LOCUS       NM_011909               1778 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 18 (Usp18), mRNA.
ACCESSION   NM_011909 XM_917506
VERSION     NM_011909.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Miyauchi,S., Arimoto,K.I., Liu,M., Zhang,Y. and Zhang,D.E.
  TITLE     Reprogramming of tumor-associated macrophages via NEDD4-mediated
            CSF1R degradation by targeting USP18
  JOURNAL   Cell Rep 42 (12), 113560 (2023)
   PUBMED   38100351
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Arimoto,K.I., Miyauchi,S., Troutman,T.D., Zhang,Y., Liu,M.,
            Stoner,S.A., Davis,A.G., Fan,J.B., Huang,Y.J., Yan,M., Glass,C.K.
            and Zhang,D.E.
  TITLE     Expansion of interferon inducible gene pool via USP18 inhibition
            promotes cancer cell pyroptosis
  JOURNAL   Nat Commun 14 (1), 251 (2023)
   PUBMED   36646704
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1778)
  AUTHORS   Chen,Z., Zheng,L., Chen,Y., Liu,X., Kawakami,M., Mustachio,L.M.,
            Roszik,J., Ferry-Galow,K.V., Parchment,R.E., Liu,X., Andresson,T.,
            Duncan,G., Kurie,J.M., Rodriguez-Canales,J., Liu,X. and
            Dmitrovsky,E.
  TITLE     Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta
            protein and represses lung cancer metastasis
  JOURNAL   Cancer Biol Ther 23 (1), 265-280 (2022)
   PUBMED   35387560
  REMARK    GeneRIF: Loss of ubiquitin-specific peptidase 18 destabilizes
            14-3-3zeta protein and represses lung cancer metastasis.
REFERENCE   5  (bases 1 to 1778)
  AUTHORS   Hu,B., Ge,C. and Zhu,C.
  TITLE     Ubiquitin-specific peptidase 18 negatively regulates and inhibits
            lipopolysaccharide-induced sepsis by targeting transforming growth
            factor-beta-activated kinase 1 activity
  JOURNAL   Int Immunol 33 (9), 461-468 (2021)
   PUBMED   34423815
  REMARK    GeneRIF: Ubiquitin-specific peptidase 18 negatively regulates and
            inhibits lipopolysaccharide-induced sepsis by targeting
            transforming growth factor-beta-activated kinase 1 activity.
REFERENCE   6  (bases 1 to 1778)
  AUTHORS   Malakhova,O.A., Yan,M., Malakhov,M.P., Yuan,Y., Ritchie,K.J.,
            Kim,K.I., Peterson,L.F., Shuai,K. and Zhang,D.E.
  TITLE     Protein ISGylation modulates the JAK-STAT signaling pathway
  JOURNAL   Genes Dev 17 (4), 455-460 (2003)
   PUBMED   12600939
  REMARK    GeneRIF: These findings identify UBP43 as a novel negative
            regulator of IFN signaling and suggest the involvement of protein
            ISGylation in the regulation of the JAK-STAT pathway.
REFERENCE   7  (bases 1 to 1778)
  AUTHORS   Ritchie,K.J., Malakhov,M.P., Hetherington,C.J., Zhou,L.,
            Little,M.T., Malakhova,O.A., Sipe,J.C., Orkin,S.H. and Zhang,D.E.
  TITLE     Dysregulation of protein modification by ISG15 results in brain
            cell injury
  JOURNAL   Genes Dev 16 (17), 2207-2212 (2002)
   PUBMED   12208842
  REMARK    GeneRIF: UBP43 plays a critical role in maintaining the homeostatic
            balance of ISG15-conjugated protein, and that regulation of
            cellular levels of ISG15 protein modification is essential for
            brain cell function.
REFERENCE   8  (bases 1 to 1778)
  AUTHORS   Malakhov,M.P., Malakhova,O.A., Kim,K.I., Ritchie,K.J. and
            Zhang,D.E.
  TITLE     UBP43 (USP18) specifically removes ISG15 from conjugated proteins
  JOURNAL   J Biol Chem 277 (12), 9976-9981 (2002)
   PUBMED   11788588
  REMARK    GeneRIF: UBP43 (USP18) specifically removes ISG15 from conjugated
            proteins
REFERENCE   9  (bases 1 to 1778)
  AUTHORS   Schwer,H., Liu,L.Q., Zhou,L., Little,M.T., Pan,Z.,
            Hetherington,C.J. and Zhang,D.E.
  TITLE     Cloning and characterization of a novel human ubiquitin-specific
            protease, a homologue of murine UBP43 (Usp18)
  JOURNAL   Genomics 65 (1), 44-52 (2000)
   PUBMED   10777664
  REMARK    Erratum:[Genomics. 2007 Mar;89(3):439]
REFERENCE   10 (bases 1 to 1778)
  AUTHORS   Liu,L.Q., Ilaria,R. Jr., Kingsley,P.D., Iwama,A., van Etten,R.A.,
            Palis,J. and Zhang,D.E.
  TITLE     A novel ubiquitin-specific protease, UBP43, cloned from leukemia
            fusion protein AML1-ETO-expressing mice, functions in hematopoietic
            cell differentiation
  JOURNAL   Mol Cell Biol 19 (4), 3029-3038 (1999)
   PUBMED   10082570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151260.1, AK153312.1 and AA286391.1.
