LOCUS       NM_024258               2926 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 16 (Usp16), mRNA.
ACCESSION   NM_024258
VERSION     NM_024258.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2926)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2926)
  AUTHORS   Tong,G., Chen,Y., Chen,X., Fan,J., Zhu,K., Hu,Z., Li,S., Zhu,J.,
            Feng,J., Wu,Z., Hu,Z., Zhou,B., Jin,L., Chen,H., Shen,J., Cong,W.
            and Li,X.
  TITLE     FGF18 alleviates hepatic ischemia-reperfusion injury via the
            USP16-mediated KEAP1/Nrf2 signaling pathway in male mice
  JOURNAL   Nat Commun 14 (1), 6107 (2023)
   PUBMED   37777507
  REMARK    GeneRIF: FGF18 alleviates hepatic ischemia-reperfusion injury via
            the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2926)
  AUTHORS   Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y.,
            Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
  REMARK    GeneRIF: USP16-mediated histone H2A lysine-119 deubiquitination
            during oocyte maturation is a prerequisite for zygotic genome
            activation.
REFERENCE   4  (bases 1 to 2926)
  AUTHORS   Reinitz,F., Chen,E.Y., Nicolis di Robilant,B., Chuluun,B.,
            Antony,J., Jones,R.C., Gubbi,N., Lee,K., Ho,W.H.D., Kolluru,S.S.,
            Qian,D., Adorno,M., Piltti,K., Anderson,A., Monje,M., Heller,H.C.,
            Quake,S.R. and Clarke,M.F.
  TITLE     Inhibiting USP16 rescues stem cell aging and memory in an
            Alzheimer's model
  JOURNAL   Elife 11, e66037 (2022)
   PUBMED   35311644
  REMARK    GeneRIF: Inhibiting USP16 rescues stem cell aging and memory in an
            Alzheimer's model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2926)
  AUTHORS   Xu,G., Yang,Z., Ding,Y., Liu,Y., Zhang,L., Wang,B., Tang,M.,
            Jing,T., Jiao,K., Xu,X., Chen,Z., Xiang,L., Xu,C., Fu,Y., Zhao,X.,
            Jin,W. and Liu,Y.
  TITLE     The deubiquitinase USP16 functions as an oncogenic factor in
            K-RAS-driven lung tumorigenesis
  JOURNAL   Oncogene 40 (36), 5482-5494 (2021)
   PUBMED   34294846
REFERENCE   6  (bases 1 to 2926)
  AUTHORS   Yang,W., Lee,Y.H., Jones,A.E., Woolnough,J.L., Zhou,D., Dai,Q.,
            Wu,Q., Giles,K.E., Townes,T.M. and Wang,H.
  TITLE     The histone H2A deubiquitinase Usp16 regulates embryonic stem cell
            gene expression and lineage commitment
  JOURNAL   Nat Commun 5, 3818 (2014)
   PUBMED   24784029
  REMARK    GeneRIF: study identifies Usp16 and H2A deubiquitination as
            critical regulators of ESC gene expression and differentiation
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2926)
  AUTHORS   Adorno,M., Sikandar,S., Mitra,S.S., Kuo,A., Nicolis Di Robilant,B.,
            Haro-Acosta,V., Ouadah,Y., Quarta,M., Rodriguez,J., Qian,D.,
            Reddy,V.M., Cheshier,S., Garner,C.C. and Clarke,M.F.
  TITLE     Usp16 contributes to somatic stem-cell defects in Down's syndrome
  JOURNAL   Nature 501 (7467), 380-384 (2013)
   PUBMED   24025767
  REMARK    GeneRIF: results suggest that USP16 has an important role in
            antagonizing the self-renewal and/or senescence pathways in Down's
            syndrome and could serve as an attractive target to ameliorate some
            of the associated pathologies
REFERENCE   8  (bases 1 to 2926)
  AUTHORS   Frangini,A., Sjoberg,M., Roman-Trufero,M., Dharmalingam,G.,
            Haberle,V., Bartke,T., Lenhard,B., Malumbres,M., Vidal,M. and
            Dillon,N.
  TITLE     The aurora B kinase and the polycomb protein ring1B combine to
            regulate active promoters in quiescent lymphocytes
  JOURNAL   Mol Cell 51 (5), 647-661 (2013)
   PUBMED   24034696
REFERENCE   9  (bases 1 to 2926)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   10 (bases 1 to 2926)
  AUTHORS   Kubota,H., Yokota,S., Yanagi,H. and Yura,T.
  TITLE     Structures and co-regulated expression of the genes encoding mouse
            cytosolic chaperonin CCT subunits
  JOURNAL   Eur J Biochem 262 (2), 492-500 (1999)
   PUBMED   10336634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154631.2, AK160038.1 and BE853521.1.
