LOCUS       NM_027804               4727 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 19 (Usp19), transcript
            variant 1, mRNA.
ACCESSION   NM_027804
VERSION     NM_027804.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4727)
  AUTHORS   Schorova,L., Bedard,N., Khayachi,A., Ho,H.H., Bolivar-Pedroso,J.,
            Huynh,J., Piccirelli,M., Wang,Y., Plourde,M., Luo,W., Del
            Cid-Pellitero,E., Shlaifer,I., Castellanos-Montiel,M.J., Yu,Z.,
            Valenzuela,D.V.C., Lacalle-Aurioles,M., Kriz,A., Ye,Y., Durcan,T.M.
            and Wing,S.S.
  TITLE     USP19 deubiquitinase inactivation regulates alpha-synuclein
            ubiquitination and inhibits accumulation of Lewy body-like
            aggregates in mice
  JOURNAL   NPJ Parkinsons Dis 9 (1), 157 (2023)
   PUBMED   38017009
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4727)
  AUTHORS   Liu,T., Wang,L., Liang,P., Wang,X., Liu,Y., Cai,J., She,Y.,
            Wang,D., Wang,Z., Guo,Z., Bates,S., Xia,X., Huang,J. and Cui,J.
  TITLE     USP19 suppresses inflammation and promotes M2-like macrophage
            polarization by manipulating NLRP3 function via autophagy
  JOURNAL   Cell Mol Immunol 18 (10), 2431-2442 (2021)
   PUBMED   33097834
  REMARK    GeneRIF: USP19 suppresses inflammation and promotes M2-like
            macrophage polarization by manipulating NLRP3 function via
            autophagy.
REFERENCE   4  (bases 1 to 4727)
  AUTHORS   Miao,R., Lu,Y., He,X., Liu,X., Chen,Z. and Wang,J.
  TITLE     Ubiquitin-specific protease 19 blunts pathological cardiac
            hypertrophy via inhibition of the TAK1-dependent pathway
  JOURNAL   J Cell Mol Med 24 (18), 10946-10957 (2020)
   PUBMED   32798288
  REMARK    GeneRIF: Ubiquitin-specific protease 19 blunts pathological cardiac
            hypertrophy via inhibition of the TAK1-dependent pathway.
REFERENCE   5  (bases 1 to 4727)
  AUTHORS   Wu,X., Lei,C., Xia,T., Zhong,X., Yang,Q. and Shu,H.B.
  TITLE     Regulation of TRIF-mediated innate immune response by K27-linked
            polyubiquitination and deubiquitination
  JOURNAL   Nat Commun 10 (1), 4115 (2019)
   PUBMED   31511519
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4727)
  AUTHORS   Wiles,B., Miao,M., Coyne,E., Larose,L., Cybulsky,A.V. and Wing,S.S.
  TITLE     USP19 deubiquitinating enzyme inhibits muscle cell differentiation
            by suppressing unfolded-protein response signaling
  JOURNAL   Mol Biol Cell 26 (5), 913-923 (2015)
   PUBMED   25568336
  REMARK    GeneRIF: Deubiquitination by USP19 does modulate muscle cell
            differentiation and that this function requires the ER-localized
            isoform and appears to act through regulation of the
            unfolded-protein response (UPR) signaling.
REFERENCE   7  (bases 1 to 4727)
  AUTHORS   Nakamura,N., Harada,K., Kato,M. and Hirose,S.
  TITLE     Ubiquitin-specific protease 19 regulates the stability of the E3
            ubiquitin ligase MARCH6
  JOURNAL   Exp Cell Res 328 (1), 207-216 (2014)
   PUBMED   25088257
REFERENCE   8  (bases 1 to 4727)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   9  (bases 1 to 4727)
  AUTHORS   Ogawa,M., Yamaji,R., Higashimura,Y., Harada,N., Ashida,H.,
            Nakano,Y. and Inui,H.
  TITLE     17beta-estradiol represses myogenic differentiation by increasing
            ubiquitin-specific peptidase 19 through estrogen receptor alpha
  JOURNAL   J Biol Chem 286 (48), 41455-41465 (2011)
   PUBMED   21971047
  REMARK    GeneRIF: E2 induces USP19 expression through nuclear ERalpha, (ii)
            increased USP19-mediated deubiquitinating activity represses
            myogenesis, and (iii) ERbeta inhibits ERalpha-activated USP19
            expression.
