LOCUS       NM_001256973            1885 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 17-like E (Usp17le),
            mRNA.
ACCESSION   NM_001256973 XM_001476444 XM_890107
VERSION     NM_001256973.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Liu,T., Yu,J., Deng,M., Yin,Y., Zhang,H., Luo,K., Qin,B., Li,Y.,
            Wu,C., Ren,T., Han,Y., Yin,P., Kim,J., Lee,S., Lin,J., Zhang,L.,
            Zhang,J., Nowsheen,S., Wang,L., Boughey,J., Goetz,M.P., Yuan,J. and
            Lou,Z.
  TITLE     CDK4/6-dependent activation of DUB3 regulates cancer metastasis
            through SNAIL1
  JOURNAL   Nat Commun 8, 13923 (2017)
   PUBMED   28067227
  REMARK    GeneRIF: CDK4/CDK6-dependent activation of DUB3 regulates cancer
            metastasis through SNAIL1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   van der Laan,S., Golfetto,E., Vanacker,J.M. and Maiorano,D.
  TITLE     Cell cycle-dependent expression of Dub3, Nanog and the p160 family
            of nuclear receptor coactivators (NCoAs) in mouse embryonic stem
            cells
  JOURNAL   PLoS One 9 (4), e93663 (2014)
   PUBMED   24695638
  REMARK    GeneRIF: Using a reporter assay, we show that NCoA1 potentiates
            Esrrb-mediated transcription of Dub3 and we present evidence of
            protein interaction between the SRC1 splice variant NCoA1 and Esrrb
            Erratum:[PLoS One. 2014;9(8):e105649]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   van der Laan,S., Tsanov,N., Crozet,C. and Maiorano,D.
  TITLE     High Dub3 expression in mouse ESCs couples the G1/S checkpoint to
            pluripotency
  JOURNAL   Mol Cell 52 (3), 366-379 (2013)
   PUBMED   24207026
  REMARK    GeneRIF: We show that Dub3 expression is strongly downregulated
            during neural conversion and precedes Cdc25A destabilization, while
            forced Dub3 expression in ESCs becomes lethal upon differentiation
REFERENCE   4  (bases 1 to 1885)
  AUTHORS   Ramakrishna,S., Suresh,B., Kang,I.C. and Baek,K.H.
  TITLE     Polyclonal and monoclonal antibodies specific for USP17, a
            proapoptotic deubiquitinating enzyme
  JOURNAL   Hybridoma (Larchmt) 29 (4), 311-319 (2010)
   PUBMED   20715989
REFERENCE   5  (bases 1 to 1885)
  AUTHORS   Burrows,J.F., Scott,C.J. and Johnston,J.A.
  TITLE     The DUB/USP17 deubiquitinating enzymes: a gene family within a
            tandemly repeated sequence, is also embedded within the copy number
            variable beta-defensin cluster
  JOURNAL   BMC Genomics 11, 250 (2010)
   PUBMED   20403174
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1885)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   7  (bases 1 to 1885)
  AUTHORS   Baek,K.H., Mondoux,M.A., Jaster,R., Fire-Levin,E. and D'Andrea,A.D.
  TITLE     DUB-2A, a new member of the DUB subfamily of hematopoietic
            deubiquitinating enzymes
  JOURNAL   Blood 98 (3), 636-642 (2001)
   PUBMED   11468161
REFERENCE   8  (bases 1 to 1885)
  AUTHORS   Bain,G., Mansergh,F.C., Wride,M.A., Hance,J.E., Isogawa,A.,
            Rancourt,S.L., Ray,W.J., Yoshimura,Y., Tsuzuki,T., Gottlieb,D.I.
            and Rancourt,D.E.
  TITLE     ES cell neural differentiation reveals a substantial number of
            novel ESTs
  JOURNAL   Funct Integr Genomics 1 (2), 127-139 (2000)
   PUBMED   11793228
  REMARK    Erratum:[Funct Integr Genomics 2000 Nov;1(3):218-9]
REFERENCE   9  (bases 1 to 1885)
  AUTHORS   Zhu,Y., Lambert,K., Corless,C., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and D'Andrea,A.D.