            
            On Jul 8, 2009 this sequence version replaced NM_024258.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003278.1, AK160038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC154631.2         121696-121726       c
            32-446              AK160038.1         2-416
            447-447             AC154631.2         111926-111926       c
            448-676             AK160038.1         418-646
            677-677             AC154631.2         106964-106964       c
            678-2606            AK160038.1         648-2576
            2607-2607           AC154631.2         93510-93510         c
            2608-2917           AK160038.1         2578-2887
            2918-2926           BE853521.1         1-9                 c
FEATURES             Location/Qualifiers
     source          1..2926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 49.54 cM"
     gene            1..2926
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /note="ubiquitin specific peptidase 16"
                     /db_xref="GeneID:74112"
                     /db_xref="MGI:MGI:1921362"
     exon            1..118
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            119..220
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2637
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 16;
                     ubiquitin-specific-processing protease 16;
                     deubiquitinating enzyme 16; ubiquitin thioesterase 16;
                     ubiquitin thiolesterase 16"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 16"
                     /protein_id="NP_077220.2"
                     /db_xref="CCDS:CCDS28291.1"
                     /db_xref="GeneID:74112"
                     /db_xref="MGI:MGI:1921362"
                     /translation="MGKKRTKGRSAPDTVASESAEPVCRHLRKGLEQGNLKKALVNVE
                     WNICQDCKTDNKVKDKPEEEAEDPSVWLCLKCGHQGCGRDSQEQHALKHYTTPRSEPH
                     YLVLSLDNWSVWCYKCDEEVKYCSSNRLGQVVDYVRKQAGVRTSKPAEKNNGHIELEN
                     KKLEKESKNEQEREKSENLAKETIPMDSASQITVKGLSNLGNTCFFNAVMQNLSQTPV
                     LRELLKEVKMSGTIVKIEPPDLALTEPLEVNLEPPGPLTLAMSQFLSEMQENKKRVVT
                     PKELFSQVCKKATRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLD
                     EEVKNKVKDYEKKKAIPSFVDRIFGGELTSTIMCDECRTVSLVHESFLDLSLPVLDDQ
                     SGKKSINDKNVKMTMEEEDKDSEEEKDDSYMKSRSDLPSGTSKHLQKKAKKQAKKQAK
                     NQRRQQKIQERFLHFNELCATDYTEDNEREADTALAGEVEVDTDSTHGSQEEATQIEL
                     SVNQKDLDGQESMIERTPDVQESPEDLGVKSANTESDLGIVTPAPECPRDFNGAFLEE
                     RTSGELDIINGLKNLNLNAAVDPDEINIEIPNDSHSAPKVYEVMNEDPETAFCTLANR
                     EAFSTDECSIQHCLYQFTRNEKLQDANKLLCEVCSRRQCNGPKANIKGDRRHVYTNAK
                     KQMLVSLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEESTR
                     VLYSLYGVVEHSGTMRSGHYTAYAKERTASCHLSNLVLHGDIPQDCEMESTKGQWFHI
                     SDTHVQAVPITKVLNSQAYLLFYERIL"
     exon            221..396
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            397..500
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            501..604
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            605..792
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            793..888
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1019
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1107
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1186
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1278
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1335
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1509
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2173
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2268
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2355
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2512
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2921
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /note="hexamer: AATAAA"