REFERENCE   10 (bases 1 to 4727)
  AUTHORS   Lu,Y., Adegoke,O.A., Nepveu,A., Nakayama,K.I., Bedard,N., Cheng,D.,
            Peng,J. and Wing,S.S.
  TITLE     USP19 deubiquitinating enzyme supports cell proliferation by
            stabilizing KPC1, a ubiquitin ligase for p27Kip1
  JOURNAL   Mol Cell Biol 29 (2), 547-558 (2009)
   PUBMED   19015242
  REMARK    GeneRIF: study reports that the USP19 deubiquitinating enzyme
            interacts with and stabilizes KPC1, thereby modulating p27(Kip1)
            levels and cell proliferation
            Erratum:[Mol Cell Biol. 2009 Jun;29(11):3241]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ075820.1, AK146504.1 and AI644135.1.
            
            On May 5, 2010 this sequence version replaced NM_027804.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060613.1, AK146504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               CJ075820.1         1-175
            176-4519            AK146504.1         2-4345
            4520-4727           AI644135.1         1-208               c
FEATURES             Location/Qualifiers
     source          1..4727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.42 cM"
     gene            1..4727
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /note="ubiquitin specific peptidase 19"
                     /db_xref="GeneID:71472"
                     /db_xref="MGI:MGI:1918722"
     exon            1..220
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            221..480
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..4439
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin specific protease 19; ubiquitin
                     carboxyl-terminal hydrolase 19; ubiquitin thiolesterase
                     19; ubiquitin-specific processing protease 19;
                     deubiquitinating enzyme 19; ubiquitin thioesterase 19"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 19 isoform
                     1"
                     /protein_id="NP_082080.3"
                     /db_xref="CCDS:CCDS23529.1"
                     /db_xref="GeneID:71472"
                     /db_xref="MGI:MGI:1918722"
                     /translation="MSAGASATGPRRGPPGLEEATSKKKQKDRANLESKDGDARRVSL
                     PRKEPTKDELLLDWRQSADEVIVKLRVGTGPVRLEDVDAAFTDTDCVVRLPDGRQWGG
                     VFFAEIQSSCTKVQARKGGLLQLVLPKKVPLLTWPSLLKPLGTQELVPGLQCQENGQE
                     LSPIALEPGSEPRRAKQEARNQKRAQGRGEVGSGAGPGTQAGPSAKRAVHLRRGPEGE
                     GSMDGPGPQGDAPSFLSDSATQVEAEEKLCAPPMNTQTSLLSSEKSLALLTVEKTVSP
                     RNDPVAPVMVQDRDPEPEQEDQVKEEMALGADPTALVEEPESMVNLAFVKNDSYEKGP
                     DSVVVHVYVKEIRRDSSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTIFRWQVKLRN
                     LIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPATRGAVGGAKVAVPTGPTPLDSTP
                     PGGGPHPLTGQEEARAVEKEKPKARSEDSGLDGVVARTPLEHVAPKPDPHLASPKPTC
                     MVPPMPHSPVSGDSVEEDEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDF
                     FHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQFT
                     GYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDS
                     FIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPIFYFAREPHSKPIK
                     FLVSVSKENSSASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDAVSPTDV
                     LLCFELLSPELAKERVVVLEVQQRPQVPSIPISKCAACQRKQQSEEEKLKRCTRCYRV
                     GYCNQFCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQ
                     PPFQPGRMALESQSPGCTTLLSTSSLEAGDSEREPIQPSELQLVTPVAEGDTGAHRVW
                     PPADRGPVPSTSGLSSEMLASGPIEGCPLLAGERVSRPEAAVPGYQHSSESVNTHTPQ
                     FFIYKIDASNREQRLEDKGETPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDP
                     GSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLI
                     VQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMI
                     GGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVER
