LOCUS       NM_198092               3882 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 2 (Usp2), transcript
            variant 3, mRNA.
ACCESSION   NM_198092
VERSION     NM_198092.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3882)
  AUTHORS   Kim,J., Yu,Y.S., Choi,Y., Lee,D.H., Han,S., Kwon,J., Noda,T.,
            Ikawa,M., Kim,D., Kim,H., Ballabio,A., Kim,K.I. and Baek,S.H.
  TITLE     USF2 and TFEB compete in regulating lysosomal and autophagy genes
  JOURNAL   Nat Commun 15 (1), 8334 (2024)
   PUBMED   39333072
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3882)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3882)
  AUTHORS   Dang,F., Bai,L., Dong,J., Hu,X., Wang,J., Paulo,J.A., Xiong,Y.,
            Liang,X., Sun,Y., Chen,Y., Guo,M., Wang,X., Huang,Z., Inuzuka,H.,
            Chen,L., Chu,C., Liu,J., Zhang,T., Rezaeian,A.H., Liu,J.,
            Kaniskan,H.U., Zhong,B., Zhang,J., Letko,M., Jin,J., Lan,K. and
            Wei,W.
  TITLE     USP2 inhibition prevents infection with ACE2-dependent
            coronaviruses in vitro and is protective against SARS-CoV-2 in mice
  JOURNAL   Sci Transl Med 15 (725), eadh7668 (2023)
   PUBMED   38055802
  REMARK    GeneRIF: USP2 inhibition prevents infection with ACE2-dependent
            coronaviruses in vitro and is protective against SARS-CoV-2 in
            mice.
REFERENCE   4  (bases 1 to 3882)
  AUTHORS   Wei,C., Zhao,X., Zhang,H. and Wang,L.
  TITLE     USP2 promotes cell proliferation and metastasis in choroidal
            melanoma via stabilizing Snail
  JOURNAL   J Cancer Res Clin Oncol 149 (11), 9263-9276 (2023)
   PUBMED   37199836
  REMARK    GeneRIF: USP2 promotes cell proliferation and metastasis in
            choroidal melanoma via stabilizing Snail.
REFERENCE   5  (bases 1 to 3882)
  AUTHORS   Hashimoto,M., Fujimoto,M., Konno,K., Lee,M.L., Yamada,Y.,
            Yamashita,K., Toda,C., Tomura,M., Watanabe,M., Inanami,O. and
            Kitamura,H.
  TITLE     Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus
            Modifies Blood Glucose Levels by Controlling Sympathetic Nervous
            Activation
  JOURNAL   J Neurosci 42 (23), 4607-4618 (2022)
   PUBMED   35504726
  REMARK    GeneRIF: Ubiquitin-Specific Protease 2 in the Ventromedial
            Hypothalamus Modifies Blood Glucose Levels by Controlling
            Sympathetic Nervous Activation.
REFERENCE   6  (bases 1 to 3882)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 3882)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   8  (bases 1 to 3882)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 3882)
  AUTHORS   Gousseva,N. and Baker,R.T.
  TITLE     Gene structure, alternate splicing, tissue distribution, cellular
            localization, and developmental expression pattern of mouse
            deubiquitinating enzyme isoforms Usp2-45 and Usp2-69
  JOURNAL   Gene Expr 11 (3-4), 163-179 (2003)
   PUBMED   14686789
REFERENCE   10 (bases 1 to 3882)
  AUTHORS   Kameya,S., Hawes,N.L., Chang,B., Heckenlively,J.R., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB617020.1, AY255638.1, AC148328.3 and BE991773.1.
            
            On Sep 6, 2006 this sequence version replaced NM_198092.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longer protein (isoform Usp2-69).