     polyA_site      2921
                     /gene="Usp16"
                     /gene_synonym="1200004E02Rik; 2810483I07Rik;
                     6330514E22Rik; UBPM"
                     /note="major polyA site"
ORIGIN      
        1 tctccgggag ggtggctggt tccaccgcgt cgctctctct gcgtcacctg gaggaagcgg
       61 agctggcggc cggctccggg cccgtcgcgg gaggcagtta tgggcgccgt cgccccggat
      121 tgtaactttg tgtcagcgtg cagtccataa agtgccagca tggggaagaa acggaccaag
      181 gggagaagtg ctccagacac ggtggcctca gagtctgcag aaccagtgtg cagacacctt
      241 agaaaagggt tggaacaagg taatttgaaa aaagctttag taaatgtgga gtggaatatc
      301 tgccaagact gtaagactga caataaagtg aaagataaac ctgaggagga agcagaagac
      361 ccttcggttt ggctctgtct taaatgtggc catcagggct gtggcagaga ttctcaggag
      421 cagcatgcct tgaagcacta cacgacaccg agatccgagc ctcactacct ggtgctcagt
      481 ctggacaact ggagcgtctg gtgctacaag tgtgacgagg aagtcaagta ctgtagctca
      541 aaccgattgg gccaagtggt tgattatgtt agaaaacaag ctggcgtaag aacttcaaaa
      601 ccagcagaga aaaataatgg acacattgag ctcgaaaata aaaaattgga gaaagagagt
      661 aaaaatgaac aagagagaga gaaatcggaa aacctggcta aagaaactat tcccatggac
      721 tctgcttccc agataactgt gaaaggactc agtaatttgg ggaatacttg tttcttcaat
      781 gcagttatgc agaacttgtc acaaacgcca gtgcttagag aactactaaa agaagtgaag
      841 atgtctggaa cgattgtaaa aatagagcca cctgatctgg cactaacaga acctttagaa
      901 gtaaacctcg agcctccagg tcctcttact ttagccatga gccagtttct cagtgagatg
      961 caagagaaca aaaagcgagt tgtgacacct aaagagctct tttctcaggt ctgtaaaaaa
     1021 gcaacacgtt ttaaagggta ccagcaacaa gacagccagg agctgcttcg ctacctactg
     1081 gatgggatga gagcggaaga acaccaaaga gtgagtaaag gaattcttaa agcatttggt
     1141 aattctactg aaaaattgga tgaagaagta aaaaataaag ttaaagatta tgaaaagaaa
     1201 aaggcaatcc cgagttttgt ggaccgcatc tttggtggcg agctgactag tacgatcatg
     1261 tgtgatgaat gcaggactgt ctccttagtg catgaatcgt tccttgattt gtctcttcca
     1321 gttttagatg atcagagtgg taagaaaagt ataaatgata aaaatgtgaa aatgacaatg
     1381 gaggaagaag ataaagacag tgaggaagag aaagatgaca gctacatgaa atcaaggagc
     1441 gatcttccgt cagggacaag caagcaccta cagaaaaagg caaagaagca ggccaaaaag
     1501 caggccaaga accaacgaag gcaacaaaaa attcaagaaa gatttcttca cttcaatgag
     1561 ctctgcgcca ctgactacac ggaagacaat gaacgtgaag ctgacacagc acttgcggga
     1621 gaagtggaag tggataccga ctccacccat ggttctcaag aggaggccac acagatagag
     1681 ctgtctgtta accagaagga tttggatggc caagagagca tgatagaaag gacacctgat
     1741 gtgcaggaaa gcccagagga cctaggagtg aaaagtgcta acaccgagag tgatctgggg
     1801 attgtgacgc ctgctcctga atgtcctagg gatttcaatg gtgccttcct ggaagaaagg
     1861 accagtggag aactagacat tatcaatggt ttaaaaaacc ttaatttgaa tgctgctgtt
     1921 gatcctgatg aaataaatat agagattccg aatgacagtc attctgcacc caaggtatat
     1981 gaggtcatga acgaggaccc agaaactgct ttctgtaccc tcgcgaaccg agaagcgttt
     2041 agtactgatg agtgttccat tcaacattgc ttatatcagt tcacccggaa tgagaaactt
     2101 caagatgcca ataaactgct ttgtgaagtg tgttcaagac ggcagtgtaa tggaccaaag
     2161 gcaaatataa aaggtgacag gagacatgtt tacaccaatg ccaagaagca gatgctggtc
     2221 tccctcgcgc ctcctgtcct cactctgcat ttaaagcgat tccagcaggc tggttttaac
     2281 ctgcgcaaag ttaacaaaca cataaagttt ccagaaatct tagatttggc tcctttttgt
     2341 acccttaaat gtaagaatgt tgctgaagaa agtacacgag tgctgtattc cttatatgga
     2401 gttgttgaac acagtggtac tatgaggtca gggcattaca ctgcctatgc gaaggagaga
     2461 actgcaagct gtcacctctc caatcttgtt cttcacggtg acattccaca agattgtgaa
     2521 atggaatcaa ccaaagggca gtggtttcac atcagcgata cacatgtgca agctgtgcct
     2581 ataactaaag tactgaactc acaagcgtat ctcctatttt atgagagaat actgtgataa
     2641 caaaaagtgc tttctctgga aatacaccta tggcttttat actggctatt ataacaataa
     2701 aaagttaaac tataaattat gttcacctaa gtaaatgaca gaaaaaaaat catgtttatt
     2761 tatttaaata caggcaaaat aatttacagc ggttttgtat tagcatactg gtttttattc
     2821 cttctagttt caactttagg aaggatttga ataactaagt tctgtgctta ctctgactgg
     2881 gtggtagtgc ttgacacatc aataaactga tattcccaaa aaaaaa
//