                     PPRASHSEHHPDLGPAAEAAASQASRIWQELEAEEEMVPEGPGPLGPWGPQDWVGPPP
                     RGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR"
     exon            481..513
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            514..642
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            643..776
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1076
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1299
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1456
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1528
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1644
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1865
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2061
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2195
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2354
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2465
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2576
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2678
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2819
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2938
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3076
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3390
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3501
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3718
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3871
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            3872..4032
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4211
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4717
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4694..4699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /note="hexamer: AATAAA"
     polyA_site      4717
                     /gene="Usp19"
                     /gene_synonym="8430421I07Rik; Zmynd9"
                     /note="major polyA site"
ORIGIN      
        1 tcttgccgga agtgcgtcat cagctcggca ccccgcctcc cgtagccgta gctagaagtc
       61 gaaacaaaac aagcggctga agcagcggcg aaggcggcgg tggcggagga gccgggacgg
      121 gggaggggcg cgccggaacc ggaaccgacc cgacgccgga accggaatcg agagcgtgtt
      181 gccagggccc gaagagggct ggtggcggcg gtctcgctcg gctcttggtt ctttgctgaa
      241 gaatttggcc acaaagagtt gccaagatag ctgggccggg aagaaagcgc cgcagccctg
      301 acccagacgc tgttgccgac tctgggccac tctggctggc taccaagcgg ctcaagatgt
      361 ctgcaggggc cagtgctaca gggcccagga gggggccgcc aggactggaa gaggccacta
      421 gtaagaagaa acagaaggat cgagcaaacc tggaaagtaa agatggagat gctaggagag
      481 tgtcccttcc tcgaaaggaa ccaaccaaag atgaattgtt gctcgattgg aggcagagtg
      541 cagatgaggt gattgttaag ctgcgcgtgg gaacaggtcc cgtacgtctg gaggatgtag
      601 atgctgcgtt cacagacacg gactgtgtgg tgaggcttcc agatggtcgg cagtggggtg
      661 gtgtcttctt tgctgaaata caaagttctt gcaccaaagt gcaggctcgc aagggtggtc
      721 ttctacagct agtactaccc aagaaggtgc ctctgctcac gtggccctct ctcctgaaac
      781 ctctgggaac ccaagagctg gtgccaggtt tgcagtgcca ggagaacggg caagagctgt
      841 ctcccattgc cctggagcca ggctctgagc cccgcagagc taaacaggaa gcccgaaacc
      901 agaagcgggc ccagggccgt ggtgaggtag gctcgggggc tggccctggg acacaggcag
      961 ggcccagcgc caagagggct gttcacctcc gcagagggcc agaaggggaa gggtccatgg
     1021 atggccccgg cccccagggt gatgccccgt ctttcctgtc tgactcagct acccaggttg
     1081 aggctgagga gaagctctgt gctccaccaa tgaacactca aacaagtctc ttgagctcag
     1141 agaagagttt agcccttctg acagtagaga agacagtgtc ccccaggaat gacccagtcg
     1201 ccccggttat ggtccaggac agagaccctg agcctgagca agaagaccaa gtcaaagagg
     1261 agatggcact tggggctgat cctacagcct tggtggagga accagagtct atggtgaacc
     1321 tggcatttgt caagaacgac tcgtatgaga agggcccgga ttcggtggtg gtgcacgtgt
     1381 acgtgaagga gatccgcagg gacagctccc gagtgctctt ccgagagcag gacttcacac
     1441 tgatcttcca gaccagggac ggaaactttc tgaggctgca tccgggctgt gggccccaca
     1501 ccatcttccg atggcaggtg aagctcagaa acttgattga accagagcag tgtacgttct
