LOCUS       NP_036039                368 aa            linear   ROD 06-NOV-2024
DEFINITION  ubl carboxyl-terminal hydrolase 18 [Mus musculus].
ACCESSION   NP_036039 XP_922599
VERSION     NP_036039.2
DBSOURCE    REFSEQ: accession NM_011909.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 368)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 368)
  AUTHORS   Miyauchi,S., Arimoto,K.I., Liu,M., Zhang,Y. and Zhang,D.E.
  TITLE     Reprogramming of tumor-associated macrophages via NEDD4-mediated
            CSF1R degradation by targeting USP18
  JOURNAL   Cell Rep 42 (12), 113560 (2023)
   PUBMED   38100351
REFERENCE   3  (residues 1 to 368)
  AUTHORS   Arimoto,K.I., Miyauchi,S., Troutman,T.D., Zhang,Y., Liu,M.,
            Stoner,S.A., Davis,A.G., Fan,J.B., Huang,Y.J., Yan,M., Glass,C.K.
            and Zhang,D.E.
  TITLE     Expansion of interferon inducible gene pool via USP18 inhibition
            promotes cancer cell pyroptosis
  JOURNAL   Nat Commun 14 (1), 251 (2023)
   PUBMED   36646704
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 368)
  AUTHORS   Chen,Z., Zheng,L., Chen,Y., Liu,X., Kawakami,M., Mustachio,L.M.,
            Roszik,J., Ferry-Galow,K.V., Parchment,R.E., Liu,X., Andresson,T.,
            Duncan,G., Kurie,J.M., Rodriguez-Canales,J., Liu,X. and
            Dmitrovsky,E.
  TITLE     Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta
            protein and represses lung cancer metastasis
  JOURNAL   Cancer Biol Ther 23 (1), 265-280 (2022)
   PUBMED   35387560
  REMARK    GeneRIF: Loss of ubiquitin-specific peptidase 18 destabilizes
            14-3-3zeta protein and represses lung cancer metastasis.
REFERENCE   5  (residues 1 to 368)
  AUTHORS   Hu,B., Ge,C. and Zhu,C.
  TITLE     Ubiquitin-specific peptidase 18 negatively regulates and inhibits
            lipopolysaccharide-induced sepsis by targeting transforming growth
            factor-beta-activated kinase 1 activity
  JOURNAL   Int Immunol 33 (9), 461-468 (2021)
   PUBMED   34423815
  REMARK    GeneRIF: Ubiquitin-specific peptidase 18 negatively regulates and
            inhibits lipopolysaccharide-induced sepsis by targeting
            transforming growth factor-beta-activated kinase 1 activity.
REFERENCE   6  (residues 1 to 368)
  AUTHORS   Malakhova,O.A., Yan,M., Malakhov,M.P., Yuan,Y., Ritchie,K.J.,
            Kim,K.I., Peterson,L.F., Shuai,K. and Zhang,D.E.
  TITLE     Protein ISGylation modulates the JAK-STAT signaling pathway
  JOURNAL   Genes Dev 17 (4), 455-460 (2003)
   PUBMED   12600939
  REMARK    GeneRIF: These findings identify UBP43 as a novel negative
            regulator of IFN signaling and suggest the involvement of protein
            ISGylation in the regulation of the JAK-STAT pathway.
REFERENCE   7  (residues 1 to 368)
  AUTHORS   Ritchie,K.J., Malakhov,M.P., Hetherington,C.J., Zhou,L.,
            Little,M.T., Malakhova,O.A., Sipe,J.C., Orkin,S.H. and Zhang,D.E.
  TITLE     Dysregulation of protein modification by ISG15 results in brain
            cell injury
  JOURNAL   Genes Dev 16 (17), 2207-2212 (2002)
   PUBMED   12208842
  REMARK    GeneRIF: UBP43 plays a critical role in maintaining the homeostatic
            balance of ISG15-conjugated protein, and that regulation of
            cellular levels of ISG15 protein modification is essential for
            brain cell function.
REFERENCE   8  (residues 1 to 368)
  AUTHORS   Malakhov,M.P., Malakhova,O.A., Kim,K.I., Ritchie,K.J. and
            Zhang,D.E.