            
            On May 14, 2008 this sequence version replaced NM_011909.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF069502.1, AK151011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-613               AK151260.1         2-614
            614-1752            AK153312.1         584-1722
            1753-1778           AA286391.1         232-257
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.17 cM"
     gene            1..1778
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /note="ubiquitin specific peptidase 18"
                     /db_xref="GeneID:24110"
                     /db_xref="MGI:MGI:1344364"
     exon            1..157
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            158..412
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1371
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /EC_number="3.4.19.12"
                     /note="ubl thioesterase 18; 43 kDa ISG15-specific
                     protease; ISG15-specific-processing protease; ubl
                     thiolesterase 18; ubiquitin specific protease 15;
                     ubiquitin specific protease 18"
                     /codon_start=1
                     /product="ubl carboxyl-terminal hydrolase 18"
                     /protein_id="NP_036039.2"
                     /db_xref="CCDS:CCDS20489.1"
                     /db_xref="GeneID:24110"
                     /db_xref="MGI:MGI:1344364"
                     /translation="MGKGFGLLRKPCQSVVAEPQQYSALEEERTMKRKRVLSRDLCSA
                     WDSPHGLVGLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEERKRSVPFQLLL
                     LLEKMQDSRQKAVLPTELVQCLQKYNVPLFVQHDAAQLYLTIWNLTKDQITDTDLTER
                     LQGLFTIWTQESLICVGCTAESSRRSKLLTLSLPLFDKDAKPLKTLEDALRCFVQPKE
                     LASSDMCCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSARNSRTEKICHSVNFPQSLD
                     FSQVLPTEEDLGDTKEQSEIHYELFAVIAHVGMADFGHYCAYIRNPVDGKWFCFNDSH
                     VCWVTWKDVQCTYGNHRYRWRETAYLLVYTKTGS"
     exon            413..509
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            510..655
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            656..735
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            736..882
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            883..975
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1143
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1275
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1325
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1771
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /note="hexamer: AATAAA"
     polyA_site      1771
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /note="major polyA site"
ORIGIN      
        1 agtgccaggg cggctgtgcc taggggacag cagacactcc tgagctgaga ggctgggagg
       61 cagcaagact gctctgctcc gcggtgccgc gtcctcttct gtagcccttt gcagatgctg
      121 ctcggtcttc gctctttggc ttgactccgt gcttgagagg gtcatttgtc tccggcttgt
      181 gtagactctg cctggaagtg aagttgtgga ctcccgacct ccagtcccgc cagtcccaac
      241 ctcggagttt gagtgtgatc actaatgggc aaggggtttg ggctcctgag gaaaccctgc
      301 cagtcagttg tggctgagcc gcagcagtac tcagcgctgg aggaagagag gaccatgaag
      361 aggaagagag tgctgtctag agacctctgc agtgcctggg acagccctca tggtctggtt
      421 ggtttacaca acatcggaca gacgtgttgc cttaactcct tgcttcaagt gttcatgatg
      481 aacatggact tcagaatgat attgaagagg ataacagtgc ctcggagtgc agaagagagg
      541 aagagaagtg tccccttcca gctgcttttg ctgctggaga agatgcagga cagtcgacag
      601 aaagccgtgc tgcccacgga gctcgttcag tgcctgcaga aatacaacgt gccgttgttt
      661 gtccagcacg atgctgctca actctacctt acaatctgga acctgactaa ggaccagatc
      721 acggacacag acttgacaga gcggctgcag ggtctgttca ccatctggac gcaggagtcc
      781 ctgatttgcg tgggctgtac agcagagagc agcaggagga gcaaactgct cacactctct
      841 cttcctcttt ttgataagga cgcaaagcct ctgaaaaccc tggaggatgc cttgagatgt
      901 ttcgtccagc ccaaagagtt agcaagctcc gacatgtgct gcgagagctg tggggagaag
      961 acgccttgga aacaggttct gaagctgact catctgcccc aaaccttgac cattcacctc
     1021 atgagattct ctgccaggaa ctcgaggacg gaaaagatct gtcactcagt taatttccct
     1081 cagagcttgg atttcagtca ggttctgcca accgaggaag acctcggtga taccaaggaa
     1141 cagtctgaaa tacactatga actctttgcc gtgattgccc acgttgggat ggctgacttt
     1201 ggtcattact gtgcctacat ccggaatccc gtggatggaa agtggttctg cttcaatgac
     1261 tcacatgttt gttgggtcac ctggaaggat gtccagtgta cctatgggaa ccacagatac
     1321 cgctggcggg aaacggccta tctcttggtt tacacgaaga ctggatcctg acagatatac
     1381 tcacacctcc agagagggat agactcttat ctcctctcct gtacccttgt ctgctgcatt
     1441 tcaacgagaa taataattta aaaacaatta agccctattt ataagcaaaa ctattattgc
     1501 aatggcttag atgtagtttg tctcctgaaa gctcacacac ggaaggcttg gtctttagat
     1561 ggcagtgctt aggtgacaga acttgtaaga gacagggacc agtgggagat catcggttca
     1621 tgggatctct ctcctgagca ctaatagttc ttcttcctgt ttctctacac atgttgtgat
     1681 gcaaatgtgg gggatacaac atgccagggc caagctggtt ggagcctcca gccttcaaaa
     1741 ttctgaatct aataaacatt attgcacact aaaaaaaa
//