     1561 gtttcacggc ctctcgaatc gatatctgcc tccggaagcg gcagagtcag cgctgggggg
     1621 gactggaggc ccctgctaca cgaggtgcag tgggtggtgc aaaggttgcc gtgccgacag
     1681 gcccaacccc tttggattca acccctccag gaggtggccc ccaccccctg acaggccagg
     1741 aggaagccag ggctgtggag aaggaaaaac ccaaggctcg atcagaggac tcagggctgg
     1801 atggtgtggt ggcccgcacc cccttggagc atgtagcccc aaagccagac ccacacttgg
     1861 cctcgcccaa acccacgtgt atggtgcctc caatgccgca cagtccagtt agtggggata
     1921 gtgtggagga ggacgaagag gaagagaaga aggtgtgcct gccaggcttc actggccttg
     1981 tcaacttagg gaacacctgc ttcatgaata gcgtcattca gtctttgtcc aacactcggg
     2041 aacttcgtga cttctttcac gaccgatcct ttgaagctga gattaactac aataacccat
     2101 tggggactgg tgggcgcctc gccattggct ttgctgtgct gctccgggcc ctatggaagg
     2161 gtactcacca agcctttcag ccctccaagc taaaggccat tgtggcaagc aaggccagcc
     2221 agttcacagg ctatgcacag catgatgctc aagagttcat ggctttcttg ttggatgggc
     2281 tacatgaaga cctcaatcga atccaaaaca aaccctacac agagactgtg gactcggacg
     2341 ggcggcccga tgaggtggta gccgaggaag catggcagcg gcacaagatg agaaatgatt
     2401 cattcattgt ggacctgttt cagggccagt acaagtcaaa gctggtgtgc cctgtgtgtg
     2461 ccaaggtctc catcactttt gacccgttcc tttatctgcc ggtacccttg ccacaaaagc
     2521 aaaaggttct ccccatattt tattttgcca gggagcccca cagcaagccc atcaagttcc
     2581 tggtgagtgt cagcaaggag aactccagcg cgagtgaagt gttggactcc ctctctcaga
     2641 gtgtccacgt gaagcctgag aacctgcgcc tagccgaggt aattaagaac cgtttccacc
     2701 gtgttttctt gccctcccac tcactggacg ctgtgtcccc cacggacgtg ctcctctgct
     2761 ttgagctgct ctccccagaa ctggctaagg agcgggtagt agtgctggag gtgcagcagc
     2821 gcccccaggt acccagcatc cctatctcca agtgcgcagc ctgccagcgg aagcagcaat
     2881 cagaagaaga aaagctgaag cgctgtaccc gttgctaccg tgtgggctac tgcaaccagt
     2941 tctgccagaa aacccattgg cctgaccaca aaggcctctg ccgccctgag aacattggct
     3001 accccttcct ggtcagtgtg cctgcttcac gcctcactta tgcccgtctt gctcagctac
     3061 tagaaggtta tgcccggtac tctgtgagtg tattccaacc gcccttccag cctggccgca
     3121 tggctttgga atcgcagagc cctggctgta ccacgttgct ttcaaccagc tctctggagg
     3181 ctggggacag tgaaagagaa cccattcagc cttctgagct ccagctggtg acccctgtgg
     3241 ctgaagggga tacaggggct caccgagtat ggccgcctgc tgataggggt cctgtgccta
     3301 gcaccagtgg actctcttct gagatgctgg ccagtgggcc tatcgaaggt tgtcccttgc
     3361 ttgctggtga gagggtatct cggcctgaag ctgctgtgcc tgggtaccaa cactcaagtg
     3421 aatctgtgaa tacccacacg ccccagttct tcatctataa aattgatgca tcaaaccgtg
     3481 agcagcggct ggaggacaaa ggggagacac cattggagct aggtgatgac tgtagcctgg
     3541 ctctggtgtg gcggaacaat gaacgcctgc aggagtttgt gttggtagcc tccaaggagc
     3601 tggaatgtgc tgaagatcca ggctctgctg gtgaggctgc ccgtgctggc cacttcaccc
     3661 tggaccagtg cctcaacctc tttacacggc ctgaagtgct ggcacctgag gaggcctggt
     3721 actgcccaca gtgcaaacag catcgtgagg cctccaaaca gctgctgttg tggcgcctac
     3781 cgaacgtgct gattgtgcag ctcaagcgct tctcctttcg tagtttcatt tggcgagaca
     3841 agatcaatga cttggtggag tttcctgttc ggaacctgga cttgagcaag ttctgtatcg
     3901 gtcagaaaga ggagcagctg cctagctatg acctgtatgc tgtcatcaac cactacggag
     3961 gcatgatcgg tggccactat actgcttgtg cacggctgcc caatgatcgc agtagccagc
     4021 gcagtgacgt gggctggcgc ttgtttgatg acagcacggt gacaacagta gacgaaagcc
     4081 aggtcgtgac gcgctatgcc tatgttctct tctaccgtcg tcggaactct cctgtggaga
     4141 gaccccccag ggcaagtcac tctgaacacc acccagacct aggccctgca gctgaggctg
     4201 ctgccagcca ggcttcccgg atttggcagg agctcgaggc cgaggaggag atggtacctg
     4261 aggggcctgg gcctctgggt ccttgggggc cccaagactg ggtggggccc ccgccacgtg
     4321 gccctaccac accagacgag ggttgcctcc gatactttgt cctgggtacc gtggcggctt
     4381 tggtggccct tgtgctcaac gtattctatc ctctggtatc tcagagtcgc tggagatgag
     4441 ctcacctgca ggcacctgct gtgagctggc ctacctgtct gctcaccagg tcatgcctac
     4501 ctttgtggtg ggaaacaact ctgggctctg agcctcagtg tatgtatctg gtgggagact
     4561 tgtggggact gcagtctctg caggggcaga gtatcctagg gtgtgtgtcc atccagttgt
     4621 ctgtcgtcct gtttctctga cccttgtcct agggcttggc cctgctggaa ctatttcctg
     4681 tatttaaagt gttaataaaa tgagtattca ggcccaaaaa aaaaaaa
//