  TITLE     DUB-2 is a member of a novel family of cytokine-inducible
            deubiquitinating enzymes
  JOURNAL   J Biol Chem 272 (1), 51-57 (1997)
   PUBMED   8995226
REFERENCE   10 (bases 1 to 1885)
  AUTHORS   Zhu,Y., Pless,M., Inhorn,R., Mathey-Prevot,B. and D'Andrea,A.D.
  TITLE     The murine DUB-1 gene is specifically induced by the betac subunit
            of interleukin-3 receptor
  JOURNAL   Mol Cell Biol 16 (9), 4808-4817 (1996)
   PUBMED   8756639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110621.6.
            
            On or before Mar 10, 2012 this sequence version replaced
            XM_001476444.2, XM_890107.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY749173.1, BY748110.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849383,
                                           SAMN01164134 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC110621.6         128528-128555       c
            29-130              AC110621.6         121665-121766       c
            131-1885            AC110621.6         119134-120888       c
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.69 cM"
     gene            1..1885
                     /gene="Usp17le"
                     /gene_synonym="DUB-3; Dub3; Dub6; EG625530; Gm6596; USP17;
                     USP17-E; Usp17l2"
                     /note="ubiquitin specific peptidase 17-like E"
                     /db_xref="GeneID:625530"
                     /db_xref="MGI:MGI:107697"
     CDS             1..1623
                     /gene="Usp17le"
                     /gene_synonym="DUB-3; Dub3; Dub6; EG625530; Gm6596; USP17;
                     USP17-E; Usp17l2"
                     /EC_number="3.4.19.12"
                     /note="deubiquitinating enzyme 6; ubiquitin
                     carboxyl-terminal hydrolase 17-like protein 2;
                     deubiquitinating protein 3; deubiquitinating protein 6;
                     ubiquitin thioesterase 17-like protein 2; deubiquitinating
                     enzyme 17-like protein 2; ubiquitin-specific-processing
                     protease 17-like protein 2; ubiquitin thiolesterase
                     17-like protein 2; deubiquitinating enzyme 3"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 17-like
                     protein E"
                     /protein_id="NP_001243902.1"
                     /db_xref="CCDS:CCDS85368.1"
                     /db_xref="GeneID:625530"
                     /db_xref="MGI:MGI:107697"
                     /translation="MVVSLSFPEETGGENLPSAPLEDSSKFFEEVFGDMVVALSFPEA
                     DPALSSPDAPELHQDEAQVVEELTTNGKHSLSWESPQGPGCGLQNTGNSCYLNAALQC
                     LTHTPPLADYMLSQEHSQTCCSPEGCKMCAMEAHVTQSLLHSHSGDVMKPSQILTSAF
                     HKHQQEDAHEFLMFTLETMHESCLQVHRQSDPTPQDTSPIHDIFGGWWRSQIKCLHCQ
                     GTSHTFDPFLDVPLDISSAQSVNQALWDTGKSEELLGENAYYCGRCRQKMPASKTLHV
                     HIAPKVLLLVLKRFSAFTGNKLDRKVSYPEFLDLKPYLSEPTGGPLPYALYAVLVHDG
                     ATSNSGHYFCCVKAGHGKWYKMDDTKVTRCDVTSVLNENAYVLFYVQQTDLKQVSIDM
                     PEGRVHEVLDPKYQLKKSRRKKRKKQCHCTDDAGEACENREKRAKKETSLGEGKVPQE
                     VNHEKAGQKHGNTKLVPQEQNHQRAGQNLRNTEVELDLPVDAIVIHQPRSTANWGTDA