            Variants 1 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY255638.1, SRR1660811.87904.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               BB617020.1         1-118
            119-2190            AY255638.1         1-2072
            2191-3677           AC148328.3         85431-86917
            3678-3882           BE991773.1         1-205               c
FEATURES             Location/Qualifiers
     source          1..3882
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.53 cM"
     gene            1..3882
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /note="ubiquitin specific peptidase 2"
                     /db_xref="GeneID:53376"
                     /db_xref="MGI:MGI:1858178"
     exon            1..200
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            201..1057
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2101
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /EC_number="3.4.19.12"
                     /note="isoform Usp2-69 is encoded by transcript variant 3;
                     ubiquitin carboxyl-terminal hydrolase 2; ubiquitin
                     thioesterase 2; deubiquitinating enzyme 2; 41 kDa
                     ubiquitin-specific protease; ubiquitin-specific-processing
                     protease 2; ubiquitin thiolesterase 2; ubiquitin specific
                     protease 2"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 2 isoform
                     Usp2-69"
                     /protein_id="NP_932760.2"
                     /db_xref="CCDS:CCDS23094.1"
                     /db_xref="GeneID:53376"
                     /db_xref="MGI:MGI:1858178"
                     /translation="MSQLSSTLKRYTESSRYTDAPYAKPGYGTYTPSSYGANLAASFL
                     EKEKLGFKPVSPTSFLPRPRTYGPSSILDCDRGRPLLRSDIIGSSKRSESQTRGNERP
                     SGSGLNGGSGFSYGVSSNSLSYLPMNARDQGVTLSQKKSNSQSDLARDFSSLRTSDGY
                     RTSDGYRTSEGFRIDPGNLGRSPMLARTRKELCALQGLYQAASRSEYLTDYLENYGRK
                     GSAPQVLTQAPPPSRVPEVLSPTYRPSGRYTLWEKSKGQASGPSRSSSPGRDTMNSKS
                     AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAHTALMEEFAK
                     LIQTIWTSSPNDVVSPSEFKTQIQRYAPRFMGYNQQDAQEFLRFLLDGLHNEVNRVAA
                     RPKASPETLDHLPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFD
                     PFWDLSLPIAKRGYPEVTLMDCMRLFTKEDILDGDEKPTCCRCRARKRCIKKFSVQRF
                     PKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGT
                     TMGGHYTAYCRSPVTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM"
     exon            1058..1108
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1232
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1344
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1455
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1520
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1624
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1705
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1784
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1892
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2013
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..3867
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3843..3848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /note="hexamer: AATAAA"
     polyA_site      3867
                     /gene="Usp2"
                     /gene_synonym="B930035K21Rik; Ubp41"
                     /note="major polyA site"
ORIGIN      
        1 gctgggtggc gccgatttcc cggggaggtc ctttctgggc ccccggcgga ggtgggggag
       61 aggcgggcag gcaccgagcg aggccaggga gccctctgcg tcagccactg ctcgctgcgc
      121 cgcgccagta ccagccagga ctcatccgca gctccatgct tgtgcccggt tcgactcgtc
      181 catcctccga gaagaggcag cccatgaggc tcccagtacc cactgagtac caccctgaag
      241 gatgtcccag ctctcctcca ccctgaagcg ctatacagaa tcgtcccgct acacagatgc
      301 cccctatgcc aaaccgggct atggcaccta caccccttct tcctatgggg ccaacctggc
      361 cgcctccttc ctggagaagg aaaaacttgg tttcaagccg gtctccccca ccagcttcct
      421 cccacggccc cgcacctacg gcccctcctc cattctggac tgtgacaggg gccgccccct
      481 gctgagatct gacatcattg ggagtagtaa gcggtcagag agccagaccc gtggcaatga