  TITLE     UBP43 (USP18) specifically removes ISG15 from conjugated proteins
  JOURNAL   J Biol Chem 277 (12), 9976-9981 (2002)
   PUBMED   11788588
  REMARK    GeneRIF: UBP43 (USP18) specifically removes ISG15 from conjugated
            proteins
REFERENCE   9  (residues 1 to 368)
  AUTHORS   Schwer,H., Liu,L.Q., Zhou,L., Little,M.T., Pan,Z.,
            Hetherington,C.J. and Zhang,D.E.
  TITLE     Cloning and characterization of a novel human ubiquitin-specific
            protease, a homologue of murine UBP43 (Usp18)
  JOURNAL   Genomics 65 (1), 44-52 (2000)
   PUBMED   10777664
  REMARK    Erratum:[Genomics. 2007 Mar;89(3):439]
REFERENCE   10 (residues 1 to 368)
  AUTHORS   Liu,L.Q., Ilaria,R. Jr., Kingsley,P.D., Iwama,A., van Etten,R.A.,
            Palis,J. and Zhang,D.E.
  TITLE     A novel ubiquitin-specific protease, UBP43, cloned from leukemia
            fusion protein AML1-ETO-expressing mice, functions in hematopoietic
            cell differentiation
  JOURNAL   Mol Cell Biol 19 (4), 3029-3038 (1999)
   PUBMED   10082570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151260.1, AK153312.1 and AA286391.1.
            
            On May 14, 2008 this sequence version replaced NP_036039.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF069502.1, AK151011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.17 cM"
     Protein         1..368
                     /product="ubl carboxyl-terminal hydrolase 18"
                     /EC_number="3.4.19.12"
                     /note="ubl thioesterase 18; 43 kDa ISG15-specific
                     protease; ISG15-specific-processing protease; ubl
                     thiolesterase 18; ubiquitin specific protease 15;
                     ubiquitin specific protease 18"
                     /calculated_mol_wt=42341
     Region          31..48
                     /region_name="Mediates interaction with IFNAR2.
                     /evidence=ECO:0000250|UniProtKB:Q9UMW8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTV6.2)"
     Region          48..109
                     /region_name="Mediates interaction with STAT2.
                     /evidence=ECO:0000250|UniProtKB:Q9UMW8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTV6.2)"
     Region          52..363
                     /region_name="UCH"
                     /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443"
                     /db_xref="CDD:425685"
     Site            order(56,61,314,332)
                     /site_type="active"
                     /db_xref="CDD:239072"
     Region          299..308
                     /region_name="Mediates interaction with STAT2 and
                     necessary for the negative regulation of the type I IFN
                     signaling pathway. /evidence=ECO:0000250|UniProtKB:Q9UMW8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTV6.2)"
     Region          309..368
                     /region_name="Mediates interaction with IFNAR2.
                     /evidence=ECO:0000250|UniProtKB:Q9UMW8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTV6.2)"
     CDS             1..368
                     /gene="Usp18"
                     /gene_synonym="1110058H21Rik; Ubp15; UBP43"
                     /coded_by="NM_011909.2:265..1371"
                     /db_xref="CCDS:CCDS20489.1"
                     /db_xref="GeneID:24110"
                     /db_xref="MGI:MGI:1344364"
ORIGIN      
        1 mgkgfgllrk pcqsvvaepq qysaleeert mkrkrvlsrd lcsawdsphg lvglhnigqt
       61 cclnsllqvf mmnmdfrmil kritvprsae erkrsvpfql llllekmqds rqkavlptel
      121 vqclqkynvp lfvqhdaaql yltiwnltkd qitdtdlter lqglftiwtq eslicvgcta
      181 essrrskllt lslplfdkda kplktledal rcfvqpkela ssdmccescg ektpwkqvlk
      241 lthlpqtlti hlmrfsarns rtekichsvn fpqsldfsqv lpteedlgdt keqseihyel
      301 faviahvgma dfghycayir npvdgkwfcf ndshvcwvtw kdvqctygnh ryrwretayl
      361 lvytktgs
//