                     PDKENQPWHNGDRLLTSQGLMSPGQLCSQGGR"
     exon            1..28
                     /gene="Usp17le"
                     /gene_synonym="DUB-3; Dub3; Dub6; EG625530; Gm6596; USP17;
                     USP17-E; Usp17l2"
                     /inference="alignment:Splign:2.1.0"
     exon            29..130
                     /gene="Usp17le"
                     /gene_synonym="DUB-3; Dub3; Dub6; EG625530; Gm6596; USP17;
                     USP17-E; Usp17l2"
                     /inference="alignment:Splign:2.1.0"
     exon            131..1885
                     /gene="Usp17le"
                     /gene_synonym="DUB-3; Dub3; Dub6; EG625530; Gm6596; USP17;
                     USP17-E; Usp17l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtggttt ctctttcctt cccagaagag actggagggg aaaatcttcc ttctgctccc
       61 ttagaagact ccagcaagtt ctttgaagag gtctttggag acatggtggt tgctctttcc
      121 ttcccagaag cagatccagc actatcatct cctgatgccc cagagctgca tcaggatgaa
      181 gctcaggtgg tggaggagct aactaccaat ggaaagcaca gtctgagttg ggagagtccc
      241 caaggaccag gatgcgggct ccagaacaca ggcaacagct gctacctgaa cgcagccctg
      301 cagtgcttga cacacacacc acctctagct gactacatgc tgtcccagga gcacagtcaa
      361 acctgttgtt ccccagaagg ctgtaagatg tgtgctatgg aagcccatgt gacccagagt
      421 ctcctgcact ctcactcggg ggatgtcatg aagccctccc agattttgac ctctgccttc
      481 cacaagcacc agcaggaaga tgcccatgag tttctcatgt tcaccttgga aacaatgcat
      541 gaatcctgcc ttcaagtgca cagacaatca gatcccaccc ctcaggatac gtcacccatt
      601 catgacatat ttggaggctg gtggaggtct cagatcaagt gtctccattg ccagggcacc
      661 tcacatacct tcgatccctt cctggatgtc cccctggata tcagctcagc tcagagtgta
      721 aatcaagcct tgtgggatac agggaagtca gaagagctac ttggagagaa tgcctactac
      781 tgtggtaggt gtagacagaa gatgccagct tctaagaccc tgcatgttca tattgctcca
      841 aaggtactcc tgctagtgtt aaagcgcttc tcagccttca cgggtaacaa gttagacaga
      901 aaagtaagct acccggagtt ccttgacctg aagccatacc tgtctgagcc tactggagga
      961 cctttgcctt atgccctcta tgccgtcctg gtccatgatg gtgcgacttc taacagtgga
     1021 cattacttct gttgtgtcaa agctggtcat gggaagtggt acaagatgga tgatactaag
     1081 gtcaccaggt gtgatgtgac ttctgtcctg aatgagaatg cctatgtgct cttctatgtg
     1141 cagcagaccg acctcaaaca ggtcagtatt gacatgccag agggcagagt acatgaggtt
     1201 cttgacccta aataccagct gaagaaatcc cggagaaaaa agcgtaagaa gcaatgccat
     1261 tgcacagatg atgccggaga ggcatgcgaa aacagggaga agagagcaaa gaaagaaacc
     1321 tccttagggg aggggaaagt gcctcaggaa gtgaaccacg agaaagctgg gcagaaacat
     1381 gggaatacca aactcgtgcc tcaggaacag aaccaccaga gagctgggca gaacctcagg
     1441 aatactgaag ttgaacttga tctgcctgtt gatgcaattg tgattcacca gcccagatcc
     1501 acagcaaact ggggcacgga tgctccagac aaagagaatc aaccctggca caatggtgac
     1561 aggctcctca cctctcaggg cctcatgagc cctgggcagc tctgtagtca gggtgggaga
     1621 tgaagatcga agaaggggaa gaacaagaac aagcaagggc agaggcttct gcttgtttgc
     1681 tagtgctcac ccacccactc acacaggctc ctgtggacac actgttgacc caaggtgcct
     1741 ggaacaagag gtttggatct ctgtttcagg cagggacaat gccttaccct tcacgtgggg
     1801 tccacatttc ctctgggtcc ttgcctgttt ttgctgactg actctctgat cgtttgaatg
     1861 tggaaaaaat gcccaggatg ttggt
//