      541 aaggccctcg ggcagtggac tcaacggagg cagtggattt tcttatggag tttccagcaa
      601 ctccctcagc tacctgccca tgaatgccag agaccagggg gtgaccctga gccagaagaa
      661 atcgaacagc caatcagacc tggcccggga tttctccagc ctccggactt cagatggcta
      721 ccggacttca gatggctacc ggacctcaga gggctttagg atagaccctg gaaacctggg
      781 tcgcagcccc atgctggccc gcacgcgtaa ggagctctgt gccctgcagg gcctctacca
      841 agcagccagc cgttctgagt acctaacaga ctatctggag aactatggtc gaaagggcag
      901 tgcaccacag gtgctcacgc aagcccctcc tccctcccga gtccctgaag tcctcagtcc
      961 cacctaccga ccaagtggcc gttacacact gtgggagaag agcaagggcc aggcctctgg
     1021 gcccagccgc tccagttctc cagggcgaga caccatgaat tcaaagagtg cccagggtct
     1081 ggctggtctt cgaaaccttg ggaacacgtg cttcatgaac tcaattcttc agtgcctgag
     1141 caacacccga gagctgagag attactgcct ccagaggctg tacatgcggg acctcggcca
     1201 caccagcagc gctcacacgg ccctcatgga agagtttgca aaactaatcc agaccatatg
     1261 gacgtcgtcc cccaatgatg tggtgagccc atctgagttc aagacccaga tccagagata
     1321 tgcgccacgc ttcatgggct ataatcagca ggatgctcag gaattccttc gtttccttct
     1381 ggatggtctc cacaatgagg tgaaccgggt ggcagcaagg cctaaggcca gccctgagac
     1441 ccttgatcat ctccctgatg aagaaaaggg gcgacagatg tggaggaagt atctggaaag
     1501 ggaagacagt cggattgggg atctcttcgt tgggcagctg aagagctccc tcacatgcac
     1561 cgattgtggc tactgctcta cagtcttcga tcccttctgg gatctctcgt tgcccatcgc
     1621 aaagagaggt taccctgagg tgacgttaat ggattgtatg aggctcttca ccaaagagga
     1681 catattggat ggtgatgaga agccaacttg ctgccgctgc cgagccagaa aacgatgcat
     1741 aaaaaagttc tctgtccaga ggttcccaaa gatcttggtg ctccacctga agcgattctc
     1801 agaatccagg atacgaacca gcaagctcac aacatttgtg aatttcccac taagagacct
     1861 ggacttgaga gaatttgctt cagaaaacac caaccatgct gtttacaacc tgtatgctgt
     1921 gtccaatcac tccggaacca ccatgggagg ccactataca gcctactgcc gaagtccggt
     1981 tacaggcgaa tggcacactt tcaatgattc cagtgtcaca cccatgtcct ccagccaagt
     2041 gcgcaccagc gacgcctatt tgctcttcta tgaactggcc agtccaccct cccgtatgta
     2101 gcattgagga gctgcggccc ttccctcttc cctgtggtgg ccccacgtcc taagtttttt
     2161 ttaaaaaatt cagaaaaaaa aaaaaaaaaa caccacaaaa aaaaaaaaac aaaaaacaaa
     2221 aaaaccaaca aaatcctgac aagtgagaga aaaataaagt aaaataaagc tgccgagcag
     2281 aagttgatac agcctggtca gggtctggag tgaggagcca tgtgcccctg cgccacgcat
     2341 gcacacgcac ggcctggcag gaagacggac tgatgcggag acagtcagca gcatcctcgg
     2401 ctcctcggct ggcttctctc gtttgcattt ttaagcttgt ggtttttttc ctgtgtgtaa
     2461 taaaaacaag agcggtctgt gggagaggac cgtcagccca cctgctgccc ccagtgccac
     2521 acctgctggg aggacagcgc catctggagc ctgctgggag catcgctgct ggatggagct
     2581 agggaggagc ctgcgggagg ccgtcctgcc tggacctgct caccagtcca gagaggaaac
     2641 gcccatgagc caagagccct cttaacgctg ctaagtccag gggtacagat gagggtgaca
     2701 tctttgaaaa aaaaaaagct ggtttgggtt ctcaaaaacc caattttttt tttttaatta
     2761 actgtaacga acgtgttccg actggagatg tggtccttca cacctctctt cacagctggg
     2821 acattgggct ggctccctgt tttctttttt tttttgttgt tcggtttttt cttttgtttt
     2881 tttcttctcc aaacacagcc ttcctaatgc tagtccccgt gtgctgggtg agtgttggct
     2941 gggcccaagc atcgtcacag tagacctggg atctaaagtt actctgcttt gaagttgctt
     3001 tttcttttcc cctttaatat tttgaatgga atctagttgc ctccaagaat tgtgccttat
     3061 agcatttggg gaccagggga taacttcccc ttcctgagat atctccctca gctgcttccc
     3121 tttatccccg tgccatgttg aaagccactt ggggttgcgg ggtcctgccc tgaacccctg
     3181 gcttgttgtg cacagcagta aaagagggaa gtgggtaaat ggtgattctt aagatagtgt
     3241 atcaagctct tcctaccacc ctctcaccca ccccggtctc cccagctgtt tgaaggacag
     3301 cacaggctcc ttgcccctca actcccccct ccctttaatt tattctcttt ttgatgccct
     3361 tatcccccaa gcttcctgcc acctgtccct ttcccagagt ctcttagaca aaggccctct
     3421 ggactgagct tctcagggac acccacacca ccccttaccc catcttggca tcagtctttg
     3481 gtcctgtcct gggagtgtga gcctggatgg ctggggttag cttgtatgat tctttgccct
     3541 gacgttagac aaaaaaaaaa aaaaaaatac tccatgctgt cccaagagcc aagctattca
     3601 gcactaaggc atttcgcaca gtgcattttg caccccccac aggtgggcct ggcttatgcc
     3661 ctcagaacct cgagtgcttg agtgtcccag gacagggcac ccaagaaaag acaccctgag
     3721 tttacctggc ctgataccct tctctaggga agacctgtga acatgagccc aagggctggt
     3781 gtacacttgt ttactatgta agcaagagta gaatgtctag tgtacagtgg agccttgtac
     3841 agaataaata gtagctttga gaaggaaaaa aaaaaaaaaa aa
//
