgg gcaccgccaa
     1201 tcttggccag cggaccagtt ccctctccac cttgccgagg aggaggggct ctgcatgaag
     1261 aacctgagtt gagtgatgat gaccgagcca acttaatgtg gaagcgctac ctggagcgag
     1321 aagacagcaa gattgtggac ctgtttgtgg gccagttgaa aagttgcctc aagtgccagg
     1381 cctgtgggta tcgctccacg accttcgagg ttttttgtga cctgtccctg cccatcccca
     1441 agaaaggatt tgctgggggc aaagtgtctt tgcgggattg cttcagcctt ttcaccaagg
     1501 aggaagagct agagtcggag aatgccccag tgtgtgaccg atgtcggcag aaaacccgaa
     1561 gtaccaaaaa gttgacagta caaagattcc cccgaatcct cgtgctccat ctgaaccgat
     1621 tttccacctc ccgaggctcc atcaagaaaa gttcagtagg tgtagacttc ccactgcaga
     1681 gactaagcct aggggacttt gccagcgaca aagcgggaag ccctgtctac cagctgtatg
     1741 ccctttgcaa ccactcgggt agtgtccact atggccacta cacagccctg tgccggtgcc
     1801 agactggttg gcatgtctac aatgactccc gcgtttcccc tgtcagtgaa aatcaggtgg
     1861 catccagtga gggctacgtg ctgttctacc aattgatgca ggaaccactt cggtgcctgt
     1921 gacaccatct tgaagccctg gcacctgtga aaaccttccc aacaccctta agcccccagt
     1981 tacctcacag acgtctattt ttgtgtcttt ttaatcgggg aggggaggag ggttggttgt
     2041 agctcccgtt atttttttta ttaagaagta cccttccgcc ttgttttcct gtcccatgta
     2101 cagaaaccac cagacccttg accatgtaca gcccccagaa cctctgcaat ctcacttttt
     2161 tgtgaataaa tttattaaga aaaaaaaaaa aaaaaaaaaa
//
